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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 9792144 | 1998 | Cell line : - Source : - Sample Type : Blood samples No. of Sample : 44 healthy volunteers and from 28 patients CRC Stage : - | Whole blood cell culture and stimulation of cytokine secretion, ELISA | Down-regulation | - | WBCCs of colorectal cancer patients secreted significantty lower amounts of IFN-a, IFN-y, IL-1 a and IL-2. |
| 1548866 | 1995 | Cell line : WiDr, HT 29 Source : - Sample Type : - No. of Sample : - Stage : - | Receptor Binding Assay, [3H]Thymidine Uptake Studies , Affinity Cross-linking of 125I-IL-4 to Its Re | Unknown | - | IL-4 Induces the Phosphorylation of JAK2 Tyrosine Kinase in Human Colon Carcinoma Cells. |
| 19638464 | 2009 | Cell line : CT 26 Source : HarlanSprague-Dawley (Madison, WI). Sample Type : Mouse model No. of Sample : - Stage : - | Radiofrequency Tumor Ablation, HuKS-IL2 IC, Surgical Tumor Resection and Flow Cytometry. | Unknown | - | Addition of huKS-IL2 to RFA significantly enhances the antitumor response in the murine model, resulting in complete tumor resolution and induction of immunologic memory. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Interleukins and interleukin receptors |
| Description | The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008] | Chromosome | 4 |
| Location | 4q26-q27 |
| Start | 122451470 |
| End | 122456495 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 5026 |
| OMIM ID | 147680 |
| HGNC ID | HGNC:6001 |
| Unigene ID | Hs.89679 |
| Ensembl ID | ENSG00000109471 |
| PharmGKB ID | PA195 |
mRNA Information
| mRNA ID | NM_000586.3 |
|---|---|
| Exon | join(1..202,293..352,2643..2786,4634..5026) | mRNA Sequence | Download Select all |
| Length | 822 |
CDS Information
| Location | join(56..202,293..352,2643..2786,4634..4744) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS3726.1 |
Protein Information
| Protein ID | NP_000577.2 |
|---|---|
| Protein Name | Interleukin 2 |
| Molecular Wt. (Da) | 15418 |
| Protein Sequence | Download Select all |
| Length | 153 |
| Uniprot ID | P24864 |
| Ensembl Protein ID | ENSP00000262643 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Glycosylation | 23 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3439 | IFNA1 | 974 | NP_076918.1 | in vitro | 3262520 |
| 3560 | IL2RB | 896 | NP_000869.1 | in vivo | 110 350 668 049 354 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Allograft rejection | hsa05330 |
| Autoimmune thyroid disease | hsa05320 |
| Chagas disease (American trypanosomiasis) | hsa05142 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Graft-versus-host disease | hsa05332 |
| HTLV-I infection | hsa05166 |
| Inflammatory bowel disease (IBD) | hsa05321 |
| Intestinal immune network for IgA production | hsa04672 |
| Jak-STAT signaling pathway | hsa04630 |
| Measles | hsa05162 |
| PI3K-Akt signaling pathway | hsa04151 |
| T cell receptor signaling pathway | hsa04660 |
| Type I diabetes mellitus | hsa04940 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00715 | 7-150 | IL2 |
| cl23501 | 7-150 | IL2 superfamily |
| smart00189 | 1-153 | IL2 |
| cl23048 | 1-153 | IL2 superfamily |
Ontology Information
| HPRD ID | 1780 |
|---|---|
| Molecular Class | Cytokine |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P60568 | DB00852 | Pseudoephedrine | SmallMoleculeDrug |
| P60568 | DB05676 | Apremilast | SmallMoleculeDrug |