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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
IRAK2 3656 interleukin-1 receptor-associated kinase 2  3 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24973222   2014Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

ELISA, Co-immunoprecipitation, GenotypingPolymorhpism-R214G IRAK2 variant as a potential novel and broadly applicable biomarker for disease or as a therapeutic intervention point.


Gene Details



Chromosome 3 - NC_000003.12 (10164879..10243745)

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Gene Type protein coding
Gene Family
Description IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB.  
Chromosome 3
Location 3p25.2
Start 10164879  
End 10243745  
Strand +  
Gene Sequence

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Length 78867  
OMIM ID 603304   
HGNC ID HGNC:6113   
Unigene ID Hs.449207   
Ensembl ID ENSG00000134070   
PharmGKB ID -   

mRNA Information


mRNA ID NP_001561.3
Exon join(1..170,12960..13142,35491..35637,44711..44814, 48329..48523,48606..48670,52056..52170,54802..54911, 57758..57953,61493..61555,69581..69781,73870..74161, 77238..78865)  
mRNA Sequence

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Length 3469  



CDS Information


   
Locationjoin(77..170,12960..13142,35491..35637,44711..44814, 48329..48523,48606..48670,52056..52170,54802..54911, 57758..57953,61493..61555,69581..69781,73870..74161, 77238..77350)
CDS Sequence

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CCDS ID CCDS33697.1



Protein Information


      
Protein IDNP_001561.3
Protein Nameinterleukin-1 receptor-associated kinase 2
Molecular Wt. (Da)69302
Protein Sequence

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Length 625  
Uniprot IDP49773
Ensembl Protein ID ENSP00000304229  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


   
EC2.7.11.1
Namenon-specific serine/threonine protein kinase
A-kinase
AP50 kinase
ATP-protein transphosphorylase
calcium-dependent protein kinase C
calcium/phospholipid-dependent protein kinase
cAMP-dependent protein kinase
cAMP-dependent protein kinase A
casein kinase
casein kinase (phosphorylating)
casein kinase 2
casein kinase I
casein kinase II
cGMP-dependent protein kinase
CK-2
CKI
CKII
cyclic AMP-dependent protein kinase
cyclic AMP-dependent protein kinase A
cyclic monophosphate-dependent protein kinase
cyclic nucleotide-dependent protein kinase
cyclin-dependent kinase
cytidine 3',5'-cyclic monophosphate-responsive protein kinase
dsk1
glycogen synthase a kinase
glycogen synthase kinase
HIPK2
Hpr kinase
hydroxyalkyl-protein kinase
hydroxyalkyl-protein kinase
M phase-specific cdc2 kinase
mitogen-activated S6 kinase
p82 kinase
phosphorylase b kinase kinase
PKA
protein glutamyl kinase
protein kinase (phosphorylating)
protein kinase A
protein kinase CK2
protein kinase p58
protein phosphokinase
protein serine kinase
protein serine-threonine kinase
protein-aspartyl kinase
protein-cysteine kinase
protein-serine kinase
Prp4 protein kinase
Raf kinase
Raf-1
ribosomal protein S6 kinase II
ribosomal S6 protein kinase
serine kinase
serine protein kinase
serine-specific protein kinase
serine(threonine) protein kinase
serine/threonine protein kinase
STK32
T-antigen kinase
threonine-specific protein kinase
twitchin kinase
type-2 casein kinase
betaIIPKC
epsilon PKC
Wee 1-like kinase
Wee-kinase
WEE1Hu
ClassTransferases; Transferring phosphorus-containing groups; Protein-serine/threonine kinases
SysnameATP:protein phosphotransferase (non-specific)  
SubstrateATP [CPD:C00002]; protein  
ProductADP [CPD:C00008]; phosphoprotein  
Reaction (IUBMB)



PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                      
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
3265HRAS1813NP_005334.1in vivo11744690   
3554IL1R1994NP_000868.1in vitro;in vivo937   445   812   659   850   
3654IRAK12235NP_001560.2in vivo10383454   
4087SMAD23221NP_005892.1in vivo15761153   
4615MYD883703NP_002459.2in vitro;in vivo937   445   812   659   850   
7189TRAF63833NP_665802.1in vivo9374458   
57154SMURF16902NP_065162.1in vivo15761153   
57161PELI217835NP_067078.1in vitro17675297   
57162PELI117834NP_065702.2in vitro17675297   
246330PELI317535NP_659502.2in vitro17675297   


Pathway Information


                  
Pathway Name Pathway ID
Apoptosis hsa04210
Neurotrophin signaling pathway hsa04722
Tuberculosis hsa05152


Structure Information


PDB ID3MOP
Resolution3.4
Method? X-RAY DIFFRACTION
Chains K,L,M  
Molecule Interleukin-1 receptor-associated kinase-like 2  
Model View



Domain Information




ID Location Description
cd14157216-504  STKc_IRAK2
cl21453216-504  PKc_like superfamily
cd08795Mar-91  Death_IRAK2
cl14633Mar-91  DD superfamily
cd14066216-503  STKc_IRAK
cd14159216-485  STKc_IRAK1
cd14158202-485  STKc_IRAK4
cd14160216-442  PK_IRAK3
cd08309Mar-91  Death_IRAK
cd00180216-407  PKc
cd13999216-442  STKc_MAP3K-like
cd14014214-434  STKc_PknB_like
cd14664216-416  STK_BAK1_like
cd13978216-421  STKc_RIP
cd08794Apr-91  Death_IRAK1
cd14154216-409  STKc_LIMK
cd14065216-414  PKc_LIMK_like
cd13979216-413  STKc_Mos
cd06606214-413  STKc_MAPKKK
cd00192214-352  PTKc
cd05122214-413  PKc_STE
cd14064216-413  PKc_TNNI3K
cd14080214-411  STKc_TSSK-like
cd14069209-411  STKc_Chk1
cd14221251-424  STKc_LIMK1
cd14058249-410  STKc_TAK1
pfam0053114-93  Death
cd14059217-422  STKc_MAP3K12_13
cd14222251-409  STKc_LIMK2
cd14026214-410  STKc_RIP2
cd13986214-416  STKc_16
cd14007209-413  STKc_Aurora
cd14155216-414  PKc_TESK
cd05123216-413  STKc_AGC
cd07840214-415  STKc_CDK9_like
cd14025214-410  STKc_RIP4_like
cd05041214-420  PTKc_Fes_like
cd14116206-418  STKc_Aurora-A
cd14203214-417  PTKc_Src_Fyn_like
cd14012249-428  PK_eIF2AK_GCN2_rpt1
cd14146216-413  STKc_MLK4
cd14156257-414  PKc_LIMK_like_unk
cd14061216-411  STKc_MLK
cd14163214-461  STKc_TSSK3-like
cd05043216-352  PTK_Ryk
cd05070206-417  PTKc_Fyn
cd14052209-439  PTKc_Wee1_fungi
cd05117209-413  STKc_CAMK
cd07845213-413  STKc_CDK10
cd14150214-422  STKc_A-Raf
cd05071215-410  PTKc_Src
cd14081266-418  STKc_BRSK1_2
cd05034214-417  PTKc_Src_like
cd05069215-410  PTKc_Yes
cd06614215-413  STKc_PAK
cd05068214-410  PTKc_Frk_like
cd14099214-413  STKc_PLK
cd06627215-413  STKc_Cdc7_like
cd13996208-409  STKc_EIF2AK
cd14148216-411  STKc_MLK2
cd14098209-423  STKc_Rad53_Cds1
cd05118214-413  STKc_CMGC
cd14003214-411  STKc_AMPK-like
cd05048218-410  PTKc_Ror
cd05046216-410  PTK_CCK4
cd14084207-430  STKc_Chk2
cd05039216-408  PTKc_Csk_like
cd14162210-418  STKc_TSSK4-like
cd06613215-415  STKc_MAP4K3_like
cd05091215-410  PTKc_Ror2
cd08215214-351  STKc_Nek
cd14117208-417  STKc_Aurora-B_like
cd05033213-410  PTKc_EphR
cd08307Apr-90  Death_Pelle
cd06607210-407  STKc_TAO
cd05072214-418  PTKc_Lyn
cd14181216-425  STKc_PhKG2
cd08796Apr-90  Death_IRAK-M
cd06630257-418  STKc_MEKK1
cd06612208-413  STKc_MST1_2
cd06645208-352  STKc_MAP4K3
cd06609208-413  STKc_MST3_like
cd05112208-420  PTKc_Itk
cd06646209-352  STKc_MAP4K5
cd14087216-423  STKc_PSKH1
cd14147216-411  STKc_MLK3
cd06641210-413  STKc_MST3
cd07866208-490  STKc_BUR1
cd14151214-422  STKc_B-Raf
cd14008257-405  STKc_LKB1_CaMKK
cd05063212-410  PTKc_EphR_A2
cd14057215-351  PK_ILK
cd05612208-428  STKc_PRKX_like
cd14663214-425  STKc_SnRK3
cd06623208-352  PKc_MAPKK_plant_like
cd06632216-413  STKc_MEKK1_plant
cd06626212-423  STKc_MEKK4
cd05585216-427  STKc_YPK1_like
cd14165250-418  STKc_TSSK1_2-like
cd14145216-411  STKc_MLK1
cd05038214-421  PTKc_Jak_rpt2
cd06605257-411  PKc_MAPKK
cd14095210-432  STKc_DCKL
cd14149215-411  STKc_C-Raf
cd06610208-413  STKc_OSR1_SPAK
cd07831215-413  STKc_MOK
cd06635210-438  STKc_TAO1
cd14053215-421  STKc_ACVR2
cd14071214-430  STKc_SIK
cd08529209-411  STKc_FA2-like
cd05067214-417  PTKc_Lck_Blk
cd08216253-412  PK_STRAD
cd14182264-413  STKc_PhKG1
cd06642210-413  STKc_STK25
cd05082216-408  PTKc_Csk
cd06647266-413  STKc_PAK_I
cd05148209-413  PTKc_Srm_Brk
cd05611214-432  STKc_Rim15_like
cd13992266-410  PK_GC
cd06628216-438  STKc_Byr2_like
cd13982217-411  STKc_IRE1
cd14060219-410  STKc_MLTK
cd05049214-410  PTKc_Trk
cd14063215-429  PK_KSR
cd14164245-411  STKc_TSSK6-like
cd05089216-413  PTKc_Tie1
cd14019208-411  STKc_Cdc7
cd05047216-413  PTKc_Tie
cd05037212-421  PTK_Jak_rpt1
cd14002208-413  STKc_STK36
cd14045266-440  PK_GC_unk
cd05057219-416  PTKc_EGFR_like
cd14096215-344  STKc_RCK1-like
cd14001214-416  PKc_TOPK
cd06611219-434  STKc_SLK_like
cd07836210-413  STKc_Pho85
cd06644215-408  STKc_STK10
cd14166216-413  STKc_CaMKI_gamma
cd14073214-352  STKc_NUAK
cd06634210-417  STKc_TAO2
cd08226266-427  PK_STRAD_beta
cd05580208-425  STKc_PKA_like
cd05092215-410  PTKc_TrkA
cd07860210-410  STKc_CDK2_3
cd13997209-439  PKc_Wee1_like
cd07833266-442  STKc_CDKL
cd14072214-352  STKc_MARK
cd06625212-352  STKc_MEKK3_like
cd05075214-425  PTKc_Axl
cd05113214-352  PTKc_Btk_Bmx
cd05579322-413  STKc_MAST_like
cd05078213-426  PTK_Jak2_rpt1
cd14055216-352  STKc_TGFbR2_like
cd14186208-431  STKc_PLK4
cd05064214-410  PTKc_EphR_A10
cd05578319-411  STKc_Yank1
cd05096229-352  PTKc_DDR1
cd13980266-410  STKc_Vps15
cd05066252-410  PTKc_EphR_A
cd14038215-422  STKc_IKK_beta
cd08227253-447  PK_STRAD_alpha
cd05065216-410  PTKc_EphR_B
cd14662266-411  STKc_SnRK2
cd13994216-442  STKc_HAL4_like
cd06655285-417  STKc_PAK2
cd07855319-409  STKc_ERK5
cd06654285-417  STKc_PAK1
cd06608207-351  STKc_myosinIII_N_like
cd05095254-410  PTKc_DDR2
cd05035214-410  PTKc_TAM
cd07843208-413  STKc_CDC2L1
cd05581315-413  STKc_PDK1
cd05085216-420  PTKc_Fer
cd05059214-411  PTKc_Tec_like
cd14183207-413  STKc_DCKL1
cd08219209-410  STKc_Nek3
cd14050210-412  PKc_Myt1
cd05573319-425  STKc_ROCK_NDR_like
cd06629266-411  STKc_Bck1_like
cd06621257-408  PKc_Pek1_like
cd05097254-352  PTKc_DDR_like
cd14000219-452  STKc_LRRK
cd14121215-413  STKc_ULK3
cd06640210-413  STKc_MST4
cd14143216-408  STKc_TGFbR1_ACVR1b_ACVR1c
cd06633266-434  STKc_TAO3
cd07852319-413  STKc_MAPK15-like
cd05083214-410  PTKc_Chk
cd14184208-432  STKc_DCKL2
cd13968216-352  PKc_like
cd05036214-410  PTKc_ALK_LTK
cd05111266-410  PTK_HER3
cd06656285-417  STKc_PAK3
cd06648288-413  STKc_PAK_II
cd13995216-413  STKc_MAP3K8
cd14665266-421  STKc_SnRK2-3
cd14043266-410  PK_GC-2D
cd05073213-410  PTKc_Hck
cd06620257-418  PKc_Byr1_like
cd14079319-411  STKc_AMPK_alpha
cd05032208-410  PTKc_InsR_like
cd14027257-420  STKc_RIP1
cd07829214-413  STKc_CDK_like
cd14009216-413  STKc_ATG1_ULK_like
cd05572219-413  STKc_cGK
cd06652216-413  STKc_MEKK2
cd14042250-410  PK_GC-A_B
cd14206235-409  PTKc_Aatyk3
cd08224209-351  STKc_Nek6_7
cd13991215-494  STKc_NIK
cd14068219-411  STKc_LRRK2
cd0879352-91  Death_IRAK4
cd07849320-413  STKc_ERK1_2_like
cd14093314-413  STKc_PhKG
cd08223209-343  STKc_Nek4
cd14056216-409  STKc_TGFbR_I
cd14082219-411  STKc_PKD
cd14004266-351  STKc_PASK
cd05090221-410  PTKc_Ror1
cd06659311-413  STKc_PAK6
cd05050214-352  PTKc_Musk
cd05052215-352  PTKc_Abl
cd14076214-421  STKc_Kin4
cd05084215-352  PTKc_Fes
cd14142216-408  STKc_ACVR1_ALK1
cd06643215-408  STKc_SLK
cd13989314-422  STKc_IKK
cd07832261-413  STKc_CCRK
cd14205252-421  PTKc_Jak2_rpt2
cd05604216-426  STKc_SGK3
cd06653209-413  STKc_MEKK3_like_u1
cd14178257-459  STKc_RSK3_C
cd08225214-425  STKc_Nek5
cd05074202-410  PTKc_Tyro3
cd06917285-415  STKc_NAK1_like
cd05040215-410  PTKc_Ack_like
cd05598319-413  STKc_LATS
cd14204202-424  PTKc_Mer
cd05056208-352  PTKc_FAK
cd13998216-408  STKc_TGFbR-like
cd08530209-415  STKc_CNK2-like
cd13981213-350  STKc_Bub1_BubR1
cd14174202-418  STKc_Mnk1
cd05093214-410  PTKc_TrkB
cd14088208-413  STKc_CaMK_like
cd07857319-413  STKc_MPK1
cd14201209-437  STKc_ULK2
cd13975294-411  PKc_Dusty
cd13987254-343  STKc_SBK1
cd13984266-467  PK_NRBP1_like
cd14077266-351  STKc_Kin1_2
cd08228209-408  STKc_Nek6
cd14010209-413  STKc_ULK4
cd06658311-417  STKc_PAK5
cd05058266-413  PTKc_Met_Ron
cd14085207-424  STKc_CaMKIV
cd07879229-411  STKc_p38delta
cd14119236-352  STKc_LKB1
cd08218214-410  STKc_Nek1
cd14054216-348  STKc_BMPR2_AMHR2
cd05042235-408  PTKc_Aatyk
cd07830266-413  STKc_MAK_like
cd05088237-410  PTKc_Tie2
cd14194208-350  STKc_DAPK1
cd14161216-352  STKc_NUAK2
cd05584322-413  STKc_p70S6K
cd07864314-419  STKc_CDK12
cd07870214-414  STKc_PFTAIRE2
cd13993214-405  STKc_Pat1_like
cd083084-106  Death_Tube
cd05114214-410  PTKc_Tec_Rlk
cd14078322-425  STKc_MELK
cd14196205-358  STKc_DAPK2
cd05602209-413  STKc_SGK1
cd05619208-411  STKc_nPKC_theta
cd07876319-411  STKc_JNK2
cd05081252-421  PTKc_Jak3_rpt2
cd14086208-423  STKc_CaMKII
cd01670Dec-90  Death
cd06631266-413  STKc_YSK4
cd14048322-409  STKc_EIF2AK3_PERK
cd14208216-343  PTK_Jak3_rpt1
cd05574208-346  STKc_phototropin_like
cd06651209-413  STKc_MEKK3
cd05620284-411  STKc_nPKC_delta
cd14120216-438  STKc_ULK1_2-like
cd05600319-413  STKc_Sid2p_like
cd14105208-349  STKc_DAPK
cd14118319-352  STKc_CAMKK
cd05615284-416  STKc_cPKC_alpha
cd05586284-426  STKc_Sck1_like
cd13985214-343  STKc_GAK_like
cd14047323-432  STKc_EIF2AK2_PKR
cd07874319-409  STKc_JNK3
cd14223209-411  STKc_GRK2
cd14036213-405  STKc_GAK
cd14011262-420  PK_SCY1_like
cd05587280-416  STKc_cPKC
cd07875319-411  STKc_JNK1
cd14134293-354  PKc_CLK
cd06619250-411  PKc_MKK5
cd07856319-413  STKc_Sty1_Hog1
cd14070214-351  STKc_HUNK
cd05633208-411  STKc_GRK3
cd05062206-410  PTKc_IGF-1R
pfam00069210-413  Pkinase
smart00220214-434  S_TKc
COG0515214-461  SPS1
pfam07714212-426  Pkinase_Tyr
smart00219213-410  TyrKc
smart00221213-410  STYKc
PLN00113211-411  PLN00113
PTZ00263209-413  PTZ00263
PHA03210253-421  PHA03210
PHA03209304-409  PHA03209
TIGR03903231-415  TOMM_kin_cyc
PRK13184214-343  pknD
PHA03207303-409  PHA03207
PHA03211257-344  PHA03211
PHA03212266-446  PHA03212
PTZ00426324-468  PTZ00426
PLN00034115-352  PLN00034


Ontology Information


   
HPRD ID5054
Molecular ClassSerine/threonine kinase
Molecular FunctionMHC class I receptor activity (GO:0030106); MHC class II receptor activity (GO:0045012)
Biological ProcessImmune response (GO:0006955)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO