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General Information

• Evidence
• Gene
• mRNA
• CDS
• Protein
• PTM
• Enzyme
• PPi
• Pathway
• Structural
• Domain
• Ontology
• SNP
• Drug
• External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
15247132	2004	Cell line : - Source : - Sample Type : Population-based incident case-control study No. of Sample : 1,346 colon cancer cases and 1,544 population-based controls and 952 rectal cancer cases and 1,205 controls were used. Stage : -	-	Polymorhpism	-	Both IRS1 and IRS2 variants were associated with colon cancer risk independently.

Gene Details

NC_000002.11 (227596033..227664545, complement)
View Larger Image   

Gene Type	protein coding
Gene Family	Pleckstrin homology (PH) domain containing
Description	This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]
Chromosome	2
Location	2q36
Start	227596033
End	227664545
Strand	-
Gene Sequence	Download   Select all
Length	68513
OMIM ID	147545
HGNC ID	HGNC:6125
Unigene ID	Hs.471508
Ensembl ID	ENSG00000169047
PharmGKB ID	PA203

mRNA Information

mRNA ID	NM_005544.2
Exon	join(1..3802,62541..67474)
mRNA Sequence	Download   Select all
Length	8743

CDS Information

   

Location	53..3781
CDS Sequence	Download   Select all
CCDS ID	CCDS2463.1

Protein Information

      

Protein ID	NP_005535.1
Protein Name	insulin receptor substrate 1
Molecular Wt. (Da)	131460
Protein Sequence	Download   Select all
Length	1242
Uniprot ID	Q06945
Ensembl Protein ID	ENSP00000244745

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
Y	Phosphorylation	1179
S	Phosphorylation	616
S	Phosphorylation	636
S	Phosphorylation	666
S	Phosphorylation	736
S	Phosphorylation	794
T	Phosphorylation	502
S	Phosphorylation	24
S	Phosphorylation	330
T	Phosphorylation	811
T	Phosphorylation	88
S	Phosphorylation	99
Y	Phosphorylation	896
Y	Phosphorylation	612
Y	Phosphorylation	632
Y	Phosphorylation	662
Y	Phosphorylation	732
Y	Phosphorylation	1229
Y	Phosphorylation	612
Y	Phosphorylation	896
Y	Phosphorylation	941
Y	Dephosphorylation	1179
S	Phosphorylation	312
S	Phosphorylation	268
S	Phosphorylation	270
S	Phosphorylation	272
S	Phosphorylation	274
S	Phosphorylation	307
S	Phosphorylation	312
S	Phosphorylation	341
S	Phosphorylation	345
S	Phosphorylation	527
S	Phosphorylation	531
S	Phosphorylation	794
S	Phosphorylation	616
S	Phosphorylation	636
S	Phosphorylation	1101
S	Phosphorylation	1101
S	Phosphorylation	1101
S	Phosphorylation	629
S	Phosphorylation	574
S	Phosphorylation	1223
Y	Phosphorylation	46;-
Y	Phosphorylation	46;-
S	Phosphorylation	1143;-
S	Phosphorylation	1145;-
T	Phosphorylation	1103;-
S	Phosphorylation	1100
S	Phosphorylation	3
T	Phosphorylation	351
S	Phosphorylation	766
Y	Phosphorylation	87

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                              

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
238	ALK	104	NP_004295.2	in vivo	9174053
487	ATP2A1	157	NP_775293.1	in vivo	9295312
489	ATP2A3	3568	NP_777613.1	in vitro;in vivo	12524443
613	BCR	1044	NP_004318.3	in vivo	12560071
857	CAV1	3028	NP_001744.2	in vitro;in vivo	15003536
1147	CHUK	2811	NP_001269.3	in vivo	12351658
1398	CRK	1267	NP_058431.2	in vitro;in vivo	881   032   598   379   788   000   000
2241	FER	1491	NP_005237.2	in vivo	11006284
2242	FES	1814	NP_001996.1	in vitro	10856136
2690	GHR	2971	NP_000154.1	in vitro;in vivo	7782332
2885	GRB2	150	NP_002077.1	in vitro;in vivo	748   810   788   103   258   000   000
2888	GRB14	3313	NP_004481.2	in vivo;yeast 2-hybrid	9748281
4869	NPM1	1246	NP_002511.1	in vitro	8633037
4914	NTRK1	1869	NP_002520.2	in vitro;yeast 2-hybrid	11147812
5170	PDPK1	5556	NP_002604.1	in vivo	15802620
5888	RAD51	1557	NP_597994.3	in vitro;in vivo	14559999
6093	ROCK1	3414	NP_005397.1	in vitro;in vivo	11739394
57521	RPTOR	6184	NP_065812.1	in vitro	16354680

Pathway Information

                                                                                                

Pathway Name	Pathway ID
Adipocytokine signaling pathway	hsa04920
Aldosterone-regulated sodium reabsorption	hsa04960
AMPK signaling pathway	hsa04152
cGMP-PKG signaling pathway	hsa04022
FoxO signaling pathway	hsa04068
Insulin resistance	hsa04931
Insulin signaling pathway	hsa04910
Longevity regulating pathway - mammal	hsa04211
Longevity regulating pathway - multiple species	hsa04213
MicroRNAs in cancer	hsa05206
mTOR signaling pathway	hsa04150
Neurotrophin signaling pathway	hsa04722
Non-alcoholic fatty liver disease (NAFLD)	hsa04932
PI3K-Akt signaling pathway	hsa04151
Regulation of lipolysis in adipocytes	hsa04923
Type II diabetes mellitus	hsa04930

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd01204	160-263	PTB_IRS
cl17171	160-263	PH-like superfamily
cd01257	11-118	PH_IRS
cl17171	11-118	PH-like superfamily
smart00310	161-262	PTBI
pfam02174	161-262	IRS
cd00821	15-110	PH
pfam00169	13-114	PH
smart00233	13-115	PH
cd13298	13-110	PH1_PH_fungal
cd13324	17-106	PH_Gab-like
cd13267	11-110	PH_DOCK-D
cd00934	171-257	PTB
cd01266	12-113	PH_Gab1_Gab2
cd13255	13-118	PH_TAAP2-like
cd14678	15-112	PH_DOK4_DOK5_DOK6
cd13253	15-112	PH1_ARAP
cd13385	3-115	PH_Gab3
cd13281	8-110	PH_PLEKHD1
cd13276	15-110	PH_AtPH1
cd13296	15-117	PH2_MyoX
cd13302	13-110	PH2_Pleckstrin_2
cd13263	11-110	PH_RhoGap25-like
cd01252	15-110	PH_GRP1-like
cd13282	15-110	PH1_PLEKHH1_PLEKHH2
cd13271	23-109	PH2_TAPP1_2

Ontology Information

   

HPRD ID	6427
Molecular Class	Secreted polypeptide
Molecular Function	Transcription factor activity (GO:0003700)
Biological Process	Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)

SNP Information

View SNP Geneview Report   

Drug Information

No matching records could be found.

External Links

                                 

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO