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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ING4 51147 inhibitor of growth family, member 4  12p29ING4, my036 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21626442   2011Cell line : -

Source : Hospital of Harbin medical University.

Sample Type : CRC tumor

No. of Sample : 97

Stage : -

 Immunohistochemistry,Western blottingDown-regulation-ING4 protein expression was downregulated in adenoma relative to normal mucosa and further reduced in colorectal cancer tissues.


Gene Details



NC_000012.11 (6759704..6772311, complement)

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Gene Type protein coding
Gene Family Zinc fingers, PHD-type
Description This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008]  
Chromosome 12
Location 12p13.32
Start 6759704  
End 6772311  
Strand -  
Gene Sequence

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Length 12608  
OMIM ID 608524   
HGNC ID HGNC:19423   
Unigene ID Hs.524210   
Ensembl ID ENSG00000111653   
PharmGKB ID PA134976283   

mRNA Information


mRNA ID ?NM_001127582.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS44812.1



Protein Information


      
Protein IDNP_001121054.1
Protein Nameinhibitor of growth family, member 4
Molecular Wt. (Da)0
Protein Sequence

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Length 249  
Uniprot IDQ9NRA0
Ensembl Protein ID ENSP00000245222  



Post-translational Modification Information (Source : HPRD)


Residue Type site
KAcetylation145
KAcetylation147
KAcetylation155
KAcetylation145
KAcetylation147
KAcetylation155
KAcetylation235
KAcetylation127
KAcetylation129
KAcetylation127
KAcetylation129
KAcetylation112
KAcetylation112
SPhosphorylation149
SPhosphorylation149
SPhosphorylation52
SPhosphorylation52

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2033EP3004078NP_001420.2in vivo12750254   
5970RELA1241NP_068810.3in vivo;yeast 2-hybrid15029197   
7157TP531859NP_000537.3in vivo12750254   
11143MYST27135NP_008998.1in vivo16387653   
54583EGLN16971NP_071334.1in vitro;in vivo;yeast 2-hybrid15897452   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd15684197-244  PHD_ING4
cl22851197-244  PHD_SF superfamily
pfam129985-107  ING
cl152295-107  ING superfamily
cd15586198-242  PHD_ING4_5
cd15685197-245  PHD_ING5
cd15505198-242  PHD_ING
cd15585198-242  PHD_ING3
cd15584198-242  PHD_ING1_2
cd15587198-244  PHD_Yng1p_like
cd15682197-245  PHD_ING1
cd15683197-242  PHD_ING2
cd15522198-242  PHD_TAF3
pfam00628198-245  PHD
cd15568207-241  PHD5_NSD
smart00249198-242  PHD
cd15560198-242  PHD2_3_BPTF
cd15553198-242  PHD_Cfp1
cd15529207-242  PHD2_PHF10
cd15489199-242  PHD_SF
cd16039198-242  PHD_SPP1
cd15661198-240  PHD5_NSD3
cd15552198-242  PHD_PHF3_like
cd15660207-240  PHD5_NSD2
cd15518198-242  PHD_Ecm5p_Lid2p_like
cd15574209-242  PHD_AF10_AF17
cd15659207-240  PHD5_NSD1
cd15648200-243  PHD1_NSD1_2
cd15606198-242  PHD2_KDM5A
cd15538198-242  PHD_PRKCBP1
cd15516198-242  PHD2_KDM5A_like
cd15539207-242  PHD1_AIRE
cd15532198-242  PHD2_CHD_II
cd15492208-242  PHD_BRPF_JADE_like
cd15554198-242  PHD_PHF2_like
cd15535198-242  PHD1_Rco1
cd15567207-242  PHD4_NSD
cd15543199-242  PHD_RSF1
cd15517210-242  PHD_TCF19_like
cd15639198-242  PHD_DIDO1_like
cd15519207-242  PHD1_Lid2p_like
COG50347-245  TNG2
COG5141170-242  COG5141
PRK039188-115  PRK03918


Ontology Information


   
HPRD ID9650
Molecular ClassTranscription regulatory protein
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessBiological_process unknown (GO:0000004)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO