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General Information
- Evidence
- Gene
- mRNA
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24085226 | 2013 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 126 Stage : - | Western blotting,qRT-PCR. | Up-regulation | - | INHBA is useful as a predictive marker for prognosis in CRC patients. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome. [provided by RefSeq, Jul 2008] | Chromosome | 7 |
| Location | 7p15-p13 |
| Start | 41728601 |
| End | 41742706 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 14106 |
| OMIM ID | 147290 |
| HGNC ID | HGNC:6066 |
| Unigene ID | Hs.583348 |
| Ensembl ID | ENSG00000122641 |
| PharmGKB ID | PA29877 |
mRNA Information
| mRNA ID | NM_002192.2 |
|---|---|
| Exon | join(1..104,2592..3122,12567..14106) | mRNA Sequence | Download Select all |
| Length | 2175 |
Protein Information
| Protein ID | NP_002183.1 |
|---|---|
| Protein Name | inhibin, beta A |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 426 |
| Uniprot ID | P37840 |
| Ensembl Protein ID | ENSP00000338345 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 90 | ACVR1 | 21 | NP_001096.1 | in vivo | 11266516 |
| 92 | ACVR2A | 25 | NP_001607.1 | in vivo | 11266516 |
| 2022 | ENG | 565 | NP_001108225.1 | in vitro | 9872992 |
| 10468 | FST | 641 | NP_037541.1 | in vitro | 7887917 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cytokine-cytokine receptor interaction | hsa04060 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| TGF-beta signaling pathway | hsa04350 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00204 | 321-426 | TGFB |
| cl02510 | 321-426 | TGF_beta superfamily |
| pfam00019 | 319-426 | TGF_beta |
| PHA02913 | 306-425 | PHA02913 |
| pfam00688 | 31-242 | TGFb_propeptide |
| cl02928 | 31-242 | TGFb_propeptide superfamily |
| smart00041 | 348-426 | CT |
| cl21545 | 348-426 | GHB_like superfamily |
Ontology Information
| HPRD ID | 4297 |
|---|---|
| Molecular Class | Ligand |
| Molecular Function | Chaperone activity (GO:0003754) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.