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General Information

• Evidence
• Gene
• mRNA
• CDS
• Protein
• PTM
• Enzyme
• PPi
• Pathway
• Structural
• Domain
• Ontology
• SNP
• Drug
• External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
24777809	2014	Cell line : - Source : Shaoxing peoples Hospital Shaoxing Hospital zhejiang university China. Sample Type : CRC tumor and adjecent normal tissue No. of Sample : 200 Stage : -	RFLP-PCR, Immunohistochemistry	Polymorhpism	-	ITGB1 rs17468 SNP and ITGB3 rs2317676 SNP were associated with an increased risk of CRC, which suggests that these 2 SNPs might contribute to CRC risk in a Chinese population.
25894721	2015	Cell line : HCT116, HT 29, LoVo, SW 480 Source : Shanghai cell collection China Sample Type : - No. of Sample : - Stage : -	Genotyping	Polymorhpism	-	ITGB1 SNPs might be a prognostic biomarker for CRC patients, especially in those receiving chemotherapy.
25387809	2015	Cell line : - Source : Xijing and Tangdu Hospital Affiliated to the fourth military medical university in Xi'an China. Sample Type : CRC Tumor and adjecent normal tissue No. of Sample : 372 Stage : -	real time RT-PCR, Western Blotting,Cell Proliferation Assay, Immunohistochemistry.	Up-regulation	-	ITGB1 induces growth and invasion in a human colorectal cancer cell line through the hedgehog (Hh) signaling pathway in vitro and in vivo.

Gene Details

NC_000010.10 (33189246..33247293, complement)
View Larger Image   

Gene Type	protein coding
Gene Family	CD molecules, "Integrins"
Description	Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	10
Location	10p11.2
Start	33189246
End	33247293
Strand	-
Gene Sequence	Download   Select all
Length	58048
OMIM ID	135630
HGNC ID	HGNC:6153
Unigene ID	Hs.643813
Ensembl ID	ENSG00000150093
PharmGKB ID	PA29953

mRNA Information

mRNA ID	NM_002211.3
Exon	join(1..221,22808..22874,25766..25851,28322..28544, 30102..30272,32257..32495,34626..34781,35631..35726, 36020..36109,37981..38121,38282..38481,46242..46480, 46696..46918,47911..48143,49832..49998,56731..58048)
mRNA Sequence	Download   Select all
Length	3879

CDS Information

   

Location	222..2618
CDS Sequence	Download   Select all
CCDS ID	CCDS7174.1

Protein Information

      

Protein ID	NP_002202.2
Protein Name	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
Molecular Wt. (Da)	0
Protein Sequence	Download   Select all
Length	798
Uniprot ID	Q13813
Ensembl Protein ID	ENSP00000350882

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
N	Glycosylation	212
N	Glycosylation	269
N	Glycosylation	363
N	Glycosylation	406
N	Glycosylation	417
N	Glycosylation	481
N	Glycosylation	50
N	Glycosylation	520
N	Glycosylation	669
N	Glycosylation	97
N	Glycosylation	212
N	Glycosylation	269
N	Glycosylation	363
N	Glycosylation	406
N	Glycosylation	417
N	Glycosylation	481
N	Glycosylation	50
N	Glycosylation	520
N	Glycosylation	669
N	Glycosylation	97
N	Glycosylation	212
N	Glycosylation	269
N	Glycosylation	363
N	Glycosylation	406
N	Glycosylation	417
N	Glycosylation	481
N	Glycosylation	50
N	Glycosylation	520
N	Glycosylation	669
N	Glycosylation	97
N	Glycosylation	212
N	Glycosylation	269
N	Glycosylation	363
N	Glycosylation	406
N	Glycosylation	417
N	Glycosylation	481
N	Glycosylation	50
N	Glycosylation	520
N	Glycosylation	669
N	Glycosylation	97
N	Glycosylation	212
N	Glycosylation	269
N	Glycosylation	363
N	Glycosylation	406
N	Glycosylation	417
N	Glycosylation	481
N	Glycosylation	50
N	Glycosylation	520
N	Glycosylation	669
N	Glycosylation	97
N	Glycosylation	212
N	Glycosylation	269
N	Glycosylation	363
N	Glycosylation	406
N	Glycosylation	417
N	Glycosylation	481
N	Glycosylation	50
N	Glucuronosyl transfer	50
N	Glycosylation	520
N	Glycosylation	669
N	Glycosylation	97
Y	Phosphorylation	783;-
Y	Phosphorylation	783;-
K	Acetylation	794
K	Acetylation	794
N	Glycosylation	403
N	Glycosylation	411
N	Glycosylation	403
N	Glycosylation	411
N	Glycosylation	403
N	Glycosylation	411
N	Glycosylation	403
N	Glycosylation	411
N	Glycosylation	403
N	Glycosylation	411
N	Glycosylation	403
N	Glycosylation	411
T	Phosphorylation	777
T	Phosphorylation	777
N	Glycosylation	402
N	Glycosylation	405
N	Glycosylation	410
N	Glycosylation	402
N	Glycosylation	405
N	Glycosylation	410
N	Glycosylation	402
N	Glycosylation	405
N	Glycosylation	410
N	Glycosylation	402
N	Glycosylation	405
N	Glycosylation	410
N	Glycosylation	402
N	Glycosylation	405
N	Glycosylation	410
N	Glycosylation	402
N	Glycosylation	405
N	Glycosylation	410
N	Glycosylation	385
N	Glycosylation	385
N	Glycosylation	385
N	Glycosylation	385
N	Glycosylation	385
N	Glycosylation	385
N	Glycosylation	362
N	Glycosylation	362
N	Glycosylation	362
N	Glycosylation	362
N	Glycosylation	362
N	Glycosylation	362
N	Glycosylation	204
N	Glycosylation	211
N	Glycosylation	204
N	Glycosylation	211
N	Glycosylation	204
N	Glycosylation	211
N	Glycosylation	204
N	Glycosylation	211
N	Glycosylation	204
N	Glycosylation	211
N	Glycosylation	204
N	Glycosylation	211
N	Glycosylation	365
N	Glycosylation	365
N	Glycosylation	365
N	Glycosylation	365
N	Glycosylation	365
N	Glycosylation	365
Y	Phosphorylation	782
Y	Phosphorylation	782
S	Phosphorylation	785
S	Phosphorylation	785
Y	Phosphorylation	783
S	Phosphorylation	224
T	Phosphorylation	226
S	Phosphorylation	224
T	Phosphorylation	226
S	Phosphorylation	224
T	Phosphorylation	226
S	Phosphorylation	224
T	Phosphorylation	226
S	Phosphorylation	224
T	Phosphorylation	226
S	Phosphorylation	224
T	Phosphorylation	226
S	Phosphorylation	327
T	Phosphorylation	333
S	Phosphorylation	327
T	Phosphorylation	333
S	Phosphorylation	327
T	Phosphorylation	333
S	Phosphorylation	327
T	Phosphorylation	333
S	Phosphorylation	327
T	Phosphorylation	333
S	Phosphorylation	327
T	Phosphorylation	333

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING)      View   

                                                                                                                                                      

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
821	CANX	252	NP_001737.1	in vitro;in vivo	92   950   278   163   531
1462	VCAN	340	NP_004376.2	in vivo	11805102
2335	FN1	626	NP_997647.1	in vitro;in vivo	110   108   128   120   056
3329	HSPD1	318	NP_002147.2	in vitro	11888933
3339	HSPG2	804	NP_005520.4	in vitro	9431988
3386	ICAM4	198	NP_001034221.1	in vivo	11435317
3480	IGF1R	932	NP_000866.1	in vitro	1   452   290   911   884   610
3678	ITGA5	627	NP_002196.2	in vitro;in vivo	7504269
4179	CD46	406	NP_758869.1	in vivo	10741407
26548	ITGB1BP2	2271	NP_036410.1	in vitro;yeast 2-hybrid	10506186

Pathway Information

                                                                                                                                    

Pathway Name	Pathway ID
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	hsa05412
Axon guidance	hsa04360
Bacterial invasion of epithelial cells	hsa05100
Cell adhesion molecules (CAMs)	hsa04514
Dilated cardiomyopathy	hsa05414
ECM-receptor interaction	hsa04512
Focal adhesion	hsa04510
Hypertrophic cardiomyopathy (HCM)	hsa05410
Leishmaniasis	hsa05140
Leukocyte transendothelial migration	hsa04670
Pathogenic Escherichia coli infection	hsa05130
Pathways in cancer	hsa05200
Pertussis	hsa05133
Phagosome	hsa04145
PI3K-Akt signaling pathway	hsa04151
Platelet activation	hsa04611
Proteoglycans in cancer	hsa05205
Rap1 signaling pathway	hsa04015
Regulation of actin cytoskeleton	hsa04810
Shigellosis	hsa05131
Small cell lung cancer	hsa05222
Toxoplasmosis	hsa05145

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
pfam00362	34-464	Integrin_beta
cl00057	34-464	vWFA superfamily
smart00187	34-464	INB
pfam07965	640-728	Integrin_B_tail
cl06832	640-728	Integrin_B_tail superfamily
pfam08725	757-797	Integrin_b_cyt
cl07373	757-797	Integrin_b_cyt superfamily

Ontology Information

   

HPRD ID	15992
Molecular Class	Cell surface receptor
Molecular Function	Protein threonine/tyrosine kinase activity (GO:0004712)
Biological Process	Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)

SNP Information

View SNP Geneview Report   

Drug Information

Uniprot ID	DrugBank ID	Name	Type
P05556	DB00098	Anti-thymocyte Globulin (Rabbit)	BiotechDrug

External Links

                                 

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO