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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| IKZF1 | 10320 | IKAROS family zinc finger 1 (Ikaros) | 7 | hIk-1, LyF-1, Hs.54452, IKAROS, PPP1R92 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25928810 | 2015 | Cell line : - Source : Flinders Medical Centre (FMC) or Repatriation General Hospital (Adelaide, SA, Australia). Sample Type : Blood sample No. of Sample : 144 healthy controls and 74 CRC cases Stage : - | Methylation-specific PCR assays | Methylation | - | Detection of methylated BCAT1 and/or IKZF1 DNA in plasma may have clinical application as a novel blood test for CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Zinc fingers, C2H2-type, "IKAROS zinc fingers" |
| Description | This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014] | Chromosome | 7 |
| Location | 7p12.2 |
| Start | 50344378 |
| End | 50367358 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 22981 |
| OMIM ID | 603023 |
| HGNC ID | HGNC:13176 |
| Unigene ID | Hs.435949 |
| Ensembl ID | ENSG00000185811 |
| PharmGKB ID | PA37748 |
Protein Information
| Protein ID | NP_001207694.1 |
|---|---|
| Protein Name | IKAROS family zinc finger 1 (Ikaros) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 519 |
| Uniprot ID | Q96JA1 |
| Ensembl Protein ID | ENSP00000273261 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1487 | CTBP1 | 4015 | NP_001319.1 | in vivo | 10766745 |
| 3065 | HDAC1 | 3143 | NP_004955.2 | in vitro;in vivo | 10357820 |
| 6908 | TBP | 2511 | NP_003185.1 | in vitro | 11959865 |
| 7329 | UBE2I | 9045 | NP_003336.1 | yeast 2-hybrid | 16189514 |
| 10284 | SAP18 | 4256 | NP_005861.2 | in vitro;in vivo | 10357820 |
| 22806 | IKZF3 | 5869 | NP_036613.2 | in vitro;in vivo;yeast 2-hybrid | 9155026 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam13465 | 132-156 | zf-H2C2_2 |
| cl22375 | 132-156 | zf-H2C2_2 superfamily |
| pfam13465 | 159-184 | zf-H2C2_2 |
| cl22375 | 159-184 | zf-H2C2_2 superfamily |
| COG5048 | 144-218 | COG5048 |
| COG5048 | 143-299 | COG5048 |
Ontology Information
| HPRD ID | 5693 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Serine-type peptidase activity (GO:0008236) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.