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General Information
- Evidence
- Gene
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 16482637 | 2006 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 115 CRC cases and 11 cases of adenoma. Stage : Duke Stage A-D | Immunohistochemistry, Western blotting | Up-regulation | - | IL-11 and IL-11Ra are highly expressed in human colorectal adenocarcinoma and the IL-11Ra expression is correlated with clinicopathological factors. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Interleukins and interleukin receptors, "Immunoglobulin superfamily / Immunoglobulin-like domain containing" |
| Description | Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012] | Chromosome | 9 |
| Location | 9p13 |
| Start | 34652182 |
| End | 34661899 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 9718 |
| OMIM ID | 600939 |
| HGNC ID | HGNC:5967 |
| Unigene ID | Hs.591088 |
| Ensembl ID | ENSG00000137070 |
| PharmGKB ID | PA29782 |
mRNA Information
| mRNA ID | NM_001142784.2 |
|---|---|
| Exon | join(1..49,3034..3133,3421..3481,4555..4724,4851..4965, 5119..5151,5237..5403,6336..6499,7575..7716,8090..8209, 8320..8416,8670..8752,9298..9718) | mRNA Sequence | Download Select all |
| Length | 1728 |
Protein Information
| Protein ID | NP_001136256.1 |
|---|---|
| Protein Name | interleukin 11 receptor, alpha |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 422 |
| Uniprot ID | P08195 |
| Ensembl Protein ID | ENSP00000340815 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3589 | IL11 | 980 | NP_000632.1 | in vitro;in vivo | 767 009 810 504 396 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cytokine-cytokine receptor interaction | hsa04060 |
| Hematopoietic cell lineage | hsa04640 |
| Jak-STAT signaling pathway | hsa04630 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00063 | 218-310 | FN3 |
| cl21522 | 218-310 | FN3 superfamily |
| cd05730 | 32-94 | Ig3_NCAM-1_like |
| cl11960 | 32-94 | Ig superfamily |
| smart00060 | 218-297 | FN3 |
| cd05724 | 47-94 | Ig2_Robo |
| cd00096 | 44-95 | Ig |
| smart00410 | 33-109 | IG_like |
| smart00409 | 33-109 | IG |
| smart00408 | 40-95 | IGc2 |
| pfam07679 | 39-95 | I-set |
Ontology Information
| HPRD ID | 1640 |
|---|---|
| Molecular Class | Cytokine receptor |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Transport (GO:0006810) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q14626 | DB00038 | Oprelvekin | BiotechDrug |