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General Information

• Evidence
• Gene
• mRNA
• CDS
• Protein
• PTM
• Enzyme
• PPi
• Pathway
• Structural
• Domain
• Ontology
• SNP
• Drug
• External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
11453556	2001	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	RT-PCR	Up-regulation	-	HsINCENP protein levels are also significantly increased in several colorectal cancer cell lines.

Gene Details

NC_000011.9 (61891445..61920635)
View Larger Image   

Gene Type	protein coding
Gene Family	-
Description	In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008]
Chromosome	11
Location	11q12.3
Start	61891445
End	61920635
Strand	+
Gene Sequence	Download   Select all
Length	29191
OMIM ID	604411
HGNC ID	HGNC:6058
Unigene ID	Hs.142179
Ensembl ID	ENSG00000149503
PharmGKB ID	PA29868

mRNA Information

mRNA ID	NM_001040694.1
Exon	join(1..191,4179..4329,4798..4911,5810..6618,13860..13911, 14741..14798,14916..15033,16262..16313,16732..16849, 16941..17072,17528..17539,21010..21119,21197..21317, 21657..21779,22686..22930,24504..24582,24767..24874, 26085..26235,27790..29191)
mRNA Sequence	Download   Select all
Length	4146

CDS Information

   

Location	203..2959
CDS Sequence	Download   Select all
CCDS ID	CCDS31582.1

Protein Information

      

Protein ID	NP_001035784.1
Protein Name	inner centromere protein antigens 135/155kDa
Molecular Wt. (Da)	105298
Protein Sequence	Download   Select all
Length	918
Uniprot ID	Q12824
Ensembl Protein ID	ENSP00000263121

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
T	Phosphorylation	888
S	Phosphorylation	889
S	Phosphorylation	890
Y	Phosphorylation	73
S	Phosphorylation	119
S	Phosphorylation	143
S	Phosphorylation	197
S	Phosphorylation	214
T	Phosphorylation	219
T	Phosphorylation	199
T	Phosphorylation	213
T	Phosphorylation	239
S	Phosphorylation	230
S	Phosphorylation	263
S	Phosphorylation	269
S	Phosphorylation	275
S	Phosphorylation	291
T	Phosphorylation	292
T	Phosphorylation	294
S	Phosphorylation	306
S	Phosphorylation	314
S	Phosphorylation	312
S	Phosphorylation	421
T	Phosphorylation	424
S	Phosphorylation	481
S	Phosphorylation	824
S	Phosphorylation	827
T	Phosphorylation	828
S	Phosphorylation	895
S	Phosphorylation	296
S	Phosphorylation	218;-
T	Phosphorylation	195;-
S	Phosphorylation	218;-
T	Phosphorylation	195;-
S	Phosphorylation	214;-
T	Phosphorylation	219;-
T	Phosphorylation	145;-
T	Phosphorylation	145;-
S	Phosphorylation	275;-
S	Phosphorylation	263;-
S	Phosphorylation	269;-
S	Phosphorylation	421;-
T	Phosphorylation	298;-
S	Phosphorylation	312;-
T	Phosphorylation	298;-
S	Phosphorylation	314;-
S	Phosphorylation	306;-
T	Phosphorylation	292;-
T	Phosphorylation	294;-
S	Phosphorylation	119
S	Phosphorylation	142
S	Phosphorylation	148
S	Phosphorylation	142
S	Phosphorylation	148
S	Phosphorylation	143
T	Phosphorylation	150
T	Phosphorylation	150
T	Phosphorylation	153
T	Phosphorylation	153
S	Phosphorylation	197
T	Phosphorylation	213
S	Phosphorylation	202
S	Phosphorylation	202
S	Phosphorylation	230
T	Phosphorylation	239
T	Phosphorylation	232
T	Phosphorylation	232
S	Phosphorylation	235
S	Phosphorylation	235
S	Phosphorylation	291
S	Phosphorylation	296
S	Phosphorylation	300
S	Phosphorylation	311
S	Phosphorylation	300
S	Phosphorylation	311
S	Phosphorylation	446
S	Phosphorylation	446
T	Phosphorylation	507
S	Phosphorylation	510
T	Phosphorylation	507
S	Phosphorylation	510
T	Phosphorylation	509
S	Phosphorylation	514
T	Phosphorylation	509
S	Phosphorylation	514
S	Phosphorylation	794
S	Phosphorylation	799
S	Phosphorylation	798
S	Phosphorylation	803
S	Phosphorylation	828
S	Phosphorylation	831
T	Phosphorylation	832
T	Phosphorylation	892
S	Phosphorylation	894
S	Phosphorylation	899
S	Phosphorylation	893
S	Phosphorylation	910
S	Phosphorylation	914
Y	Phosphorylation	322
S	Phosphorylation	323
Y	Phosphorylation	322
S	Phosphorylation	323
T	Phosphorylation	424
S	Phosphorylation	420
S	Phosphorylation	420
S	Phosphorylation	50
S	Phosphorylation	50
Y	Phosphorylation	73
S	Phosphorylation	373
S	Phosphorylation	373
T	Phosphorylation	199
T	Phosphorylation	412
T	Phosphorylation	412
T	Phosphorylation	789
T	Phosphorylation	793
S	Phosphorylation	72
S	Phosphorylation	72
S	Phosphorylation	106
S	Phosphorylation	106
S	Phosphorylation	350
S	Phosphorylation	350
S	Phosphorylation	481
T	Phosphorylation	204
T	Phosphorylation	204
S	Phosphorylation	480
S	Phosphorylation	480
Y	Phosphorylation	818
Y	Phosphorylation	822
T	Phosphorylation	250
T	Phosphorylation	250
S	Phosphorylation	103
S	Phosphorylation	103
S	Phosphorylation	91
S	Phosphorylation	91
S	Phosphorylation	93
S	Phosphorylation	93
S	Phosphorylation	458
S	Phosphorylation	458
S	Phosphorylation	476
S	Phosphorylation	476
S	Phosphorylation	400
S	Phosphorylation	400
Y	Phosphorylation	909
Y	Phosphorylation	913
S	Phosphorylation	411
S	Phosphorylation	411
S	Phosphorylation	426
S	Phosphorylation	426
T	Phosphorylation	478
T	Phosphorylation	478
T	Phosphorylation	406
T	Phosphorylation	406
S	Phosphorylation	94
S	Phosphorylation	94
S	Phosphorylation	255
S	Phosphorylation	255
S	Phosphorylation	330
S	Phosphorylation	330
T	Phosphorylation	840
T	Phosphorylation	844
S	Phosphorylation	357
S	Phosphorylation	357
T	Phosphorylation	798
T	Phosphorylation	802

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING)      View   

                                             

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
332	BIRC5	4520	NP_001012271.1	in vitro;in vivo;yeast 2-hybrid	11516652
3015	H2AFZ	823	NP_002097.1	in vitro;in vivo;yeast 2-hybrid	12660166
6795	AURKC	4605	AAC25955.1	in vitro;in vivo	15316025

Pathway Information

No matching records could be found.

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
pfam03941	825-883	INCENP_ARK-bind
cl04337	825-883	INCENP_ARK-bind superfamily
pfam12178	May-42	INCENP_N
cl13594	May-42	INCENP_N superfamily
pfam07946	536-596	DUF1682
cl20352	536-596	DUF1682 superfamily
PTZ00121	536-790	PTZ00121
PTZ00121	537-788	PTZ00121
PTZ00121	538-788	PTZ00121
PTZ00121	536-781	PTZ00121
PTZ00121	534-683	PTZ00121
PTZ00121	537-781	PTZ00121
PTZ00121	537-789	PTZ00121
PTZ00121	536-789	PTZ00121
PTZ00121	537-789	PTZ00121
PTZ00121	537-789	PTZ00121
PTZ00121	537-789	PTZ00121
PTZ00121	537-789	PTZ00121
PTZ00121	536-789	PTZ00121
PTZ00121	537-789	PTZ00121
PTZ00121	536-784	PTZ00121
PRK12704	533-615	PRK12704
COG1196	535-788	Smc
PTZ00121	536-789	PTZ00121
PTZ00121	521-789	PTZ00121
pfam02463	536-784	SMC_N
TIGR03319	536-616	RNase_Y
pfam02463	536-790	SMC_N
PRK09510	546-685	tolA
COG3064	551-784	TolA
COG1196	521-782	Smc
TIGR02168	533-784	SMC_prok_B
COG1196	536-798	Smc
TIGR02794	535-682	tolA_full
TIGR02168	535-791	SMC_prok_B
COG1196	539-791	Smc
pfam11600	536-646	CAF-1_p150
COG0419	536-784	SbcC
PRK00409	540-671	PRK00409
COG1196	539-791	Smc
pfam02463	523-781	SMC_N
COG3064	537-682	TolA
pfam12072	543-615	DUF3552
PRK05035	539-789	PRK05035
COG1196	536-782	Smc
pfam02463	531-783	SMC_N
PRK08691	141-287	PRK08691
COG0419	535-789	SbcC
pfam02463	536-784	SMC_N
COG1196	536-791	Smc
TIGR02169	536-616	SMC_prok_A
pfam04111	527-608	APG6
PRK00409	566-682	PRK00409
PRK11448	534-617	hsdR
COG5421	531-616	COG5421
PRK02224	525-615	PRK02224
pfam13868	536-784	Trichoplein
TIGR02169	536-791	SMC_prok_A
TIGR02168	536-784	SMC_prok_B
COG3064	537-682	TolA
pfam13868	543-784	Trichoplein
TIGR02168	535-781	SMC_prok_B
pfam02463	535-782	SMC_N
COG0419	536-685	SbcC
pfam06098	538-605	Radial_spoke_3
pfam05109	188-520	Herpes_BLLF1
pfam09756	565-647	DDRGK
TIGR02169	527-677	SMC_prok_A
PTZ00266	536-618	PTZ00266
PTZ00266	517-614	PTZ00266
TIGR02168	535-800	SMC_prok_B

Ontology Information

   

HPRD ID	3435
Molecular Class	Cell cycle control protein
Molecular Function	Transcription factor activity (GO:0003700)
Biological Process	Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)

SNP Information

View SNP Geneview Report   

Drug Information

No matching records could be found.

External Links

                                 

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO