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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| IPO5 | 3843 | RAN binding protein 5 | 13 | IMB3; Pse1; imp5; KPNB3; RANBP5 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22968445 | 2012 | Cell line : - Source : Department of Pathology of Wrocaw Medical University. Sample Type : - No. of Sample : - Stage : - | Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation. | Up-regulation | - | A list of genes including this gene are differentially expressed analysed by LC-MS/MS technique. To compare the proteomes of colonic mucosa (normal or N) and colon cancer (cancer or C), we analyzed archival FFPE clinical samples originating from eight patients. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Importins |
| Description | Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. [provided by RefSeq, Jul 2008] | Chromosome | 13 |
| Location | 13q32.2 |
| Start | 97953638 |
| End | 98024296 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 70659 |
| OMIM ID | 602008 |
| HGNC ID | HGNC:6402 |
| Unigene ID | Hs.712598 |
| Ensembl ID | ENSG00000065150 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011521089.1 |
|---|---|
| Exon | join(1..79,482..561,6710..6766,9523..9645,16086..16193, 23056..23149,28866..28946,31784..31976,35425..35527, 36489..36585,36796..36900,39255..39377,39468..39588, 43894..43981,46902..47008,48830..48954,49047..49136, 49227..49400,52493..52711,54422..54505,56244..56376, 56466..56587,58609..58705,60405..60577,61893..62004, 62089..62144,63092..63214,64848..65067,65944..66172, 67355..67496,68099..70656) | mRNA Sequence | Download Select all |
| Length | 6216 |
CDS Information
| Location | join(16144..16193,23056..23149,28866..28946,31784..31976, 35425..35527,36489..36585,36796..36900,39255..39377, 39468..39588,43894..43981,46902..47008,48830..48954, 49047..49136,49227..49400,52493..52711,54422..54505, 56244..56376,56466..56587,58609..58705,60405..60577, 61893..62004,62089..62144,63092..63214,64848..65067, 65944..66172,67355..67496,68099..68185) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS31999.1 |
Protein Information
| Protein ID | NP_002262.3 |
|---|---|
| Protein Name | RAN binding protein 5 |
| Molecular Wt. (Da) | 125415 |
| Protein Sequence | Download Select all |
| Length | 1115 |
| Uniprot ID | P16671 |
| Ensembl Protein ID | ENSP00000308165 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 845;- |
| T | Phosphorylation | 651 |
| S | Phosphorylation | 670 |
| T | Phosphorylation | 322 |
| S | Phosphorylation | 89 |
| S | Phosphorylation | 101 |
| S | Phosphorylation | 38 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3005 | H1F0 | 819 | NP_005309.1 | in vitro | 10228156 |
| 4928 | NUP98 | 3012 | NP_057404.2 | in vitro;in vivo | 9114010 |
| 5901 | RAN | 3109 | NP_006316.1 | in vitro;in vivo | 9114010 |
| 5903 | RANBP2 | 3111 | NP_006258.3 | in vitro;in vivo | 9114010 |
| 6137 | RPL13 | 6428 | NP_150254.1 | in vitro | 9114010 |
| 8021 | NUP214 | 258 | NP_005076.3 | in vitro | 9114010 |
| 9349 | RPL23 | 4716 | NP_000969.1 | in vitro | 9114010 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00020 | 353-471 | ARM |
| cl22454 | 353-471 | ARM superfamily |
| pfam13513 | 372-426 | HEAT_EZ |
| pfam12755 | 374-422 | Vac14_Fab1_bd |
| cl15071 | 374-422 | Vac14_Fab1_bd superfamily |
| pfam13513 | 919-979 | HEAT_EZ |
| cl22454 | 919-979 | ARM superfamily |
| pfam02985 | 400-427 | HEAT |
| cl03819 | 400-427 | HEAT superfamily |
| pfam13646 | 363-466 | HEAT_2 |
| COG5215 | 13-634 | KAP95 |
Ontology Information
| HPRD ID | 115 |
|---|---|
| Molecular Class | Transport/cargo protein |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.