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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
JUN 3725 Jun oncogene  1AP1; AP-1; c-Jun 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21393476   2011Cell line : KM 12C, KM 12SM, HT 29

Source : ATCC.

Sample Type : -

No. of Sample : -

Stage : -

Genotyping, luciferase assays, Western blottingPolymorhpism-This study provided the first evidence that -673C>T and -1318T>G genetic variants in c-Jun promoter regions may contribute to the susceptibility to CRC in Chinese populations, possibly by elevating the transcription activity and protein expression levels that appeared to upregulate activity of c-Jun thus tumorigenesis.

The 1016 patients with newly diagnosed sporadic CRC were examined.

22930170   2012Cell line : -

Source : The First Affiliated Hospital of Sun Yat-Sen University, the Sixth Affiliated Hospital of Sun Yat-Sen University, the Cancer Center of Sun Yat- Sen University, the Affiliated Tumor Hospital of Guangzhou Medical College and Guangdong Provincial People's Hospital, PanYu People's Hospital.

Sample Type : -

No. of Sample : -

Stage : -

Microarray,Real time RT-PCR and Flow cytometryUp-regulation-Gene differentially expressed and analysed bye by Microarray.


Gene Details



Chromosome: 1; NC_000001.10 (59246463..59249785, complement)

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Gene Type protein coding
Gene Family basic leucine zipper proteins
Description This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]  
Chromosome 1
Location 1p32-p31
Start 58780791  
End 58784113  
Strand -  
Gene Sequence

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Length 3323  
OMIM ID 165160   
HGNC ID HGNC:6204   
Unigene ID Hs.696684   
Ensembl ID ENSG00000177606   
PharmGKB ID PA30006   

mRNA Information


mRNA ID NM_002228.3
Exon 1..3323  
mRNA Sequence

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Length 3338  



CDS Information


   
Location 1044..2039
CDS Sequence

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CCDS ID CCDS610.1



Protein Information


      
Protein IDNP_002219.1
Protein NameJun oncogene
Molecular Wt. (Da)35545
Protein Sequence

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Length 331  
Uniprot IDP08571
Ensembl Protein ID ENSP00000304236  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation170
SPhosphorylation249
YPhosphorylation170
SPhosphorylation63
SPhosphorylation73
KAcetylation271
TPhosphorylation231
SPhosphorylation249
SPhosphorylation73
SPhosphorylation58
TPhosphorylation239
SPhosphorylation243
TPhosphorylation62

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
466ATF1440NP_005162.1in vitro8570175   
602BCL3179NP_005169.2in vitro;in vivo10497212   
604BCL6180NP_620309.1in vitro;in vivo12165517   
672BRCA1218NP_009231.2in vitro;in vivo12080089   
861RUNX11043NP_001745.2in vitro11274169   
1386ATF2443NP_001871.2in vitro;in vivo94   450   372   320   002   100   000   000   000   000   
1649DDIT3529NP_004074.2in vivo10523647   
1958EGR1549NP_001955.1in vitro;in vivo11278640   
1999ELF33722NP_004424.3in vitro1651323   
2099ESR1589NP_000116.2in vitro;in vivo11477071   
2113ETS11260NP_001137292.1in vitro8557686   
2114ETS21263NP_005230.1in vitro;in vivo;yeast 2-hybrid9334186   
2353FOS1275NP_005243.1 in vivo;in vitro;in vitro;in vivo781   614   393   468   891   000   000   000   000   000   000   000   000   000   000   
2908NR3C1679NP_001019265.1in vitro;in vivo87   330   117   823   959   
3205HOXA9844NP_689952.1in vitro11551904   
3224HOXC8856NP_073149.1in vitro11551904   
4654MYOD11166NP_002469.2in vitro;in vivo13   108   968   380   166   
4670HNRNPM1188NP_005959.2in vitro11823437   
4779NFE2L11223NP_003195.1in vitro9872330   
4780NFE2L22732NP_006155.2in vitro12805554   
5600MAPK114208AAB05036.1in vitro9235954   
5602MAPK104207NP_620448.1in vitro121   670   881   922   387   
5970RELA1241NP_068810.3in vitro;in vivo104   881   489   468   519   
6497SKI1271NP_003027.1in vitro;in vivo12034730   
6774STAT326NP_644805.1in vitro;in vivo10490649   
6925TCF43780NP_001077431.1in vitro;in vivo16007074   
7150TOP1535NP_003277.1in vitro;in vivo15923621   
7153TOP2A536NP_001058.2in vivo8387155   
8061FOSL1643NP_005429.1in vitro;in vivo1   170   877   111   912   190   
10302SNAPC516183NP_006040.1 in vivo;in vitro15867431   
10499NCOA29066NP_006531.1in vitro11477071   


Pathway Information


                                                                                                                                                                                                                  
Pathway Name Pathway ID
AGE-RAGE signaling pathway in diabetic complications hsa04933
Amphetamine addiction hsa05031
B cell receptor signaling pathway hsa04662
cAMP signaling pathway hsa04024
Chagas disease (American trypanosomiasis) hsa05142
Choline metabolism in cancer hsa05231
Cocaine addiction hsa05030
Colorectal cancer hsa05210
Epithelial cell signaling in Helicobacter pylori infection hsa05120
Epstein-Barr virus infection hsa05169
ErbB signaling pathway hsa04012
Estrogen signaling pathway hsa04915
Focal adhesion hsa04510
GnRH signaling pathway hsa04912
Hepatitis B hsa05161
Herpes simplex infection hsa05168
HTLV-I infection hsa05166
Inflammatory bowel disease (IBD) hsa05321
Influenza A hsa05164
Leishmaniasis hsa05140
MAPK signaling pathway hsa04010
Neurotrophin signaling pathway hsa04722
Non-alcoholic fatty liver disease (NAFLD) hsa04932
Osteoclast differentiation hsa04380
Oxytocin signaling pathway hsa04921
Pathways in cancer hsa05200
Pertussis hsa05133
Renal cell carcinoma hsa05211
Rheumatoid arthritis hsa05323
Salmonella infection hsa05132
T cell receptor signaling pathway hsa04660
TNF signaling pathway hsa04668
Toll-like receptor signaling pathway hsa04620
Viral carcinogenesis hsa05203
Wnt signaling pathway hsa04310


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd14696254-314  bZIP_Jun
cl21462254-314  bZIP superfamily
pfam00170256-313  bZIP_1
cd14687257-314  bZIP_ATF2
smart00338250-313  BRLZ
cd14686255-306  bZIP
cd14698250-312  bZIP_CNC
cd14691254-311  bZIP_XBP1
cd14690254-307  bZIP_CREB1
cd14699254-309  bZIP_Fos_like
pfam07716254-310  bZIP_2
cd12193254-305  bZIP_GCN4
cd14720257-312  bZIP_NFE2-like
cd14719248-311  bZIP_BACH
cd14722254-308  bZIP_ATF3
cd14692254-310  bZIP_ATF4
cd14688254-311  bZIP_YAP
cd14704256-304  bZIP_HY5-like
pfam03131248-311  bZIP_Maf
cd14810256-305  bZIP_u1
cd14809255-297  bZIP_AUREO-like
cd14709258-314  bZIP_CREBL2
cd14703257-306  bZIP_plant_RF2
cd14705255-309  bZIP_Zip1
cd14721254-311  bZIP_Fos
cd14702257-304  bZIP_plant_GBF1
cd14697248-312  bZIP_Maf
cd14812259-294  bZIP_u3
cd14700259-305  bZIP_ATF6
cd14693257-309  bZIP_CEBP
cd14689253-329  bZIP_CREB3
cd14811256-294  bZIP_u2
cd14701254-309  bZIP_BATF
cd14710251-306  bZIP_HAC1-like
cd14713257-310  bZIP_CEBPG
cd14707257-311  bZIP_plant_BZIP46
cd14695258-310  bZIP_HLF
cd14706256-308  bZIP_CREBZF
cd14717252-311  bZIP_Maf_small
pfam039575-241  Jun
COG1842247-312  PspA
pfam11559246-312  ADIP
pfam04012274-312  PspA_IM30
PRK03918223-310  PRK03918
COG2433246-312  COG2433
COG1196248-315  Smc
TIGR02169219-312  SMC_prok_A


Ontology Information


   
HPRD ID3011
Molecular ClassTranscription factor
Molecular FunctionReceptor activity (GO:0004872)
Biological ProcessImmune response (GO:0006955)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P05412DB00570VinblastineSmallMoleculeDrug
P05412DB00852PseudoephedrineSmallMoleculeDrug
P05412DB01029IrbesartanSmallMoleculeDrug
P05412DB01169Arsenic trioxideSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO