Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ITGB3 | 3690 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 17 | CD61, GPIIIa |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24777809 | 2014 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 200 Stage : - | PCR-RFLP | Polymorhpism | - | ITGB1 rs17468 SNP and ITGB3 rs2317676 SNP were associated with an increased risk of CRC, |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, "Integrins" |
| Description | The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008] | Chromosome | 17 |
| Location | 17q21.32 |
| Start | 45331208 |
| End | 45390077 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 58870 |
| OMIM ID | 173470 |
| HGNC ID | HGNC:6156 |
| Unigene ID | Hs.218040 |
| Ensembl ID | ENSG00000259207 |
| PharmGKB ID | PA205 |
mRNA Information
| mRNA ID | NM_000212.2 |
|---|---|
| Exon | join(1..99,20578..20663,29513..29708,30602..30854, 32419..32581,33229..33390,35840..35935,36344..36433, 37113..37247,38298..38727,45467..45689,46637..46737, 48880..48999,53630..53796,56298..58870) | mRNA Sequence | Download Select all |
| Length | 4894 |
Protein Information
| Protein ID | NP_000203.2 |
|---|---|
| Protein Name | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 788 |
| Uniprot ID | P30874 |
| Ensembl Protein ID | ENSP00000350198 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 773 |
| T | Phosphorylation | 779 |
| Y | Phosphorylation | 785 |
| T | Phosphorylation | 779 |
| T | Phosphorylation | 779 |
| A | Proteolytic Cleavage | 761 |
| T | Proteolytic Cleavage | 767 |
| Y | Proteolytic Cleavage | 773 |
| F | Proteolytic Cleavage | 780 |
| Y | Proteolytic Cleavage | 785 |
| T | Phosphorylation | 779 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1278 | COL1A2 | 363 | NP_000080.2 | in vitro;in vivo | 1693626 |
| 2199 | FBLN2 | 630 | NP_001004019.1 | in vivo | 10848816 |
| 2243 | FGA | 619 | NP_000499.1 | in vitro | 11460491 |
| 2266 | FGG | 621 | NP_068656.2 | in vitro | 10747940 |
| 2335 | FN1 | 626 | NP_997647.1 | in vitro | 1694173 |
| 3678 | ITGA5 | 627 | NP_002196.2 | in vitro | 1694173 |
| 4811 | NID1 | 574 | NP_002499.2 | in vitro;in vivo | 88 318 989 686 320 |
| 5159 | PDGFRB | 1423 | NP_002600.1 | in vitro;in vivo | 10964931 |
| 5175 | PECAM1 | 1425 | NP_000433.3 | in vivo | 10982404 |
| 6464 | SHC1 | 2780 | NP_001123512.1 | in vitro;in vivo | 10964917 |
| 7448 | VTN | 1902 | NP_000629.3 | in vitro | 16195248 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | hsa05412 |
| Dilated cardiomyopathy | hsa05414 |
| ECM-receptor interaction | hsa04512 |
| Focal adhesion | hsa04510 |
| Hematopoietic cell lineage | hsa04640 |
| Hypertrophic cardiomyopathy (HCM) | hsa05410 |
| MicroRNAs in cancer | hsa05206 |
| Osteoclast differentiation | hsa04380 |
| Phagosome | hsa04145 |
| PI3K-Akt signaling pathway | hsa04151 |
| Platelet activation | hsa04611 |
| Proteoglycans in cancer | hsa05205 |
| Rap1 signaling pathway | hsa04015 |
| Regulation of actin cytoskeleton | hsa04810 |
| Thyroid hormone signaling pathway | hsa04919 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00362 | 38-461 | Integrin_beta |
| cl00057 | 38-461 | vWFA superfamily |
| smart00187 | 38-461 | INB |
| pfam07965 | 634-718 | Integrin_B_tail |
| cl06832 | 634-718 | Integrin_B_tail superfamily |
| pfam08725 | 742-787 | Integrin_b_cyt |
| cl07373 | 742-787 | Integrin_b_cyt superfamily |
Ontology Information
| HPRD ID | 1677 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | G-protein coupled receptor activity (GO:0004930) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P05106 | DB00054 | Abciximab | BiotechDrug |
| P05106 | DB00063 | Eptifibatide | BiotechDrug |
| P05106 | DB00098 | Anti-thymocyte Globulin (Rabbit) | BiotechDrug |
| P05106 | DB00775 | Tirofiban | SmallMoleculeDrug |