CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
21239167	2011	Cell line : COLO 205 Source : - Sample Type : - No. of Sample : - Stage : -	Surgical departments in Northern Germany.	Polymorhpism	-	A promoter variant (rs1800872) in the Interleukin-10 (IL-10) gene was associated with an increased lymph node metastasis involvement .
24015034	2013	Cell line : - Source : - Sample Type : - No. of Sample : 28 randomly selected PLCO participants Stage : -	Genotyping	Polymorhpism	-	IL10 rs3021094 might be a valuable prognostic biomarker for colorectal cancer patients.
15577750	2004	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	-	Up-regulation	-	Cancer cells release anti-inflammatory cytokine IL-10, which ceases the action of PMNCs.
21764327	2011	Cell line : - Source : German patients Sample Type : - No. of Sample : 614 German patients within the Kiel cohort Stage : -	High-sensitivity Luminex xMap-based multiplex panel, Spearman correlation coefficient.	Up-regulation	-	Observed fair to good reproducibility for IL-8 (ICC=0.55) and IL-10 (ICC=0.60).
22480118	2012	Cell line : - Source : China Medical University Hospital, Taiwan Sample Type : CRC tumor and normal tissue No. of Sample : 282 Stage : TNM Stage I-IV	XMap profiling technology	Up-regulation	-	Circulating levels of proinflammatory cytokines IL-1, IL-6, IL-8 and antiinflamatory cytokine IL-10 were elevated in cancer patients with respect to healthy controls.

Gene Details

Chromosome: 1; NC_000001.10 (206940948..206945839, complement)
View Larger Image

Gene Type	protein coding
Gene Family	Interleukins and interleukin receptors
Description	The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]
Chromosome	1
Location	1q31-q32
Start	206767602
End	206774607
Strand	-
Gene Sequence	>gi\|568815597:c206774607-206767602 Homo sapiens chromosome 1, GRCh38.p2 Primary Assembly AAGATGGGAAACAAAGGAAGGAGGGGTTCACAGCCTCACCCAGAGTCCAGAACCCCTGGCCTGCCTGGTG CCCATGCTGAGTCCACTTCTGGAACACCCAGCTCAGAGAGGGGGTTAGACCTGCAGGCTAACACAGACAC AGCCCAGAAAACCCAGGAGCCGAGGGGGAAGGAGAAAGGTGCAAGAAGGGGAAACCCAGGTCCTGGTCCC CTTCTCTCTGCTTCCTGGCAGCAGAACTCAGACAGAACCCTTAAGCCAGTCTAAGTCTGGCAGGACCAGT AAGTTCTGAGTTAGCTCCATACTAGTTTCTAGCAGGCTCTTTCTCACTTCCTGATTCTTAGGTTTCTACA TTGACACTCCCTGAAGAGTTGGGAAGAGACACCACAGTCCCCTGACCCTGATCCATAGGTCACACAGCAG GGACATCCACAGGGTGGGCGTGGGCCCTCTCATCCCTCCCTCCCACTCACTTCACGCTGGCTGGGCCCCA AGGTGTTTGCACCCCTTGCAGTGAGTGACCTTCTCTAGTGCAGCAAGCTCAGAACCTGCTGCCACTGGAG TTGTCCCATTGCTGATGCAGAAAGGTGAAGAACTAGCAGAACACTGGAAATGCCCTCCATCTGGGTCCAT GGCTACTTAAGCTCAATGCTCCCTGGCAGGCAGGAGGACAGGTGCTATTGCCCTGTTGGGACAGATGAAA AACAGACACAGGGAGGATGAGTGATTTGCCCTGACTATAGAGTGGCAGGGCCAAGGCAGAGCCCAGGCCT CCTGCACCTAGGTCAGTGTTCCTCCCAGTTACAGTCTAAACTGGAATGGCAGGCAAAGCCCCTGTGGAAG GGGAAGGTGAAGGCTCAATCAAAGGATCCCCAGAGACTTTCCAGATATCTGAAGAAGTCCTGATGTCACT GCCCCGGTCCTTCCCCAGGTAGAGCAACACTCCTCGCCGCAACCCAACTGGCTCCCCTTACCTTCTACAC ACACACACACACACACACACACACACACACACACACACACAAATCCAAGACAACACTACTAAGGCTTCTT TGGGAAGGGGAAGTAGGGATAGGTAAGAGGAAAGTAAGGGACCTCCTATCCAGCCTCCATGGAATCCTGA CTTCTTTTCCTTGTTATTTCAACTTCTTCCACCCCATCTTTTAAACTTTAGACTCCAGCCACAGAAGCTT ACAACTAAAAGAAACTCTAAGGCCAATTTAATCCAAGGTTTCATTCTATGTGCTGGAGATGGTGTACAGT AGGGTGAGGAAACCAAATTCTCAGTTGGCACTGGTGTACCCTTGTACAGGTGATGTAATATCTCTGTGCC TCAGTTTGCTCACTATAAAATAGAGACGGTAGGGGTCATGGTGAGCACTACCTGACTAGCATATAAGAAG CTTTCAGCAAGTGCAGACTACTCTTACCCACTTCCCCCAAGCACAGTTGGGGTGGGGGACAGCTGAAGAG GTGGAAACATGTGCCTGAGAATCCTAATGAAATCGGGGTAAAGGAGCCTGGAACACATCCTGTGACCCCG CCTGTACTGTAGGAAGCCAGTCTCTGGAAAGTAAAATGGAAGGGCTGCTTGGGAACTTTGAGGATATTTA GCCCACCCCCTCATTTTTACTTGGGGAAACTAAGGCCCAGAGACCTAAGGTGACTGCCTAAGTTAGCAAG GAGAAGTCTTGGGTATTCATCCCAGGTTGGGGGGACCCAATTATTTCTCAATCCCATTGTATTCTGGAAT GGGCAATTTGTCCACGTCACTGTGACCTAGGAACACGCGAATGAGAACCCACAGCTGAGGGCCTCTGCGC ACAGAACAGCTGTTCTCCCCAGGAAATCAACTTTTTTTAATTGAGAAGCTAAAAAATTATTCTAAGAGAG GTAGCCCATCCTAAAAATAGCTGTAATGCAGAAGTTCATGTTCAACCAATCATTTTTGCTTACGATGCAA AAATTGAAAACTAAGTTTATTAGAGAGGTTAGAGAAGGAGGAGCTCTAAGCAGAAAAAATCCTGTGCCGG GAAACCTTGATTGTGGCTTTTTAATGAATGAAGAGGCCTCCCTGAGCTTACAATATAAAAGGGGGACAGA GAGGTGAAGGTCTACACATCAGGGGCTTGCTCTTGCAAAACCAAACCACAAGACAGACTTGCAAAAGAAG GCATGCACAGCTCAGCACTGCTCTGTTGCCTGGTCCTCCTGACTGGGGTGAGGGCCAGCCCAGGCCAGGG CACCCAGTCTGAGAACAGCTGCACCCACTTCCCAGGCAACCTGCCTAACATGCTTCGAGATCTCCGAGAT GCCTTCAGCAGAGTGAAGACTTTCTTTGTGAGTATGATTCCTTCCTGTCCTTTCTCTCTTCCTGGGACTG CCTGAACTAGACATTCTCCTGGAACTATAAGAACCCTCCTCCTGCGCCTCCACCTCCATCCCCAACACCT ATTCCCCCAAACTTAAATTCTTAAGAGAATCCTAGATCAAGCCATGGGTTTGGTGAGTTAAGCTAAGCCA GATGATACAGTAAATGTGCAGGAAACCTGCCTTATAAAGTAAATGCGTTCTCTCTCGTGCTGAGAAACTT ATAAGATCCTGCTGGCGCTCTATACTTTATTGGCTAGGAGAAGTAAAGAAATGTCTGATTCGAGGTGAAG ATGCTCCCCATGCCTTGCAGCAGGGAAATTTAAATTGCCTCTGCTTAGAGCGTTTCCAGACCTGAAAGAC CAGTGGTTTAGGGAAGCACTCTACATGAGGGAAACCTGCATTAGAAGGAGCTTCTTAATCCCTGGGATCT TTCCAAGCTAAACTGGATGTCTACAGTGGGGAGAAAGAAAAGCAGAGAACAGGACATGAGGGGGGCTCAA GGCCCCGAAGGGTTGACATAGGTGTCCCTTAAAGCCGAATGTAGCTCCGCAGAAAGAAGACCAGGACTGA GTCAAGCTTCTGCTTTCCCTTCAAAATCGGCCAGATTTTTTAAATAACTTGACTCTGAGGAGGAGGACCT GATTTAAGTGATGGTCCCATCACTGTTGAATCCTCTGTTTTTAAAACTCCCCTTTTGATTTTTTTGGGCC AGAGCCAATTTTATTTAAAAAAAAAAATCTCTAAATGAAAGGGCATCAAAAAGACCGCATTTCAGTTATT TCCCCAAACCTCAAGTTCATTCTCCTTTTGTTCTTCCTGCAGCAAATGAAGGATCAGCTGGACAACTTGT TGTTAAAGGAGTCCTTGCTGGAGGACTTTAAGGTGAGAGCAGGGGCGGGGTGCTGGGGGAGTGTGCAGCA TGATTAAGGGAAGGGAGACTCTGCTTCCTGATTGCAGGGAATTGGGTTTGTTTCCTTCGCTTTGAAAAGG AGAAGTGGGAAGATGTTAACTCAGCACATCCAGCAGCCAGAGGGTTTACAAAGGGCTCAGTCCCTTCGGG GAGGCTTCTGGTGAAGGAGGATCGCTAGAACCAAGCTGTCCTCTTAAGCTAGTTGCAGCAGCCCCTCCTC CCAGCCACCTCCGCCAATCTCTCACTCACCTTTGGCTCCTGCCCTTAGGGTTACCTGGGTTGCCAAGCCT TGTCTGAGATGATCCAGTTTTACCTGGAGGAGGTGATGCCCCAAGCTGAGAACCAAGACCCAGACATCAA GGCGCATGTGAACTCCCTGGGGGAGAACCTGAAGACCCTCAGGCTGAGGCTACGGCGCTGTGTAAGTAGC AGATCAGTTTTTTCCCTTGCAGCTGCCCCCAAAATACCATCTCCTACAGACCAGCAGGGACACTCACATC CACAGACACAGCAAAGACACAGACTGGCAGAGCTAGCTGTAAATGAGGAAAGACTCCTGGAGTCAGATCT CTTGCTCATTTCTCTTTGAGCAGGCGTTGGGGGTGGCTGCTAGGCATTTACATGTGAAATTTGCAAACAG CTTTCCTGTTATTTGTGAGTCATTTGTGGGTTATTAACTACTCCCCTCTCTCTTCATAAAAGGAGCCCAG AGCTTCAGTCAGGCCTCCACTGCCTCTTTGTAACTAGACCCTGGGCGGGGAGCTAAGGTTCCCAAGCAGA GGAAACATCATTCACCTCTTTTAATCTCAATGTTTTGAAAGCAAAGCTCTAAGAAGGGCCCAATTGACTG ACAGGATTTCCCCTGGCATTTTAGAAGGGACAAGGGGGCTATTCATCCCCAGGCTAGTGTCTATGAGTAA TTCCTCCAGGTAATTTATTTCTCCAACTGAAATGATGCCCTCACTACTAATGGTTTCCCCTGTTCTGTCA CCAATATTGGAAAATCAGTTGGTGTCTATTTGTAGGACAAGGCTATGTGAAGGGTTTGGTCCCAGTAGCT TCCCTCCTCAGATGCTTAGAAGTGTTCCTCGGTGGCTGTGACTGACGGGGAGGAACAGGAGAGAGAGGCA GAAAAGGACAGGCTGAAGAATGCCTCGCTCAGCACTGCAGGAGATACTGTAGAGTTCTGGGGGAGGAAGG AATCCCAAGACCTGGGTTGTCATCCAAGCCTTGCAAACATCTTGGAGTGAGTCCTGGAGAAATACATTTA ACTCCCAGGGCCATGGAAGCAGGGCTCAGTTCTCTCTGGGAGCTGTGAGGCAAGGCATTTGGATAAATCT GGCCTCCTCATGATGCCACCAGCTTGTCCCCTAAGTGTGATGGACATGGAGCTGGAAGCCAGGATCACCA ACACTTTCTCTTTTCTTCCACAGCATCGATTTCTTCCCTGTGAAAACAAGAGCAAGGCCGTGGAGCAGGT GAAGAATGCCTTTAATAAGGTGAGCTTGGATGGTGGCAGAGAGGGTCTGCAGAGCACAACCCATGCCCAC TCCCCAACCCCAAAGCATGGAAGGTGGTGGGGACTCAATAGGCCCCATTCTTCATTGGAGAGAGTGTGGG AACCTGACAGATGGTATGACCTGCTCAGCCAGTGAGGAGCTGCTGCCTTGATTGTATTTGTTTTCTGTTA AGTGTCTTTGGGGGTTTCTAAATGACTGCTCGCTGCCTTTGCAGGCTTGCGGGTTAGGCTGGCCGGCCAG CCTGTGAACACAGTGAGCTGCATGCTGGGGAGAGTGACAAAGGAAACAGAAAGTACAGAAAGTAGCTTGT TGGGAATCTAGGCTGAACCCACACGTGCAGGAAGCTGGCACATAAATGTGCACATACAAATACACCTGGG GGTTCAGCCCAGACTCCCCAGAACTCAGAATGAGCAGGAAGCTGGATTCTCACTTAACCTGGAGTTGGTT CAAGCCCGCTTTCCATCTGCCCTTCGCACCTGCGGAGGTGCCTGAGAATGTCAGTTCCCAAACGAAATGG GGTTTCACACTTCCAACTGTGCGTGAACTTTTTCAGTCTGATTTCCCAGAAACCGTGCGGCCTATGTCCT CCTCGTGGGCTGGGGACAGACACTGCACAGAGTGCCAACATCAGGGGGTGTGAATTTCTCATAGTAGGTC AGGGCGGCAGGGCAGGGCCTGCTCAGTGTGTTGGTGGGAGAACACAGACATTTAAAAGGCTCCCTCCTCT CCTCTCACCGTCTTGCTTTCGAAGCGCTTCCTCTAATGTCTTTTCATCAAACTCTGCATAATCATCATGT GAATACGTGACCTTTAAAATTGTTGAAAAGGCATCATTTTGAAGACAGTGCTTTGCAAAATGAATGCTCC CCTTGCTAGGGGGAGGCCTGGAGGAGATGAAGGTCAATGCACAGCCTTTCCCAAGGCAGCTAGGCCTATC CTCTGGTTTACTTCCCAGCGTGAGGGAGAACAAGCAACCTCTGCACTCAAGGTCATGCCCATCCATGAGC ATGAGGGAGGGGAGCCTATTTAGTCCCCAGAAAGGATTTTAACTGTATGTTTCTTATCTCTCTGCACAGC TCCAAGAGAAAGGCATCTACAAAGCCATGAGTGAGTTTGACATCTTCATCAACTACATAGAAGCCTACAT GACAATGAAGATACGAAACTGAGACATCAGGGTGGCGACTCTATAGACTCTAGGACATAAATTAGAGGTC TCCAAAATCGGATCTGGGGCTCTGGGATAGCTGACCCAGCCCCTTGAGAAACCTTATTGTACCTCTCTTA TAGAATATTTATTACCTCTGATACCTCAACCCCCATTTCTATTTATTTACTGAGCTTCTCTGTGAACGAT TTAGAAAGAAGCCCAATATTATAATTTTTTTCAATATTTATTATTTTCACCTGTTTTTAAGCTGTTTCCA TAGGGTGACACACTATGGTATTTGAGTGTTTTAAGATAAATTATAAGTTACATAAGGGAGGAAAAAAAAT GTTCTTTGGGGAGCCAACAGAAGCTTCCATTCCAAGCCTGACCACGCTTTCTAGCTGTTGAGCTGTTTTC CCTGACCTCCCTCTAATTTATCTTGTCTCTGGGCTTGGGGCTTCCTAACTGCTACAAATACTCTTAGGAA GAGAAACCAGGGAGCCCCTTTGATGATTAATTCACCTTCCAGTGTCTCGGAGGGATTCCCCTAACCTCAT TCCCCAACCACTTCATTCTTGAAAGCTGTGGCCAGCTTGTTATTTATAACAACCTAAATTTGGTTCTAGG CCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACTTGAGGTC AGGAGTTCCTAACCAGCCTGGTCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCGGG CATGGTGGCGCGCACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAAGAGAATTGCTTGAACCCAGGAG ATGGAAGTTGCAGTGAGCTGATATCATGCCCCTGTACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTC AAAAAATAAAAATAAAAATAAATTTGGTTCTAATAGAACTCAGTTTTAACTAGAATTTATTCAATTCCTC TGGGAATGTTACATTGTTTGTCTGTCTTCATAGCAGATTTTAATTTTGAATAAATAAATGTATCTTATTC ACATCA Download Select all
Length	7006
OMIM ID	124092
HGNC ID	HGNC:5962
Unigene ID	Hs.193717
Ensembl ID	ENSG00000136634
PharmGKB ID	PA29778

mRNA Information

mRNA ID	XM_011509506.1
Exon	join(1..278,1172..2337,3193..3252,3549..3701,4714..4779, 5880..7006)
mRNA Sequence	>3586 ACACATCAGGGGCTTGCTCTTGCAAAACCAAACCACAAGACAGACTTGCAAAAGAAGGCATGCA CAGCTCAGCACTGCTCTGTTGCCTGGTCCTCCTGACTGGGGTGAGGGCCAGCCCAGGCCAGGGC ACCCAGTCTGAGAACAGCTGCACCCACTTCCCAGGCAACCTGCCTAACATGCTTCGAGATCTCC GAGATGCCTTCAGCAGAGTGAAGACTTTCTTTCAAATGAAGGATCAGCTGGACAACTTGTTGTT AAAGGAGTCCTTGCTGGAGGACTTTAAGGGTTACCTGGGTTGCCAAGCCTTGTCTGAGATGATC CAGTTTTACCTGGAGGAGGTGATGCCCCAAGCTGAGAACCAAGACCCAGACATCAAGGCGCATG TGAACTCCCTGGGGGAGAACCTGAAGACCCTCAGGCTGAGGCTACGGCGCTGTCATCGATTTCT TCCCTGTGAAAACAAGAGCAAGGCCGTGGAGCAGGTGAAGAATGCCTTTAATAAGCTCCAAGAG AAAGGCATCTACAAAGCCATGAGTGAGTTTGACATCTTCATCAACTACATAGAAGCCTACATGA CAATGAAGATACGAAACTGAGACATCAGGGTGGCGACTCTATAGACTCTAGGACATAAATTAGA GGTCTCCAAAATCGGATCTGGGGCTCTGGGATAGCTGACCCAGCCCCTTGAGAAACCTTATTGT ACCTCTCTTATAGAATATTTATTACCTCTGATACCTCAACCCCCATTTCTATTTATTTACTGAG CTTCTCTGTGAACGATTTAGAAAGAAGCCCAATATTATAATTTTTTTCAATATTTATTATTTTC ACCTGTTTTTAAGCTGTTTCCATAGGGTGACACACTATGGTATTTGAGTGTTTTAAGATAAATT ATAAGTTACATAAGGGAGGAAAAAAAATGTTCTTTGGGGAGCCAACAGAAGCTTCCATTCCAAG CCTGACCACGCTTTCTAGCTGTTGAGCTGTTTTCCCTGACCTCCCTCTAATTTATCTTGTCTCT GGGCTTGGGGCTTCCTAACTGCTACAAATACTCTTAGGAAGAGAAACCAGGGAGCCCCTTTGAT GATTAATTCACCTTCCAGTGTCTCGGAGGGATTCCCCTAACCTCATTCCCCAACCACTTCATTC TTGAAAGCTGTGGCCAGCTTGTTATTTATAACAACCTAAATTTGGTTCTAGGCCGGGCGCGGTG GCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACTTGAGGTCAGGAGT TCCTAACCAGCCTGGTCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCGGG CATGGTGGCGCGCACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAAGAGAATTGCTTGAACC CAGGAGATGGAAGTTGCAGTGAGCTGATATCATGCCCCTGTACTCCAGCCTGGGTGACAGAGCA AGACTCTGTCTCAAAAAATAAAAATAAAAATAAATTTGGTTCTAATAGAACTCAGTTTTAACTA GAATTTATTCAATTCCTCTGGGAATGTTACATTGTTTGTCTGTCTTCATAGCAGATTTTAATTT TGAATAAATAAATGTATCTTATTCACATC Download Select all
Length	1629

CDS Information

Location	join(2173..2337,3193..3252,3549..3701,4714..4779, 5880..5972)
CDS Sequence	>gi\|24430216:60-596 Homo sapiens interleukin 10 (IL10), mRNA ATGCACAGCTCAGCACTGCTCTGTTGCCTGGTCCTCCTGACTGGGGTGAGGGCCAGCCCAGGCCAGGGCA CCCAGTCTGAGAACAGCTGCACCCACTTCCCAGGCAACCTGCCTAACATGCTTCGAGATCTCCGAGATGC CTTCAGCAGAGTGAAGACTTTCTTTCAAATGAAGGATCAGCTGGACAACTTGTTGTTAAAGGAGTCCTTG CTGGAGGACTTTAAGGGTTACCTGGGTTGCCAAGCCTTGTCTGAGATGATCCAGTTTTACCTGGAGGAGG TGATGCCCCAAGCTGAGAACCAAGACCCAGACATCAAGGCGCATGTGAACTCCCTGGGGGAGAACCTGAA GACCCTCAGGCTGAGGCTACGGCGCTGTCATCGATTTCTTCCCTGTGAAAACAAGAGCAAGGCCGTGGAG CAGGTGAAGAATGCCTTTAATAAGCTCCAAGAGAAAGGCATCTACAAAGCCATGAGTGAGTTTGACATCT TCATCAACTACATAGAAGCCTACATGACAATGAAGATACGAAACTGA Download Select all
CCDS ID	CCDS1467.1

Protein Information

Protein ID	NP_000563.1
Protein Name	Interleukin 10
Molecular Wt. (Da)	18648
Protein Sequence	>3586 MHSSALLCCLVLLTGVRASPGQGTQSENSCTHFPGNLPNMLRDLRDAFSRVKTFFQMKDQLDNL LLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENQDPDIKAHVNSLGENLKTLRLRLRRCHR FLPCENKSKAVEQVKNAFNKLQEKGIYKAMSEFDIFINYIEAYMTMKIRN Download Select all
Length	178
Uniprot ID	Q16589
Ensembl Protein ID	ENSP00000315743

Post-translational Modification Information (Source : HPRD)

No matching records could be found.

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
2	A2M	72	NP_000005.2	in vitro	10714547
3588	IL10RB	473	NP_000619.3	in vitro;in vivo	114 857 369 312 047

Pathway Information

Pathway Name	Pathway ID
African trypanosomiasis	hsa05143
Allograft rejection	hsa05330
Amoebiasis	hsa05146
Asthma	hsa05310
Autoimmune thyroid disease	hsa05320
Chagas disease (American trypanosomiasis)	hsa05142
Cytokine-cytokine receptor interaction	hsa04060
Epstein-Barr virus infection	hsa05169
FoxO signaling pathway	hsa04068
Inflammatory bowel disease (IBD)	hsa05321
Intestinal immune network for IgA production	hsa04672
Jak-STAT signaling pathway	hsa04630
Leishmaniasis	hsa05140
Malaria	hsa05144
Pertussis	hsa05133
Staphylococcus aureus infection	hsa05150
Systemic lupus erythematosus	hsa05322
T cell receptor signaling pathway	hsa04660
Toxoplasmosis	hsa05145
Tuberculosis	hsa05152

Structure Information

PDB ID	1ILK
Resolution	1.8
Method	X-RAY DIFFRACTION
Chains	A
Molecule	INTERLEUKIN-10
Model	View

Domain Information

ID	Location	Description
pfam00726	5-174	IL10
cl02501	5-174	IL10 superfamily
smart00188	37-173	IL10

Ontology Information

HPRD ID	1151
Molecular Class	Unknown
Molecular Function	Receptor activity (GO:0004872)
Biological Process	Immune response (GO:0006955)

SNP Information

View SNP Geneview Report