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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20633766 | 2010 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 47 Stage : - | LOH analysis | Loss of heterozygosity | - | Tumor suppressor genes, including RASAL1, ITGA7, STAB2, GLIPR1, and SLC5A8. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Integrins |
| Description | The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2009] | Chromosome | 12 |
| Location | 12q13 |
| Start | 56078352 |
| End | 56109821 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 31470 |
| OMIM ID | 600536 |
| HGNC ID | HGNC:6143 |
| Unigene ID | Hs.524484 |
| Ensembl ID | - |
| PharmGKB ID | PA29943 |
mRNA Information
| mRNA ID | NM_152637.2 |
|---|---|
| Exon | complement(<31427..>31470) | mRNA Sequence | Download Select all |
| Length | 1531 |
Protein Information
| Protein ID | NP_689850.2 |
|---|---|
| Protein Name | integrin, alpha 7 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 244 |
| Uniprot ID | P35326 |
| Ensembl Protein ID | ENSP00000376423 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 1007;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1134 | CHRNA1 | 7 | NP_001034612.1 | in vivo | 10910772 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | hsa05412 |
| Dilated cardiomyopathy | hsa05414 |
| ECM-receptor interaction | hsa04512 |
| Focal adhesion | hsa04510 |
| Hypertrophic cardiomyopathy (HCM) | hsa05410 |
| PI3K-Akt signaling pathway | hsa04151 |
| Regulation of actin cytoskeleton | hsa04810 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00191 | 421-473 | Int_alpha |
| cl21611 | 421-473 | Int_alpha superfamily |
| smart00191 | 362-415 | Int_alpha |
| cl21611 | 362-415 | Int_alpha superfamily |
| pfam13517 | 372-445 | VCBS |
| cl21563 | 372-445 | VCBS superfamily |
| smart00191 | 48-109 | Int_alpha |
| cl21611 | 48-109 | Int_alpha superfamily |
| pfam01839 | 364-402 | FG-GAP |
| cl21621 | 364-402 | FG-GAP superfamily |
| pfam01839 | 425-458 | FG-GAP |
| cl21621 | 425-458 | FG-GAP superfamily |
| pfam13517 | 434-503 | VCBS |
| cl21563 | 434-503 | VCBS superfamily |
| smart00191 | 483-522 | Int_alpha |
| cl21611 | 483-522 | Int_alpha superfamily |
| smart00191 | 304-345 | Int_alpha |
| cl21611 | 304-345 | Int_alpha superfamily |
| pfam13517 | 361-383 | VCBS |
| pfam08441 | 515-1006 | Integrin_alpha2 |
Ontology Information
| HPRD ID | 1652 |
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Structural molecule activity (GO:0005198) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.