Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| IKBKB | 3551 | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 8 | IKK2, NFKBIKB, IKK-beta, IKKB |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17190815 | 2007 | Cell line : HEK 293, HS27, HT 29, HT 29 M6, HCT 116, CaCo2, SW480, MCF7 Source : - Sample Type : CRC Tumor No. of Sample : 6 Stage : - | Cell Fractionation,EMSA,Protein Kinase Assays,Immunofluorescence,Luciferase Assays,Chromatin immunoprecepetation Assay,Flow Cytometry, real time RT-PCR | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011] | Chromosome | 8 |
| Location | 8p11.2 |
| Start | 42128820 |
| End | 42190171 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 61352 |
| OMIM ID | 603258 |
| HGNC ID | HGNC:5960 |
| Unigene ID | Hs.597664 |
| Ensembl ID | ENSG00000104365 |
| PharmGKB ID | PA29776 |
mRNA Information
| mRNA ID | NM_001556.2 |
|---|---|
| Exon | join(1..168,782..904,17333..17427,18855..18972, 22142..22211,33886..33974,35042..35131,37600..37724, 43021..43128,44909..45038,45409..45603,46356..46470, 47251..47374,47969..48120,48284..48345,49434..49543, 50595..50644,50753..50852,51046..51193,54669..54796, 57823..57913,59613..61352) | mRNA Sequence | Download Select all |
| Length | 4131 |
Protein Information
| Protein ID | NP_001547.1 |
|---|---|
| Protein Name | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta |
| Molecular Wt. (Da) | 86433 |
| Protein Sequence | Download Select all |
| Length | 756 |
| Uniprot ID | P15907 |
| Ensembl Protein ID | ENSP00000169298 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 177 |
| S | Phosphorylation | 181 |
| S | Phosphorylation | 177 |
| S | Phosphorylation | 181 |
| S | Phosphorylation | 177 |
| S | Phosphorylation | 181 |
| S | Phosphorylation | 670 |
| S | Phosphorylation | 672 |
| S | Phosphorylation | 675 |
| S | Phosphorylation | 679 |
| S | Phosphorylation | 682 |
| S | Phosphorylation | 689 |
| S | Phosphorylation | 692 |
| S | Phosphorylation | 695 |
| S | Phosphorylation | 697 |
| S | Phosphorylation | 705 |
| S | Phosphorylation | 733 |
| S | Phosphorylation | 740 |
| S | Phosphorylation | 750 |
| S | Phosphorylation | 756 |
| S | Dephosphorylation | 177 |
| S | Dephosphorylation | 181 |
| S | Phosphorylation | 177 |
| S | Phosphorylation | 181 |
| S | Phosphorylation | 177 |
| S | Phosphorylation | 181 |
| C | Phosphorylation | 179 |
| S | Phosphorylation | 177 |
| S | Phosphorylation | 181 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 841 | CASP8 | 3459 | NP_001073594.1 | in vivo | 11002417 |
| 1499 | CTNNB1 | 286 | NP_001895.1 | in vitro;in vivo | 11527961 |
| 3320 | HSP90AA1 | 777 | NP_001017963.2 | in vivo | 11864612 |
| 3326 | HSP90AB1 | 6763 | NP_031381.2 | in vitro | 14743216 |
| 3667 | IRS1 | 943 | NP_005535.1 | in vitro;in vivo | 123 516 581 160 656 000 000 000 |
| 4296 | MAP3K11 | 2502 | NP_002410.1 | in vivo | 10713178 |
| 4790 | NFKB1 | 1238 | NP_003989.2 | in vitro;in vivo | 104 696 551 115 829 000 000 000 |
| 4792 | NFKBIA | 1235 | NP_065390.1 | in vitro | 97 211 031 631 905 800 000 000 |
| 4793 | NFKBIB | 7260 | NP_002494.2 | in vitro | 96 890 789 721 103 |
| 5037 | PEBP1 | 6850 | NP_002558.1 | in vivo | 11585904 |
| 5588 | PRKCQ | 2710 | NP_006248.1 | in vivo | 11120819 |
| 5610 | EIF2AK2 | 1468 | NP_002750.1 | in vitro;in vivo | 10848580 |
| 5970 | RELA | 1241 | NP_068810.3 | in vitro;in vivo | 1 052 140 916 046 470 |
| 7046 | TGFBR1 | 1822 | NP_004603.1 | in vivo | 15761153 |
| 7128 | TNFAIP3 | 1857 | NP_006281.1 | in vitro;in vivo | 11594795 |
| 7186 | TRAF2 | 3538 | NP_066961.2 | in vitro | 11359906 |
| 7529 | YWHAB | 3184 | NP_003395.1 | in vitro | 16024783 |
| 8202 | NCOA3 | 3570 | NP_858045.1 | in vitro | 119 719 851 613 581 000 000 000 |
| 29110 | TBK1 | 5322 | NP_037386.1 | in vitro | 14560022 |
| 55620 | STAP2 | 7430 | NP_060190.2 | in vivo | 16365431 |
| 57805 | KIAA1967 | 9159 | NP_066997.3 | in vitro | 14743216 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Acute myeloid leukemia | hsa05221 |
| Adipocytokine signaling pathway | hsa04920 |
| Apoptosis | hsa04210 |
| B cell receptor signaling pathway | hsa04662 |
| Chagas disease (American trypanosomiasis) | hsa05142 |
| Chemokine signaling pathway | hsa04062 |
| Chronic myeloid leukemia | hsa05220 |
| Cytosolic DNA-sensing pathway | hsa04623 |
| Epithelial cell signaling in Helicobacter pylori infection | hsa05120 |
| Epstein-Barr virus infection | hsa05169 |
| FoxO signaling pathway | hsa04068 |
| Hepatitis B | hsa05161 |
| Hepatitis C | hsa05160 |
| Herpes simplex infection | hsa05168 |
| HTLV-I infection | hsa05166 |
| Influenza A | hsa05164 |
| Insulin resistance | hsa04931 |
| Insulin signaling pathway | hsa04910 |
| MAPK signaling pathway | hsa04010 |
| MicroRNAs in cancer | hsa05206 |
| mTOR signaling pathway | hsa04150 |
| Neurotrophin signaling pathway | hsa04722 |
| NF-kappa B signaling pathway | hsa04064 |
| NOD-like receptor signaling pathway | hsa04621 |
| Non-alcoholic fatty liver disease (NAFLD) | hsa04932 |
| Osteoclast differentiation | hsa04380 |
| Pancreatic cancer | hsa05212 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Prostate cancer | hsa05215 |
| Ras signaling pathway | hsa04014 |
| RIG-I-like receptor signaling pathway | hsa04622 |
| Shigellosis | hsa05131 |
| Small cell lung cancer | hsa05222 |
| T cell receptor signaling pathway | hsa04660 |
| TNF signaling pathway | hsa04668 |
| Toll-like receptor signaling pathway | hsa04620 |
| Toxoplasmosis | hsa05145 |
| Type II diabetes mellitus | hsa04930 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd14038 | 20-309 | STKc_IKK_beta |
| cl21453 | 20-309 | PKc_like superfamily |
| cd13989 | 21-308 | STKc_IKK |
| cd14039 | 21-308 | STKc_IKK_alpha |
| cd00180 | 21-215 | PKc |
| cd14014 | 19-288 | STKc_PknB_like |
| cd05117 | 15-222 | STKc_CAMK |
| cd05123 | 21-222 | STKc_AGC |
| cd14003 | 15-222 | STKc_AMPK-like |
| cd14009 | 21-222 | STKc_ATG1_ULK_like |
| cd13999 | 21-227 | STKc_MAP3K-like |
| cd08215 | 19-222 | STKc_Nek |
| cd05122 | 15-222 | PKc_STE |
| cd06606 | 15-290 | STKc_MAPKKK |
| cd14098 | 15-222 | STKc_Rad53_Cds1 |
| cd14007 | 16-225 | STKc_Aurora |
| cd14084 | 17-222 | STKc_Chk2 |
| cd13988 | 21-323 | STKc_TBK1 |
| cd14120 | 21-222 | STKc_ULK1_2-like |
| cd14201 | 10-225 | STKc_ULK2 |
| cd14002 | 19-231 | STKc_STK36 |
| cd14121 | 19-222 | STKc_ULK3 |
| cd14202 | 18-222 | STKc_ULK1 |
| cd05581 | 19-222 | STKc_PDK1 |
| cd14006 | 21-223 | STKc_MLCK-like |
| cd05578 | 22-222 | STKc_Yank1 |
| cd14073 | 15-222 | STKc_NUAK |
| cd06623 | 16-231 | PKc_MAPKK_plant_like |
| cd06614 | 19-223 | STKc_PAK |
| cd14137 | 19-224 | STKc_GSK3 |
| cd07829 | 16-288 | STKc_CDK_like |
| cd07838 | 19-216 | STKc_CDK4_6_like |
| cd14008 | 21-249 | STKc_LKB1_CaMKK |
| cd05118 | 20-288 | STKc_CMGC |
| cd14083 | 15-222 | STKc_CaMKI |
| cd00192 | 19-217 | PTKc |
| cd05580 | 16-222 | STKc_PKA_like |
| cd13996 | 21-219 | STKc_EIF2AK |
| cd14077 | 13-290 | STKc_Kin1_2 |
| cd05572 | 21-222 | STKc_cGK |
| cd07830 | 16-224 | STKc_MAK_like |
| cd14072 | 21-222 | STKc_MARK |
| cd08217 | 14-254 | STKc_Nek2 |
| cd14167 | 15-222 | STKc_CaMKI_alpha |
| cd14093 | 14-234 | STKc_PhKG |
| cd08218 | 19-222 | STKc_Nek1 |
| cd14091 | 15-222 | STKc_RSK_C |
| cd08529 | 15-222 | STKc_FA2-like |
| cd06610 | 14-222 | STKc_OSR1_SPAK |
| cd06627 | 19-222 | STKc_Cdc7_like |
| cd14078 | 12-222 | STKc_MELK |
| cd14081 | 13-222 | STKc_BRSK1_2 |
| cd14089 | 18-225 | STKc_MAPKAPK |
| cd05579 | 24-222 | STKc_MAST_like |
| cd05038 | 21-288 | PTKc_Jak_rpt2 |
| cd14099 | 21-222 | STKc_PLK |
| cd14169 | 14-254 | STKc_CaMKI_beta |
| cd14194 | 15-223 | STKc_DAPK1 |
| cd14166 | 18-222 | STKc_CaMKI_gamma |
| cd14105 | 15-223 | STKc_DAPK |
| cd13990 | 21-222 | STKc_TLK |
| cd14059 | 21-222 | STKc_MAP3K12_13 |
| cd06626 | 15-227 | STKc_MEKK4 |
| cd14196 | 15-223 | STKc_DAPK2 |
| cd14103 | 21-223 | STKc_MLCK |
| cd14190 | 18-223 | STKc_MLCK2 |
| cd14096 | 15-222 | STKc_RCK1-like |
| cd14069 | 15-221 | STKc_Chk1 |
| cd07836 | 19-224 | STKc_Pho85 |
| cd05630 | 21-247 | STKc_GRK6 |
| cd14663 | 15-222 | STKc_SnRK3 |
| cd08223 | 14-217 | STKc_Nek4 |
| cd13983 | 19-237 | STKc_WNK |
| cd14195 | 15-223 | STKc_DAPK3 |
| cd06612 | 16-228 | STKc_MST1_2 |
| cd05605 | 21-260 | STKc_GRK4_like |
| cd06647 | 19-230 | STKc_PAK_I |
| cd05631 | 21-256 | STKc_GRK4 |
| cd14074 | 13-222 | STKc_SNRK |
| cd07841 | 15-224 | STKc_CDK7 |
| cd07845 | 20-290 | STKc_CDK10 |
| cd08225 | 15-225 | STKc_Nek5 |
| cd14075 | 13-222 | STKc_NIM1 |
| cd05574 | 19-222 | STKc_phototropin_like |
| cd05577 | 21-258 | STKc_GRK |
| cd05612 | 16-222 | STKc_PRKX_like |
| cd14161 | 15-222 | STKc_NUAK2 |
| cd07833 | 13-224 | STKc_CDKL |
| cd08530 | 21-222 | STKc_CNK2-like |
| cd14113 | 21-223 | STKc_Trio_C |
| cd06632 | 15-241 | STKc_MEKK1_plant |
| cd14061 | 21-222 | STKc_MLK |
| cd14168 | 15-254 | STKc_CaMKI_delta |
| cd14209 | 15-259 | STKc_PKA |
| cd05041 | 19-226 | PTKc_Fes_like |
| cd08219 | 15-227 | STKc_Nek3 |
| cd06628 | 15-230 | STKc_Byr2_like |
| cd14097 | 20-223 | STKc_STK33 |
| cd06605 | 16-231 | PKc_MAPKK |
| cd05584 | 21-222 | STKc_p70S6K |
| cd14095 | 21-222 | STKc_DCKL |
| cd14086 | 15-222 | STKc_CaMKII |
| cd05582 | 21-222 | STKc_RSK_N |
| cd06609 | 19-221 | STKc_MST3_like |
| cd06621 | 16-228 | PKc_Pek1_like |
| cd14082 | 19-222 | STKc_PKD |
| cd14106 | 18-222 | STKc_DRAK |
| cd07840 | 16-290 | STKc_CDK9_like |
| cd14191 | 15-223 | STKc_MLCK1 |
| cd07834 | 21-224 | STKc_MAPK |
| cd14010 | 61-223 | STKc_ULK4 |
| cd05632 | 21-248 | STKc_GRK5 |
| cd06608 | 13-222 | STKc_myosinIII_N_like |
| cd13978 | 21-237 | STKc_RIP |
| cd14172 | 18-225 | STKc_MAPKAPK3 |
| cd14066 | 21-222 | STKc_IRAK |
| cd05570 | 96-222 | STKc_PKC |
| cd06613 | 15-214 | STKc_MAP4K3_like |
| cd05607 | 21-222 | STKc_GRK7 |
| cd13994 | 21-222 | STKc_HAL4_like |
| cd14087 | 15-222 | STKc_PSKH1 |
| cd08220 | 18-222 | STKc_Nek8 |
| cd14052 | 19-290 | PTKc_Wee1_fungi |
| cd13993 | 16-292 | STKc_Pat1_like |
| cd08224 | 15-222 | STKc_Nek6_7 |
| cd06611 | 15-308 | STKc_SLK_like |
| cd05080 | 16-217 | PTKc_Tyk2_rpt2 |
| cd14193 | 16-223 | STKc_MLCK4 |
| cd13997 | 19-237 | PKc_Wee1_like |
| cd05603 | 21-222 | STKc_SGK2 |
| cd14176 | 8-290 | STKc_RSK2_C |
| cd14178 | 14-222 | STKc_RSK3_C |
| cd07877 | 15-224 | STKc_p38alpha |
| cd14114 | 15-222 | STKc_Twitchin_like |
| cd14185 | 15-222 | STKc_DCKL3 |
| cd14210 | 16-224 | PKc_DYRK |
| cd05600 | 21-222 | STKc_Sid2p_like |
| cd06654 | 19-230 | STKc_PAK1 |
| cd08221 | 21-222 | STKc_Nek9 |
| cd07832 | 15-218 | STKc_CCRK |
| cd07851 | 14-224 | STKc_p38 |
| cd14117 | 15-222 | STKc_Aurora-B_like |
| cd14092 | 19-244 | STKc_MSK_C |
| cd05608 | 15-256 | STKc_GRK1 |
| cd07863 | 15-214 | STKc_CDK4 |
| cd14192 | 19-259 | STKc_MLCK3 |
| cd06624 | 16-222 | STKc_ASK |
| cd05575 | 128-222 | STKc_SGK |
| cd13987 | 21-234 | STKc_SBK1 |
| cd07839 | 15-224 | STKc_CDK5 |
| cd14184 | 21-279 | STKc_DCKL2 |
| cd06656 | 19-230 | STKc_PAK3 |
| cd14079 | 13-222 | STKc_AMPK_alpha |
| cd14145 | 17-222 | STKc_MLK1 |
| cd14146 | 21-222 | STKc_MLK4 |
| cd05595 | 21-222 | STKc_PKB_beta |
| cd05573 | 21-222 | STKc_ROCK_NDR_like |
| cd14116 | 15-222 | STKc_Aurora-A |
| cd05056 | 16-290 | PTKc_FAK |
| cd06655 | 19-230 | STKc_PAK2 |
| cd14148 | 21-222 | STKc_MLK2 |
| cd06648 | 20-290 | STKc_PAK_II |
| cd14076 | 13-222 | STKc_Kin4 |
| cd14048 | 15-219 | STKc_EIF2AK3_PERK |
| cd05604 | 21-222 | STKc_SGK3 |
| cd08528 | 15-222 | STKc_Nek10 |
| cd14058 | 21-222 | STKc_TAK1 |
| cd14147 | 17-222 | STKc_MLK3 |
| cd07855 | 15-278 | STKc_ERK5 |
| cd05571 | 21-222 | STKc_PKB |
| cd07880 | 14-290 | STKc_p38gamma |
| cd14665 | 15-250 | STKc_SnRK2-3 |
| cd14094 | 12-223 | STKc_CASK |
| cd14080 | 17-222 | STKc_TSSK-like |
| cd14198 | 18-222 | STKc_DRAK2 |
| cd07846 | 15-224 | STKc_CDKL2_3 |
| cd07856 | 21-288 | STKc_Sty1_Hog1 |
| cd14164 | 19-222 | STKc_TSSK6-like |
| cd13979 | 19-222 | STKc_Mos |
| cd14175 | 17-222 | STKc_RSK1_C |
| cd06629 | 14-221 | STKc_Bck1_like |
| cd13985 | 21-225 | STKc_GAK_like |
| cd05602 | 21-222 | STKc_SGK1 |
| cd14183 | 15-279 | STKc_DCKL1 |
| cd07879 | 14-218 | STKc_p38delta |
| cd06630 | 15-222 | STKc_MEKK1 |
| cd07847 | 15-218 | STKc_CDKL1_4 |
| cd14070 | 13-222 | STKc_HUNK |
| cd14071 | 15-222 | STKc_SIK |
| cd07860 | 19-217 | STKc_CDK2_3 |
| cd06643 | 15-285 | STKc_SLK |
| cd05592 | 96-222 | STKc_nPKC_theta_like |
| cd08222 | 15-214 | STKc_Nek11 |
| cd05601 | 94-222 | STKc_CRIK |
| cd14047 | 19-214 | STKc_EIF2AK2_PKR |
| cd05589 | 21-222 | STKc_PKN |
| cd05084 | 19-222 | PTKc_Fes |
| cd14046 | 19-214 | STKc_EIF2AK4_GCN2_rpt2 |
| cd07843 | 20-224 | STKc_CDC2L1 |
| cd14119 | 21-222 | STKc_LKB1 |
| cd14085 | 15-222 | STKc_CaMKIV |
| cd05620 | 21-222 | STKc_nPKC_delta |
| cd06917 | 19-222 | STKc_NAK1_like |
| cd05587 | 21-222 | STKc_cPKC |
| cd05593 | 21-222 | STKc_PKB_gamma |
| cd05616 | 21-222 | STKc_cPKC_beta |
| cd05590 | 21-222 | STKc_nPKC_eta |
| cd14065 | 21-216 | PKc_LIMK_like |
| cd07849 | 15-224 | STKc_ERK1_2_like |
| cd14177 | 15-228 | STKc_RSK4_C |
| cd14180 | 21-222 | STKc_MSK2_C |
| cd07831 | 20-224 | STKc_MOK |
| cd14040 | 21-254 | STKc_TLK1 |
| cd05591 | 21-222 | STKc_nPKC_epsilon |
| cd05615 | 21-222 | STKc_cPKC_alpha |
| cd07835 | 19-224 | STKc_CDK1_CdkB_like |
| cd07866 | 15-290 | STKc_BUR1 |
| cd14187 | 21-308 | STKc_PLK1 |
| cd14205 | 19-217 | PTKc_Jak2_rpt2 |
| cd06644 | 15-214 | STKc_STK10 |
| cd06631 | 15-221 | STKc_YSK4 |
| cd06620 | 21-222 | PKc_Byr1_like |
| cd05613 | 15-299 | STKc_MSK1_N |
| cd05619 | 21-222 | STKc_nPKC_theta |
| cd14181 | 15-234 | STKc_PhKG2 |
| cd06639 | 13-230 | STKc_myosinIIIB_N |
| cd14662 | 15-222 | STKc_SnRK2 |
| cd06638 | 15-230 | STKc_myosinIIIA_N |
| cd05594 | 11-222 | STKc_PKB_alpha |
| cd05611 | 24-222 | STKc_Rim15_like |
| cd14107 | 15-222 | STKc_obscurin_rpt1 |
| cd14041 | 21-222 | STKc_TLK2 |
| cd05599 | 16-222 | STKc_NDR_like |
| cd05583 | 94-222 | STKc_MSK_N |
| cd07878 | 15-218 | STKc_p38beta |
| cd14162 | 21-222 | STKc_TSSK4-like |
| cd14197 | 21-225 | STKc_DRAK1 |
| cd07842 | 22-216 | STKc_CDK8_like |
| cd14182 | 15-234 | STKc_PhKG1 |
| cd07861 | 19-217 | STKc_CDK1_euk |
| cd14170 | 21-290 | STKc_MAPKAPK2 |
| cd06659 | 20-290 | STKc_PAK6 |
| cd07871 | 19-224 | STKc_PCTAIRE3 |
| cd14179 | 16-222 | STKc_MSK1_C |
| cd14115 | 21-223 | STKc_Kalirin_C |
| cd05039 | 16-214 | PTKc_Csk_like |
| cd05585 | 21-222 | STKc_YPK1_like |
| cd05085 | 19-222 | PTKc_Fer |
| cd14133 | 15-225 | PKc_DYRK_like |
| cd14004 | 19-222 | STKc_PASK |
| cd07854 | 21-224 | STKc_MAPK4_6 |
| cd05609 | 24-222 | STKc_MAST |
| cd06636 | 13-222 | STKc_MAP4K4_6_N |
| cd14108 | 15-222 | STKc_SPEG_rpt1 |
| cd06625 | 15-217 | STKc_MEKK3_like |
| cd05036 | 21-222 | PTKc_ALK_LTK |
| cd07848 | 21-224 | STKc_CDKL5 |
| cd14158 | 20-228 | STKc_IRAK4 |
| cd14171 | 18-238 | STKc_MAPKAPK5 |
| cd05065 | 16-295 | PTKc_EphR_B |
| cd05059 | 17-226 | PTKc_Tec_like |
| cd05048 | 19-222 | PTKc_Ror |
| cd14110 | 43-222 | STKc_obscurin_rpt2 |
| cd08228 | 15-222 | STKc_Nek6 |
| cd05586 | 21-222 | STKc_Sck1_like |
| cd06652 | 15-222 | STKc_MEKK2 |
| cd07859 | 15-292 | STKc_TDY_MAPK |
| cd07862 | 15-214 | STKc_CDK6 |
| cd14090 | 19-222 | STKc_Mnk |
| cd05033 | 17-295 | PTKc_EphR |
| cd14165 | 21-254 | STKc_TSSK1_2-like |
| cd07873 | 19-224 | STKc_PCTAIRE1 |
| cd06658 | 20-290 | STKc_PAK5 |
| cd14111 | 19-290 | STKc_SPEG_rpt2 |
| cd06637 | 13-222 | STKc_TNIK |
| cd14064 | 21-222 | PKc_TNNI3K |
| cd14104 | 15-223 | STKc_Titin |
| cd14033 | 21-235 | STKc_WNK4 |
| cd07858 | 21-224 | STKc_TEY_MAPK |
| cd06633 | 21-214 | STKc_TAO3 |
| cd05617 | 93-222 | STKc_aPKC_zeta |
| cd14060 | 22-222 | STKc_MLTK |
| cd05614 | 94-222 | STKc_MSK2_N |
| cd14000 | 21-223 | STKc_LRRK |
| cd14664 | 21-251 | STK_BAK1_like |
| cd05618 | 21-222 | STKc_aPKC_iota |
| cd05060 | 19-222 | PTKc_Syk_like |
| cd06607 | 21-214 | STKc_TAO |
| cd06642 | 19-222 | STKc_STK25 |
| cd07865 | 20-216 | STKc_CDK9 |
| cd05057 | 13-222 | PTKc_EGFR_like |
| cd06622 | 16-224 | PKc_PBS2_like |
| cd14001 | 17-217 | PKc_TOPK |
| cd05034 | 19-217 | PTKc_Src_like |
| cd05588 | 96-222 | STKc_aPKC |
| cd14150 | 16-222 | STKc_A-Raf |
| cd14174 | 19-225 | STKc_Mnk1 |
| cd14132 | 16-222 | STKc_CK2_alpha |
| cd14163 | 15-285 | STKc_TSSK3-like |
| cd06650 | 15-224 | PKc_MEK1 |
| cd07872 | 19-224 | STKc_PCTAIRE2 |
| cd14037 | 19-288 | STKc_NAK_like |
| cd05148 | 15-217 | PTKc_Srm_Brk |
| cd05116 | 21-223 | PTKc_Syk |
| cd06615 | 16-224 | PKc_MEK |
| cd14155 | 21-216 | PKc_TESK |
| cd05068 | 16-230 | PTKc_Frk_like |
| cd14221 | 21-216 | STKc_LIMK1 |
| cd13982 | 70-222 | STKc_IRE1 |
| cd05079 | 21-217 | PTKc_Jak1_rpt2 |
| cd14118 | 44-249 | STKc_CAMKK |
| cd07852 | 16-224 | STKc_MAPK15-like |
| cd14031 | 21-235 | STKc_WNK3 |
| cd05081 | 21-217 | PTKc_Jak3_rpt2 |
| cd14101 | 15-222 | STKc_PIM2 |
| cd14229 | 15-312 | STKc_HIPK3 |
| cd14189 | 21-222 | STKc_PLK3 |
| cd05044 | 21-222 | PTKc_c-ros |
| cd06653 | 15-222 | STKc_MEKK3_like_u1 |
| cd05629 | 21-288 | STKc_NDR_like_fungal |
| cd05598 | 21-225 | STKc_LATS |
| cd05063 | 21-222 | PTKc_EphR_A2 |
| cd14186 | 21-222 | STKc_PLK4 |
| cd14188 | 21-222 | STKc_PLK2 |
| cd14032 | 21-235 | STKc_WNK2_like |
| cd06641 | 19-221 | STKc_MST3 |
| cd08229 | 5-222 | STKc_Nek7 |
| cd05091 | 19-222 | PTKc_Ror2 |
| cd14068 | 21-218 | STKc_LRRK2 |
| cd14154 | 21-216 | STKc_LIMK |
| cd14225 | 15-224 | PKc_DYRK4 |
| cd07864 | 15-218 | STKc_CDK12 |
| cd06640 | 19-221 | STKc_MST4 |
| cd14030 | 21-235 | STKc_WNK1 |
| cd14173 | 18-223 | STKc_Mnk2 |
| cd14050 | 14-209 | PKc_Myt1 |
| cd14049 | 20-222 | STKc_EIF2AK1_HRI |
| cd05052 | 17-222 | PTKc_Abl |
| cd14136 | 132-221 | STKc_SRPK |
| cd05097 | 17-217 | PTKc_DDR_like |
| cd05597 | 94-222 | STKc_DMPK_like |
| cd05045 | 21-222 | PTKc_RET |
| cd07844 | 19-224 | STKc_PCTAIRE_like |
| cd14156 | 21-214 | PKc_LIMK_like_unk |
| cd14222 | 21-216 | STKc_LIMK2 |
| cd05624 | 94-222 | STKc_MRCK_beta |
| cd14005 | 21-222 | STKc_PIM |
| cd14109 | 61-223 | PK_Unc-89_rpt1 |
| cd06651 | 15-222 | STKc_MEKK3 |
| cd07837 | 14-216 | STKc_CdkB_plant |
| cd07857 | 15-288 | STKc_MPK1 |
| cd14199 | 15-239 | STKc_CaMKK2 |
| cd06635 | 21-214 | STKc_TAO1 |
| cd07869 | 14-230 | STKc_PFTAIRE1 |
| cd05115 | 21-222 | PTKc_Zap-70 |
| cd05040 | 19-223 | PTKc_Ack_like |
| cd14212 | 18-224 | PKc_YAK1 |
| cd14016 | 15-188 | STKc_CK1 |
| cd06649 | 21-224 | PKc_MEK2 |
| cd14203 | 20-220 | PTKc_Src_Fyn_like |
| cd14159 | 21-289 | STKc_IRAK1 |
| cd14062 | 21-222 | STKc_Raf |
| cd14131 | 19-222 | PKc_Mps1 |
| cd14223 | 21-278 | STKc_GRK2 |
| cd14224 | 15-224 | PKc_DYRK2_3 |
| cd06645 | 15-214 | STKc_MAP4K3 |
| cd05112 | 19-214 | PTKc_Itk |
| cd14138 | 19-237 | PTKc_Wee1a |
| pfam12179 | 705-742 | IKKbetaNEMObind |
| cl13595 | 705-742 | IKKbetaNEMObind superfamily |
| cd06657 | 20-236 | STKc_PAK4 |
| cd05032 | 16-295 | PTKc_InsR_like |
| cd14149 | 17-222 | STKc_C-Raf |
| cd14088 | 15-222 | STKc_CaMK_like |
| cd06617 | 19-241 | PKc_MKK3_6 |
| cd06646 | 15-214 | STKc_MAP4K5 |
| cd05066 | 21-222 | PTKc_EphR_A |
| cd05633 | 21-278 | STKc_GRK3 |
| cd07870 | 19-224 | STKc_PFTAIRE2 |
| cd05053 | 14-217 | PTKc_FGFR |
| cd05049 | 17-217 | PTKc_Trk |
| cd05621 | 94-222 | STKc_ROCK2 |
| cd14206 | 19-214 | PTKc_Aatyk3 |
| cd13977 | 15-288 | STKc_PDIK1L |
| cd05114 | 17-222 | PTKc_Tec_Rlk |
| cd07850 | 21-218 | STKc_JNK |
| cd05610 | 94-222 | STKc_MASTL |
| cd05067 | 16-217 | PTKc_Lck_Blk |
| cd13998 | 19-248 | STKc_TGFbR-like |
| cd13995 | 24-223 | STKc_MAP3K8 |
| cd05090 | 19-222 | PTKc_Ror1 |
| cd05623 | 94-222 | STKc_MRCK_alpha |
| cd05089 | 15-222 | PTKc_Tie1 |
| cd14151 | 13-222 | STKc_B-Raf |
| cd05070 | 14-224 | PTKc_Fyn |
| cd08216 | 61-222 | PK_STRAD |
| cd05108 | 21-222 | PTKc_EGFR |
| cd14063 | 16-222 | PK_KSR |
| cd05047 | 21-222 | PTKc_Tie |
| cd05035 | 21-222 | PTKc_TAM |
| cd07868 | 59-217 | STKc_CDK8 |
| cd05064 | 19-222 | PTKc_EphR_A10 |
| cd07876 | 21-237 | STKc_JNK2 |
| cd06634 | 21-214 | STKc_TAO2 |
| cd05099 | 15-314 | PTKc_FGFR4 |
| cd14134 | 21-222 | PKc_CLK |
| cd05075 | 21-237 | PTKc_Axl |
| cd07867 | 20-217 | STKc_CDC2L6 |
| cd05083 | 19-214 | PTKc_Chk |
| cd05082 | 16-214 | PTKc_Csk |
| cd05074 | 21-222 | PTKc_Tyro3 |
| cd14027 | 21-222 | STKc_RIP1 |
| cd14211 | 15-224 | STKc_HIPK |
| cd05058 | 21-222 | PTKc_Met_Ron |
| cd05606 | 21-242 | STKc_beta_ARK |
| cd14019 | 19-222 | STKc_Cdc7 |
| cd14204 | 21-222 | PTKc_Mer |
| cd05072 | 14-217 | PTKc_Lyn |
| cd05095 | 18-217 | PTKc_DDR2 |
| cd05596 | 94-223 | STKc_ROCK |
| cd06616 | 18-303 | PKc_MKK4 |
| cd05622 | 94-222 | STKc_ROCK1 |
| cd14227 | 15-262 | STKc_HIPK2 |
| cd14228 | 14-224 | STKc_HIPK1 |
| cd14056 | 19-209 | STKc_TGFbR_I |
| cd14017 | 15-188 | STKc_TTBK |
| cd05096 | 18-214 | PTKc_DDR1 |
| cd05055 | 14-222 | PTKc_PDGFR |
| cd05054 | 15-222 | PTKc_VEGFR |
| cd07853 | 126-218 | STKc_NLK |
| cd14143 | 19-233 | STKc_TGFbR1_ACVR1b_ACVR1c |
| cd05051 | 16-217 | PTKc_DDR |
| cd05092 | 17-237 | PTKc_TrkA |
| cd13975 | 115-211 | PKc_Dusty |
| cd13991 | 20-222 | STKc_NIK |
| cd06619 | 18-223 | PKc_MKK5 |
| cd14054 | 19-195 | STKc_BMPR2_AMHR2 |
| cd05069 | 14-224 | PTKc_Yes |
| cd14112 | 119-222 | STKc_Unc-89_rpt2 |
| cd05071 | 14-224 | PTKc_Src |
| cd05626 | 21-223 | STKc_LATS2 |
| cd13986 | 17-227 | STKc_16 |
| cd14226 | 15-218 | PKc_DYRK1 |
| cd07874 | 21-237 | STKc_JNK3 |
| cd05113 | 17-222 | PTKc_Btk_Bmx |
| cd05043 | 7-217 | PTK_Ryk |
| cd05061 | 21-294 | PTKc_InsR |
| cd14067 | 21-227 | STKc_LRRK1 |
| cd05100 | 3-222 | PTKc_FGFR3 |
| cd05098 | 21-222 | PTKc_FGFR1 |
| cd14012 | 39-290 | PK_eIF2AK_GCN2_rpt1 |
| cd14142 | 19-218 | STKc_ACVR1_ALK1 |
| cd05109 | 21-222 | PTKc_HER2 |
| cd14051 | 19-237 | PTKc_Wee1 |
| cd06618 | 16-222 | PKc_MKK7 |
| cd14200 | 56-249 | STKc_CaMKK1 |
| cd07875 | 21-237 | STKc_JNK1 |
| cd14214 | 15-222 | PKc_CLK3 |
| cd05073 | 14-222 | PTKc_Hck |
| cd05042 | 19-214 | PTKc_Aatyk |
| cd05110 | 21-222 | PTKc_HER4 |
| cd05101 | 21-222 | PTKc_FGFR2 |
| cd14053 | 24-195 | STKc_ACVR2 |
| cd05088 | 16-217 | PTKc_Tie2 |
| cd14135 | 21-218 | STKc_PRP4 |
| cd14011 | 126-214 | PK_SCY1_like |
| cd13968 | 21-168 | PKc_like |
| cd14102 | 14-222 | STKc_PIM3 |
| cd05627 | 15-222 | STKc_NDR2 |
| cd14055 | 19-195 | STKc_TGFbR2_like |
| cd05037 | 19-222 | PTK_Jak_rpt1 |
| cd14220 | 20-218 | STKc_BMPR1a |
| cd14100 | 21-222 | STKc_PIM1 |
| cd05628 | 94-222 | STKc_NDR1 |
| cd14215 | 129-222 | PKc_CLK2 |
| cd05105 | 116-214 | PTKc_PDGFR_alpha |
| cd14026 | 21-261 | STKc_RIP2 |
| cd05050 | 21-222 | PTKc_Musk |
| cd14139 | 19-237 | PTKc_Wee1b |
| COG3642 | 54-171 | Bud32 |
| TIGR03724 | 54-171 | arch_bud32 |
| smart00220 | 15-290 | S_TKc |
| pfam00069 | 15-222 | Pkinase |
| COG0515 | 15-290 | SPS1 |
| smart00219 | 16-237 | TyrKc |
| smart00221 | 16-237 | STYKc |
| pfam07714 | 16-222 | Pkinase_Tyr |
| PTZ00263 | 16-222 | PTZ00263 |
| PTZ00266 | 15-254 | PTZ00266 |
| PTZ00036 | 14-222 | PTZ00036 |
| PTZ00267 | 61-222 | PTZ00267 |
| TIGR03903 | 36-218 | TOMM_kin_cyc |
| PLN00034 | 20-222 | PLN00034 |
| PTZ00024 | 16-224 | PTZ00024 |
| PLN00009 | 15-224 | PLN00009 |
| PHA03390 | 93-222 | pk1 |
| PRK13184 | 13-222 | pknD |
| PHA03209 | 60-216 | PHA03209 |
| PTZ00426 | 21-235 | PTZ00426 |
| PTZ00283 | 21-222 | PTZ00283 |
| PHA03212 | 61-218 | PHA03212 |
| PHA03211 | 61-214 | PHA03211 |
| PHA03207 | 122-222 | PHA03207 |
| PLN03225 | 118-176 | PLN03225 |
Ontology Information
| HPRD ID | 3713 |
|---|---|
| Molecular Class | Serine/threonine kinase |
| Molecular Function | GTPase activator activity (GO:0005096) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| O14920 | DB00244 | Mesalazine | SmallMoleculeDrug |
| O14920 | DB00795 | Sulfasalazine | SmallMoleculeDrug |
| O14920 | DB00945 | Acetylsalicylic acid | SmallMoleculeDrug |
| O14920 | DB00995 | Auranofin | SmallMoleculeDrug |
| O14920 | DB01169 | Arsenic trioxide | SmallMoleculeDrug |
| O14920 | DB06151 | Acetylcysteine | SmallMoleculeDrug |