Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| IL24 | 11009 | Interleukin 24 | 1 | C49A; FISP; MDA7; MOB5; ST16; IL10B |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 16000066 | 2005 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Down-regulation | - | Oncolytic adenovirus expressing IL-24 could exert potential antitumor activity and offer a novel approach to cancer therapy. ZD55-IL-24 exerted a strong cytopathic effect and significant apoptosis in tumor cells with p53 dysfunction. Activation of caspase 3 and caspase 9, and induction of bax gene expression, were involved in tumor cell apoptosis induced by ZD55-IL-24. |
| 16924242 | 2007 | Cell line : HCT 15, HCT 116, SW620 , HT 29 Source : ATCC Sample Type : - No. of Sample : - Stage : - | MTT viability assays, Apoptosis and necrosis assay (Annexin-V-binding assay). | Down-regulation | - | Simultaneous inhibition of K-ras and expression of mda-7/IL-24 enhanced killing of colorectal carcinoma cells with mutated K-ras. |
| 18025283 | 2007 | Cell line : SW 620 Source : ATCC Sample Type : Mouse model No. of Sample : - Stage : - | Viability Assays, Transfection Assayswith Small Interfering RNA, Apoptosis Assay | Down-regulation | - | mda-7/IL-24 is a potent MDR reversal agent, preferentially causing apoptosis in P-gp-overexpressing MDR cells, suggesting significant expanded clinical implications for the use of mda-7/IL-24 in treating neoplasms that have failed chemotherapy mediated by the P-gp MDR mechanism.
|
| 20354907 | 2011 | Cell line : HT 29, HT 29/oxa Source : Cell and Molecular Biology Institute of Soochow University (Suzhou, China). Sample Type : - No. of Sample : - Stage : - | Generation of recombinant adenoviral vectors, Expression of IL-24 in HT-29 cells, RT-PCR, MTT | Down-regulation | - | This study supports a potential therapeutic effect for melanoma differentiation associated gene-7 on colon cancer. Melanoma differentiation associated gene-7 induced expression of a growth arrest and DNA damage (GADD) gene and reduced the expression of both VEGF and MVD in xenograft tumors. |
| 23481022 | 2013 | Cell line : - Source : Yokohama City Medical Center, Gastroenterological Center and at Kanagawa Cancer Center, American Type Cell Culture (Manassas, Virginia, USA), Dr. Ed Chu (Yale Cancer Center) and Dr. Paddy Johnston (Queen?s University Belfast, Belfast City Hospital, Northern Ireland) Sample Type : CRC tumor and normal tissue No. of Sample : 202 Stage : - | Western blotting, Real-time RT- PCR | Down-regulation | - | MDA-7/IL-24 level is both a diagnostic and prognostic biomarker for CRC, and support the role of MDA-7/IL-24 in the treatment of CRC. Compared with the adjacent mucosa, CRC tissues displayed significantly lower MDA-7/IL-24 levels. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Interleukins and interleukin receptors |
| Description | This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] | Chromosome | 1 |
| Location | 1q32 |
| Start | 206897098 |
| End | 206904139 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 7042 |
| OMIM ID | 604136 |
| HGNC ID | HGNC:11346 |
| Unigene ID | Hs.58831 |
| Ensembl ID | ENSG00000162892 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011509101.1 |
|---|---|
| Exon | join(1..518,2220..2418,3198..3260,4397..4555,4901..4975, 5879..6768) | mRNA Sequence | Download Select all |
| Length | 1904 |
CDS Information
| Location | join(736..779,2220..2418,3198..3260,4397..4555,4901..4975, 5879..5962) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS53465.1 |
Protein Information
| Protein ID | NP_001172085.1 |
|---|---|
| Protein Name | Interleukin 24 |
| Molecular Wt. (Da) | 18163 |
| Protein Sequence | Download Select all |
| Length | 207 |
| Uniprot ID | P03372 |
| Ensembl Protein ID | ENSP00000206249 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cytokine-cytokine receptor interaction | hsa04060 |
| Jak-STAT signaling pathway | hsa04630 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| PHA02839 | 73-200 | PHA02839 |
| cl14433 | 73-200 | PHA02839 superfamily |
| pfam14565 | 84-201 | IL22 |
| cl02501 | 84-201 | IL10 superfamily |
| pfam00726 | 67-203 | IL10 |
Ontology Information
| HPRD ID | 9035 |
|---|---|
| Molecular Class | Unknown |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.