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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20372795 | 2010 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 84 Stage : - | Real-time RT-PCR, oligoarray expression analyses | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Integrins |
| Description | This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013] | Chromosome | 12 |
| Location | 12q13.1 |
| Start | 53585102 |
| End | 53601065 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 15964 |
| OMIM ID | 147559 |
| HGNC ID | HGNC:6162 |
| Unigene ID | Hs.654470 |
| Ensembl ID | - |
| PharmGKB ID | PA29961 |
mRNA Information
| mRNA ID | XM_005268851.2 |
|---|---|
| Exon | join(1..109,6117..6193,6865..7068,9360..9561,9648..9818, 10491..10732,11112..11270,11590..11685,11848..11937, 12967..13113,13410..13603,13948..14171,14401..14620, 14773..14981,15292..15452,15675..15993) | mRNA Sequence | Download Select all |
| Length | 2824 |
Protein Information
| Protein ID | XP_005268908.1 |
|---|---|
| Protein Name | integrin, beta 7 |
| Molecular Wt. (Da) | 86773 |
| Protein Sequence | Download Select all |
| Length | 798 |
| Uniprot ID | Q16385 |
| Ensembl Protein ID | ENSP00000338796 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 783 |
| T | Phosphorylation | 783 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2335 | FN1 | 626 | NP_997647.1 | in vivo | 1372909 |
| 7412 | VCAM1 | 1888 | NP_001069.1 | in vitro | 12682249 |
| 8174 | MADCAM1 | 35 | NP_570117.1 | in vitro | 9233649 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | hsa05412 |
| Cell adhesion molecules (CAMs) | hsa04514 |
| Dilated cardiomyopathy | hsa05414 |
| ECM-receptor interaction | hsa04512 |
| Focal adhesion | hsa04510 |
| Hypertrophic cardiomyopathy (HCM) | hsa05410 |
| Intestinal immune network for IgA production | hsa04672 |
| PI3K-Akt signaling pathway | hsa04151 |
| Regulation of actin cytoskeleton | hsa04810 |
| Transcriptional misregulation in cancer | hsa05202 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00198 | 152-204 | vWFA |
| cl00057 | 152-204 | vWFA superfamily |
| pfam00362 | 50-476 | Integrin_beta |
| smart00187 | 50-476 | INB |
| pfam07965 | 645-718 | Integrin_B_tail |
| cl06832 | 645-718 | Integrin_B_tail superfamily |
| pfam08725 | 747-792 | Integrin_b_cyt |
| cl07373 | 747-792 | Integrin_b_cyt superfamily |
Ontology Information
| HPRD ID | 8426 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Receptor signaling complex scaffold activity (GO:0030159) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P26010 | DB09033 | Vedolizumab | BiotechDrug |