Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ITGB2 | 3689 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | 21 | LFA-1, MAC-1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26054784 | 2015 | Cell line : - Source : Department of Pathology, Yonsei University (Seoul, South Korea) and the Liver Cancer Specimen Bank of the National Research Resource Bank program of the Korea Science and Engineering Foundation of the Ministry of Science and Technology (Seoul, South Korea). Sample Type : CRC tumor and normal tissues No. of Sample : 8 Stage : - | SDS-PAGE and in-gel digestion,LCMS/MS analysis,Protein identification and data analysis | Up-regulation | - | Cancer associated proteins such as FN1, TNC, DEFA1, ITGB2, MLEC, CDH17, EZR and pathways including actin cytoskeleton and RhoGDI signaling were deregulated. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, "Complement system", "Integrins" |
| Description | This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] | Chromosome | 21 |
| Location | 21q22.3 |
| Start | 46305864 |
| End | 46348753 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 42890 |
| OMIM ID | 600065 |
| HGNC ID | HGNC:6155 |
| Unigene ID | Hs.375957 |
| Ensembl ID | ENSG00000160255 |
| PharmGKB ID | PA29955 |
mRNA Information
| mRNA ID | XM_006724001.1 |
|---|---|
| Exon | join(7932..8053,18089..18274,18502..18590,21779..21959, 25339..25509,27141..27382,28399..28554,29712..29807, 33814..33903,35330..35470,36878..37065,38652..38896, 39379..39598,39979..40181,41972..42138,42444..42925) | mRNA Sequence | Download Select all |
| Length | 2979 |
Protein Information
| Protein ID | XP_006724064.1 |
|---|---|
| Protein Name | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) |
| Molecular Wt. (Da) | 77224 |
| Protein Sequence | Download Select all |
| Length | 700 |
| Uniprot ID | Q96SB4 |
| Ensembl Protein ID | ENSP00000362931 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 758 |
| T | Phosphorylation | 760 |
| S | Phosphorylation | 745 |
| T | Phosphorylation | 758 |
| S | Phosphorylation | 745 |
| S | Phosphorylation | 756 |
| T | Phosphorylation | 758 |
| T | Phosphorylation | 758 |
| N | Glycosylation | 50 |
| N | Glycosylation | 642 |
| N | Glycosylation | 115 |
| N | Glycosylation | 49 |
| N | Glycosylation | 211 |
| N | Glycosylation | 212 |
| N | Glycosylation | 214 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 929 | CD14 | 1151 | NP_000582.1 | in vitro | 11745332 |
| 2208 | FCER2 | 1049 | NP_001993.2 | in vivo | 7621072 |
| 2526 | FUT4 | 83 | NP_002024.1 | in vivo | 3305706 |
| 3240 | HP | 772 | NP_005134.1 | in vivo | 11967116 |
| 3383 | ICAM1 | 996 | NP_000192.2 | in vitro;in vivo | 764 256 111 279 101 |
| 3384 | ICAM2 | 888 | NP_000864.2 | in vivo | 9786897 |
| 3385 | ICAM3 | 889 | NP_002153.2 | in vitro;in vivo | 113 538 287 822 326 |
| 3386 | ICAM4 | 198 | NP_001034221.1 | in vivo | 10846180 |
| 3684 | ITGAM | 411 | NP_000623.2 | in vivo | 2454931 |
| 3687 | ITGAX | 1051 | NP_000878.2 | in vivo | 119 375 437 621 072 |
| 3827 | KNG1 | 1970 | NP_001095886.1 | in vitro;in vivo | 10845911 |
| 5657 | PRTN3 | 1512 | NP_002768.3 | in vivo | 12960243 |
| 5962 | RDX | 1534 | NP_002897.1 | in vitro | 17321526 |
| 7094 | TLN1 | 1726 | NP_006280.3 | in vitro;in vivo | 215 048 412 606 711 |
| 9267 | CYTH1 | 1630 | NP_004753.1 | in vitro;yeast 2-hybrid | 1 083 535 117 321 520 |
| 10399 | GNB2L1 | 1503 | NP_006089.1 | in vitro;in vivo;yeast 2-hybrid | 9442085 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Amoebiasis | hsa05146 |
| Cell adhesion molecules (CAMs) | hsa04514 |
| Complement and coagulation cascades | hsa04610 |
| Hippo signaling pathway | hsa04390 |
| HTLV-I infection | hsa05166 |
| Legionellosis | hsa05134 |
| Leishmaniasis | hsa05140 |
| Leukocyte transendothelial migration | hsa04670 |
| Malaria | hsa05144 |
| Natural killer cell mediated cytotoxicity | hsa04650 |
| Pertussis | hsa05133 |
| Phagosome | hsa04145 |
| Rap1 signaling pathway | hsa04015 |
| Regulation of actin cytoskeleton | hsa04810 |
| Rheumatoid arthritis | hsa05323 |
| Staphylococcus aureus infection | hsa05150 |
| Tuberculosis | hsa05152 |
| Viral myocarditis | hsa05416 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00362 | 32-447 | Integrin_beta |
| cl00057 | 32-447 | vWFA superfamily |
| smart00187 | 32-447 | INB |
| pfam07965 | 622-700 | Integrin_B_tail |
| cl06832 | 622-700 | Integrin_B_tail superfamily |
| pfam08725 | 724-768 | Integrin_b_cyt |
| cl07373 | 724-768 | Integrin_b_cyt superfamily |
Ontology Information
| HPRD ID | 1674 |
|---|---|
| Molecular Class | Not Available |
| Molecular Function | G-protein coupled receptor activity (GO:0004930) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P05107 | DB00641 | Simvastatin | SmallMoleculeDrug |