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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ILK 3611 integrin-linked kinase  11- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23108908   2013Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 102 archived, paraffin-embedded CRC samples and expression of ILK in 25 paired primary CRC samples and adjacent noncancerous tissues

Stage : -

real-time PCR and Western blotting,ImmunohistochemistryUp-regulation- ILK overexpression is associated with tumor progression and a poor prognosis in CRC patients and may represent a novel potential prognostic marker for patients with CRC.


Gene Details



NC_000011.9 (6624938..6632105)

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Gene Type protein coding
Gene Family Ankyrin repeat domain containing
Description This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]  
Chromosome 11
Location 11p15.4
Start 6624938  
End 6632105  
Strand +  
Gene Sequence

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Length 7168  
OMIM ID 602366   
HGNC ID HGNC:6040   
Unigene ID Hs.706355   
Ensembl ID ENSG00000166333   
PharmGKB ID PA29855   

mRNA Information


mRNA ID NM_004517.3
Exon join(1..115,473..653,4339..4504,4687..4782,4987..5083, 5177..5260,5364..5449,5592..5701,5805..5932,6017..6138, 6229..6328,6441..6571,6755..7167)  
mRNA Sequence

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Length 1843  



CDS Information


   
Location208..1566
CDS Sequence

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CCDS ID CCDS60712.1



Protein Information


      
Protein IDNP_004508.1
Protein Nameintegrin-linked kinase
Molecular Wt. (Da)51288
Protein Sequence

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Length 452  
Uniprot IDP51532
Ensembl Protein ID ENSP00000343896  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation343
SPhosphorylation343
SPhosphorylation343

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                        
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
207AKT11261NP_005154.2in vitro;in vivo9   736   715   121   763   370   000   000   000   000   000   000   000   000   000   000   000   000   000   
841CASP83459NP_001073594.1in vivo16936772   
842CASP93756NP_001220.2in vivo16936772   
3688ITGB1628NP_391987.1in vitro;in vivo85   387   499   736   715   
3689ITGB22506NP_000202.2in vivo9736715   
3690ITGB31428NP_000203.2in vivo12372433   
4659PPP1R12A3606NP_002471.1in vitro12   600   888   106   013   000   000   000   000   000   000   
7114TMSB4X2153NP_066932.1in vitro15565145   


Pathway Information


                        
Pathway Name Pathway ID
Bacterial invasion of epithelial cells hsa05100
Endometrial cancer hsa05213
Focal adhesion hsa04510
PPAR signaling pathway hsa03320


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd14057197-449  PK_ILK
cl21453197-449  PKc_like superfamily
cd0020428-140  ANK
cl0252928-140  ANK superfamily
cd13999199-446  STKc_MAP3K-like
cd00192205-447  PTKc
cd14060205-449  STKc_MLTK
cd14064205-447  PKc_TNNI3K
cd002048-120  ANK
cd05038190-447  PTKc_Jak_rpt2
cd14061205-449  STKc_MLK
cd14058205-451  STKc_TAK1
cd05039205-439  PTKc_Csk_like
cd14148205-447  STKc_MLK2
cd14066205-449  STKc_IRAK
cd14059205-447  STKc_MAP3K12_13
cd13978204-439  STKc_RIP
cd14204188-452  PTKc_Mer
cd05083188-449  PTKc_Chk
cd14145188-443  STKc_MLK1
cd05034198-447  PTKc_Src_like
cd05068188-440  PTKc_Frk_like
cd14146205-443  STKc_MLK4
cd14147189-449  STKc_MLK3
cd05075199-449  PTKc_Axl
cd05035199-449  PTKc_TAM
cd05082188-451  PTKc_Csk
cd14062205-447  STKc_Raf
cd05148191-439  PTKc_Srm_Brk
cd14203198-447  PTKc_Src_Fyn_like
cd05047199-451  PTKc_Tie
cd14150192-450  STKc_A-Raf
cd05041198-442  PTKc_Fes_like
cd05074214-447  PTKc_Tyro3
cd05033205-449  PTKc_EphR
cd14042210-451  PK_GC-A_B
cd13992210-449  PK_GC
cd05046205-448  PTK_CCK4
cd05069191-447  PTKc_Yes
cd14056205-437  STKc_TGFbR_I
cd13998205-436  STKc_TGFbR-like
cd05113188-443  PTKc_Btk_Bmx
cd05066217-449  PTKc_EphR_A
cd05085199-442  PTKc_Fer
cd14053205-436  STKc_ACVR2
cd05043242-446  PTK_Ryk
cd05063205-449  PTKc_EphR_A2
cd05052198-449  PTKc_Abl
cd05059188-439  PTKc_Tec_like
cd14149188-450  STKc_C-Raf
cd14063192-452  PK_KSR
cd14151192-449  STKc_B-Raf
cd00180205-443  PKc
cd05045209-452  PTKc_RET
cd05089190-451  PTKc_Tie1
cd05084205-442  PTKc_Fes
cd14014205-438  STKc_PknB_like
cd05112188-443  PTKc_Itk
cd14054201-436  STKc_BMPR2_AMHR2
cd05070193-447  PTKc_Fyn
cd05088188-449  PTKc_Tie2
cd05072188-447  PTKc_Lyn
cd14026245-439  STKc_RIP2
cd14025237-442  STKc_RIP4_like
cd05048192-442  PTKc_Ror
cd14205191-450  PTKc_Jak2_rpt2
cd14142191-436  STKc_ACVR1_ALK1
cd05058242-443  PTKc_Met_Ron
cd05090193-442  PTKc_Ror1
cd14144205-436  STKc_BMPR1
cd14000205-446  STKc_LRRK
cd14065205-443  PKc_LIMK_like
cd05067193-447  PTKc_Lck_Blk
cd05080214-449  PTKc_Tyk2_rpt2
cd14154211-451  STKc_LIMK
cd05055217-449  PTKc_PDGFR
cd05071191-447  PTKc_Src
cd05065205-449  PTKc_EphR_B
cd05032219-447  PTKc_InsR_like
cd05081218-450  PTKc_Jak3_rpt2
cd05064205-449  PTKc_EphR_A10
cd14219191-451  STKc_BMPR1b
cd14153205-449  PK_KSR2
cd14220205-449  STKc_BMPR1a
cd05053192-449  PTKc_FGFR
cd13979189-447  STKc_Mos
cd05057205-449  PTKc_EGFR_like
cd14045210-449  PK_GC_unk
cd05056198-447  PTKc_FAK
cd14155246-452  PKc_TESK
cd05040198-446  PTKc_Ack_like
cd14143205-436  STKc_TGFbR1_ACVR1b_ACVR1c
cd14221211-450  STKc_LIMK1
cd06606217-437  STKc_MAPKKK
cd05114188-446  PTKc_Tec_Rlk
cd05061191-448  PTKc_InsR
cd05122204-437  PKc_STE
cd14152205-449  STKc_KSR1
cd05079195-449  PTKc_Jak1_rpt2
cd14664205-447  STK_BAK1_like
cd05108205-449  PTKc_EGFR
cd05050217-448  PTKc_Musk
cd05051191-442  PTKc_DDR
cd05060209-439  PTKc_Syk_like
cd05044245-447  PTKc_c-ros
cd05097191-442  PTKc_DDR_like
cd14043241-442  PK_GC-2D
cd14001236-448  PKc_TOPK
cd14156217-449  PKc_LIMK_like_unk
cd14158198-449  STKc_IRAK4
cd05099212-449  PTKc_FGFR4
cd14008247-436  STKc_LKB1_CaMKK
cd05109205-449  PTKc_HER2
cd14222211-439  STKc_LIMK2
cd05092217-436  PTKc_TrkA
cd05037209-443  PTK_Jak_rpt1
cd05091188-442  PTKc_Ror2
cd05098217-449  PTKc_FGFR1
cd05096213-442  PTKc_DDR1
cd05110205-449  PTKc_HER4
cd05095191-448  PTKc_DDR2
cd05042217-437  PTKc_Aatyk
cd06630237-438  STKc_MEKK1
cd06610264-437  STKc_OSR1_SPAK
cd05100217-449  PTKc_FGFR3
cd05054217-446  PTKc_VEGFR
cd05049217-448  PTKc_Trk
cd05107295-449  PTKc_PDGFR_beta
cd14067215-451  STKc_LRRK1
cd06625214-437  STKc_MEKK3_like
cd13994218-443  STKc_HAL4_like
cd14003325-437  STKc_AMPK-like
cd14140205-436  STKc_ACVR2b
cd05102215-446  PTKc_VEGFR3
cd05062292-443  PTKc_IGF-1R
cd05101217-449  PTKc_FGFR2
cd14207295-451  PTKc_VEGFR1
cd05073198-447  PTKc_Hck
cd14080208-442  STKc_TSSK-like
cd06614193-442  STKc_PAK
cd06632205-442  STKc_MEKK1_plant
cd13975281-452  PKc_Dusty
cd05036191-443  PTKc_ALK_LTK
cd14055205-436  STKc_TGFbR2_like
cd14009208-440  STKc_ATG1_ULK_like
cd08530353-442  STKc_CNK2-like
cd06628242-440  STKc_Byr2_like
cd06618353-442  PKc_MKK7
cd14044275-449  PK_GC-C
cd05580236-436  STKc_PKA_like
cd14206217-437  PTKc_Aatyk3
cd08223192-437  STKc_Nek4
cd06653214-437  STKc_MEKK3_like_u1
cd08529267-437  STKc_FA2-like
cd14027266-439  STKc_RIP1
cd05111205-439  PTK_HER3
cd05116197-446  PTKc_Syk
cd14068205-446  STKc_LRRK2
cd06652214-426  STKc_MEKK2
cd08215357-437  STKc_Nek
cd14002205-436  STKc_STK36
cd14665243-436  STKc_SnRK2-3
cd06631213-437  STKc_YSK4
cd05572353-436  STKc_cGK
cd05104283-448  PTKc_Kit
cd14033222-436  STKc_WNK4
cd05093217-449  PTKc_TrkB
cd14159205-387  STKc_IRAK1
cd14141205-436  STKc_ACVR2a
cd14199237-436  STKc_CaMKK2
cd06648214-436  STKc_PAK_II
cd14031222-436  STKc_WNK3
cd13985243-448  STKc_GAK_like
cd14081242-436  STKc_BRSK1_2
cd05123267-436  STKc_AGC
cd05106289-449  PTKc_CSF-1R
cd14030222-436  STKc_WNK1
pfam0002368-98  Ank
cd06640267-437  STKc_MST4
cd05103217-443  PTKc_VEGFR2
cd05086205-400  PTKc_Aatyk2
cd06627242-437  STKc_Cdc7_like
cd06641196-437  STKc_MST3
cd05077221-443  PTK_Jak1_rpt1
cd05616193-436  STKc_cPKC_beta
cd14663242-436  STKc_SnRK3
cd14157208-387  STKc_IRAK2
cd05105226-449  PTKc_PDGFR_alpha
cd08220217-446  STKc_Nek8
cd05087217-437  PTKc_Aatyk1
cd08217353-437  STKc_Nek2
cd05577264-436  STKc_GRK
cd06659198-436  STKc_PAK6
cd08222288-437  STKc_Nek11
cd14010264-443  STKc_ULK4
cd06658214-415  STKc_PAK5
cd14007267-437  STKc_Aurora
cd13997195-443  PKc_Wee1_like
cd05612206-436  STKc_PRKX_like
cd06611234-437  STKc_SLK_like
cd13986243-451  STKc_16
cd14078352-436  STKc_MELK
smart0024867-95  ANK
cd05078221-443  PTK_Jak2_rpt1
cd06609353-437  STKc_MST3_like
cd14012246-437  PK_eIF2AK_GCN2_rpt1
cd06644301-437  STKc_STK10
cd06620247-437  PKc_Byr1_like
pfam0002333-65  Ank
cd05118198-438  STKc_CMGC
cd14194214-392  STKc_DAPK1
cd14167231-436  STKc_CaMKI_alpha
cd05117219-437  STKc_CAMK
cd14165290-407  STKc_TSSK1_2-like
cd14077243-436  STKc_Kin1_2
cd14032222-436  STKc_WNK2_like
cd14118242-436  STKc_CAMKK
cd14072320-452  STKc_MARK
cd05582221-436  STKc_RSK_N
cd05615291-436  STKc_cPKC_alpha
cd14106267-440  STKc_DRAK
cd06642267-437  STKc_STK25
cd05094217-449  PTKc_TrkC
cd14185214-436  STKc_DCKL3
cd14005371-442  STKc_PIM
cd14011241-445  PK_SCY1_like
cd14004241-443  STKc_PASK
cd14070214-437  STKc_HUNK
cd06626219-437  STKc_MEKK4
cd05581353-437  STKc_PDK1
cd14202207-440  STKc_ULK1
cd05115216-439  PTKc_Zap-70
cd08218196-448  STKc_Nek1
cd14176214-394  STKc_RSK2_C
cd05587293-436  STKc_cPKC
cd14116247-437  STKc_Aurora-A
cd06629236-437  STKc_Bck1_like
cd05570353-436  STKc_PKC
cd05620290-436  STKc_nPKC_delta
cd14115216-437  STKc_Kalirin_C
cd06651238-437  STKc_MEKK3
cd06624355-438  STKc_ASK
cd14209267-436  STKc_PKA
cd14169238-400  STKc_CaMKI_beta
cd05595275-436  STKc_PKB_beta
cd06612325-437  STKc_MST1_2
cd08225207-443  STKc_Nek5
pfam1360669-95  Ank_3
cd06617296-449  PKc_MKK3_6
cd13976353-437  PK_TRB
cd14177230-397  STKc_RSK4_C
cd06622354-450  PKc_PBS2_like
cd14172267-436  STKc_MAPKAPK3
cd05630267-436  STKc_GRK6
cd06917353-436  STKc_NAK1_like
cd08227243-414  PK_STRAD_alpha
cd14074214-443  STKc_SNRK
cd14182267-392  STKc_PhKG1
cd06657211-436  STKc_PAK4
cd14175222-394  STKc_RSK1_C
cd06655267-436  STKc_PAK2
cd14195209-392  STKc_DAPK3
cd05579353-437  STKc_MAST_like
cd05583355-436  STKc_MSK_N
smart0024833-62  ANK
cd14208355-443  PTK_Jak3_rpt1
cd14181247-392  STKc_PhKG2
pfam0002399-131  Ank
cd14024240-436  PK_TRB3
cd06623358-437  PKc_MAPKK_plant_like
cd14071320-442  STKc_SIK
cd05594275-436  STKc_PKB_alpha
cd05604291-436  STKc_SGK3
cd06643353-436  STKc_SLK
cd14102349-442  STKc_PIM3
cd14022353-436  PK_TRB2
cd14023353-443  PK_TRB1
cd14120208-440  STKc_ULK1_2-like
cd14201334-447  STKc_ULK2
cd14191198-392  STKc_MLCK1
cd14168231-436  STKc_CaMKI_delta
cd14098353-437  STKc_Rad53_Cds1
cd05614355-436  STKc_MSK2_N
cd05619290-392  STKc_nPKC_theta
cd08528273-437  STKc_Nek10
cd08229353-450  STKc_Nek7
cd14198267-405  STKc_DRAK2
cd05622267-392  STKc_ROCK1
cd14662243-394  STKc_SnRK2
cd05592293-436  STKc_nPKC_theta_like
cd14187353-440  STKc_PLK1
cd14100349-443  STKc_PIM1
cd05603353-436  STKc_SGK2
cd14163354-394  STKc_TSSK3-like
pfam1360633-62  Ank_3
cd06607300-437  STKc_TAO
cd05631277-392  STKc_GRK4
cd14075247-442  STKc_NIM1
cd14200237-436  STKc_CaMKK1
cd08228353-450  STKc_Nek6
cd14113300-437  STKc_Trio_C
cd14101349-443  STKc_PIM2
cd14178230-394  STKc_RSK3_C
cd14094348-436  STKc_CASK
cd05607264-394  STKc_GRK7
cd14160206-447  PK_IRAK3
cd05621264-392  STKc_ROCK2
cd05602193-436  STKc_SGK1
cd05585353-436  STKc_YPK1_like
cd14087222-394  STKc_PSKH1
cd14131357-437  PKc_Mps1
cd14170351-436  STKc_MAPKAPK2
cd06654267-436  STKc_PAK1
smart00750352-437  KIND
cd14037353-437  STKc_NAK_like
cd06605193-442  PKc_MAPKK
cd05632277-392  STKc_GRK5
cd05617291-436  STKc_aPKC_zeta
cd08221353-446  STKc_Nek9
cd06635303-443  STKc_TAO1
cd08224353-437  STKc_Nek6_7
cd08219353-437  STKc_Nek3
cd05575353-436  STKc_SGK
cd14105220-392  STKc_DAPK
cd14018357-446  STKc_PINK1
cd05613355-436  STKc_MSK1_N
cd06616355-442  PKc_MKK4
cd13993242-436  STKc_Pat1_like
cd14039207-399  STKc_IKK_alpha
cd06613353-437  STKc_MAP4K3_like
cd14096243-436  STKc_RCK1-like
cd05571353-436  STKc_PKB
cd14119371-437  STKc_LKB1
cd05593353-436  STKc_PKB_gamma
cd05573353-432  STKc_ROCK_NDR_like
cd06634303-443  STKc_TAO2
cd14121353-440  STKc_ULK3
cd05591290-392  STKc_nPKC_epsilon
cd05590290-436  STKc_nPKC_eta
cd14197350-392  STKc_DRAK1
cd07855242-388  STKc_ERK5
cd14171247-392  STKc_MAPKAPK5
cd14189353-443  STKc_PLK3
cd14164277-394  STKc_TSSK6-like
cd14082353-392  STKc_PKD
pfam07714193-446  Pkinase_Tyr
pfam1279638-130  Ank_2
pfam13637Apr-54  Ank_4
smart00221193-446  STYKc
smart00219193-446  TyrKc
pfam00069204-443  Pkinase
smart00220205-437  S_TKc
pfam12796Aug-97  Ank_2
COG066627-169  ANKYR
PHA0287826-107  PHA02878
COG06662-108  ANKYR
COG0515194-438  SPS1
COG066610-107  ANKYR
PTZ00283304-437  PTZ00283
PHA0309526-138  PHA03095
PHA0310026-137  PHA03100
pfam1279671-140  Ank_2
PHA0287512-137  PHA02875
PHA0310026-108  PHA03100
pfam1363734-87  Ank_4
PTZ00322Nov-89  PTZ00322
PHA0287411-136  PHA02874
PHA0287426-140  PHA02874
PHA030953-140  PHA03095
PHA0310022-136  PHA03100
pfam1363769-120  Ank_4
PHA0287427-140  PHA02874
PHA028749-140  PHA02874
PHA0287426-143  PHA02874
pfam1385752-107  Ank_5
PHA0309516-105  PHA03095
PHA0310026-99  PHA03100
PTZ00267353-437  PTZ00267
PHA0287849-137  PHA02878
PHA0287825-140  PHA02878
pfam1385720-74  Ank_5
PHA0310026-131  PHA03100
PHA02988201-437  PHA02988
PHA0287510-124  PHA02875
PHA0287626-140  PHA02876
PHA0287627-140  PHA02876
PHA0294628-134  PHA02946
PTZ00263207-436  PTZ00263
pfam1385786-140  Ank_5
PHA028594-108  PHA02859
PLN0319218-149  PLN03192
PTZ0032212-119  PTZ00322
PTZ0032272-140  PTZ00322
PLN00113196-391  PLN00113
PHA027438-124  PHA02743
PLN0319226-151  PLN03192
PHA0287820-140  PHA02878
PHA0287626-137  PHA02876
PHA02876May-93  PHA02876
PHA0287649-107  PHA02876
COG066631-134  ANKYR
PHA0294650-106  PHA02946
PHA0309526-96  PHA03095
PHA0287534-130  PHA02875
TIGR0087033-147  trp
PHA0287527-96  PHA02875
PHA0279123-120  PHA02791
PHA0279826-96  PHA02798
PHA0287535-104  PHA02875
TIGR0087062-121  trp


Ontology Information


   
HPRD ID3364
Molecular ClassSerine/threonine kinase
Molecular FunctionDNA binding (GO:0003677)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO