Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| IL17A | 3605 | Interleukin 17A | 6 | IL17; CTLA8; IL-17; IL-17A |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22509371 | 2012 | Cell line : - Source : Department of Oncology, Zhongnan Hospital ofWuhan University. Sample Type : CRC tumor and normal tissue No. of Sample : 40 Stage : - | Histochemistry, FACS, ELISA, RT-PCR, Western blotting | Down-regulation | - | IL-17F is expressed in normal human colonic epithelial cells, which is down-regulated in colon cancer tissues.
L-17F is expressed in human colonic epithelial cells and inhibits colon tumorigenesis in vivo, possibly by inhibiting angiogenesis. |
| 24699997 | 2014 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 241 subjects (102 CRCr and 139 healthy controls) Stage : TNM Stage I-IV | Fluorescent-based RFLP | Polymorhpism | - | IL17A polymorphism may serve as biomarker of disease location and progression. Allele of IL17A gene is involved in susceptibility to colorectal cancer and is associated with clinical features as tumor location, tumor differentiation, and TNM stage. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Interleukins and interleukin receptors |
| Description | The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008] | Chromosome | 6 |
| Location | 6p12 |
| Start | 52186387 |
| End | 52190638 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 4252 |
| OMIM ID | 603149 |
| HGNC ID | HGNC:5981 |
| Unigene ID | Hs.41724 |
| Ensembl ID | ENSG00000112115 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_002190.2 |
|---|---|
| Exon | join(1..72,1217..1419,2669..4252) | mRNA Sequence | Download Select all |
| Length | 1859 |
CDS Information
| Location | join(46..72,1217..1419,2669..2906) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS4937.1 |
Protein Information
| Protein ID | NP_002181.1 |
|---|---|
| Protein Name | Interleukin 17A |
| Molecular Wt. (Da) | 15124 |
| Protein Sequence | Download Select all |
| Length | 155 |
| Uniprot ID | P15813 |
| Ensembl Protein ID | ENSP00000357153 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cytokine-cytokine receptor interaction | hsa04060 |
| Inflammatory bowel disease (IBD) | hsa05321 |
| Rheumatoid arthritis | hsa05323 |
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 1727 |
|---|---|
| Molecular Class | Cytokine |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q16552 | DB09029 | Secukinumab | BiotechDrug |