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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ITGAV 3685 integrin, alpha V  2CD51 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23128103   2013Cell line : -

Source : -

Sample Type : CRC Tumor

No. of Sample : 115

Stage : TNM stage I-IV

 real-time RT-PCR, immunohistochemistryUp-regulation-The overexpression of the ITGAV gene and protein was correlated with an increased risk of perineural invasion.

23705994   2013Cell line : -

Source : Department, Barretos Cancer Hospital, Brazil.

Sample Type : -

No. of Sample : 114

Stage : TNM stage I-IV

RT-PCR,tissue microarray.Up-regulation-In relation to TNM staging, ITGB5 and ITGA3 were over-expressed in stages III versus I.

25275062   2014Cell line : -

Source : -

Sample Type : -

No. of Sample : 114

Stage : -

real time RT-PCR, immunohistochemistryUp-regulation-The overexpression of ITGAV gene was associated with higher progression and spread of CRC via perineural invasion.


Gene Details



NC_000002.11 (187454058..187545629)

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Gene Type protein coding
Gene Family CD molecules, "Integrins"
Description The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]  
Chromosome 2
Location 2q31-q32
Start 187454058  
End 187545629  
Strand +  
Gene Sequence

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Length 91572  
OMIM ID 193210   
HGNC ID HGNC:6150   
Unigene ID Hs.436873   
Ensembl ID ENSG00000138448   
PharmGKB ID PA37336   

mRNA Information


mRNA ID NM_002210.4
Exon join(1..461,11959..12089,32277..32368,35411..35525, 40735..40796,43267..43312,46020..46145,47003..47047, 48215..48258,48347..48403,50853..50905,51324..51526, 56624..56815,59778..59823,61920..62027,64588..64646, 66185..66339,68976..69113,73706..73773,74432..74579, 75064..75156,76642..76721,77088..77168,77609..77714, 78700..78858,79639..79752,85542..85655,85758..85865, 86751..86873,87135..90840)  
mRNA Sequence

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Length 7053  



CDS Information


   
Location 277..3423
CDS Sequence

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CCDS ID CCDS2292.1



Protein Information


      
Protein IDNP_002201.1
Protein Nameintegrin, alpha V
Molecular Wt. (Da)0
Protein Sequence

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Length 1048  
Uniprot IDQ9UBC9
Ensembl Protein ID ENSP00000295367  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation1048;-
TPhosphorylation279
YPhosphorylation284
TPhosphorylation586
YPhosphorylation591
NGlycosylation74
NGlycosylation874
YPhosphorylation225
SPhosphorylation1046

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                    
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
811CALR169NP_004334.1in vitro;in vivo12196561   
2149F2R1763NP_001983.2in vitro11278329   
3386ICAM4198NP_001034221.1in vitro11435317   
3688ITGB1628NP_391987.1in vivo16   907   182   138   612   
3690ITGB31428NP_000203.2in vitro968   632   011   884   718   
3693ITGB5949NP_002204.2in vitro7689573   
3694ITGB6947NP_000879.2in vivo15   325   728   120   056   
4313MMP2386NP_004521.1in vivo11134507   
4811NID1574NP_002499.2in vitro9686320   
5156PDGFRA1429NP_006197.1in vitro;in vivo11953315   
6696SPP11325NP_001035147.1in vitro;in vivo10835423   
7040TGFB11821NP_000651.3in vivo11970960   


Pathway Information


                                                                              
Pathway Name Pathway ID
Arrhythmogenic right ventricular cardiomyopathy (ARVC) hsa05412
Cell adhesion molecules (CAMs) hsa04514
Dilated cardiomyopathy hsa05414
ECM-receptor interaction hsa04512
Focal adhesion hsa04510
Hypertrophic cardiomyopathy (HCM) hsa05410
Pathways in cancer hsa05200
Phagosome hsa04145
PI3K-Akt signaling pathway hsa04151
Proteoglycans in cancer hsa05205
Regulation of actin cytoskeleton hsa04810
Small cell lung cancer hsa05222
Thyroid hormone signaling pathway hsa04919


Structure Information


No matching records could be found.

Domain Information




ID Location Description
smart00191367-421  Int_alpha
cl21611367-421  Int_alpha superfamily
smart00191248-288  Int_alpha
cl21611248-288  Int_alpha superfamily
smart00191302-355  Int_alpha
cl21611302-355  Int_alpha superfamily
smart00191434-476  Int_alpha
cl21611434-476  Int_alpha superfamily
pfam13517260-325  VCBS
cl21563260-325  VCBS superfamily
smart0019146-103  Int_alpha
cl2161146-103  Int_alpha superfamily
pfam01839253-286  FG-GAP
cl21621253-286  FG-GAP superfamily
pfam13517314-390  VCBS
cl21563314-390  VCBS superfamily
pfam13517221-270  VCBS
cl21563221-270  VCBS superfamily
pfam13517379-454  VCBS
pfam08441467-914  Integrin_alpha2


Ontology Information


   
HPRD ID1684
Molecular ClassCell surface receptor
Molecular FunctionStructural constituent of cytoskeleton (GO:0005200)
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P06756DB00098Anti-thymocyte Globulin (Rabbit)BiotechDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO