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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23705994 | 2013 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 114 Stage : TNM Stage I-IV. | RT-PCR,tissue microarray | Up-regulation | - | This study suggest that over-expression of some integrins is associated with TNM III stage, increased risk of vascular and neural invasion, and mucinous histology in patients with CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Integrins |
| Description | - | Chromosome | 3 |
| Location | 3q21.2 |
| Start | 124480795 |
| End | 124606500 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 125706 |
| OMIM ID | 147561 |
| HGNC ID | HGNC:6160 |
| Unigene ID | Hs.13155 |
| Ensembl ID | ENSG00000082781 |
| PharmGKB ID | PA29959 |
mRNA Information
| mRNA ID | NM_002213.4 |
|---|---|
| Exon | join(234..608,14008..14093,28093..28297,38981..39230, 45988..46156,66065..66226,67705..67800,69829..69918, 78383..78517,90722..91151,113627..113849,118426..118526, 121194..121313,122982..123148,123821..125591) | mRNA Sequence | Download Select all |
| Length | 4392 |
Protein Information
| Protein ID | NP_002204.2 |
|---|---|
| Protein Name | integrin, beta 5 |
| Molecular Wt. (Da) | 85592 |
| Protein Sequence | Download Select all |
| Length | 799 |
| Uniprot ID | P35346 |
| Ensembl Protein ID | ENSP00000293897 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 779 |
| T | Phosphorylation | 780 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 308 | ANXA5 | 568 | NP_001145.1 | in vitro | 12769841 |
| 2274 | FHL2 | 4026 | NP_001441.4 | yeast 2-hybrid | 16355270 |
| 2316 | FLNA | 2060 | NP_001104026.1 | yeast 2-hybrid | 16355270 |
| 3491 | CYR61 | 9089 | NP_001545.2 | in vitro | 11287419 |
| 3678 | ITGA5 | 627 | NP_002196.2 | in vitro;in vivo | 759 282 911 462 216 |
| 4651 | MYO10 | 3283 | NP_036466.2 | in vivo;yeast 2-hybrid | 15156152 |
| 23022 | PALLD | 9731 | NP_057165.3 | yeast 2-hybrid | 16355270 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | hsa05412 |
| Dilated cardiomyopathy | hsa05414 |
| ECM-receptor interaction | hsa04512 |
| Focal adhesion | hsa04510 |
| Hypertrophic cardiomyopathy (HCM) | hsa05410 |
| Phagosome | hsa04145 |
| PI3K-Akt signaling pathway | hsa04151 |
| Proteoglycans in cancer | hsa05205 |
| Regulation of actin cytoskeleton | hsa04810 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00187 | 35-463 | INB |
| cl00057 | 35-463 | vWFA superfamily |
| pfam00362 | 35-463 | Integrin_beta |
| pfam07965 | 635-719 | Integrin_B_tail |
| cl06832 | 635-719 | Integrin_B_tail superfamily |
| pfam08725 | 743-788 | Integrin_b_cyt |
| cl07373 | 743-788 | Integrin_b_cyt superfamily |
Ontology Information
| HPRD ID | 2180 |
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219); Immune response (GO:0006955) |
Drug Information
No matching records could be found.