Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| IHH | 3549 | Indian hedgehog homolog (Drosophila) | 2 | BDA1; HHG2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15170664 | 2004 | Cell line : AA/C1, RG/C2,CaCo 2, HT 29 and SW 480 Source : - Sample Type : - No. of Sample : - Stage : - | RT-PCR, Western Blotting | Methylation | - | The adenoma-derived cell lines exhibited higher levels of IHH expression than the carcinoma-derived cell lines. |
| 19856079 | 2010 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 25 Stage : TNM stage I-IV | RT-PCR,Immunohistochemistry, Methylation speicifRT-PCR and Bisulfate sequencing | Methylation | - | IHH promoter was hypermethylated in colon cancer cell lines. |
| 20854074 | 2010 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 36 CRCs, 21 hyperplastic polyps and 32 colorectal adenoma Stage : - | RT-PCR, Immunohistochemistry | Methylation | - | Down-regulation of IHH expression as a result of hypermethylation, may be an early event in colorectal carcinogenesiss. |
| 17683069 | 2007 | Cell line : SW 480, Colo 320, HCT 116 cells, Colo205, HT 29 and WiDr Source : - Sample Type : - No. of Sample : - Stage : - | RT-PCR, Western blotting | Unknown | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the hedgehog family of secreted signaling molecules. Hedgehog proteins are essential regulators of a variety of developmental processes including growth, patterning and morphogenesis. The encoded protein specifically plays a role in bone growth an differentiation. Mutations in this gene are the cause of brachydactyly type A1 which is characterized by shortening or malformation of the phalanges. Mutations in this gene are also the cause of acrocapitofemoral dysplasia. [provided by RefSeq, Feb 2010] | Chromosome | 2 |
| Location | 2q33-q35 |
| Start | 219054420 |
| End | 219060516 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 6097 |
| OMIM ID | 600726 |
| HGNC ID | HGNC:5956 |
| Unigene ID | Hs.654504 |
| Ensembl ID | ENSG00000163501 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_002181.3 |
|---|---|
| Exon | join(1..364,2823..3084,4652..6097) | mRNA Sequence | Download Select all |
| Length | 2074 |
CDS Information
| Location | join(50..364,2823..3084,4652..5310) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS33380.1 |
Protein Information
| Protein ID | NP_002172.2 |
|---|---|
| Protein Name | Indian hedgehog homolog (Drosophila) |
| Molecular Wt. (Da) | 42226 |
| Protein Sequence | Download Select all |
| Length | 411 |
| Uniprot ID | P30279 |
| Ensembl Protein ID | ENSP00000261254 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 64399 | HHIP | 6937 | NP_071920.1 | in vivo | 1 005 085 511 435 700 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Hedgehog signaling pathway | hsa04340 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00081 | 203-347 | Hint |
| cl22434 | 203-347 | Hint superfamily |
| pfam01085 | 44-189 | HH_signal |
| cl03090 | 44-189 | HH_signal superfamily |
| smart00306 | 202-307 | HintN |
| smart00305 | 311-351 | HintC |
| cl22898 | 311-351 | HintC superfamily |
| pfam01079 | 192-386 | Hint |
| pfam05203 | 203-324 | Hom_end_hint |
Ontology Information
| HPRD ID | 3345 |
|---|---|
| Molecular Class | Ligand |
| Molecular Function | Kinase regulator activity (GO:0019207) |
| Biological Process | Regulation of cell cycle (GO:0000074) |
Drug Information
No matching records could be found.