Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ITIH4 | 3700 | inter-alpha-trypsin inhibitor heavy chain family, member 4 | 3 | IHRP, H4P |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18226209 | 2008 | Cell line : - Source : University Hospitals of Aachen, Jena and Regensburg, Germany. Sample Type : - No. of Sample : - Stage : TNM Stage I-IV | cDNA dot blot analysis , RT-PCR, immunohistochemistry | Down-regulation | - | t ITIH genes are clearly downregulated in multiple human solid tumors, including breast, colon and lung cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] | Chromosome | 3 |
| Location | 3p21.1 |
| Start | 52847006 |
| End | 52864717 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 17712 |
| OMIM ID | 600564 |
| HGNC ID | HGNC:6169 |
| Unigene ID | Hs.709406 |
| Ensembl ID | ENSG00000055955 |
| PharmGKB ID | PA29967 |
mRNA Information
| mRNA ID | NM_001166449.1 |
|---|---|
| Exon | join(1..149,1423..1583,3505..3609,3749..3911,4051..4161, 4688..4816,5744..5860,6137..6305,6387..6512,6698..6879, 6961..7146,9572..9711,9917..10071,10385..10411, 11184..11309,12166..12240,12419..12445,12534..12650, 13644..13818,16339..16493,16631..16727,17212..17712) | mRNA Sequence | Download Select all |
| Length | 3193 |
Protein Information
| Protein ID | NP_001159921.1 |
|---|---|
| Protein Name | inter-alpha-trypsin inhibitor heavy chain family, member 4 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 900 |
| Uniprot ID | P50502 |
| Ensembl Protein ID | ENSP00000216218 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 207 |
| N | Glycosylation | 81 |
| N | Glycosylation | 517 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01461 | 271-452 | vWA_interalpha_trypsin_inhibitor |
| cl00057 | 271-452 | vWFA superfamily |
| smart00609 | 21-148 | VIT |
| cl02699 | 21-148 | VIT superfamily |
| pfam08487 | 31-148 | VIT |
| pfam06668 | 764-930 | ITI_HC_C |
| cl05947 | 764-930 | ITI_HC_C superfamily |
| smart00327 | 274-452 | VWA |
| cd01465 | 274-435 | vWA_subgroup |
| cd00198 | 274-435 | vWFA |
| pfam00092 | 274-452 | VWA |
| cd01466 | 275-436 | vWA_C3HC4_type |
| pfam13519 | 274-457 | VWA_2 |
| pfam13768 | 273-438 | VWA_3 |
| cd01450 | 274-430 | vWFA_subfamily_ECM |
| cd01463 | 270-388 | vWA_VGCC_like |
| cd01462 | 273-386 | VWA_YIEM_type |
| cd01451 | 275-391 | vWA_Magnesium_chelatase |
| cd01456 | 263-446 | vWA_ywmD_type |
| cd01467 | 274-425 | vWA_BatA_type |
| cd01464 | 275-389 | vWA_subfamily |
| pfam10138 | 275-448 | vWA-TerF-like |
| cd01454 | 275-422 | vWA_norD_type |
| cd01476 | 273-386 | VWA_integrin_invertebrates |
| COG4245 | 275-389 | TerY |
| cd01471 | 274-388 | vWA_micronemal_protein |
| cd01474 | 277-386 | vWA_ATR |
| cd01472 | 273-386 | vWA_collagen |
| cd01470 | 274-406 | vWA_complement_factors |
| pfam13444 | 733-760 | Acetyltransf_5 |
| cl17185 | 733-760 | LPLAT superfamily |
| TIGR03788 | 40-626 | marine_srt_targ |
| COG2304 | 263-586 | YfbK |
| COG1240 | 275-407 | ChlD |
| TIGR02031 | 275-405 | BchD-ChlD |
| TIGR03436 | 262-437 | acidobact_VWFA |
| TIGR02442 | 275-395 | Cob-chelat-sub |
| COG2425 | 275-386 | ViaA |
| TIGR00868 | 275-387 | hCaCC |
| TIGR04286 | 72-173 | MSEP-CTERM |
Ontology Information
| HPRD ID | 6005 |
|---|---|
| Molecular Class | Protease inhibitor |
| Molecular Function | Serine-type peptidase activity (GO:0008236) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.