Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| IL13 | 3596 | interleukin 13 | 5 | P600, IL-13, ALRH, BHR1, MGC116786, MGC116788, MGC116789 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24833143 | 2014 | Cell line : - Source : Mie University Graduate School of Medicine. Sample Type : CRC tumor and normal tissues No. of Sample : 241 Stage : TNM Stage I-IV | ELISA, Multivariate analysis | Down-regulation | - | Low serum IL-13 levels may be a useful predictive marker for poor prognosis in colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Interleukins and interleukin receptors |
| Description | This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008] | Chromosome | 5 |
| Location | 5q31 |
| Start | 131993865 |
| End | 131996801 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 2937 |
| OMIM ID | 147683 |
| HGNC ID | HGNC:5973 |
| Unigene ID | Hs.845 |
| Ensembl ID | ENSG00000169194 |
| PharmGKB ID | PA199 |
mRNA Information
| mRNA ID | NM_002188.2 |
|---|---|
| Exon | join(1..188,1246..1299,1552..1656,2003..2937) | mRNA Sequence | Download Select all |
| Length | 1282 |
Protein Information
| Protein ID | NP_002179.2 |
|---|---|
| Protein Name | interleukin 13 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 146 |
| Uniprot ID | P55011 |
| Ensembl Protein ID | ENSP00000262461 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Asthma | hsa05310 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Fc epsilon RI signaling pathway | hsa04664 |
| Inflammatory bowel disease (IBD) | hsa05321 |
| Jak-STAT signaling pathway | hsa04630 |
| Measles | hsa05162 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00190 | 20-145 | IL4_13 |
| cl11518 | 20-145 | IL4 superfamily |
| pfam03487 | 20-57 | IL13 |
| cl23333 | 20-57 | IL13 superfamily |
Ontology Information
| HPRD ID | 5328 |
|---|---|
| Molecular Class | Cytokine |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.