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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
IQGAP1 8826 IQ motif containing GTPase activating protein 1  15p195, KIAA0051, SAR1, HUMORFA01 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
19856315   2010Cell line : SW837, WiDr, HT 29

Source : Dainihon Seiyaku (Osaka, Japan).Tissue sample from Department of Pathology, Fukuoka University Hospital.

Sample Type : CRC tumor and normal tissue

No. of Sample : 85

Stage : TNM Stage III

real time RT-PCR,ImmunohistochemistryUp-regulation-IQGAP1 plays a critical role in colon cancer cell invasion, and therefore diffuse and high expression of IQGAP1 predicts poor prognosis in patients with colorectal carcinoma.


Gene Details



NC_000015.9 (90931473..91045475)

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Gene Type protein coding
Gene Family -
Description This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008]  
Chromosome 15
Location 15q26.1
Start 90931473  
End 91045475  
Strand +  
Gene Sequence

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Length 114003  
OMIM ID 603379   
HGNC ID HGNC:6110   
Unigene ID Hs.430551   
Ensembl ID ENSG00000140575   
PharmGKB ID PA29910   

mRNA Information


mRNA ID ?NM_003870.3
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS10362.1



Protein Information


      
Protein IDNP_003861.1
Protein NameIQ motif containing GTPase activating protein 1
Molecular Wt. (Da)0
Protein Sequence

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Length 1657  
Uniprot IDO75365
Ensembl Protein ID ENSP00000332274  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation330
YPhosphorylation654;-
YPhosphorylation1510;-
SPhosphorylation2;-
SPhosphorylation1441
SPhosphorylation1443
YPhosphorylation172
TPhosphorylation1403
SPhosphorylation730
YPhosphorylation736
SPhosphorylation1147
SPhosphorylation1151
SPhosphorylation1152
YPhosphorylation1158
TPhosphorylation1451
TPhosphorylation1467
TPhosphorylation1359

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                     
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
58ACTA130NP_001091.1in vitro9199170   
801CALM1241NP_008819.1in vivo867   080   112   446   675   
998CDC42309NP_001782.1in vitro;in vivo1   290   041   386   708   010   000   000   000   000   000   000   000   000   000   
999CDH11885BAA88957.1in vitro;in vivo10608854   
1499CTNNB1286NP_001895.1in vitro;in vivo117   345   501   244   667   000   000   000   
5566PRKACA3382NP_002721.1in vitro;in vivo12938160   
5879RAC13627NP_061485.1in vitro;in vivo867   080   187   029   688   000   000   000   000   000   000   000   
6249CLIP11568NP_002947.1in vitro;in vivo12110184   
6285S100B1505NP_006263.1in vitro;in vivo12377780   
6780STAU13422NP_059347.2in vitro15121898   
9255AIMP14676NP_001135888.1in vitro9368021   


Pathway Information


                  
Pathway Name Pathway ID
Adherens junction hsa04520
Proteoglycans in cancer hsa05205
Regulation of actin cytoskeleton hsa04810


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd051331003-1382  RasGAP_IQGAP1
cl025691003-1382  RasGAP superfamily
cd0001445-159  CH
cl0003045-159  CH superfamily
cd00201685-710  WW
cl00157685-710  WW superfamily
cd051311003-1354  RasGAP_IQGAP2
cd051271013-1343  RasGAP_IQGAP_like
cd122071003-1350  RasGAP_IQGAP3
cd051321001-1335  RasGAP_GAPA
pfam006161025-1237  RasGAP
cd045191018-1271  RasGAP
pfam038361451-1581  RasGAP_C
cl042841451-1581  RasGAP_C superfamily
cd122061011-1334  RasGAP_IQGAP_related
cd05392967-1344  RasGAP_Neurofibromin_like
cd051301129-1317  RasGAP_Neurofibromin
smart0003348-155  CH
pfam0030748-158  CH
cd05129970-1322  RasGAP_RAP6
cd051351068-1233  RasGAP_RASAL
cd051281021-1234  RasGAP_GAP1_like
cd051361136-1348  RasGAP_DAB2IP
smart00456685-712  WW
cd053911143-1290  RasGAP_p120GAP
cd051371064-1273  RasGAP_CLA2_BUD2
pfam1101624-109  DUF2854
cl1258624-109  DUF2854 superfamily
smart00015774-796  IQ
cl23346774-796  IQ superfamily
pfam00397685-710  WW
smart00323992-1344  RasGAP
COG5261876-1657  IQG1
COG526126-214  IQG1
COG519948-168  SCP1
COG5022748-973  COG5022


Ontology Information


   
HPRD ID5816
Molecular ClassGTPase activating protein
Molecular FunctionReceptor binding (GO:0005102)
Biological ProcessSignal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO