Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
JUP 3728 junction plakoglobin  17DP3, PDGB, PKGB, DPIII 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20049862   2010Cell line : KM12C, KM12SM

Source : -

Sample Type : -

No. of Sample : -

Stage : -

 Nanoflow LC-ESI-LTQ,Western blotting, confocal microscopy and flow cytometry, ImmunohistochemistryUp-regulation1.5 Fold A good correlation with a major abundance in late tumor stages was observed for JUP and 17-beta-hydroxysteroid dehydrogenase type 8 (HSD17B8).

22564821   2012Cell line : -

Source : Chonnam National University Hwasun Hospital�National Biobank of Korea.

Sample Type : -

No. of Sample : 13

Stage : TNM stage I-IV

 Protein extraction, in-gel tryptic digestion,Nano-UPLC-MSE tandem mass spectrometry,Protein identification and quantitative analysis,Immunohistochemistry, Western blotting.Up-regulation--


Gene Details



NC_000017.10 (39910859..39942964, complement)

View Larger Image
   
Gene Type protein coding
Gene Family Armadillo repeat containing
Description This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]  
Chromosome 17
Location 17q21
Start 39910859  
End 39942964  
Strand -  
Gene Sequence

   Download   Select all

Length 32106  
OMIM ID 173325   
HGNC ID HGNC:6207   
Unigene ID Hs.514174   
Ensembl ID ENSG00000173801   
PharmGKB ID PA30009   

mRNA Information


mRNA ID NM_021991.2
Exon join(1..125,14851..15066,17036..17295,17506..17744, 19133..19334,21646..21790,21897..22000,23392..23730, 27843..27998,28195..28314,28929..29079,29177..29298, 30499..30538,30818..30983,31281..32106)  
mRNA Sequence

   Download   Select all

Length 3211  



CDS Information


   
Location134..2371
CDS Sequence

   Download   Select all

CCDS ID CCDS11407.1



Protein Information


      
Protein IDNP_068831.1
Protein Namejunction plakoglobin
Molecular Wt. (Da)33677
Protein Sequence

   Download   Select all

Length 745  
Uniprot IDP42229
Ensembl Protein ID ENSP00000341208  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation644
YPhosphorylation550
YPhosphorylation550
YPhosphorylation133
YPhosphorylation644
YPhosphorylation550
YPhosphorylation550
YPhosphorylation133
YPhosphorylation20;-
YPhosphorylation20;-
YPhosphorylation660;-
YPhosphorylation660;-
SPhosphorylation182;-
SPhosphorylation182;-
SPhosphorylation665;-
SPhosphorylation665;-
YPhosphorylation22
YPhosphorylation22
SPhosphorylation120
SPhosphorylation120

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
329BIRC23419NP_001157.1yeast 2-hybrid16189514   
1000CDH2226NP_001783.2in vitro;in vivo1   639   850   126   046   120   000   000   
1013CDH15225NP_004924.1in vitro9168809   
1495CTNNA1285NP_001894.2in vitro;in vivo765   003   991   109   937   000   000   
1823DSC1511NP_077739.1in vitro96   062   147   971   964   
1824DSC2512NP_077740.1in vivo9443898   
1828DSG1515NP_001933.2in vitro;in vivo7   738   346   960   621   410   000   000   
1829DSG2516NP_001934.2in vivo11   710   948   107   692   000   000   000   
1830DSG31355NP_001935.2in vitro;in vivo7738346   
1832DSP513NP_004406.2in vivo;yeast 2-hybrid9348293   
2064ERBB21281NP_004439.2in vitro;in vivo7702605   
4582MUC11152P15941in vivo913   969   812   939   402   
4794NFKBIE5181NP_004547.2yeast 2-hybrid16189514   
9372ZFYVE94782NP_004790.2yeast 2-hybrid15231748   
26150RIBC211493NP_056468.2yeast 2-hybrid16189514   
55093WDYHV17653NP_060494.1yeast 2-hybrid16189514   
56998CTNNBIP19677NP_064633.1yeast 2-hybrid16189514   


Pathway Information


                        
Pathway Name Pathway ID
Acute myeloid leukemia hsa05221
Arrhythmogenic right ventricular cardiomyopathy (ARVC) hsa05412
Pathways in cancer hsa05200
Transcriptional misregulation in cancer hsa05202


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00020476-613  ARM
cl22454476-613  ARM superfamily
cd00020309-419  ARM
cl22454309-419  ARM superfamily
cd00020220-339  ARM
cl22454220-339  ARM superfamily
cd00020579-657  ARM
cl22454579-657  ARM superfamily
cd00020143-213  ARM
cl22454143-213  ARM superfamily
cd00020390-509  ARM
cd00020185-296  ARM
cd00020516-654  ARM
cd00020347-464  ARM
smart00185341-381  ARM
pfam00514341-381  Arm
pfam00514573-612  Arm
pfam00514221-253  Arm
smart00185221-253  ARM
smart00185573-613  ARM
PLN03200328-658  PLN03200


Ontology Information


   
HPRD ID5037
Molecular ClassAdhesion molecule
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO