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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ILF2 | 3608 | interleukin enhancer binding factor 2 | 1 | NF45 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
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- PPi
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- Structural
- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23799036 | 2013 | Cell line : - Source : Gyorffy group [30] on genome-wide gene expression profile Sample Type : CRC tumor and normal tissue No. of Sample : 53 Stage : - | Microarray | Up-regulation | - | Among the 16 candidate cancer genes that encoded transcription factors, 13 were known to be tumorigenic and three were novel: CDK1, SNRPF, and ILF2. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The encoded 45 kDa protein (NF45, ILF2) forms a complex with the 90 kDa interleukin enhancer-binding factor 3 (NF90, ILF3), and this complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm, to repair DNA breaks by nonhomologous end joining, and to negatively regulate the microRNA processing pathway. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14. [provided by RefSeq, Dec 2014] | Chromosome | 1 |
| Location | 1q21.3 |
| Start | 153634264 |
| End | 153643504 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 9241 |
| OMIM ID | 603181 |
| HGNC ID | HGNC:6037 |
| Unigene ID | Hs.75117 |
| Ensembl ID | ENSG00000143621 |
| PharmGKB ID | PA29852 |
mRNA Information
| mRNA ID | NM_012437.5 |
|---|---|
| Exon | complement(<9177..>9241) | mRNA Sequence | Download Select all |
| Length | 1052 |
Protein Information
| Protein ID | NP_036569.1 |
|---|---|
| Protein Name | interleukin enhancer binding factor 2 |
| Molecular Wt. (Da) | 14743 |
| Protein Sequence | Download Select all |
| Length | 136 |
| Uniprot ID | Q14527 |
| Ensembl Protein ID | ENSP00000308944 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 388;- |
| D | Proteolytic Cleavage | 289 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1937 | EEF1G | 11745 | NP_001395.1 | yeast 2-hybrid | 16189514 |
| 5591 | PRKDC | 2941 | NP_008835.5 | in vitro;in vivo | 9442054 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00572 | 98-338 | DZF |
| cl02675 | 98-338 | DZF superfamily |
| pfam07528 | 104-337 | DZF |
Ontology Information
| HPRD ID | 4459 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.