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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
JUND 3727 jun D proto-oncogene  19AP-1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
10874008   2000Cell line : -

Source : -

Sample Type : CRC tumor and normal tissues

No. of Sample : 25

Stage : -

Western immunoblotting,immunohistochemistryUp-regulation-JunB proteins were undetectable or barely detectable in normal mucosa but their expression levels were significantly increased in human colorectal adenocarcinomas.


Gene Details



NC_000019.9 (18390563..18392432, complement)

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Gene Type protein coding
Gene Family basic leucine zipper proteins
Description The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]  
Chromosome 19
Location 19p13.2
Start 18390563  
End 18392432  
Strand -  
Gene Sequence

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Length 1870  
OMIM ID 165162   
HGNC ID HGNC:6206   
Unigene ID Hs.2780   
Ensembl ID -   
PharmGKB ID PA30008   

mRNA Information


mRNA ID NM_005354.5
Exon 1..1963  
mRNA Sequence

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Length 1963  



CDS Information


   
Location 173..1216
CDS Sequence

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CCDS ID CCDS32959.1



Protein Information


      
Protein IDNP_005345.3
Protein Namejun D proto-oncogene
Molecular Wt. (Da)81614
Protein Sequence

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Length 347  
Uniprot IDQ14765
Ensembl Protein ID ENSP00000351255  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation259
SPhosphorylation255
SPhosphorylation251
TPhosphorylation265
SPhosphorylation100
TPhosphorylation117
TPhosphorylation245

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                       
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
604BCL6180NP_620309.1in vitro;in vivo12165517   
672BRCA1218NP_009231.2in vitro;in vivo12080089   
1649DDIT3529NP_004074.2in vitro;in vivo10523647   
2353FOS1275NP_005243.1 in vivo;in vitro;in vitro1   219   341   015   867   430   
4088SMAD34380NP_005893.1in vitro10220381   
4221MEN1564NP_000235.2in vitro;in vivo998   950   512   226   747   
4779NFE2L11223NP_003195.1in vitro;in vivo9872330   
5594MAPK11496NP_002736.3in vitro;in vivo14676207   
5595MAPK33479NP_002737.2in vitro;in vivo14676207   


Pathway Information


            
Pathway Name Pathway ID
MAPK signaling pathway hsa04010
Osteoclast differentiation hsa04380


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd14696270-329  bZIP_Jun
cl21462270-329  bZIP superfamily
pfam00170272-328  bZIP_1
cd14687273-329  bZIP_ATF2
smart00338266-328  BRLZ
cd14686271-322  bZIP
cd14698266-328  bZIP_CNC
cd14691270-327  bZIP_XBP1
cd14699270-325  bZIP_Fos_like
cd14690270-330  bZIP_CREB1
pfam07716270-326  bZIP_2
cd14704272-320  bZIP_HY5-like
cd14722270-324  bZIP_ATF3
cd14720273-328  bZIP_NFE2-like
cd12193270-321  bZIP_GCN4
cd14692270-326  bZIP_ATF4
cd14719273-327  bZIP_BACH
pfam03131264-327  bZIP_Maf
cd14810272-321  bZIP_u1
cd14688270-330  bZIP_YAP
cd14809271-313  bZIP_AUREO-like
cd14703273-322  bZIP_plant_RF2
cd14709274-328  bZIP_CREBL2
cd14697264-328  bZIP_Maf
cd14705271-325  bZIP_Zip1
cd14721270-331  bZIP_Fos
cd14693273-325  bZIP_CEBP
cd14689269-325  bZIP_CREB3
cd14700277-321  bZIP_ATF6
cd14812272-310  bZIP_u3
cd14701270-325  bZIP_BATF
cd14811272-310  bZIP_u2
cd14706277-324  bZIP_CREBZF
cd14713273-326  bZIP_CEBPG
cd14702272-320  bZIP_plant_GBF1
cd14717268-327  bZIP_Maf_small
cd14710267-322  bZIP_HAC1-like
pfam039571-257  Jun
pfam11559264-328  ADIP
COG1842263-328  PspA
PRK04863260-325  mukB
PRK03918267-326  PRK03918


Ontology Information


   
HPRD ID3301
Molecular ClassTranscription factor
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO