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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| IL1A | 3552 | Interleukin 1, alpha | 2 | IL1; IL-1A; IL1F1; IL1-ALPHA |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 9792144 | 1998 | Cell line : - Source : - Sample Type : Blood samples No. of Sample : 44 healthy volunteers and from 28 patients CRC Stage : - | Whole blood cell culture and stimulation of cytokine secretion, ELISA | Down-regulation | - | The differential expression of Blood protien were analysed by ELISA in colorectal cancer and normal colorectal tissue. |
| 19204921 | 2009 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | RT-PCR, ELISA, MTS, Matrigel-double chamber assay and angiogenesis assay. | Unknown | - | Colon cancer cell-derived IL-1alpha up-regulates angiogenesis by modulating stromal cells within the tumor cells' microenvironment. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Interleukins and interleukin receptors |
| Description | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008] | Chromosome | 2 |
| Location | 2q14 |
| Start | 112773915 |
| End | 112785394 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 11480 |
| OMIM ID | 147760 |
| HGNC ID | HGNC:5991 |
| Unigene ID | Hs.1722 |
| Ensembl ID | ENSG00000115008 |
| PharmGKB ID | PA29807 |
mRNA Information
| mRNA ID | NM_000575.3 |
|---|---|
| Exon | join(1..952,1617..1671,2631..2679,3569..3791,5729..5899, 7284..7408,10128..11480) | mRNA Sequence | Download Select all |
| Length | 2943 |
CDS Information
| Location | join(1625..1671,2631..2679,3569..3791,5729..5899, 7284..7408,10128..10328) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS2101.1 |
Protein Information
| Protein ID | NP_000566.3 |
|---|---|
| Protein Name | Interleukin 1, alpha |
| Molecular Wt. (Da) | 30476 |
| Protein Sequence | Download Select all |
| Length | 271 |
| Uniprot ID | P30281 |
| Ensembl Protein ID | ENSP00000362079 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 87 |
| F | Proteolytic Cleavage | 118 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3554 | IL1R1 | 994 | NP_000868.1 | in vitro;in vivo | 2946959 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| AGE-RAGE signaling pathway in diabetic complications | hsa04933 |
| Apoptosis | hsa04210 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Graft-versus-host disease | hsa05332 |
| Hematopoietic cell lineage | hsa04640 |
| Inflammatory bowel disease (IBD) | hsa05321 |
| Influenza A | hsa05164 |
| Leishmaniasis | hsa05140 |
| MAPK signaling pathway | hsa04010 |
| Measles | hsa05162 |
| Non-alcoholic fatty liver disease (NAFLD) | hsa04932 |
| Osteoclast differentiation | hsa04380 |
| Pertussis | hsa05133 |
| Prion diseases | hsa05020 |
| Rheumatoid arthritis | hsa05323 |
| Salmonella infection | hsa05132 |
| Tuberculosis | hsa05152 |
| Type I diabetes mellitus | hsa04940 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00100 | 133-267 | IL1 |
| cl00094 | 133-267 | IL1 superfamily |
| smart00125 | 129-267 | IL1 |
| pfam00340 | 155-266 | IL1 |
| pfam02394 | 1-109 | IL1_propep |
| cl03569 | 1-109 | IL1_propep superfamily |
Ontology Information
| HPRD ID | 4438 |
|---|---|
| Molecular Class | Cytokine |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P01583 | DB06372 | Rilonacept | BiotechDrug |