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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21393476    | 2011 | Cell line : KM 12C, KM 12SM, HT 29 Source : ATCC. Sample Type : - No. of Sample : - Stage : - | Genotyping, luciferase assays, Western blotting | Polymorhpism | - | This study provided the first evidence that -673C>T and -1318T>G genetic variants in c-Jun promoter regions may contribute to the susceptibility to CRC in Chinese populations, possibly by elevating the transcription activity and protein expression levels that appeared to upregulate activity of c-Jun thus tumorigenesis. The 1016 patients with newly diagnosed sporadic CRC were examined. |
| 22930170    | 2012 | Cell line : - Source : The First Affiliated Hospital of Sun Yat-Sen University, the Sixth Affiliated Hospital of Sun Yat-Sen University, the Cancer Center of Sun Yat- Sen University, the Affiliated Tumor Hospital of Guangzhou Medical College and Guangdong Provincial People's Hospital, PanYu People's Hospital. Sample Type : - No. of Sample : - Stage : - | Microarray,Real time RT-PCR and Flow cytometry | Up-regulation | - | Gene differentially expressed and analysed bye by Microarray. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | basic leucine zipper proteins |
| Description | This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]   | Chromosome | 1 |
| Location | 1p32-p31 |
| Start | 58780791   |
| End | 58784113   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 3323   |
| OMIM ID | 165160    |
| HGNC ID | HGNC:6204    |
| Unigene ID | Hs.696684    |
| Ensembl ID | ENSG00000177606    |
| PharmGKB ID | PA30006    |
mRNA Information
| mRNA ID | NM_002228.3 |
|---|---|
| Exon | 1..3323   | mRNA Sequence |    Download   Select all |
| Length | 3338   |
CDS Information
| Location | 1044..2039 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS610.1 |    
Protein Information
| Protein ID | NP_002219.1 |
|---|---|
| Protein Name | Jun oncogene |
| Molecular Wt. (Da) | 35545 |
| Protein Sequence |    Download   Select all |
| Length | 331   |
| Uniprot ID | P08571 |    
| Ensembl Protein ID | ENSP00000304236   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 170 |
| S | Phosphorylation | 249 |
| Y | Phosphorylation | 170 |
| S | Phosphorylation | 63 |
| S | Phosphorylation | 73 |
| K | Acetylation | 271 |
| T | Phosphorylation | 231 |
| S | Phosphorylation | 249 |
| S | Phosphorylation | 73 |
| S | Phosphorylation | 58 |
| T | Phosphorylation | 239 |
| S | Phosphorylation | 243 |
| T | Phosphorylation | 62 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 466 |    ATF1 |    440 |    NP_005162.1 |    in vitro |    8570175    |
| 602 |    BCL3 |    179 |    NP_005169.2 |    in vitro;in vivo |    10497212    |
| 604 |    BCL6 |    180 |    NP_620309.1 |    in vitro;in vivo |    12165517    |
| 672 |    BRCA1 |    218 |    NP_009231.2 |    in vitro;in vivo |    12080089    |
| 861 |    RUNX1 |    1043 |    NP_001745.2 |    in vitro |    11274169    |
| 1386 |    ATF2 |    443 |    NP_001871.2 |    in vitro;in vivo |    94   450   372   320   002   100   000   000   000   000    |
| 1649 |    DDIT3 |    529 |    NP_004074.2 |    in vivo |    10523647    |
| 1958 |    EGR1 |    549 |    NP_001955.1 |    in vitro;in vivo |    11278640    |
| 1999 |    ELF3 |    3722 |    NP_004424.3 |    in vitro |    1651323    |
| 2099 |    ESR1 |    589 |    NP_000116.2 |    in vitro;in vivo |    11477071    |
| 2113 |    ETS1 |    1260 |    NP_001137292.1 |    in vitro |    8557686    |
| 2114 |    ETS2 |    1263 |    NP_005230.1 |    in vitro;in vivo;yeast 2-hybrid |    9334186    |
| 2353 |    FOS |    1275 |    NP_005243.1 |    in vivo;in vitro;in vitro;in vivo |    781   614   393   468   891   000   000   000   000   000   000   000   000   000   000    |
| 2908 |    NR3C1 |    679 |    NP_001019265.1 |    in vitro;in vivo |    87   330   117   823   959    |
| 3205 |    HOXA9 |    844 |    NP_689952.1 |    in vitro |    11551904    |
| 3224 |    HOXC8 |    856 |    NP_073149.1 |    in vitro |    11551904    |
| 4654 |    MYOD1 |    1166 |    NP_002469.2 |    in vitro;in vivo |    13   108   968   380   166    |
| 4670 |    HNRNPM |    1188 |    NP_005959.2 |    in vitro |    11823437    |
| 4779 |    NFE2L1 |    1223 |    NP_003195.1 |    in vitro |    9872330    |
| 4780 |    NFE2L2 |    2732 |    NP_006155.2 |    in vitro |    12805554    |
| 5600 |    MAPK11 |    4208 |    AAB05036.1 |    in vitro |    9235954    |
| 5602 |    MAPK10 |    4207 |    NP_620448.1 |    in vitro |    121   670   881   922   387    |
| 5970 |    RELA |    1241 |    NP_068810.3 |    in vitro;in vivo |    104   881   489   468   519    |
| 6497 |    SKI |    1271 |    NP_003027.1 |    in vitro;in vivo |    12034730    |
| 6774 |    STAT3 |    26 |    NP_644805.1 |    in vitro;in vivo |    10490649    |
| 6925 |    TCF4 |    3780 |    NP_001077431.1 |    in vitro;in vivo |    16007074    |
| 7150 |    TOP1 |    535 |    NP_003277.1 |    in vitro;in vivo |    15923621    |
| 7153 |    TOP2A |    536 |    NP_001058.2 |    in vivo |    8387155    |
| 8061 |    FOSL1 |    643 |    NP_005429.1 |    in vitro;in vivo |    1   170   877   111   912   190    |
| 10302 |    SNAPC5 |    16183 |    NP_006040.1 |    in vivo;in vitro |    15867431    |
| 10499 |    NCOA2 |    9066 |    NP_006531.1 |    in vitro |    11477071    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| AGE-RAGE signaling pathway in diabetic complications |    hsa04933 |    
| Amphetamine addiction |    hsa05031 |    
| B cell receptor signaling pathway |    hsa04662 |    
| cAMP signaling pathway |    hsa04024 |    
| Chagas disease (American trypanosomiasis) |    hsa05142 |    
| Choline metabolism in cancer |    hsa05231 |    
| Cocaine addiction |    hsa05030 |    
| Colorectal cancer |    hsa05210 |    
| Epithelial cell signaling in Helicobacter pylori infection |    hsa05120 |    
| Epstein-Barr virus infection |    hsa05169 |    
| ErbB signaling pathway |    hsa04012 |    
| Estrogen signaling pathway |    hsa04915 |    
| Focal adhesion |    hsa04510 |    
| GnRH signaling pathway |    hsa04912 |    
| Hepatitis B |    hsa05161 |    
| Herpes simplex infection |    hsa05168 |    
| HTLV-I infection |    hsa05166 |    
| Inflammatory bowel disease (IBD) |    hsa05321 |    
| Influenza A |    hsa05164 |    
| Leishmaniasis |    hsa05140 |    
| MAPK signaling pathway |    hsa04010 |    
| Neurotrophin signaling pathway |    hsa04722 |    
| Non-alcoholic fatty liver disease (NAFLD) |    hsa04932 |    
| Osteoclast differentiation |    hsa04380 |    
| Oxytocin signaling pathway |    hsa04921 |    
| Pathways in cancer |    hsa05200 |    
| Pertussis |    hsa05133 |    
| Renal cell carcinoma |    hsa05211 |    
| Rheumatoid arthritis |    hsa05323 |    
| Salmonella infection |    hsa05132 |    
| T cell receptor signaling pathway |    hsa04660 |    
| TNF signaling pathway |    hsa04668 |    
| Toll-like receptor signaling pathway |    hsa04620 |    
| Viral carcinogenesis |    hsa05203 |    
| Wnt signaling pathway |    hsa04310 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd14696 | 254-314  | bZIP_Jun |
| cl21462 | 254-314  | bZIP superfamily |
| pfam00170 | 256-313  | bZIP_1 |
| cd14687 | 257-314  | bZIP_ATF2 |
| smart00338 | 250-313  | BRLZ |
| cd14686 | 255-306  | bZIP |
| cd14698 | 250-312  | bZIP_CNC |
| cd14691 | 254-311  | bZIP_XBP1 |
| cd14690 | 254-307  | bZIP_CREB1 |
| cd14699 | 254-309  | bZIP_Fos_like |
| pfam07716 | 254-310  | bZIP_2 |
| cd12193 | 254-305  | bZIP_GCN4 |
| cd14720 | 257-312  | bZIP_NFE2-like |
| cd14719 | 248-311  | bZIP_BACH |
| cd14722 | 254-308  | bZIP_ATF3 |
| cd14692 | 254-310  | bZIP_ATF4 |
| cd14688 | 254-311  | bZIP_YAP |
| cd14704 | 256-304  | bZIP_HY5-like |
| pfam03131 | 248-311  | bZIP_Maf |
| cd14810 | 256-305  | bZIP_u1 |
| cd14809 | 255-297  | bZIP_AUREO-like |
| cd14709 | 258-314  | bZIP_CREBL2 |
| cd14703 | 257-306  | bZIP_plant_RF2 |
| cd14705 | 255-309  | bZIP_Zip1 |
| cd14721 | 254-311  | bZIP_Fos |
| cd14702 | 257-304  | bZIP_plant_GBF1 |
| cd14697 | 248-312  | bZIP_Maf |
| cd14812 | 259-294  | bZIP_u3 |
| cd14700 | 259-305  | bZIP_ATF6 |
| cd14693 | 257-309  | bZIP_CEBP |
| cd14689 | 253-329  | bZIP_CREB3 |
| cd14811 | 256-294  | bZIP_u2 |
| cd14701 | 254-309  | bZIP_BATF |
| cd14710 | 251-306  | bZIP_HAC1-like |
| cd14713 | 257-310  | bZIP_CEBPG |
| cd14707 | 257-311  | bZIP_plant_BZIP46 |
| cd14695 | 258-310  | bZIP_HLF |
| cd14706 | 256-308  | bZIP_CREBZF |
| cd14717 | 252-311  | bZIP_Maf_small |
| pfam03957 | 5-241  | Jun |
| COG1842 | 247-312  | PspA |
| pfam11559 | 246-312  | ADIP |
| pfam04012 | 274-312  | PspA_IM30 |
| PRK03918 | 223-310  | PRK03918 |
| COG2433 | 246-312  | COG2433 |
| COG1196 | 248-315  | Smc |
| TIGR02169 | 219-312  | SMC_prok_A |
Ontology Information
| HPRD ID | 3011 |    
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Immune response (GO:0006955)   |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P05412 | DB00570 | Vinblastine | SmallMoleculeDrug |
| P05412 | DB00852 | Pseudoephedrine | SmallMoleculeDrug |
| P05412 | DB01029 | Irbesartan | SmallMoleculeDrug |
| P05412 | DB01169 | Arsenic trioxide | SmallMoleculeDrug |
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
