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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23053983 | 2012 | Cell line : - Source : Bulgarian patient Sample Type : CRC tumor and normal tissues No. of Sample : 20 Stage : - | real time RT-PCR | Up-regulation | - | Altered gene expression profiles of IL-12A, IL-12B, IL-23A at mRNA level in CRC monocytes was associated with tumor development and can be attributed to anticancer immune response. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Interleukins and interleukin receptors |
| Description | This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008] | Chromosome | 3 |
| Location | 3q25.33 |
| Start | 159988836 |
| End | 159996019 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 7184 |
| OMIM ID | 161560 |
| HGNC ID | HGNC:5969 |
| Unigene ID | Hs.673 |
| Ensembl ID | ENSG00000168811 |
| PharmGKB ID | PA29784 |
mRNA Information
| mRNA ID | NM_000882.3 |
|---|---|
| Exon | join(1..339,1332..1477,4177..4290,4616..4657,4733..4774, 4866..5009,6569..7184) | mRNA Sequence | Download Select all |
| Length | 1450 |
Protein Information
| Protein ID | NP_000873.2 |
|---|---|
| Protein Name | interleukin 12A |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 253 |
| Uniprot ID | P31645 |
| Ensembl Protein ID | ENSP00000261707 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3576 | IL8 | 909 | NP_000575.1 | in vitro | 16862120 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| African trypanosomiasis | hsa05143 |
| Allograft rejection | hsa05330 |
| Amoebiasis | hsa05146 |
| Chagas disease (American trypanosomiasis) | hsa05142 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Herpes simplex infection | hsa05168 |
| Inflammatory bowel disease (IBD) | hsa05321 |
| Influenza A | hsa05164 |
| Jak-STAT signaling pathway | hsa04630 |
| Legionellosis | hsa05134 |
| Leishmaniasis | hsa05140 |
| Malaria | hsa05144 |
| Measles | hsa05162 |
| Pertussis | hsa05133 |
| RIG-I-like receptor signaling pathway | hsa04622 |
| Toll-like receptor signaling pathway | hsa04620 |
| Toxoplasmosis | hsa05145 |
| Tuberculosis | hsa05152 |
| Type I diabetes mellitus | hsa04940 |
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 6775 |
|---|---|
| Molecular Class | Cytokine |
| Molecular Function | Auxiliary transport protein activity (GO:0015457) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.