CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
ITGB4	3691	Integrin, beta 4	17	CD104

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
20089989	2010	Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : -	Biochemical isolation to nano-LC-MS/MS analysis	Up-regulation	-	This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue.

Gene Details

Chromosome: 17; NC_000017.10 (73717516..73753899)
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Gene Type	protein coding
Gene Family	CD molecules, Integrins, Fibronectin type III domain containing
Description	Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	17
Location	17q25
Start	75721342
End	75757819
Strand	+
Gene Sequence	>gi\|568815581:75721342-75757819 Homo sapiens chromosome 17, GRCh38.p2 Primary Assembly CAGCTCCTGCCCCGACAGGTGCGCGCCGCGCGAAGGAATGCAGCCGGTCTGACTCACCAGCGCCTCCTTC CTACCTGCGCGCCCGCCCCATAAAGCGCTGCCCGCCTCGTCCCCACCCCCCCAACCCCCGCGCCCGCCCT CGGACAGTCCCTGCTCGCCCGCGCGCTGCAGCCCCATCTCCTAGCGGCAGCCCAGGCGCGGAGGGAGCGA GTCCGCCCCGAGGTAGGTCCAGGACGGGCGCACAGCAGCAGCCGAGGCTGGCCGGGAGAGGGTGAGTGCC CGCCCCAGCTGGGCAGCCGCGCAGGGGAGCTGGTCGGGCAGGGCCGGTGGCTTTTGTCTCCCCTTCCCCT CCCTGAAGGCTGACAGGCCCCGGTCCCTCTGTCCACGCTGCGCAGGACAGGTGCCCAGCCTCCCCGGGGT GCGCCGGGGGCAGCTGGCAGCCAAGGGGCAGGGCAGCTAGAGAAGGGTGGTGCCCATCAGACCTCCAGGC CAGAGGAGCGCCTTGGGTGCGCCTGCGGGAGAAGTGGGCAGAGGCCAGTGGCTGGTAGCCCTCTGGGGCT GGGCCCCTCCAGGGTTTGCAAAGAAGGTGGAGTAGACACCAGCCTGAGTGCTGGGCCCAGCCCATCATGG CGCATCTAATGATAAACCAACATTCCTGACTTTTATGTGAAATTTCGTTCTTTCTAACATTGGCTCCTAC TTTTAAAAGCCACCCTGAGAGGCAGACGCCATCCCGGCTCCAGGCAGGGCTTGCTCTATGCGGTGCCACA GTCCATCTGGGGCTGGGGAGTCCCTGATTTTCCTTTTCTCTTGGCCAAGCACAGGCCTGCCTTCCTCCCA AAGTCAGCCCCAGGCGCCTTCCTTCAGGAAGCTCTACAGGCCTCACCCACCAGCCCCAGGGCTGTGCCCA ACACTGCCACCTCCTGCAGCATCCGCCCTCTTTCCCATGGCTCAGCCTCTGGGGTGGCCCTCTGGCTGGG ACTGGGGCTCTGGGGCTCCTGGTGACTCCCAGGAGCAGGGACAGGGCTTCTCCTCTGCCCCCATGGCCTT GCCACACCCTGAGGACAAGGACCAGGCACAGGTGGCATGGTTGTTGCTGTCCGAAACAGAGCTGGCAGTG AAGGCTTGGAGTCTCCATCCTGGGGGCTGAGGGAAGGACAGCAGGAGGGACAGGAGGGGAGGTATGTCTG TCTACTCGACCCTGATTTCTCAGGGAGACAGAACAGCCAAGGGCCTGGGGTCCCCAGACTTCTGGCCAGC TGCCTCTCTGGGGCGAGGAAGGGCCTGGGTCCCTGAGGGGAGGAGATGTGACAGCGGGAGAGGATAGTGG ACAGGAGCAGGTGTGCCCAGAGGGGTCCCCAGGGGTTGGGATGGGGGCCAGGGGAGCTCTGAGCCTGTGG GTGGGTGGGCATGGCCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCCCTGTGGGGGGGAAACTG CCTGTGCTGCAGTGTGATGGCATTCAGGGTGGCAGTCACACACTCCAGGGACCTGCTGGTACATAAAGTC GGGGCAGCCTGGTGGGGTCCGGGCCGCCTGGAGAGTAGGTGTCCTGAGCGCTGGGCCCAGCCCATCGTGA TACATCTAATGATAAACACAAATTCCTAACTTTTATGGGAAATCTCGTTGTTTCTAACATTGGCTCCTAC TTTTAAAACTTTCTAAACAAATGAAGCCAAACACTCTTGGGTGCCTCGCCAACCCTCTAACTGCCATTTT GTAGCTTCTGCGTGGAGGCTGCCATGGAGGTTAAAGGCAGGGCCTGCAGAGCAGGGCCCTGTCCTGGCCC TCCCAGTGCTGTCCGCGGGATGGGGAAGTTCCACAGCCTTCTGTGCCTGGTCTCTCATCTGGGAAACGGG CAGAATGAAATCATCTCCCGCCGGGCTCCTGTGCTGAGCAATCTCCTCCGTGAAGCCCTGGGCTCATATG GCAGTCACAGTGTGGGAATCAGCACTGCCTGAGGGGCTGTGGCCAGGGACAGTGGGAGGAAGAGCTGGGC TCAGCTCTCCAGGCCTGTACCTGCCTGTGTAATGATGCCTGGGAGGCCTGAGCCTGCAGCCTGTATTGTG TAGCATGTGGGTGTGGCGGCTACACCCCGAGGCTGCAAGGAAGTCATTTCCCTCTAGGAACCCTGCTGTC CCCACCCTTTCCCTGCTGGCTCAGGGCTGCCTCCCAGTCCCTGTGCCACAACAGGTCTGACCTGCATGTG TTGGCGCTGCTGTGGCCTCCTCCAGGCTGCACGCCTTAGAAGCAGGCTACGCCTTCCTGCCCTTGGCCTG AGAAGGGCTTCTCCAGCACCTCGGGGACCCCAGCCCCCAGACCCTGGGGTGGCCACTGCCCCAGAAGCCG GGCTGAGACAGGATTCAATGGGGAGGGCCCGTGGGCAGGGCAGAGGCTTGGGCCCCTGGGAGACCTGGCC CTAGAGAAAGAGGCGCGGTGCTCACCTTTGCCCCGGCCTTGCAGGCCTGGATGGCTCTGCCGCCAGCCTC TTTTCTTGTCCAGGCTTCAGGCTGAGCATCTCTTAGAGGGCCTCAGGGATGTCCAGTCCTGCCCTGAAGG CCGCTGAGGACTTAGGATGGTTTAATACTGAACCCACAGCCGCTGGGGACGCCTTGAGGGGAGCCACAGT GTGTGTGCATGTCTCACTCTGGGCTAACTTGTGAAAGGGTGAACAGCTCAGGGGCCCAGAAAACTTAACT CTGGGGCAGGCAGAGGTACAGGGGAGGGCAGATGATTCAGACCCCACCCTGATGGGCCGGGCAGTCACTG CAGAACCCAACCCGGTGCAGTAAGCCACTGCGGGCAGCTGTGGCCCAGCCCCAGGCCCCAGATATTGGGA GGGGCCCCTCTCCTCCCGGCTGTGCCACCCTCACCAAAGGGTAAGTGGGCCAGGACAGAAGGAGCAGGAG GCAGAGCTGCGGCCCCCTCTCAGGGAGGCACCCTCATTGGATGACCCTGTCATGGCCAAGCCTGACCCAG GCTCACTGGGAGCTAAAAGGCAAAGAAGAATAAACCCACATCTGCCCTCAGGGAGCCCAGTGCTGAGAGG CCTGGCACTGGGACAAACTCGCAAACCAGAGTCCTTGAGGGCTGGAGGGGGCCTCCCGGGGCAGGGCATA GGCCACTGCAGGGATGGCACGGAACAGGGCAGCGGAAAAGGCAGGAGTCCGAGGCCCAGGGCCCTGCCTC TGGCGGCTGGGCGCCCTTGGTCACATTGTTGGTGCTCAGAGCCTCAGTTCCCACAGCTGTGCAGCGAGAG GAAGCTGACGGCACCGACCATGGCTGTGGAGGCCTCATGTGTCAATTGTTGCTGTTCTGCAGGAGGAAGA GGATGGCAGGGCCACGCCCCAGCCCATGGGCCAGGCTGCTCCTGGCAGCCTTGATCAGCGTCAGCCTCTC TGGGACCTTGGGTGAGTCCACGTTGCCCTGCAGCCCCCTCCTGGCAGGATCATCCCTTGGGCAGGCATTG CCCTTGCACGGGGATCTCACGGTGTCTCACCTAAACACGCTTGGCCATTCAGCAACTGACCACTGCCCAC CTTCAGGGCTGGAAAACTTGAGGCTCCAAGCTCTTCAGCCTAGAGAAGCTTGAGCCCTGACCACGGGGCC TGAGAATAGGAGCGAAGGAGGCTGTGTCTAGAGGAAAGAGGAGACACCCACCCAGGACTGAGGCACCCAG AGGATGCACTGAGGCCCCAGAGGTGTAGTCAAGAGGGTTATAGGAATTTGGAGAAGAGAGGCACTGCTGA CGTGTCACTTGCTCTCTGAGTGTCACTAGTGGACAAATCACTGGAGCCAGCTCCTACCACTTGAATTTTG TCTGTTAGAGGGGGTCCTGCTGGTGGCTTGAAATAGACCACGACAGAAATGTTTACACCACAGAAATTGG CAAACGCTACACGTCAAGCACCAGAGACCAGAGCCGTTGTTATTTTTTTATTTAATTCAATGTATATGTA GAAACATGCTCTCACTCTGTCGTCCCGGTGAAATGCAGTGATGCCATCGTGGCTCACTGCAGCCTCAACT TCCCAGGCTCAAGCAATCCTCCCACCTTAGCCTCCCATGTAGCTAGGACCACAGGCATGCACCACCATGC CTGGCTAATTAAAAACAATTTTTTTGTAGAGACAGTCTCACTATGTTACCCAGGCTGGTCTCAAACTCCT GAGCTTAAGCAATCTTCCTACCTCGGCTTCCCAAAGTGCTGGGATTACAGGTGTGAGCCATCGCACTGGC CACCACAGCCATTGTTAAACACTGACCAGCACACCATTGCCTGAAGCCCAGGAGACCTCTTACTGTGTAC ACCAGGTGCACACAGTAGGTCCTCACTGTGATTTTTAACTGAGCAGAGCCAAAGGGAAATCTAGAGTTTT ACTTCATTCGTTACTGAGGACCCACTGTGTGCCAGGTGTGCCGGGTGCTAGGGCTACCGTGATAAACAAG ACACCATTCCCTTCACCCTAGAAGGGGCTCAGAGGACAGACAGGCCATGTGGCAGTGGTCTCGCCGTGAG GCACAAGCTGTGATGGAGGAGGTACCTGAAAAGGGTGCTAGGTGCAGCTCATCAAAGGTAATGGGGAAGG CTGAGGACCGTCTGGCTGGACCTGAGGAGGCAGCAGGCCAGGGGGTGGCCAGGGTGTGCCAGCACCGAGT GTGCCAGTGCCACTGTCTCAGTCCCCACCTTCTGTCCTTCTGGCTTGAGTGGGAAGTCCCAGGTTTGAAA TCACAGCTTGTTTCTAGCTGTGCTACCTGGGGCAGATCACATACCCCTGGCCTCTGTAAAATAGGGAACG GCTGGGTGCAGTGGCTCACGCCTATAATTCCCAGCACTTTGGGAGGCCAAGGTGGGAGGATCTCCTGAAC CCAGGAATATGAGACCATCCTGAGCAACATAGGGAGCCCCTGTCTCTACATAAAATAAAAAATTAGCTGG GCTACTTGGGAGGCTGAGGTGGGAGGATTGCCTGAGCCCAGGATGTCGAGACTGCAGTGAGCTGTGATCA TGCCACTGCACTCCAGCCTGGGCGACACAGCAAGACCGTATCTCAAAACTAAATAAAATTGAAATGCAGG TTGGGCACAGTAGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATGATTTGAGGTC AGGAGTTCGAGACCAGCCTAGCCAACATGGTGGAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGG CATGGTGGTGCCCACCCATTATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAG GCGGAGGTTGAAGTGAGCTGAGATCGCACCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTGA AAAATAAAGTAAAACAAAATAAAAATACAACAACAACAACAAACCAAAATAAATACATAAGGCCGGGCCC GGTGGCTCCCACCTGTAATCCCAGCACTTTGGAAGGCCAAGGCGGGTGGATCACAAGGTCAGGAGATCGA GACCATCCTGGCTAACACGGTGAAACCCTGTCTCTACTAAAAATACAAAAAATTAGCCGGGCGTGGTGGC GGGCGCCTGTAGTCTCAGCTACTCCAGAGGCTGAGGTGGGAGAATGGCGTGAACACGGGTGGTGGAGCTT GCAGTGAGCCAGGATCACGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAATAAAT AAATAAATAACATAAGGAGGGAATCCCCATCTCTCCAGGTGAAGGTGCAGGTGGGAAAGTGCTTGCCTTT GCTGAGCGCCTCCCCATTCATGTGCCCACATCTGTCCCCCCAGCAAACCGCTGCAAGAAGGCCCCAGTGA AGAGCTGCACGGAGTGTGTCCGTGTGGATAAGGACTGCGCCTACTGCACAGACGAGGTGAGGACCTGGCC CGGGTTGGTGTGGAACAGGCAAGGGTCGGGAATAGCTGGTGGAAATGAATCTAGGGTTGGGGCAGCCAGG GAATGGGTGCTGCCCCCAGTGACCCCCTGTCCTTCTGGCCAGATGTTCAGGGACCGGCGCTGCAACACCC AGGCGGAGCTGCTGGCCGCGGGCTGCCAGCGGGAGAGCATCGTGGTCATGGAGAGCAGCTTCCAAATCAC AGAGGTGCCTGGTGTGGGGACTGGGGTGGGGGCTCCCCATGCTCAGCCTGGCTATTTATGGGGGTGTATA GTGCCCCTTGGCCGGGCTGGGCCCCCATCGGGCCTCCGGAGTGACCCTCTAGCCAGCTGTCCCCTTCCAC TGGCTGCAGGAGACCCAGATTGACACCACCCTGCGGCGCAGCCAGATGTCCCCCCAAGGCCTGCGGGTCC GTCTGCGGCCCGGTGAGGAGCGGCATTTTGAGCTGGAGGTGTTTGAGCCACTGGAGAGCCCCGTGGACCT GTACATCCTCATGGACTTCTCCAACTCCATGTCCGATGATCTGGACAACCTCAAGAAGATGGGGCAGAAC CTGGGTACGGCAGGGCCAGAGTGGAGGACAGCAGGGCAGGAGGGGGACAGGTGGGCGTCTGCTTGGGAGG CCAGGACTCAGGACAGCTGCACCCACCCAGAAGGAAACACTGGACATTTGAGCCCCCAAAAACCTTCCCT TCCATTCTCAAGGGAAGAATCTCGGTCAGACCCTACTCACCACTGGGGACTTCTGAGAAGGCCCAGGGCA GGCGGGCAGTGGAGCCATCTGGCCCTGACAAGGAGGGCACCCCCTGCCACGAGGCTGTGGGGAAGCTTCT GCTCCTCAGAGCTGGGCTGCATTCCCAGCCACCCTGCCCTTGCTGTACGCATAACTCCAGACCCCCAGTC CCATTTCCCTCATCCATAAATAGGAACAGACAATGTTGTGAGCATGAACCTTTGTCCAGCATGCAAAGCG TTAACCTCCCTCTTCCTCCCTTCTGAGCCAGCCCTTGGTGGGGGGCCCGTGTTTATGCCAGGCATCAGGG CTCAGCTATCCCCTCTCTGTCCTTTTGACATCCAGCTCGGGTCCTGAGCCAGCTCACCAGCGACTACACT ATTGGATTTGGCAAGTTTGTGGACAAAGTCAGCGTCCCGCAGACGGACATGAGGCCTGAGAAGTAAGTGA CTGTGTGGGTCCCGCAGGTGGGCAAGGGTCCAGGCCATGTGACCCCCACTCCTCTTTCACCCACAACTTA AAATTATCCTTCTACGGCTGGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGACCAGGGCGG GCAGATCACCTGAGGTCAGAAGTTCAAGACCAGCCTGGGCAACATGGCAAAACCCCATCTCTACTAAAAA ATACAAAAATTGGCTGGGCGCGGTGGTTCACGCCTGTAATCCTAGCACTTTGGGAGGCCAAGGCGGGTGG ATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAA AGATTAGCCAGGCGTGATGGTGGGCACCGGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCG TGAACCCGGGAGGCGGAGCTTGCAATGAGCCAGGATTGCGCCACTGCACTCCAGCCTGGGCGACAGAATG AGACTCTGTCTCAACAAAAAAAAAAAAAAAAAAAAAATTAGCCAGGTGTGGTGGTGGGCGCCTGTAATTC CAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGAT CGTGCATACCGCACACCAGCCTGGGTGATAAAGCGAGACTTGGTCTCAAAAAAAAAAAAAAAAATTCTCC TTCTAGTTGAAACGAGCCAGGGGCACTGGGGTCTGCGGCGTCTTCCCCCTGTGACACTCTCTCTCCCTCC CACCTCTGCCCAGGCTGAAGGAGCCCTGGCCCAACAGTGACCCCCCCTTCTCCTTCAAGAACGTCATCAG CCTGACAGAAGATGTGGATGAGTTCCGGAATAAACTGCAGGGAGAGCGGATCTCAGGCAACCTGGATGCT CCTGAGGGCGGCTTCGATGCCATCCTGCAGACAGCTGTGTGCACGGTGGGCACTGGGAAGGGTGCTGCCA GCCTAGGCCAGGGGTGAGCACTTCTGGGCAAGGGCCTGAGCTGCCCCCTGGCCTGCTCTGGTGCCAGGCT CACAGGCCCTGAGGGAAAGCCTGGGAGCCTGCAACCCCTTCACCCTGAGACAAGCTCAGACTCTGTGAGT AGGTCTCAGTTACAATCTGAGTTCAGATGTGCCTGGAGCCACGGTCCCCTGGCCTGAGCAGTCACAGCCT GGTTTCGTATCAGCTACCAAGGCAGACCTGGGCTTTAGCGTTCTGGAATCTTTAGTACCCTGAACCCACC AGCTGCCCAGACTCCACCTGTTCTGGGCATCCAAATAAGCCATTTCCTTTGATATGTACATCCATTTGTT CATTCTGAAAATGACATACCCATATTACTAGGTTAGAAAACAAAGAGCTAGCCAAGGCGTGGTGGCTCAC ACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGGGGATTGCTTGAATTCAGGATTTGAGACCAGCCT GGGAAACATGGCAAGACCCTGTCTCTACAGAAAACACAAAAATTAGCTGGGTGTGATGCACGCCTGTGGC CCCAGCGCCTTGCGGGGGCCGCATCTCCAGCTCCTGTTTCTCAGCGTTGTCACTCAGTCATGTGCCGTCA GATGCATCTTTCATGAGGGCACTTGCTGTGAATCCAGTGGCTTAAGCCCAGCCCCATGTTGGGACCCGCG TTCCCCGTCCTACACGACGCCGTGATGCGTGTCAGCAGGCAGCCTGCTCAGTGGGCACGCCCCGCCTTGC CTTCCCCAGAGGGACATTGGCTGGCGCCCGGACAGCACCCACCTGCTGGTCTTCTCCACCGAGTCAGCCT TCCACTATGAGGCTGATGGCGCCAACGTGCTGGCTGGCATCATGAGCCGCAACGATGAACGGTGCCACCT GGACACCACGGGCACCTACACCCAGTACAGGACACAGGACTACCCGTCGGTGCCCACCCTGGTGCGCCTG CTCGCCAAGCACAACATCATCCCCATCTTTGCTGTCACCAACTACTCCTATAGCTACTACGAGGTGCGGG GCCCAGGTCCCACGGGTGGGAGGTGGTCAAGGTAGGGGGTCCATGGAGCTTCTCAGACACCTCTCCCTCC CTCCCTCCCTCCCTCCCTCCCTTCCTCCCTTCCTCCCTCCCTCTTTTCCTCCCTTTCCTTCCTCCCTTCC CAAAGCCTTTAGACCCCCCAAAATGTGGGCCCTAGTGGGAAGGGGAGGTCATGTGCCCATCTTCCACCCC AACTCCCAAGCAGGTGGGGGCTAAGAGGGCAGGCTCTGCGACACCACAGTAGGTTCCAGGCCTCAGTTTC CCCATCCTCAAAGTGGGAAGAATCCTAGAGCTGTTCAGATTCATGGAGATGCTTAGCCTGAGACCTGGCC TTCTCTCCCGCAGAAGCTTCACACCTATTTCCCTGTCTCCTCACTGGGGGTGCTGCAGGAGGACTCGTCC AACATCGTGGAGCTGCTGGAGGAGGCCTTCAATGTGAGGGCAGCTCAGGCTCCAGAGTCTGAGCCCTTCT GGGGCAGGGCAGGAAGTGGGCAGGGTGGGCAAGAGGTGTCTTGGATCACGGTGGAGAAATGGGTCTGGGA CAGACCAGTGAGGAAGGGTCTCTAGCTATCCCTGAGGCCCCGAGGGGCCACCTGGGCCTGGCCCTGGCTC CTGCAGGCTCTGTGATACCCCGCATGATGCCAGCCACACTTGGAGGTTGGGGTGGAGCACAGAGGCCCCC CACAGAGCACTGATCAACCTCCTTCCTCCTTTAGCGGATCCGCTCCAACCTGGACATCCGGGCCCTAGAC AGCCCCCGAGGCCTTCGGACAGAGGTCACCTCCAAGATGTTCCAGAAGACGAGGACTGGGTCCTTTCACA TCCGGCGGGGGGAAGTGGTACGCCTCTGTGGGGGCAGCGGGGTGGGGGATAGGCACAGCGCCCCACACCG AGTGGAATCGTTTAAAACAGCGGTCAAGAGCGTGGCCCCTGGAGTCAGGCAGGCCTGGGTGCAGATCCCT GGGCCTAGCCGCTCGGATGAGCCTAGGTTGCTCCTCTGCTTGTTGGTTTCCTCGGCATGCAAGCGTCGAG CCCGGAGGCTTGCTGGGGCAGTAAATGGGTTAGTGTCACGAAGCCCAGAGGCCCTGGCCACTGTCATTGT CGCTATGATTGTGACTGCGCTGGGAAGGAGGGAGTTTCCAGCCCTGAGGGAGGTGAGCAGGAGCTCATTT CAGGGATCCAGACATCTCCTAGGAACTTGGGGGCCGAGGGCCTTCAGGCATCGATGGCCCCCTGGTCCTT GGGGCTGGGCCTGCCTTGGCTGACCACGGGGCCCCTGCAGGGTATATACCAGGTGCAGCTGCGGGCCCTT GAGCACGTGGATGGGACGCACGTGTGCCAGCTGCCGGAGGACCAGAAGGGCAACATCCATCTGAAACCTT CCTTCTCCGACGGCCTCAAGATGGACGCGGGCATCATCTGTGATGTGTGCACCTGCGAGCTGGTACAACG CAGCCCCGCAGGGCGGGAGGGGAGAGCTGAGCCAAGCACCCAGGGACCCTGAGGAATGAAGCAGGACTCC TGTGCCCCATATCCCTTGTGGGGTTTCCCGAGGCACACAGGAGAGCGGAAGTGTCCAGTGGCCCCGGTCC TGCTCCCCCGACGCACCCCACCATGGTCTCTCTCATTCCAGCAAAAAGAGGTGCGGTCAGCTCGCTGCAG CTTCAACGGAGACTTCGTGTGCGGACAGTGTGTGTGCAGCGAGGGCTGGTGAGTGGGGAAGGGAGTTGGG CACCCAGGACACCAGTGGCCCCTGATGGGAAAGCTGGGCTCCTGCAGGGGCCTGGCCCTGGGTGCACCTT GTACACCTGGCTGGGGGTGGGGCGGCAATCAAAGAAACGGCTAAGGGCGGGGCACACCCAGTTGTTGGTC AAACCCAGGTCAAAGCACTTTGAAATACAGAGATATATGGGCTGTCTCTAGAAAGAGGTGTGAGGATTGA GACGGGGTTGGCTGTTGGGGCTGGGGTCTGGATCTTGGGGGACAGGCACACGAGGCTTCCTTTTTGCTCC ATGCCTTTGGTATTCTGAGTCCTGTGTCATATTGCCTGATCAGAAGAGAGCTCGTAAATGCACGGCAGTA AGGGCTTTAGCTTCAGGACACTGGGCGAGCTTGCCACAACTTGAGGCAGAGCAGTGGGGAAAGGACACTG GAAGGGGTGACATGACAGGGCACTGGGGTTTAGGTCTCAGCTCAGCCACTTCTGTCTGCATGACTGGGAG CTGCCTCGGCCCTCTCAGAGCCTCAGTTTCCTCATCTGTAAAATGGGACAGCAGGCCAGGCGAGGTGGCT CACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACCTGAGGTCAGGAGTTCAAGACCA GCCTGGCCAACATGGTGAAATCCCATCTCTACTAAAAATACAAAAAAGTAGCTGGGCGTGGTGGTGCATG CCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGAATTGCTTGCACCTAGAAGGCGGAGGTTGCCGTGAG CTGAGATCGCGCCACTGCACTCCAGCCTGGGCAAGAAGAGCGAAACTCTGTCTTGAAAAAAAATAAAATA AAATAGGCCAGGCGCGGTGGCTTACGCCTGTAATTTCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACA AGGTCAGGAGATCGAGACCATCCTGGCTAACATGGTGAAACCCCGTCTACTAAAAATACAAAAAATTAGC CGGGCGTAGTGGCGGGTGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATGGCGTGAACCCA AGAGGCAGAGCTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGCGACAAGGCGAGACTCCG TCTCAAAAAAAAAAATAAAATAATTAAATTAAATTAAATTAAATGGGACAGCAAAAGCCCCAGCTTTCCT CCTGGGCTGTTTCGGGGAATGACCAGTTCCTCCTTCAGGAGTGGCCAGACCTGCAACTGCTCCACCGGCT CTCTGAGTGACATTCAGCCCTGCCTGCGGGAGGGCGAGGACAAGCCGTGCTCCGGCCGTGGGGAGTGCCA GTGCGGGCACTGTGTGTGCTACGGCGAAGGCCGCTACGAGGGTCAGTTCTGCGAGTATGACAACTTCCAG TGTCCCCGCACTTCCGGGTTCCTCTGCAATGGTGAGCACAACAACTGCGGCCAATGCTGATGGCGGGGTA GGGAGTGGACAGCAAGCATGACTTTCCCGTCAGGACCCAGGTTGGGAGAGCCAGACTTGGAATCAGAATC CCCAAGTTCAGGCCCAGCCCACTCTGGATGCCCTGAGGGCCGCCCCTGAGTCCTGCCCCAACCTGGGCCT GACTTCCCTCATCTGTAACGTCCATGCCCAAGGTCACTGTTGGCAGGACTTTCCCCTGGTTTTAAGATTC CAACTCCCCTGAGGTTCTCTCTGGAAGTTCAGTTCTATGCCCACCCCACTTCTCCACACCCCTATCTCAT TAGAGTGGGTGCCACCCAGCTCAGCCCTCCAATGGCTGGCAGGTATATGGCATTATGATCTTTCCTCTCT CCAAAGATGCTAAATTTCTGTGGGTTTTTTGTTGTTGTTGCTGCTGTTTTTTTTTTTTTTTTTTTTTTTT TTGAGACAGAGTTTCACTCTTGTCGCCCAGGCTGGAGTGCAATAGCACAATCTTGGCTCACTGCAACCTC TGCCTCCTGGGTTCAGGCGATTCTCCTGCCTCAGCCTCCCTAGTAGGTGGGACTATAGGCATGCACCACC ATGCCCAGCTAATTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTC CTGACCTCAGGTGATCTGCCCGCCTCAGCCTCCCAAAGTACACATCTGTAATCACACCTGGGATTACAGG TGTGAGCCACTGAGCCCGGCCCAAAGATGCTAAATTTCTACCTGGAAGGCCTGGAGCTTCCTCTGTATTC CCATGGGTCCAGGCCATAGGCATACAGTCTGGCCAGGAACATCAGAGCTGGGCAGGATCACAGAACTCAG ACAAGGGGACATAGGGAAGGATTGGTAGTTGAATGGAGGAGGATGAATGAAAATCTACTCATCAAATACT TATGAAGCCCTCACTGTATACTTTCCAAGCCCCTGCTTTTCTACTCTTTCTTCTGTTCTTGCTTTTGTTC ACCATTTCTTCTCTTCGACTGTCTGTCCCTGAGTGTGCTCAGAGAAACAGAAGAGAGAACTGGGCACCAC TGGAGAAAGGCAGACAAGTGGCACAGAGGGAGGTATGAGAGAGGAAGGGAGGAAGGTGCCTCTGGGGAAG GAGGCAGGGCCAGAGTACAAAGGGCTTCGGTTCTAGTCCAGAGCAGGACTTCATCCTTTGGACAAAAGGG GGTCACTGGAGGTTTTACTTTCATTTTCTAACTATTTGCATATTAACCTTGTATCTAGTCACCTTGCTAA ACGCACTTATGAAATCTAATAATTTGTCTGTAGATTCTTCTGGATACTTTGTGACATGTTCCTCACACTT GCAAATAAAGACAATTTTATTGATTGATTGATTGATTGATTTTTGAGACGGAGTCTTGCTCTGTCACCCA GGCTAGAGTGCAGTGGCATGATCTCAGCTCACTACAACCTCTGCCTCCCAGGTTCAAGCAATTCTCCTGC CTCAGCCTCCCAAGAAGCTGGGATTACAGGGGCCCACCACCAAGCCCAGCTAATTTTTGTATTTTTAGTG GAAATAGAGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGAGCTCAAGTGATCCTCCCGCCTCGG CCTCCCAAAGTGTGGGATTACAGGTGTGAGCCACCACGCCCGGCTGACAGTTTTATTTCTTTTTTCTTTT CTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCACCAGGCTGGAGTGCAGTGGCGTGATCTC GGCTCACTGCAACCTCTACCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAACTGGGACT ACAGGCATGCGCCACCATGACCAGCTAATTTTTGTATTTTTAGTAGAGACGAGGTTTCTCCATGTTGGCC AGGATGGTCTCAGTCTCTTGACCTTGTGATCTGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCG TGAGCCACCTTGCCTGGACTTATTTCTTACCTTCTAATGCTTATACATCTTATTTCTTTTTCTGACCTTA TTGCATTGGCAGGGACCCATTAGAGGTTCTTAGCCAGGGGAGCAGGAGCCACATGATTGGATTTGTTTTG AGATAATTACTCAGGCTGCAGAGTGGAAGGTAGGTAGGATGGAGGCAGAGATGGAGGGAAGGAGATTCCA GGAAAGTGAGGAAGAGATGACTTCTACCCCAGGCTAGCGGCACCCTGGCTCCCACAGCTCTGTTCCCACA GGCCCTCCCTGCCAGGTGGGCAGCCTGGACTACAGGCACAGATGTAGCTCTCATCTCCCTTCCTTGTCCC TCTCTGCAGACCGAGGACGCTGCTCCATGGGCCAGTGTGTGTGTGAGCCTGGTTGGACAGGCCCAAGCTG TGACTGTCCCCTCAGCAATGCCACCTGCATCGACAGCAATGGGGTAGGCCTGGGCATAAGACAGACAGTG TCTGTCAGCACCACCCACCCTCTCCAGAGAGAACCCTATGGAGAGAGGAGAGGGAGCAGGCAGGGATGGG GCACAGCTGGCTCACTGGTGCCCCCTCCTACCCCAGGGCATCTGTAATGGACGTGGCCACTGTGAGTGTG GCCGCTGCCACTGCCACCAGCAGTCGCTCTACACGGACACCATCTGCGAGATCAACTACTCGGCGGTGAG GCTAAGACCTACGAGGTGTGGGCGTGGGAACAGGGCAGGCACAGGGCAGTGTGGGCAGGAGGGGCTAAGC CTGATGCCACAGGAGCTGGCCAAGGGCAAGAGGTTTGGGGAGCGGGGGTCTGGCAGAGGCCCACCCAACA CAGTGCCTGTCTGCCCCGCCTTTCCCCGCCAAGATCCACCCGGGCCTCTGCGAGGACCTACGCTCCTGCG TGCAGTGCCAGGCGTGGGGCACCGGCGAGAAGAAGGGGCGCACGTGTGAGGAATGCAACTTCAAGGTCAA GATGGTGGACGAGCTTAAGAGAGGTAGGGGCAGGGGCTGAGGGTTGGGGTTGCTGAGAGCCTAGGCAGCG GGCATCCAACGGGGCAAGGGTGTCATCACCTGGACGGGGGCTTGCAGTCTGGGCTAAGGTCACACAGTCC GGACAGGAACTCCAGAGCTGGGAGGGACCACAGAACCCAGATAGAGGACACCGAATCCCAGAAAAGGGTA AAAGCCTGAGCAGGAGGCACAGAACCCAGGCGGTGGGACACAGTCTGGCCCAGGAAGGGACCAAGAGTCT TGGTGGGAGGCACCTGACTTGGGCAGGGGCATGCACCCAGCAGGGGTACATGGTCACGCTGTGGAGACAC GCAGCCTCCCCTCCTCGAGATCAGATACGTTTTCTGGACCCTGAGTTCCTGGGTGATGTCCAGGTCAGGG AAGTGGGGGAGGTAGGTTTCTAGGCTCTGATGCTCCTGAGCAGGGGAGCCCCCACCACACCCGTTCCTGT GCCTGGTGAGAGCACGGCTTTGCAAGGACTTCCACTCTTCCCCAGGAGGCCCTGCCGTGGGTGAGGCAGA TCGCAGAGTAGGGGCCCCCTCACCAGACCCTGGGTCCTCTGGGGCGGAGGGGTGTGGCTGGGGTGCCCTG CTGACTGGCTGTGGGTACAGCCGAGGAGGTGGTGGTGCGCTGCTCCTTCCGGGACGAGGATGACGACTGC ACCTACAGCTACACCATGGAAGGTGACGGCGCCCCTGGGCCCAACAGCACTGTCCTGGTGCACAAGAAGA AGGGTGAGCTGGTGGGGCCGGGCGCAGGGAGGGGGCGTGTGGCCAGAGCTCGGTGGGGAGGACAGGCACC ACCTCCCCCTGCCTCCTCCTCTCCAGACTGCCCTCCGGGCTCCTTCTGGTGGCTCATCCCCCTGCTCCTC CTCCTCCTGCCGCTCCTGGCCCTGCTACTGCTGCTATGCTGGAAGTACTGTGCCTGCTGCAAGGTGAGCA CCCAGGGTGCCTCCCAAGGCCCCACATCCCAGGGTCCCCACCCCAACAGGGCCCCCACCCTCCACCAGGG TCCCCAGTCCCCGCCTGAGTTCTCATCTCCCCAGGGTCCCCAACCCCTTCCTGGGTCCCCACCTCCCCAG GGTCCCCATCCCAACAGGGTCCCCATCCTCCACCACGGTCCCCACCTCCCCAGTGTCCTCAACCCCCTCC TGGGTCCCCACCTCACCAGGGTCCCCTCTCTGACAGGGTCTCCACCCTCCATCAGGGTCCTCCTCAGGGT CCCCAACCCCCACCAGGGTCCCCAGCCTCTCCACCCACCATCCCCACTCCTGCAGCTTTCTAGCCAGAGG CTTCAGCCCGTAGAGTCCAGCTGTCTGGATTCTGGTCCCAGCTCTGTGACCTTGGGCAAATTACTTAATC TCTCCATGCCTCAGTTCCCTCATCTGTAAAATGAAGATCATAGAATTGACCTCAGAAAGTGGAGCTGAAG CTTAAATTAGTGAAGTTCAGAAGGGACTGACCCATAGCATGCACCATCGCCCCCACCCCCACCTTGGCAA GACCCACACCAACCCCATCCAGCTTCCGGAGTGACAGTAATGATGATGACACCCATGAGCTCTTAGCCCG AGTCATCCTGGAGCCCCAGCCCCCAGCTCAGCCCTTGCCAGCATCCGTTCTCTGCTTAGCTCAGTGTTCC TCTTTGTGCTGTCGCCACAGCATGTCCACGTGACTCCATTTCCCCGCCCCCCATCACCCCATGAGGTCAG TGGGGCAAGGTCACCATGCCCTATGACAGATGGAGAAATTGGGGCTGAGAGGCAGGTGATAAATGCACAG TCCTCAGAAGGGGCTGAGGCAAGCTGAGCCCACATCTTCCCCAGCTCTAGTGCCCGCCCAGGACCCCCAC TCCATCAGCCATCAGTGGCCAGATCCCTGAGAGCACCTGCTCTGGGGTCAGCCACGTGCAAAAGGCCTGG GAGCCACAACAGGGAAGAAAGGGCCCTGCCCGCCCGCAGCTGGCGGTCACTGGGGAGAACAGACAAGAGA AAGCGTGGAGGATGGCATAGCTCAGAGTAGGGATTGTAGGCGGCAGACCACACTCCGTAGTAACCCCCAG TGTTGTGGGATATTAATGTGCATTACATAGGCAAGGAGTTATGTGATCAAATAGGTTTGAGCTAGGCACG GCTGCGCGTGCCTGTAGTCCCAGCTACTCAGAAAGCTGAGGCAGGAGGATCACGAGTCTGGGAGTTTGAG GCTACAGTGAGCTATGATTATGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCAAAAAGAAAAAA AAAAAGAAGGTTTAAGAAACAAGTTTCTTAAATTTAAGTTACAGTGGCTCACACTTGTAACCCCAGCACT TTGGGAGGCCAAGGCGGGTGGATCACTTGAGGTCAGGAGTTGGAGACAAGCCCGGCCAATATGGTGACAC CCCATCTCTACTAGAAATACAAAATTAGCTGGGCATGGAGGTGGATGCCTATAATCCCAGTTACTAGGGG GGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGTAGAGGTTGCAGTGAGCCGCGATCGTGCCACTGCAT TCCAGCCTGGGCAACAGAGCGAGACCCTGTCTCAAAAAAAAAAAAAAGAAAAGAAACAAGTTTCTTCTCT GCAGGACTTCTCAGAGGCTTTGATAAAGTCCTGTGCCTAACCTGCAAGAGGGGCATGGGGAATGAATTCA GTGCTTCCCAAGTGAACCTGACCACAGAACCTTTACAGAGCACCCGGCAGGATGAGAGTTCCACGGCGCA AACTTTGGGAACCCTCTGCCCCCATCCCCCTCTATGCCCTTGTGTGCCATGCTTACACCCTGCTACCACC TGGATATTCTGGTGTCTGGGGAGGCACTGTCACCCCTCTTGACCATTGGCATGGGGCGGGGTGGCTGGAA GGGCTTACCTGGGCCAGGGCAGCTGTCTCAGGCCTCACCCTCACCCACCTTGTCTCCTAGGCCTGCCTGG CACTTCTCCCGTGCTGCAACCGAGGTATGGGCCTGGCATCGCAGGGGCAGCAGGGGCTCTGACTGCTCTT TCTCTGAGCTGGGGTGGAGGGAAGCTGAACCTGGAACGGCAGAGGCTGGAGGCTCTGGGGTCCCACCTGA AGAGGTTGGGCTGTGCGGGTCTAGGGAGGGGTGCCGTGCTGAGGACCCCATCCTGCAGGTCACATGGTGG GCTTTAAGGAAGACCACTACATGCTGCGGGAGAACCTGATGGCCTCTGACCACTTGGACACGCCCATGCT GCGCAGCGGGAACCTCAAGGGCCGTGACGTGGTCCGCTGGAAGGTCACCAACAACATGCAGCGGCCTGGC TTTGCCACTCATGCCGCCAGCATCAACCCCACAGAGCTGGGTGAGGGCGGGGCTGGGCGCCACAGCTCTG GGCAGTGCCCTTCGGGCCCTCTGTTCCAGATCTGGGATCACAGCATGCCTCTTCTCTGGGTGTGGGGTGC AGGCACAGGGCTCAGCCACCTTTTGCCCTGTGCTGATGGTGCTATGAACCTCATGCCTCGGTGTGCGTGG CCTGCTGGCCAGGCATCCCCTGATCCTAGCATGGTTGCTGGAGGGATGCTCTGTGGTGCCTGTCATGCAG GGGGCTGACCACCTCCATCTCACCCCCTCCCACCGCCTTTCCTTAGTGCCCTACGGGCTGTCCTTGCGCC TGGCCCGCCTTTGCACCGAGAACCTGCTGAAGCCTGACACTCGGGAGTGCGCCCAGCTGCGCCAGGAGGT GGAGGAGAACGTAAGGACCCAGGAACTAGGCCTGGCCGGAGATGTGGGTATGAGGGCGGGTGAGGTGGGC AGGGCAGAGCGAATGCGGTCGTGGTACCGAGATTCATTAACTAGGGGAGAGGGGTCTCTCTGGACCTGTG CCTGGCAGGGGGCATCCTGGGATCTGTTTCCAGAGGGCAGAAGGCCAGAGCCTGGGCCCAGGATGCTGCC CCACGGGGCATGCCCCAGCCAACCCTGAGGATCTCTGGGTACAGAGGCTGCCTGGCTCCCTGGGTCCCCA GCCTGAGGGCTTGCCACGGGGTGGCCTAGGCCCAGCCTCACGCCCCTCCCTTGCCTGGCAGCTGAACGAG GTCTACAGGCAGATCTCCGGTGTACACAAGCTCCAGCAGACCAAGTTCCGGTGAGTCCCGGGGTGCCCGG GTTGGGTGGGGGAGCCGCTCCTACCGGGACTCCAGGAGCCGAAGCCCCCAGGCCGATCAGGCCTCCACTT CAGGGCTATCTAGCTCACAGCGCCCTCTTTGTCCCCACAGGCAGCAGCCCAATGCCGGGAAAAAGTGAGT AGAAGACTCGTGGGTGAGAGGGCCCCCACTTCCTGCCCGCCTGTCCCCAGCCCAGCCACTGCCTCGTCCG TCCCTACTCCATCTCCATCCCATAGGAAGGGAGGGTCAGATGTGTCCGTCAGGTTCGGACCTTCATTCGT TCCTTTGACCATTTCTTCAACAAATGCTAATGTGAAGTGCTTGCTATGAAGTGGCCCCTGGACTAGAGCA GGCAAAAGCAAATCAACCCAGTCCCTGCCCTCATATAGGTGACTGTCCAGCCCCCCACCCGGTACCAGCG ATAGCAGGTACCCATCTCCATCCGCTCCAGTGTCCAAGACCCTGATCTTGGGTGCACCTCTGGGGACCAG GCAGGTTACCGAGAGGATGGGCCAGCAGGTCACACACCTTTTTTCCCAGGTCCTACATCGAGTCCTGGCC CTTCATGGGGAGAGAGAGGGAGTGAGGAGGGGGTCTTGATGCAGGGACAGAAGAGCTAGAATCTCAGCAC ATGACCATCAGTAAGAACCGTTGGCTGTGCGTGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCT GAGGCGGGTGGATCACCTCAGGTCAGGAGTTTAAGACTAGCCAGGCCAACATGGTGAAACCCCACCTCTA CTAAAAATACAAAAATTAGCCAGGTGTGTTGGTGGGCACCTGTAATCCCAGCTACTTGGGAGGCTGAGGC AGGAGAATCCCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTG GGCGACTGAGTGAGAATCCGTCTTGAAAAAAAAAAAAAAGAATGGCTGACCAGCATTTCTTATCCTGCTA CGGGCCAAGCATTGTCCTAAGGGCTTTCCGTGTGTGGTCATCTTATCCAACCCTCTCGTCAAGCCTGTGA GGTAGAGATCACTGCTGTTCCCATTTTGCAGATGAGGAAGCTGAGGCTCAAAAGGGTTAAGTGACTTGCC CAAGGTTACCCAGCTATCGAGAACTAGAACCAGGGCTAGGGCCGCGGCAGCCTGGCCTGAGCACACACAC CCTTAGCATCTTTGCTGTCCAGCCCTTGATGAGGTGGGCAGAGAAGCCCATTTCACAGAGGAGGACGCTG AGGACAGGGAGGCGCCATGGCTGGGCTGAGGCTGCAGGGTAAAGGGTATGGGGCTGGCATAGGCCTGGAG CACTGCCTGCCTCTGAAGACCCTGCACTTCTTGCTGTCTTACATCCTGGCCCCTGAAGGGGAGAAGACAG GCAGGAGGGACAGGGCAGCAGGTGCCAGCCTGACCCCTCCGCTGCCTGAACCTTCCACCCTCGACCCAGG CAAGACCACACCATTGTGGACACAGTGCTGATGGCGCCCCGCTCGGCCAAGCCGGCCCTGCTGAAGCTTA CAGAGAAGCAGGTGGAACAGAGGGCCTTCCACGACCTCAAGGTGGCCCCCGGCTACTACACCCTCACTGC AGACCAGGGTAGGAGGGCGGGTCCGCTGTGCCACTGCCTCGCACCTCCCGCCTGTGTGGCCCTGTGACCC ACCTCTGACCACCTCCGAACCCCCACCCAGACGCCCGGGGCATGGTGGAGTTCCAGGAGGGCGTGGAGCT GGTGGACGTACGGGTGCCCCTCTTTATCCGGCCTGAGGATGACGACGAGAAGCAGCTGCTGGTGGAGGCC ATCGACGTGCCCGCAGGCACTGCCACCCTCGGCCGCCGCCTGGTAAACATCACCATCATCAAGGAGCAAG GTGGGTCTGGGTGGGGAGAGTGGGGAAGGCAGACGGGGGCTCGGGGGCACTGGTTCCTCCTGCTTAAGTG GAATTGCGACCTGGCCACGTGGCCTGGGCTAGTCACTTAACCTCTGCAAGCCTTGGTTTCTCCATCTGTA AAATGGGTAAGGGCTCTTTTACGGAATGCGTGGCTGTTCACCTCGCCACAGTGCCTGCCTGGTGGTGAGC GCTCAGTAAATGGAAGCTTCTGTTGCATCCTCATAAGGGCCAGCCCCTTGCTCCTCTCTATCTAGAAAAA GGGTTGGCCAAGGCATCACACCGTGGACATCTGACCCCTCCTCCCACCTGTGCCGGAAGCCACAGGCCTC AGGCCTGTTCCTGCTCTCCTCCAGCCCTGGGGCTGAAGGCTCCATCTCTGGTCCTGCCCGTGACTGGCCT CCCTCCTCTGCCTGGCCCTTCCAGGATGTCTGCTGGACACTTTGTTCCAGAACCACTTTTTTTTTTCTTG GGACAGAGTCTTGCTCTGCCACCCAGGCTGGAGTGCAATGGCACCATCTTGGCTCACTGCAACCGCTGCC TCCCAGGTTGAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACTCGCCACCACGC CCAGCTAATTTTTCTATCTTTAGTAGAGATGGGGTTTCGCCATGTTGGCCAGGCTGGTCTCGAACTCCTG ACCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCACAAGCCACTGCGCCCGGC CCCTCATCTTTTTCTGGAAGGATTTTCCGTTTCGCTCCTGTGCCCTTCCCAGAGGGCAATGCATAGAGGG AACCAAGCGGACTCCTGGATTCTGGGCTGGGCTGGGCAGGGTCACAGGAGAGCAGGAGGTGGGAAGGGAC TGGGCCCAGCACACTCTGACAAATGCCCGGGCTCCTTGCAGCCAGAGACGTGGTGTCCTTTGAGCAGCCT GAGTTCTCGGTCAGCCGCGGGGACCAGGTGGCCCGCATCCCTGTCATCCGGCGTGTCCTGGACGGCGGGA AGTCCCAGGTCTCCTACCGCACACAGGATGGCACCGCGCAGGGCAACCGGGTGAGGCTGCGCCACAGGGT CGAGGGTGCAGCCCGGGGGGCTGCGTGGGCACCGCATTGGGTTCCCAAGACAAAGCAGCACATGGCAGCT GCTTGAGTCCCTGGATACTGGCCGTGCCCCTGGCTGGCCTCCCAAGGACACGTCCACCTGCTCCTGCCAC CCTGTGGCAGGGGAGTCTCACCTGCCCAGGGTGCCAGTGACACGCTGGATGAGGCTCCATTGCTGCCAGG GACTCAGGCCAAGAGGGCTCGCTCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTTTCGCTCTTGTTGC CCAGGCTGGAGTGCAATGGCACAATCTCAGCTCACCGCAACCTCCACCTCTCGGGTTCAAGCGATTCTGC TGCCTCAGCCTCCCTAGTAGCTGGGATTACAGGCATGTGCCACCACGCATGTCTAATTTTGTGTTTTTAG TAGAGACGGGGTTTCTCCATGTTGGTCAGGCTGGTCTGGAACTCCCGACCTCAGGTGATCCGCCCGCCTT GGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCCAAGAGGGCTCTTTCTTCCTTC ATGGGCCAGGGACCTGCCCAGACCATTCCTGTCCCCTCCTACAACTCAGGATCCACAGGGTAGCCAAACC TCTTGGAGATAAACTCCCCCTATATGCCCCAGTCCAGGGGGCTTTGGGTTTCTTGAGCTGGGATCGAAGA CCCCATGTCCCCAGGCCAGACTCCCCAAGGGCTGTCACAATTTGCCAAGCAGCAGGAGCAACCCTTCAAG GCAGGGAGTGCCATGGCTGGACCAGCATCACCTTCACTGCTGAGCCCCAGTGCTGGGGTACAGCCAAATC AGGTGGCACACAGGCTGGACTGGGTTTACAGGCTTCATAGTTTTGTTTCTTTTGTTTTGTGTGGGGATTT TTTGCTTCTTAATTTTTGGGGGAGACAGGGTCTTGCTATGTTGCCCAAGCTGGTCTTGAACTCCTGACCT CAAGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGAGTGAGCTACCACGCCCGGCCTAG TTTTTGTATTTTTAGAAGAGATGGGGTTTTGCCATGTTGGCCAGGCTGGTCTTAAACTCCTGATCTCAAG TGATCCGCCCACCTCGGCTTCCCAAAGTGCAGGGATTACAGGTGTAAGCCAGTGCACCTGGCCTTTCTAG TTTTTAAATGTTGGCAACAAATCCATAATTAAAAACAAAGGCGGGGCATGGTGGCTCACACCTGTAATCC CAGCACTTTGGGAGGCTAAGGTGGGAGAATCACTTAAACCCAGGAGTTCAAGACCAGCCTAGGCAACGTG GTGAGACCATGTCTATACATATAATTTAAACATTAGCTGGGCATGGTAGTGCATACTTGTGGACCCAGCT ACTTGGAAGGCTGAGGCAGGAAGATCACTTGAGGCCAGGAGGTTGAGGCTACAGTGAGCCATGTTCATGC CACTGTACTTCAGCCTAGGCAACAGAGTAAGACCCTGTCTAAAAAAATAATAATAATTAATTTTTTAAAA ATCAAACAAAAAAACAAAGAAACAAAACCTGGCTCAGTGCAGTAGCTCATGCATGTAATCCCAACACTGT GGGAGGGCACAGTGGGAGGATCACTTGAGCCCAGGAGTTGCAGGCCAGCTTGGGCAACATAGTAAGACCC TGTCTCTATTTTAAAAAAATAATAATAATAATAAAGGCCAGGCGAGGTGGCGTATGCCTGTAATCCTAGC ACTGTGGGAGGCCAAGGCAGGTGGATCGCCTGAGGTCACGAGTTCGAGACCAGCCTGGCCAACATGGTGA AACCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGCATGGTGACACGTGCCTCTAATCCCAGCTACCC GGGAGGCCGAGGCAGGAGAATTGCTGGAAACCAGGAGGTGGAGGCTGCAGTGAACCGAGATCATGCCACT GCACTACAGCTTGAGCGACAGAGTGAGACTCTGTCTCGAAAAAAGAAAAAAAAAATTATCTCAAAAGTAA TAAAGTCTCGCCTCCCTGGGCCCACAGGCCCATTCAGCAAACATAGGGGAGCGCGTAGTCAGCAGGCCCG GGCTGCCTGGCCACATCCTAATTTTATTTACTTCTTTTTATTGACAGGAACTGTTCTCATTATTTTTCCA ATGTCCCCCCATAAAAATTCCAAAGAATAATTTTTTTCTTTTAAGAGACAAGGTCTCCCTCTAGTCCAGG GTGGAGTACAGGGGCACAGTCCTAGCTCTCTGCAATCTTGAACTCCTGGGCTCAAGCAGTCCTTCAACCT CAACCTCCCAAGTAGCTGGGACTACAGATGTCCACCACCGCACGGCTAATTTTGTATTTTTTTTTCTTTG AGACGGAGTCTCACTCTGTTGCCCAGGCTGGCGCGATCTCAGCTTACTGCAACCTCCACCTCCAGGGTTC AAGCGATTCTCCTGCCTCAGCCTCCCAAGTAACAGGGACTACAGGTGCGCACCACCACACCCAGCTAAAT TTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCGTGAT CCGCCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATCAGCCACCGCGCCCGGCCATTTTATATTT TTAGTAGAGATAGGGTTTCGCCATGTTGCCCAGGCTGGTCTCAAACTCCTAGGATAACATGATCCTTTTG CCTTGCCTTCTGGCTACCCTGTTACACTTGTATAAAGATGCTTTGAGGCTGGGTACAGTGGCTCATGCCT GTAATCCCAGCACTTTGGGAGGCCAGGGCGGGCAGATCGCTTGAGATCAGGAGTTCAAGACCAGCCTGGC CAACATGGCGAAACCCTGTCTGTACCAAAAATACAGAAAATTATCTGGGTGTTGTGGTGTGCACCTGTGG TCCCAGCTACTCGGGAGGCTGAGGTAGAGCCCAGTAGGTGGAGGTTGCAGTTAGCCGAGATAGTGCCACT GCACTCCAGCCTGGGTGACAGAGTGAAACCCCTGTCTCAAAAAAAAAAAAAAAAAAAAAGCTTTGATATT TGTTTTTTAAAACATTTTAATTTCTCACCTTTTTATTTTTAAAAACTTCAACTTACAGAAAAATGGAAGG AACAGTAAAACTAGCACCCATTTACCCTTTACATAGATTCACCGATTGCTAATATTTGCTTTCTCTCTCT TTCTATATAGATAGCAACATAGAAATATAAATAGAGATGTGGACATCTGTATCTTCACATTGATTATACT AGTACCTAAAATTAGTCCATATTCCAGCCAGGCGTGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAG GCTGAGGCAGGTGGATCACCTGAAGTCAGGAGTTTGACACCAGCCTGACCAACATGGAGAAACCCCATCT CTACTAAAAATACAAAAATTAGCCGGGCATGGTGGCACACGCCTGTAATCTCAGCTACTAGGGAGGCTGA GGCAGGAGAATCATTTGAACCCAGTGGGTGGAGGTTGCAGTGAGCCAAGATTGCGCCACTTCACTCCAGT CTGGGCAAAAGAGCAAAACTCCATCCCAAAAAATATATAAAATAAAATAAAATAGGTCCATATTCCAATG TCCCCTTGTTCGGATGTCCCAATAATGTCCTTTATAGCGTTTTTCCCCCCAATGCAGGAACTAATCAAGG ATTTGGCATTGACTTTTGTCACGTGTCTTGACTCCTTTAATCTAGAAAAGTTTCCTGGCTTTGTCTTCCG TGACACTGACTTTTGTTAAGACAAGGTCTCGCTCTGTCACCCAGGCTGGAGTACAGTGCCTCACTGCAAC CTCTGCCTCCCGGGTTCAAGCAATTCTCCTGCCTTAGCCTCCCGAGTAGCTGGGATTACAGGCACCGGCC ACCATGCCGGGCTAATGACACTGACGTTTTTGAAGTATCCATGTAGGTTGCTTGCAGGCAGCTCCCTGGT TTGTTTTTTGTTTGTTTGTTTTACAACTATGGGTCTCACTTTCTGAGTTGGGTGGCATGAGGTTGCCTCC CCAGCCATCGCCCTGGCTGCTGCGCCTGGAATTGAAATCTTGCCCTGAAGTGCCACCTAGTGGTCTTCTA TGTGAAGGATTTTCTTTTTCCTCCCAGTTCTTATCCTGGAAAGCTCAGGCATGCTCCACGGCACTGAAAG GAAGATGGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCGGATCGCTTGAGGCCG GGAGTTCAAGACCAGCCTAGGCAACATAGGGTAACCGTGCCTCTACAAAAAAAAAAAAAAAAAAAATAGC CAGGTGTGGTGCACGCCTGTAGTCCCAGCTACTCAGGCGGCTGAGGGGAAGGATGGCCTGAGCCCAGGAG GTCAAGGCTTCAGTGAGCTGTGATTGTGCCCCTACACTCCAGCCTGGGTGACAGAGTGAGACCCTGTCTC AAAAACAAACAAACAAACAGAAACGTGGCTGGGCATGGTGGCTCATGTCTGTAATCCCAGCACTTTGGGA GGCCAAGGTGGGAGGATCACTTGAAGTCAGGAGTTCGAGACCAGCCTGGCCAACATAGTGAAACCCCATC TCTACTAAAAATACAAAAATTAGCTAGGCGTGGTGGCAGGTGCCTGTAATCCCAGCTACTCAGGAAGATG AGGTGTGAGAATCATTTGAACCTGGAAGGTGGAGGTTGCAGTAAGCCGAGATCATGCCACTGCACTCCAG CCTAGGTGACAGAGTGAGATTACGCCTCAAAAAAAAAAACAAACAAAAAAAACACAAAAACCTGAACCTC GTGTAAGTACTCCACCCAGCAAGCAGGGATGGTCTCTGCAGTGTCCATGAGGTTGGGAGGGAGCGTGTGG CCATGACTCTTGCCTCAGCCCCCAGCCATGACCCTGACCCTGACCCCCTCCACTCCCAGGACTACATCCC CGTGGAGGGTGAGCTGCTGTTCCAGCCTGGGGAGGCCTGGAAAGAGCTGCAGGTGAAGCTCCTGGAGCTG CAAGAAGTTGACTCCCTCCTGCGGGGCCGCCAGGTCCGCCGTTTCCACGTCCAGCTCAGCAACCCTAAGT TTGGGGCCCACCTGGGCCAGCCCCACTCCACCACCATCATCATCAGGGACCCAGGTAGGCAGAGCCTGGG GGTCGGCTTAAGCAGGAGGAGAGGGAAGACTGGGGGGTCTCTCAACTAGGTCTGTCAGACTTAGCAAATC CAAACACAGGACGCCCAGGTAAATCTGAATTTCAGGTAAACAACATACACGTTGGTAGGATAAGTATGTC CCATGCAATATTTGGAACATACTTATCCTTTTTTTTGCAAAATGGGCTGGGTATACTGGCTCACACCTGT AATCCCAGCATTTTGGGAGGCCAAGGTGGGAGGATCACTTGAGCCCAGGAGTTCTAGACCAGCCTGGGCA ACATAGTGAGACCTCGTCTCTACAAAAAATAAACAAATTAGCTTGGCATAGTGGTGTGCACCTGCAGTCC CAGCTATTCCGGAGACTGAGGTGGGAGGATCACTTGAGCCCAGGGGGTCTGGGCCGCAGCAAGCTGTGAT CGCACCACTGCACAGCACCTGGGCCATGGAATGAGATCCTGTCCCCCAAGAAAAAATAATCTTGTTGTTT ATCTGAAATTCAAATGTAACTAGGCATCCTGCATTTTATCTGGCAACCCTACAGCTAGAGAGGCTGTTGT CACCACACAATAGGAATTCTCCCATCAGACCCTGGCCCTTTGGCTTCAGCCTCAATTCCAACTAACATGC AGATGCTTGTGGAAGGAAGGAGTGGGCCAGTTAGTTCCTATCAGCCCTCAGCCTCCCAACTGGGAGAAAG CCTGCCAGGAAGATGGGAGAGGAGGGAGATACTCAGGGTACAGTGTGGAGATGGGGTGGGGAGCAAATGT TCTCATGTGGAATGTTCCCTGAGCTGCCAAGGGAGAAAGGGGCAGACCAACTCCCTCCCGCTTCTGTTCC TCCAGAGACCCTCCTGGGTCCTCCGCCAAGCTTGGCAGGATGCTCTATGTGGCAGCAATGGGGCACCACC AGGTCTCCAGAGACGCGGGTGGGCAGGTCTGAGTTGAATGCGCTGGGTAGAGCGCCCTGGGTGTTGAAGT GGGTCTCTGGCGCCCCCTGGTGGTGAAGGGGGATCTGAGTGGTTGCCCGGCCCCAACCTGACCCGTTAGA TGAACTGGACCGGAGCTTCACGAGTCAGATGTTGTCATCACAGCCACCCCCTCACGGCGACCTGGGCGCC CCGCAGAACCCCAATGCTAAGGCCGCTGGGTCCAGGAAGATCCATTTCAACTGGCTGCCCCCTTCTGGCA AGCCAATGGGGTACAGGGTAAGGCGGGGGGCTGAGGGTCACGACAGGTGGATGGGCGGTCTGGCACCAGC ACTCACAGAAGAGGTGGGCCGTCCAAGGCCAGGGCCCCCTGAGAGAGAGCAGACAGTGGAACCTAGCACA GGTGGTCAGAGGGAAACCCGGTCTGTGCTGGGAAAGAGGGAAGACCCATTCCTGAGTTTATCAGACATTT GCCCTCCTTCCTAGAATGGGGCCCCCTCCCACCCCCGCATGGGAGATACCCCCACCTGCTCTGCCCTAGT CCTGACGTGTGCACATGGCAGATCTCTCAGCCCCTCCCTCGGGCCTCATCTGTGCAAAGAGGACAGTAAG GGCAGAGGTCAGAGGAGGGACAGGCAGCTTGGGTGCCTGCTGCTCCCTGCTGACCAGGACCCCTGTCCCT GGGGGTAGGTAAAGTACTGGATTCAGGGTGACTCCGAATCCGAAGCCCACCTGCTCGACAGCAAGGTGCC CTCAGTGGAGCTCACCAACCTGTACCCGTATTGCGACTATGAGATGAAGGTGTGCGCCTACGGGGCTCAG GGCGAGGGACCCTACAGCTCCCTGGTGTCCTGCCGCACCCACCAGGAAGGTGAGGCCTCGCCATGTCTGT CCATTTGTCCCCTGGCTGCCCTGATGCCAGCATGCCCAGACCTCCCTCCCTCTGCCACTGACAGCACTCT TCCTGTATTCCCCGCTCCCTAGTGCCCAGCGAGCCAGGGCGTCTGGCCTTCAATGTCGTCTCCTCCACGG TGACCCAGCTGAGCTGGGCTGAGCCGGCTGAGACCAACGGTGAGATCACAGCCTACGAGGTCTGCTATGG CCTGGTCAACGATGACAACCGTAAGAACCAGATCCTTCTTTCCTGCCCACAGGGAGAACAGCCATGGAAG GGGAGGGGACAAAGCTGGAGGGAGCTCTTGGTCACTCCCTGGACCTGCTGTGCAGGGCACTCGAGGCCTT CATCCTGGTCAGCGGATAAGCCTGAGGCATCTTTAGGGTTTTGGCCAGATTTGGGCTGGGTTGCATTCTA AGACCAAACCCAGAAGGTTGCAGGGTGGGTGGTTACCTATGTGGAGTGAGGTCACAGGCCCAGGGGTACC CCTCCCCATGCAGGTAACCAGGGAGCTCACACGTGCATGGTTTTCTTAGGGTGAGAGGAAAGTTACCGGA TTTAGCAAACAGAAATACAGGAGGTTCTGAATTTCAGATAGCACTTTAAAAGATTATTTTGTACATTGAG AGGCCGAGGCAGGTGGACTGCTTGAGGTCAGGAGTTCAAGACCAGCCTGGCTAACATGGTGAAACCGTTT CTACTAAAAATTAGACAGGCATGGTGGCTCATGCCTGTAGTCCCAGCTAGTCAGGAGGCTGAGGCAGGAG AATCACTTGAACCCAGAAGGCGCAGGTTGCAGTGAACCGAGATCGTGTTACCGCACTCCAGACAGGGTGA CAGAGCCAGACTCCGTCTAAAAATAAATAAATAAAAAGGATTATTTTATACATTATTTTATCTAGCAGCC CGAGATCAGAGGTGCCTAGCAGAACAGTTATTTCTCCAGTCCTGGAAGGGAGGCAGGGTGGGCAACCCCT ATGCGTGCCCTTGCCTTGTGTGGAGGCACCGTGGATATATGGGTAGAGGTGACATCGAGGCCAACTTGAG TCCAGCCCTGGCTCTGCCACTTACTCAGCAGAGTCCCTTGGAGGACTGGTGACATATGTCCACGCCAGTC ATGCTGACGCTCAGGGCTCCGCAGGCGGCAATTCAGCAGTGGCTGGCTTTGCCTTGCTTCCCCAGCCCCT GGGTGCCATCCAGGGGATGCACGGCCGTCCTGCTGTGTCAGGGGTGGTGTTGGGACCAGGCTGGGACCTG GGTGACCCTCTGAAGCACTCTCTCTGCCCCAGGACCTATTGGGCCCATGAAGAAAGTGCTGGTTGACAAC CCTAAGAACCGGATGCTGCTTATTGAGAACCTTCGGGAGTCCCAGCCCTACCGCTACACGGTGAAGGCGC GCAACGGGGCCGGCTGGGGGCCTGAGCGGGAGGCCATCATCAACCTGGCCACCCAGCCCAAGAGGCCCAT GTCCAGTGAGTGGTGGGCAGGGAGGTGAGGGGCAGACCGGGCAGGGGGGCAGGGGGCAGCAGCCAGGGCC CTGGCTCACTCCCCTGCCCTGCAGTCCCCATCATCCCTGACATCCCTATCGTGGACGCCCAGAGCGGGGA GGACTACGACAGCTTCCTTATGTACAGCGATGACGTTCTACGCTCTCCATCGGGCAGCCAGAGGCCCAGC GTCTCCGATGACACTGGTGAGTGGAGACCTGGGACCCACAAGAGGACAGTGGGGGTCTTGGGTACAGAGT GAGTCCACTGGGTCCAGAGAGGGCAAAGGGGCCAGCAACTAGAGGACATGGAGGTTAAGGCAGCCTTGGA CAAATGCAATGGAGTGCACATCTGTGCATGGGGCACAGGAACCAGTGCCTGGGGGACAGACACACACAGC CTTGTGCAAGCGCACATGAGTTCATGCCCACGGGACCACGAAGAAACACAGCTTCACAAGTTGAAGGTTC ACCAGCTGTGCCATGCACACAGGACACTCAGGCCACCCCCCAGGGGCAGGCCTGGCCCAGGAGCCCTGGG CAGCCACCAGGCGGCCACCTGGCAGGGGTAGGGGAGCCAAGGAGACAAGAACACCCCCAACAGCTCTGTC CTTCCTCCTTGATTCCCAGCACAAAGTGCTGCGGAGCCCTTAGCTGGGCCTCCTGAGTGCTCAGTGTCAG CTGTGGCTCCACCTGTGGGACATCAGATGAATCACTCATCCTTTCCATGCCTCACTTTTCTGCTCTGTAT AATGGGATACCAATCACACAGTACCATGAGTGGAAAAACCTCTGGGGCACGTATATCTTTTGTATTTTCT TCTGTCCCTGCCGATGCCTCAAGCTGCCCCCGGTGAACACATACTGGCCCCCACGGGGCTCAGCTTGGGC TTAAGGAGCCATTTTGAGGGGTTCAGGTGGAGCGCAGCTGGTGTGACTCTGGAACCCCAGCTCAGCTGCT TCTAACACTACCTGCGAAGCGCTCGGTGGCTTGCGGAACGGTCCCTGGGAGGCGGGCAGGGGCAAGATTC CTCTCTCCATTGTACAAACGGGAAACTGAGTCTCGGAGAGGTTAAGTAAAGCAAGGGAGACCTCACAGCT GGTGACAGAGCCCAGACTTCCCCCAGGTTTCTGGCGGGTCCGGGGGTCTCTCCTCCCCAGCTGTGCCGAG GCTGCACTCGCTCATCTGGAAAGGCTTCAGCCGCGCAAGGGTTTCACCTGCCGCGGCCTTCCCGCTCCGG CCGTGCGCATCTACCCCCGCCCCCAACACACACCCCGGGATCCCGGGAGCTGGAGACGGGCTCCCCTCGC AGAGCCTACGGCCTTCCCCCGCCTGGCCCTGCTCGGCCCGGCGCCCCCCGGCGGTGCCAACGCGGCCCTT CGTTGTTCCCAAGGCTGCGGCTGGAAGTTCGAGCCCCTGCTGGGGGAGGAGCTGGACCTGCGGCGCGTCA CGTGGCGGCTGCCCCCGGAGCTCATCCCGCGCCTGTCGGCCAGCAGCGGGCGCTCCTCCGACGCCGAGGC GCCCCACGGGCCCCCGGACGACGGCGGCGCGGGCGGGAAGGGCGGCAGCCTGCCCCGCAGTGCGACACCC GGGCCCCCCGGAGGTGACAGGCTCACCCGCCGCCCCCCGATCCGCGCCCACCCAGCCTCACTCGCGCCTG AGGGCCTGGGGTGGGCGTCTGCGCTGCCTCGGGGGCCCCAGTTTCAGCCAGGCCCGGGCCTTGGCGGCTG GGAGCACAGCTGCTCAGAGGCAGGGCCCAGTGCCAGGGGACGCGTGAGGCAGGCGCTTGGGCCCTTATGG TGCCTGCCTGGCCAGGGGGTGCAAATTCAGAAGTCTGCCCGGGAAGCGGACCCTGGCACCCAAGTAGACC CCTCAGGGGCCTCAAAGGACAGGAGGGAAGGCTTGGGGATCTCCCCAGGGCAGAGCTGACTGCAGACGCA GCAAACCCCCGCCACTGCCAGGGTCAGCAGTGCTCACACCGATAGAGTGGCCGGCCAGAGGATATGGGCT GTGGAAGCCTGGGTGGCCCTTGGGCTCCTGCAGGGACAGAGGGCCTCTGTCCCTAGTGGTTTGAGGGAAA CTGGTTGTATTTAAGCAAAAGCCACCCAGAGGGTGGGTGACCAGGAATGTGCAGGGCCCAGCCTGCCCCA CGGGGCCCGGGTCTGGGGCAGGCCTGACCAAGGGACCCTGCTCTCCCCCTGCAGAGCACCTGGTGAATGG CCGGATGGACTTTGCCTTCCCGGGCAGCACCAACTCCCTGCACAGGATGACCACGACCAGTGCTGCTGCC TATGGCACCCACCTGAGCCCACACGTGCCCCACCGCGTGCTAAGCACATCCTCCACCCTCACACGGGACT ACAACTCACTGACCCGCTCAGAACACTCACACTCGACCACACTGCCCAGGGACTACTCCACCCTCACCTC CGTCTCCTCCCACGGTGAGTGACCTCAGCCAACCCTGCCTCTCCCACTAACCCTTCCTCTCTTCCAGCTC CTGGAGCCTCGGGCTTCTGTCTGCTGTCCCCACCGCCCATTCTCCAACATACACACACGCATGCACACAT GCACGCACACACGTGCACACGCATGCACACATGTACACAGACATGCATGCGCACACGTACACACATGCAT GCACACTCCCTGCTCCTCTCACTCTTGTTTTGTCCTGCCCTAGGCCTCCCTCCCATCTGGGAACACGGGA GGAGCAGGCTTCCGCTGTCCTGGGCCCTGGGGTCCCGGAGTCGGGCTCAGATGAAAGGGTTCCCCCCTTC CAGGGGCCCACGAGACTCTATAATCCTGGCTGGGAGGCCAGCAGCGCCCTCCTGGGGCCCAGGTAGTACA GGGGTGGCCATCCTGTCTCCACAGCTGTCCTGCTCCATCTGTCATCCAGCCACCATAGCAGCCGCCAGCT GTGCCCACTGCTTCCCCTCCATTCCATCCACAGGACCCCCGCCTGCCCACAGGCGCTAACCACCTGCCCT ACCATCAGTGCTGATGCCTAACTCTGCCTCTGCCCTCCCAGGGGGCGGGGCTGGGGCTGGGGCAGGAGAG GGGCCAGGCCAGCTGAGCAGTTGAGGGGGTGGGGCTGGCAGACTCACGGGGCTCACTCTCTTTTGGCACA AGCAGGGCCTGCACCCTGCTGGAGGATGTGCGGTAGGTGCTGGGCAGCCTGGACAGGGTGTTGCAGGGTG AGTGAGTTGTCCAGCCAGCGGTCAGTGTAGACATGCCAGCTGAGGGAGGGAGGTCAGGGGGCAGCACTGT GACTCCCACTGAGACCCTAGCCCCTGCATCTCTGGCTGACTGCGGCCTCCTGTCCCCAGACTCTCGCCTG ACTGCTGGTGTGCCCGACACGCCCACCCGCCTGGTGTTCTCTGCCCTGGGGCCCACATCTCTCAGAGTGA GCTGGCAGGAGCCGCGGTGCGAGCGGCCGCTGCAGGGCTACAGTGTGGAGTACCAGCTGCTGAACGGCGG TGAGGCATGGTGGCTGCCAGGCTGCGGGGTGCAGCCCTGCAAGGCCTGGCCCCAGTGTGACACATAGGGT ACCTCAGCTGTGTCAGGAACCCACCCAAGTCCCTTGAGCGCTAAAGCCCCCATCCAGCCTGAGAGGGTCT CCCACCCCATTCTCCACCCCACTTCTTTGCCTCCCCTCTTCTGAGGTCTCACCCACCTCCCTGGGCCTCT CTCCTGGTCATTCTCTGCTAGGTTTTGCCTAACAAGGCCCCTTTGGGCTGGGATCCTAGGGCCTCTGCTG GCCTGAGATGCCTTTGGGGGAACAAGGAAGTGGCACTTCCCTGGGCAGGCACATTCAAAGCAGCATGACC AGGATGCAGGATGTTGCCTAAACATGAGTGGGATTACAGGCTCCACTCTTGTATAGTACACAATCTGAAC AACCAGCCATACCATACTGTACCCAACCTGTACCCAAACCACAGCTAGTCCTGGGTGGGTGATAACTAGG TCTCGATGGCAGCTTAGGGACGAGGAGGATCAGGCCAGGGGTGGGAGTAACACTGCACTACTGTGTGCCC CCACCTGATCCCCCCAGGTGAGCTGCATCGGCTCAACATCCCCAACCCTGCCCAGACCTCGGTGGTGGTG GAAGACCTCCTGCCCAACCACTCCTACGTGTTCCGCGTGCGGGCCCAGAGCCAGGAAGGCTGGGGCCGAG AGCGTGAGGGTGTCATCACCATTGAATCCCAGGTGCACCCGCAGAGCCCACTGTGTCCCCTGCCAGGTGA GTTGCCTCCCCCAGCCCCAGAGCTGCCCCCATCATGCCCACCACCCACCCACAGGCTGATGCTCTTCCTC TACTGCCCCCAGGCTCCGCCTTCACTTTGAGCACTCCCAGTGCCCCAGGCCCGCTGGTGTTCACTGCCCT GAGCCCAGACTCGCTGCAGCTGAGCTGGGAGCGGCCACGGAGGCCCAATGGGGATATCGTCGGCTACCTG GTGACCTGTGAGATGGCCCAAGGAGGAGGTGCTGCCCACCCCGGGGGCAGGAGTGGCCAGGGGAGGGGTA AAGAGGGGGCCGCAGACGCTGAAGGCATCTTCCCTGCTCAGGGCCAGCCACCGCATTCCGGGTGGATGGA GACAGCCCCGAGAGCCGGCTGACCGTGCCGGGCCTCAGCGAGAACGTGCCCTACAAGTTCAAGGTGCAGG CCAGGACCACTGAGGGCTTCGGGCCAGAGCGCGAGGGCATCATCACCATAGAGTCCCAGGATGGAGGTAG GCACCTGTCCTTTCCTTCACCCCCACCCCTCCTCGGGCCGTGCCTCCTTCTGGCACCACCCTCTGACTGG CCTATCTGCCCACCCCAGGACCCTTCCCGCAGCTGGGCAGCCGTGCCGGGCTCTTCCAGCACCCGCTGCA AAGCGAGTACAGCAGCATCACCACCACCCACACCAGCGCCACCGAGCCCTTCCTAGTGGGTGAGCACTGA GGGCTAGGGGATCCCGGCTCTCCTGGGACAGGGAGCTAGCAGAGGGAGAAGGGCAGACCCCAAGCCAGGT CATCTAATGCCTCCTCCTCCACAGATGGGCTGACCCTGGGGGCCCAGCACCTGGAGGCAGGCGGCTCCCT CACCCGGCATGTGACCCAGGAGTTTGTGAGCCGGACACTGACCACCAGCGGAACCCTTAGCACCCACATG GACCAACAGTTCTTCCAAACTTGACCGCACCCTGCCCCACCCCCGCCACGTCCCACTAGGCGTCCTCCCG ACTCCTCTCCCGGAGCCTCCTCAGCTACTCCATCCTTGCACCCCTGGGGGCCCAGCCCACCCGCATGCAC AGAGCAGGGGCTAGGTGTCTCCTGGGAGGCATGAAGGGGGCAAGGTCCGTCCTCTGTGGGCCCAAACCTA TTTGTAACCAAAGAGCTGGGAGCAGCACAAGGACCCAGCCTTTGTTCTGCACTTAATAAATGGTTTTGCT ACTGCTAG Download Select all
Length	36478
OMIM ID	147557
HGNC ID	HGNC:6158
Unigene ID	Hs.632226
Ensembl ID	ENSG00000132470
PharmGKB ID	-

mRNA Information

mRNA ID	XM_005257311.3
Exon	join(1..271,3353..3441,5854..5936,6063..6164,6310..6514, 7036..7132,7924..8095,8900..9163,9534..9623,9905..10027, 10471..10632,10822..10898,12149..12351,14710..14813, 14947..15045,15224..15353,15981..16103,16197..16303, 18331..18364,18539..18730,19017..19120,19452..19510, 19641..19664,21000..21148,21241..21420,22372..22520, 27500..27704,28770..28927,29339..29519,29633..29770, 30833..31015,31105..31236,32424..32633,33235..33474, 33714..33872,34360..34509,35088..35276,35363..35518, 35602..35766,35859..35969,36075..36478)
mRNA Sequence	>3691 GCGCTGCCCGCCTCGTCCCCACCCCCCCAACCCCCGCGCCCGCCCTCGGACAGTCCCTGCTCGC CCGCGCGCTGCAGCCCCATCTCCTAGCGGCAGCCCAGGCGCGGAGGGAGCGAGTCCGCCCCGAG GTAGGTCCAGGACGGGCGCACAGCAGCAGCCGAGGCTGGCCGGGAGAGGGAGGAAGAGGATGGC AGGGCCACGCCCCAGCCCATGGGCCAGGCTGCTCCTGGCAGCCTTGATCAGCGTCAGCCTCTCT GGGACCTTGGCAAACCGCTGCAAGAAGGCCCCAGTGAAGAGCTGCACGGAGTGTGTCCGTGTGG ATAAGGACTGCGCCTACTGCACAGACGAGATGTTCAGGGACCGGCGCTGCAACACCCAGGCGGA GCTGCTGGCCGCGGGCTGCCAGCGGGAGAGCATCGTGGTCATGGAGAGCAGCTTCCAAATCACA GAGGAGACCCAGATTGACACCACCCTGCGGCGCAGCCAGATGTCCCCCCAAGGCCTGCGGGTCC GTCTGCGGCCCGGTGAGGAGCGGCATTTTGAGCTGGAGGTGTTTGAGCCACTGGAGAGCCCCGT GGACCTGTACATCCTCATGGACTTCTCCAACTCCATGTCCGATGATCTGGACAACCTCAAGAAG ATGGGGCAGAACCTGGCTCGGGTCCTGAGCCAGCTCACCAGCGACTACACTATTGGATTTGGCA AGTTTGTGGACAAAGTCAGCGTCCCGCAGACGGACATGAGGCCTGAGAAGCTGAAGGAGCCCTG GCCCAACAGTGACCCCCCCTTCTCCTTCAAGAACGTCATCAGCCTGACAGAAGATGTGGATGAG TTCCGGAATAAACTGCAGGGAGAGCGGATCTCAGGCAACCTGGATGCTCCTGAGGGCGGCTTCG ATGCCATCCTGCAGACAGCTGTGTGCACGAGGGACATTGGCTGGCGCCCGGACAGCACCCACCT GCTGGTCTTCTCCACCGAGTCAGCCTTCCACTATGAGGCTGATGGCGCCAACGTGCTGGCTGGC ATCATGAGCCGCAACGATGAACGGTGCCACCTGGACACCACGGGCACCTACACCCAGTACAGGA CACAGGACTACCCGTCGGTGCCCACCCTGGTGCGCCTGCTCGCCAAGCACAACATCATCCCCAT CTTTGCTGTCACCAACTACTCCTATAGCTACTACGAGAAGCTTCACACCTATTTCCCTGTCTCC TCACTGGGGGTGCTGCAGGAGGACTCGTCCAACATCGTGGAGCTGCTGGAGGAGGCCTTCAATC GGATCCGCTCCAACCTGGACATCCGGGCCCTAGACAGCCCCCGAGGCCTTCGGACAGAGGTCAC CTCCAAGATGTTCCAGAAGACGAGGACTGGGTCCTTTCACATCCGGCGGGGGGAAGTGGGTATA TACCAGGTGCAGCTGCGGGCCCTTGAGCACGTGGATGGGACGCACGTGTGCCAGCTGCCGGAGG ACCAGAAGGGCAACATCCATCTGAAACCTTCCTTCTCCGACGGCCTCAAGATGGACGCGGGCAT CATCTGTGATGTGTGCACCTGCGAGCTGCAAAAAGAGGTGCGGTCAGCTCGCTGCAGCTTCAAC GGAGACTTCGTGTGCGGACAGTGTGTGTGCAGCGAGGGCTGGAGTGGCCAGACCTGCAACTGCT CCACCGGCTCTCTGAGTGACATTCAGCCCTGCCTGCGGGAGGGCGAGGACAAGCCGTGCTCCGG CCGTGGGGAGTGCCAGTGCGGGCACTGTGTGTGCTACGGCGAAGGCCGCTACGAGGGTCAGTTC TGCGAGTATGACAACTTCCAGTGTCCCCGCACTTCCGGGTTCCTCTGCAATGACCGAGGACGCT GCTCCATGGGCCAGTGTGTGTGTGAGCCTGGTTGGACAGGCCCAAGCTGTGACTGTCCCCTCAG CAATGCCACCTGCATCGACAGCAATGGGGGCATCTGTAATGGACGTGGCCACTGTGAGTGTGGC CGCTGCCACTGCCACCAGCAGTCGCTCTACACGGACACCATCTGCGAGATCAACTACTCGGCGA TCCACCCGGGCCTCTGCGAGGACCTACGCTCCTGCGTGCAGTGCCAGGCGTGGGGCACCGGCGA GAAGAAGGGGCGCACGTGTGAGGAATGCAACTTCAAGGTCAAGATGGTGGACGAGCTTAAGAGA GCCGAGGAGGTGGTGGTGCGCTGCTCCTTCCGGGACGAGGATGACGACTGCACCTACAGCTACA CCATGGAAGGTGACGGCGCCCCTGGGCCCAACAGCACTGTCCTGGTGCACAAGAAGAAGGACTG CCCTCCGGGCTCCTTCTGGTGGCTCATCCCCCTGCTCCTCCTCCTCCTGCCGCTCCTGGCCCTG CTACTGCTGCTATGCTGGAAGTACTGTGCCTGCTGCAAGGCCTGCCTGGCACTTCTCCCGTGCT GCAACCGAGGTCACATGGTGGGCTTTAAGGAAGACCACTACATGCTGCGGGAGAACCTGATGGC CTCTGACCACTTGGACACGCCCATGCTGCGCAGCGGGAACCTCAAGGGCCGTGACGTGGTCCGC TGGAAGGTCACCAACAACATGCAGCGGCCTGGCTTTGCCACTCATGCCGCCAGCATCAACCCCA CAGAGCTGGTGCCCTACGGGCTGTCCTTGCGCCTGGCCCGCCTTTGCACCGAGAACCTGCTGAA GCCTGACACTCGGGAGTGCGCCCAGCTGCGCCAGGAGGTGGAGGAGAACCTGAACGAGGTCTAC AGGCAGATCTCCGGTGTACACAAGCTCCAGCAGACCAAGTTCCGGCAGCAGCCCAATGCCGGGA AAAAGCAAGACCACACCATTGTGGACACAGTGCTGATGGCGCCCCGCTCGGCCAAGCCGGCCCT GCTGAAGCTTACAGAGAAGCAGGTGGAACAGAGGGCCTTCCACGACCTCAAGGTGGCCCCCGGC TACTACACCCTCACTGCAGACCAGGACGCCCGGGGCATGGTGGAGTTCCAGGAGGGCGTGGAGC TGGTGGACGTACGGGTGCCCCTCTTTATCCGGCCTGAGGATGACGACGAGAAGCAGCTGCTGGT GGAGGCCATCGACGTGCCCGCAGGCACTGCCACCCTCGGCCGCCGCCTGGTAAACATCACCATC ATCAAGGAGCAAGCCAGAGACGTGGTGTCCTTTGAGCAGCCTGAGTTCTCGGTCAGCCGCGGGG ACCAGGTGGCCCGCATCCCTGTCATCCGGCGTGTCCTGGACGGCGGGAAGTCCCAGGTCTCCTA CCGCACACAGGATGGCACCGCGCAGGGCAACCGGGACTACATCCCCGTGGAGGGTGAGCTGCTG TTCCAGCCTGGGGAGGCCTGGAAAGAGCTGCAGGTGAAGCTCCTGGAGCTGCAAGAAGTTGACT CCCTCCTGCGGGGCCGCCAGGTCCGCCGTTTCCACGTCCAGCTCAGCAACCCTAAGTTTGGGGC CCACCTGGGCCAGCCCCACTCCACCACCATCATCATCAGGGACCCAGATGAACTGGACCGGAGC TTCACGAGTCAGATGTTGTCATCACAGCCACCCCCTCACGGCGACCTGGGCGCCCCGCAGAACC CCAATGCTAAGGCCGCTGGGTCCAGGAAGATCCATTTCAACTGGCTGCCCCCTTCTGGCAAGCC AATGGGGTACAGGGTAAAGTACTGGATTCAGGGTGACTCCGAATCCGAAGCCCACCTGCTCGAC AGCAAGGTGCCCTCAGTGGAGCTCACCAACCTGTACCCGTATTGCGACTATGAGATGAAGGTGT GCGCCTACGGGGCTCAGGGCGAGGGACCCTACAGCTCCCTGGTGTCCTGCCGCACCCACCAGGA AGTGCCCAGCGAGCCAGGGCGTCTGGCCTTCAATGTCGTCTCCTCCACGGTGACCCAGCTGAGC TGGGCTGAGCCGGCTGAGACCAACGGTGAGATCACAGCCTACGAGGTCTGCTATGGCCTGGTCA ACGATGACAACCGACCTATTGGGCCCATGAAGAAAGTGCTGGTTGACAACCCTAAGAACCGGAT GCTGCTTATTGAGAACCTTCGGGAGTCCCAGCCCTACCGCTACACGGTGAAGGCGCGCAACGGG GCCGGCTGGGGGCCTGAGCGGGAGGCCATCATCAACCTGGCCACCCAGCCCAAGAGGCCCATGT CCATCCCCATCATCCCTGACATCCCTATCGTGGACGCCCAGAGCGGGGAGGACTACGACAGCTT CCTTATGTACAGCGATGACGTTCTACGCTCTCCATCGGGCAGCCAGAGGCCCAGCGTCTCCGAT GACACTGGCTGCGGCTGGAAGTTCGAGCCCCTGCTGGGGGAGGAGCTGGACCTGCGGCGCGTCA CGTGGCGGCTGCCCCCGGAGCTCATCCCGCGCCTGTCGGCCAGCAGCGGGCGCTCCTCCGACGC CGAGGCGCCCCACGGGCCCCCGGACGACGGCGGCGCGGGCGGGAAGGGCGGCAGCCTGCCCCGC AGTGCGACACCCGGGCCCCCCGGAGAGCACCTGGTGAATGGCCGGATGGACTTTGCCTTCCCGG GCAGCACCAACTCCCTGCACAGGATGACCACGACCAGTGCTGCTGCCTATGGCACCCACCTGAG CCCACACGTGCCCCACCGCGTGCTAAGCACATCCTCCACCCTCACACGGGACTACAACTCACTG ACCCGCTCAGAACACTCACACTCGACCACACTGCCCAGGGACTACTCCACCCTCACCTCCGTCT CCTCCCACGACTCTCGCCTGACTGCTGGTGTGCCCGACACGCCCACCCGCCTGGTGTTCTCTGC CCTGGGGCCCACATCTCTCAGAGTGAGCTGGCAGGAGCCGCGGTGCGAGCGGCCGCTGCAGGGC TACAGTGTGGAGTACCAGCTGCTGAACGGCGGTGAGCTGCATCGGCTCAACATCCCCAACCCTG CCCAGACCTCGGTGGTGGTGGAAGACCTCCTGCCCAACCACTCCTACGTGTTCCGCGTGCGGGC CCAGAGCCAGGAAGGCTGGGGCCGAGAGCGTGAGGGTGTCATCACCATTGAATCCCAGGTGCAC CCGCAGAGCCCACTGTGTCCCCTGCCAGGCTCCGCCTTCACTTTGAGCACTCCCAGTGCCCCAG GCCCGCTGGTGTTCACTGCCCTGAGCCCAGACTCGCTGCAGCTGAGCTGGGAGCGGCCACGGAG GCCCAATGGGGATATCGTCGGCTACCTGGTGACCTGTGAGATGGCCCAAGGAGGAGGGCCAGCC ACCGCATTCCGGGTGGATGGAGACAGCCCCGAGAGCCGGCTGACCGTGCCGGGCCTCAGCGAGA ACGTGCCCTACAAGTTCAAGGTGCAGGCCAGGACCACTGAGGGCTTCGGGCCAGAGCGCGAGGG CATCATCACCATAGAGTCCCAGGATGGAGGACCCTTCCCGCAGCTGGGCAGCCGTGCCGGGCTC TTCCAGCACCCGCTGCAAAGCGAGTACAGCAGCATCACCACCACCCACACCAGCGCCACCGAGC CCTTCCTAGTGGATGGGCTGACCCTGGGGGCCCAGCACCTGGAGGCAGGCGGCTCCCTCACCCG GCATGTGACCCAGGAGTTTGTGAGCCGGACACTGACCACCAGCGGAACCCTTAGCACCCACATG GACCAACAGTTCTTCCAAACTTGACCGCACCCTGCCCCACCCCCGCCACGTCCCACTAGGCGTC CTCCCGACTCCTCTCCCGGAGCCTCCTCAGCTACTCCATCCTTGCACCCCTGGGGGCCCAGCCC ACCCGCATGCACAGAGCAGGGGCTAGGTGTCTCCTGGGAGGCATGAAGGGGGCAAGGTCCGTCC TCTGTGGGCCCAAACCTATTTGTAACCAAAGAGCTGGGAGCAGCACAAGGACCCAGCCTTTGTT CTGCACTTAATAAATGGTTTTGCTACTGCTAAAAAAA Download Select all
Length	5925

CDS Information

Location	join(1087..1181,3353..3441,5854..5936,6063..6164, 6310..6514,7036..7132,7924..8095,8900..9163,9534..9623, 9905..10027,10471..10632,10822..10898,12149..12351, 14710..14813,14947..15045,15224..15353,15981..16103, 16197..16303,18331..18364,18539..18730,19017..19120, 19452..19510,19641..19664,21000..21148,21241..21420, 22372..22520,27500..27704,28770..28927,29339..29519,
CDS Sequence	>gi\|54607034:188-5656 Homo sapiens integrin, beta 4 (ITGB4), transcript variant 1, mRNA ATGGCAGGGCCACGCCCCAGCCCATGGGCCAGGCTGCTCCTGGCAGCCTTGATCAGCGTCAGCCTCTCTG GGACCTTGGCAAACCGCTGCAAGAAGGCCCCAGTGAAGAGCTGCACGGAGTGTGTCCGTGTGGATAAGGA CTGCGCCTACTGCACAGACGAGATGTTCAGGGACCGGCGCTGCAACACCCAGGCGGAGCTGCTGGCCGCG GGCTGCCAGCGGGAGAGCATCGTGGTCATGGAGAGCAGCTTCCAAATCACAGAGGAGACCCAGATTGACA CCACCCTGCGGCGCAGCCAGATGTCCCCCCAAGGCCTGCGGGTCCGTCTGCGGCCCGGTGAGGAGCGGCA TTTTGAGCTGGAGGTGTTTGAGCCACTGGAGAGCCCCGTGGACCTGTACATCCTCATGGACTTCTCCAAC TCCATGTCCGATGATCTGGACAACCTCAAGAAGATGGGGCAGAACCTGGCTCGGGTCCTGAGCCAGCTCA CCAGCGACTACACTATTGGATTTGGCAAGTTTGTGGACAAAGTCAGCGTCCCGCAGACGGACATGAGGCC TGAGAAGCTGAAGGAGCCCTGGCCCAACAGTGACCCCCCCTTCTCCTTCAAGAACGTCATCAGCCTGACA GAAGATGTGGATGAGTTCCGGAATAAACTGCAGGGAGAGCGGATCTCAGGCAACCTGGATGCTCCTGAGG GCGGCTTCGATGCCATCCTGCAGACAGCTGTGTGCACGAGGGACATTGGCTGGCGCCCGGACAGCACCCA CCTGCTGGTCTTCTCCACCGAGTCAGCCTTCCACTATGAGGCTGATGGCGCCAACGTGCTGGCTGGCATC ATGAGCCGCAACGATGAACGGTGCCACCTGGACACCACGGGCACCTACACCCAGTACAGGACACAGGACT ACCCGTCGGTGCCCACCCTGGTGCGCCTGCTCGCCAAGCACAACATCATCCCCATCTTTGCTGTCACCAA CTACTCCTATAGCTACTACGAGAAGCTTCACACCTATTTCCCTGTCTCCTCACTGGGGGTGCTGCAGGAG GACTCGTCCAACATCGTGGAGCTGCTGGAGGAGGCCTTCAATCGGATCCGCTCCAACCTGGACATCCGGG CCCTAGACAGCCCCCGAGGCCTTCGGACAGAGGTCACCTCCAAGATGTTCCAGAAGACGAGGACTGGGTC CTTTCACATCCGGCGGGGGGAAGTGGGTATATACCAGGTGCAGCTGCGGGCCCTTGAGCACGTGGATGGG ACGCACGTGTGCCAGCTGCCGGAGGACCAGAAGGGCAACATCCATCTGAAACCTTCCTTCTCCGACGGCC TCAAGATGGACGCGGGCATCATCTGTGATGTGTGCACCTGCGAGCTGCAAAAAGAGGTGCGGTCAGCTCG CTGCAGCTTCAACGGAGACTTCGTGTGCGGACAGTGTGTGTGCAGCGAGGGCTGGAGTGGCCAGACCTGC AACTGCTCCACCGGCTCTCTGAGTGACATTCAGCCCTGCCTGCGGGAGGGCGAGGACAAGCCGTGCTCCG GCCGTGGGGAGTGCCAGTGCGGGCACTGTGTGTGCTACGGCGAAGGCCGCTACGAGGGTCAGTTCTGCGA GTATGACAACTTCCAGTGTCCCCGCACTTCCGGGTTCCTCTGCAATGACCGAGGACGCTGCTCCATGGGC CAGTGTGTGTGTGAGCCTGGTTGGACAGGCCCAAGCTGTGACTGTCCCCTCAGCAATGCCACCTGCATCG ACAGCAATGGGGGCATCTGTAATGGACGTGGCCACTGTGAGTGTGGCCGCTGCCACTGCCACCAGCAGTC GCTCTACACGGACACCATCTGCGAGATCAACTACTCGGCGATCCACCCGGGCCTCTGCGAGGACCTACGC TCCTGCGTGCAGTGCCAGGCGTGGGGCACCGGCGAGAAGAAGGGGCGCACGTGTGAGGAATGCAACTTCA AGGTCAAGATGGTGGACGAGCTTAAGAGAGCCGAGGAGGTGGTGGTGCGCTGCTCCTTCCGGGACGAGGA TGACGACTGCACCTACAGCTACACCATGGAAGGTGACGGCGCCCCTGGGCCCAACAGCACTGTCCTGGTG CACAAGAAGAAGGACTGCCCTCCGGGCTCCTTCTGGTGGCTCATCCCCCTGCTCCTCCTCCTCCTGCCGC TCCTGGCCCTGCTACTGCTGCTATGCTGGAAGTACTGTGCCTGCTGCAAGGCCTGCCTGGCACTTCTCCC GTGCTGCAACCGAGGTCACATGGTGGGCTTTAAGGAAGACCACTACATGCTGCGGGAGAACCTGATGGCC TCTGACCACTTGGACACGCCCATGCTGCGCAGCGGGAACCTCAAGGGCCGTGACGTGGTCCGCTGGAAGG TCACCAACAACATGCAGCGGCCTGGCTTTGCCACTCATGCCGCCAGCATCAACCCCACAGAGCTGGTGCC CTACGGGCTGTCCTTGCGCCTGGCCCGCCTTTGCACCGAGAACCTGCTGAAGCCTGACACTCGGGAGTGC GCCCAGCTGCGCCAGGAGGTGGAGGAGAACCTGAACGAGGTCTACAGGCAGATCTCCGGTGTACACAAGC TCCAGCAGACCAAGTTCCGGCAGCAGCCCAATGCCGGGAAAAAGCAAGACCACACCATTGTGGACACAGT GCTGATGGCGCCCCGCTCGGCCAAGCCGGCCCTGCTGAAGCTTACAGAGAAGCAGGTGGAACAGAGGGCC TTCCACGACCTCAAGGTGGCCCCCGGCTACTACACCCTCACTGCAGACCAGGACGCCCGGGGCATGGTGG AGTTCCAGGAGGGCGTGGAGCTGGTGGACGTACGGGTGCCCCTCTTTATCCGGCCTGAGGATGACGACGA GAAGCAGCTGCTGGTGGAGGCCATCGACGTGCCCGCAGGCACTGCCACCCTCGGCCGCCGCCTGGTAAAC ATCACCATCATCAAGGAGCAAGCCAGAGACGTGGTGTCCTTTGAGCAGCCTGAGTTCTCGGTCAGCCGCG GGGACCAGGTGGCCCGCATCCCTGTCATCCGGCGTGTCCTGGACGGCGGGAAGTCCCAGGTCTCCTACCG CACACAGGATGGCACCGCGCAGGGCAACCGGGACTACATCCCCGTGGAGGGTGAGCTGCTGTTCCAGCCT GGGGAGGCCTGGAAAGAGCTGCAGGTGAAGCTCCTGGAGCTGCAAGAAGTTGACTCCCTCCTGCGGGGCC GCCAGGTCCGCCGTTTCCACGTCCAGCTCAGCAACCCTAAGTTTGGGGCCCACCTGGGCCAGCCCCACTC CACCACCATCATCATCAGGGACCCAGATGAACTGGACCGGAGCTTCACGAGTCAGATGTTGTCATCACAG CCACCCCCTCACGGCGACCTGGGCGCCCCGCAGAACCCCAATGCTAAGGCCGCTGGGTCCAGGAAGATCC ATTTCAACTGGCTGCCCCCTTCTGGCAAGCCAATGGGGTACAGGGTAAAGTACTGGATTCAGGGTGACTC CGAATCCGAAGCCCACCTGCTCGACAGCAAGGTGCCCTCAGTGGAGCTCACCAACCTGTACCCGTATTGC GACTATGAGATGAAGGTGTGCGCCTACGGGGCTCAGGGCGAGGGACCCTACAGCTCCCTGGTGTCCTGCC GCACCCACCAGGAAGTGCCCAGCGAGCCAGGGCGTCTGGCCTTCAATGTCGTCTCCTCCACGGTGACCCA GCTGAGCTGGGCTGAGCCGGCTGAGACCAACGGTGAGATCACAGCCTACGAGGTCTGCTATGGCCTGGTC AACGATGACAACCGACCTATTGGGCCCATGAAGAAAGTGCTGGTTGACAACCCTAAGAACCGGATGCTGC TTATTGAGAACCTTCGGGAGTCCCAGCCCTACCGCTACACGGTGAAGGCGCGCAACGGGGCCGGCTGGGG GCCTGAGCGGGAGGCCATCATCAACCTGGCCACCCAGCCCAAGAGGCCCATGTCCATCCCCATCATCCCT GACATCCCTATCGTGGACGCCCAGAGCGGGGAGGACTACGACAGCTTCCTTATGTACAGCGATGACGTTC TACGCTCTCCATCGGGCAGCCAGAGGCCCAGCGTCTCCGATGACACTGGCTGCGGCTGGAAGTTCGAGCC CCTGCTGGGGGAGGAGCTGGACCTGCGGCGCGTCACGTGGCGGCTGCCCCCGGAGCTCATCCCGCGCCTG TCGGCCAGCAGCGGGCGCTCCTCCGACGCCGAGGCGCCCCACGGGCCCCCGGACGACGGCGGCGCGGGCG GGAAGGGCGGCAGCCTGCCCCGCAGTGCGACACCCGGGCCCCCCGGAGAGCACCTGGTGAATGGCCGGAT GGACTTTGCCTTCCCGGGCAGCACCAACTCCCTGCACAGGATGACCACGACCAGTGCTGCTGCCTATGGC ACCCACCTGAGCCCACACGTGCCCCACCGCGTGCTAAGCACATCCTCCACCCTCACACGGGACTACAACT CACTGACCCGCTCAGAACACTCACACTCGACCACACTGCCCAGGGACTACTCCACCCTCACCTCCGTCTC CTCCCACGACTCTCGCCTGACTGCTGGTGTGCCCGACACGCCCACCCGCCTGGTGTTCTCTGCCCTGGGG CCCACATCTCTCAGAGTGAGCTGGCAGGAGCCGCGGTGCGAGCGGCCGCTGCAGGGCTACAGTGTGGAGT ACCAGCTGCTGAACGGCGGTGAGCTGCATCGGCTCAACATCCCCAACCCTGCCCAGACCTCGGTGGTGGT GGAAGACCTCCTGCCCAACCACTCCTACGTGTTCCGCGTGCGGGCCCAGAGCCAGGAAGGCTGGGGCCGA GAGCGTGAGGGTGTCATCACCATTGAATCCCAGGTGCACCCGCAGAGCCCACTGTGTCCCCTGCCAGGCT CCGCCTTCACTTTGAGCACTCCCAGTGCCCCAGGCCCGCTGGTGTTCACTGCCCTGAGCCCAGACTCGCT GCAGCTGAGCTGGGAGCGGCCACGGAGGCCCAATGGGGATATCGTCGGCTACCTGGTGACCTGTGAGATG GCCCAAGGAGGAGGGCCAGCCACCGCATTCCGGGTGGATGGAGACAGCCCCGAGAGCCGGCTGACCGTGC CGGGCCTCAGCGAGAACGTGCCCTACAAGTTCAAGGTGCAGGCCAGGACCACTGAGGGCTTCGGGCCAGA GCGCGAGGGCATCATCACCATAGAGTCCCAGGATGGAGGACCCTTCCCGCAGCTGGGCAGCCGTGCCGGG CTCTTCCAGCACCCGCTGCAAAGCGAGTACAGCAGCATCACCACCACCCACACCAGCGCCACCGAGCCCT TCCTAGTGGATGGGCTGACCCTGGGGGCCCAGCACCTGGAGGCAGGCGGCTCCCTCACCCGGCATGTGAC CCAGGAGTTTGTGAGCCGGACACTGACCACCAGCGGAACCCTTAGCACCCACATGGACCAACAGTTCTTC CAAACTTGA Download Select all
CCDS ID	-

Protein Information

Protein ID	XP_005257366.1
Protein Name	Integrin, beta 4
Molecular Wt. (Da)	207749
Protein Sequence	>3691 MAGPRPSPWARLLLAALISVSLSGTLANRCKKAPVKSCTECVRVDKDCAYCTDEMFRDRRCNTQ AELLAAGCQRESIVVMESSFQITEETQIDTTLRRSQMSPQGLRVRLRPGEERHFELEVFEPLES PVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKE PWPNSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDST HLLVFSTESAFHYEADGANVLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNII PIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLEEAFNRIRSNLDIRALDSPRGLRTE VTSKMFQKTRTGSFHIRRGEVGIYQVQLRALEHVDGTHVCQLPEDQKGNIHLKPSFSDGLKMDA GIICDVCTCELQKEVRSARCSFNGDFVCGQCVCSEGWSGQTCNCSTGSLSDIQPCLREGEDKPC SGRGECQCGHCVCYGEGRYEGQFCEYDNFQCPRTSGFLCNDRGRCSMGQCVCEPGWTGPSCDCP LSNATCIDSNGGICNGRGHCECGRCHCHQQSLYTDTICEINYSAIHPGLCEDLRSCVQCQAWGT GEKKGRTCEECNFKVKMVDELKRAEEVVVRCSFRDEDDDCTYSYTMEGDGAPGPNSTVLVHKKK DCPPGSFWWLIPLLLLLLPLLALLLLLCWKYCACCKACLALLPCCNRGHMVGFKEDHYMLRENL MASDHLDTPMLRSGNLKGRDVVRWKVTNNMQRPGFATHAASINPTELVPYGLSLRLARLCTENL LKPDTRECAQLRQEVEENLNEVYRQISGVHKLQQTKFRQQPNAGKKQDHTIVDTVLMAPRSAKP ALLKLTEKQVEQRAFHDLKVAPGYYTLTADQDARGMVEFQEGVELVDVRVPLFIRPEDDDEKQL LVEAIDVPAGTATLGRRLVNITIIKEQARDVVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQV SYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVDSLLRGRQVRRFHVQLSNPKF GAHLGQPHSTTIIIRDPDELDRSFTSQMLSSQPPPHGDLGAPQNPNAKAAGSRKIHFNWLPPSG KPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTH QEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNRPIGPMKKVLVDNPKN RMLLIENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQSGEDYD SFLMYSDDVLRSPSGSQRPSVSDDTGCGWKFEPLLGEELDLRRVTWRLPPELIPRLSASSGRSS DAEAPHGPPDDGGAGGKGGSLPRSATPGPPGEHLVNGRMDFAFPGSTNSLHRMTTTSAAAYGTH LSPHVPHRVLSTSSTLTRDYNSLTRSEHSHSTTLPRDYSTLTSVSSHGLPPIWEHGRSRLPLSW ALGSRSRAQMKGFPPSRGPRDSIILAGRPAAPSWGPDSRLTAGVPDTPTRLVFSALGPTSLRVS WQEPRCERPLQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGRE REGVITIESQVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYL VTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQDG GPFPQLGSRAGLFQHPLQSEYSSITTTHTSATEPFLVDGLTLGAQHLEAGGSLTRHVTQEFVSR TLTTSGTLSTHMDQQFFQT Download Select all
Length	1875
Uniprot ID	P21926
Ensembl Protein ID	ENSP00000009180

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
Y	Phosphorylation	1207;-
Y	Phosphorylation	1207;-
Y	Phosphorylation	1207;-
Y	Phosphorylation	1207;-
Y	Phosphorylation	1207;-
Y	Phosphorylation	1207;-
Y	Phosphorylation	1469;-
Y	Phosphorylation	1399;-
Y	Phosphorylation	1399;-
S	Phosphorylation	1474;-
S	Phosphorylation	1404;-
S	Phosphorylation	1404;-
Y	Phosphorylation	1510
Y	Phosphorylation	1440
S	Phosphorylation	1084
S	Phosphorylation	1084
S	Phosphorylation	1084
T	Phosphorylation	1471
T	Phosphorylation	1401
T	Phosphorylation	1401
T	Phosphorylation	1530
T	Phosphorylation	1513
T	Phosphorylation	1460
Y	Phosphorylation	1188
Y	Phosphorylation	1188
Y	Phosphorylation	1188
Y	Phosphorylation	1198
Y	Phosphorylation	1198
Y	Phosphorylation	1198
Y	Phosphorylation	1206
Y	Phosphorylation	1206
Y	Phosphorylation	1206
Y	Phosphorylation	1509
Y	Phosphorylation	1439
S	Phosphorylation	179
S	Phosphorylation	179
S	Phosphorylation	179

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
667	DST	222	NP_001138241.1	in vivo;yeast 2-hybrid	1 063 730 814 668 470
1179	CLCA1	4880	NP_001276.2	in vitro;in vivo	1 451 241 912 110 680
1308	COL17A1	223	NP_000485.3	in vivo;yeast 2-hybrid	966 088 014 668 477
2885	GRB2	150	NP_002077.1	in vivo	9171350
3655	ITGA6	945	NP_001073286.1	in vivo	9660880
4233	MET	1280	NP_001120972.1	in vivo	1 173 306 314 602 070
5578	PRKCA	1498	NP_002728.1	in vitro	104 777 661 512 185 000 000 000
5747	PTK2	2859	NP_005598.3	in vitro	12110680
6310	ATXN1	3333	NP_000323.2	yeast 2-hybrid	16713569
7431	VIM	1899	NP_003371.2	in vivo	12441134
7525	YES1	1285	NP_005424.1	in vivo	11684709
7529	YWHAB	3184	NP_003395.1	in vitro;yeast 2-hybrid	12919677
9635	CLCA2	4923	NP_006527.1	in vitro;in vivo	1 451 241 912 110 680

Pathway Information

Pathway Name	Pathway ID
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	hsa05412
Dilated cardiomyopathy	hsa05414
ECM-receptor interaction	hsa04512
Focal adhesion	hsa04510
Hypertrophic cardiomyopathy (HCM)	hsa05410
PI3K-Akt signaling pathway	hsa04151
Regulation of actin cytoskeleton	hsa04810

Structure Information

PDB ID	1QCT
Resolution	2.7
Method	X-RAY DIFFRACTION
Chains	A
Molecule	DNA (5'-D(DTPDTPDGPDGPDAPDAPDAPDAPDTPDTPDTPDGPDTPDTPDTPDCPDAPDTPDAPDG)-3')
Model	View

Domain Information

ID	Location	Description
cd00063	1528-1609	FN3
cl21522	1528-1609	FN3 superfamily
cd00063	1641-1726	FN3
cl21522	1641-1726	FN3 superfamily
cd00063	1220-1313	FN3
cl21522	1220-1313	FN3 superfamily
cd00063	1128-1215	FN3
cl21522	1128-1215	FN3 superfamily
smart00187	37-453	INB
cl00057	37-453	vWFA superfamily
pfam00362	37-453	Integrin_beta
pfam03160	990-1084	Calx-beta
cl02522	990-1084	Calx-beta superfamily
smart00237	991-1084	Calx_beta
pfam00041	1529-1611	fn3
pfam07965	626-711	Integrin_B_tail
cl06832	626-711	Integrin_B_tail superfamily
pfam00041	1642-1727	fn3
pfam00041	1128-1208	fn3
smart00060	1528-1609	FN3
smart00060	1641-1725	FN3
pfam00041	1221-1309	fn3
smart00060	1128-1205	FN3
smart00060	1220-1307	FN3
pfam07974	547-573	EGF_2
cl21504	547-573	EGF_CA superfamily
TIGR00845	992-1106	caca
TIGR00845	978-1087	caca

Ontology Information

HPRD ID	202
Molecular Class	Adhesion molecule
Molecular Function	Receptor activity (GO:0004872)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO