Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| KCNK9 | 51305 | potassium channel, subfamily K, member 9 | 8 | K2p9.1, TASK3, TASK-3 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15601307 | 2004 | Cell line : - Source : - Sample Type : CRC tumor No. of Sample : 124 Stage : - | Immunohistochemistry, tissue microarray and PCR-SSCP | Up-regulation | - | �Overexpression rather than mutation of the�KCNK9�gene may contribute to the development of�colorectal�cancers and suggest that the development of�KCNK9-targeted agents may provide new possibilities in the treatment of�colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Potassium channels, "Voltage-gated ion channels / Potassium channels, Two-P" |
| Description | This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH-dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel mental retardation dysmorphism syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] | Chromosome | 8 |
| Location | 8q24.3 |
| Start | 140613081 |
| End | 140715299 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 102219 |
| OMIM ID | 605874 |
| HGNC ID | HGNC:6283 |
| Unigene ID | Hs.493037 |
| Ensembl ID | ENSG00000169427 |
| PharmGKB ID | PA30065 |
Protein Information
| Protein ID | NP_001269463.1 |
|---|---|
| Protein Name | potassium channel, subfamily K, member 9 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 374 |
| Uniprot ID | Q9NRW4 |
| Ensembl Protein ID | ENSP00000345281 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2810 | SFN | 3185 | NP_006133.1 | in vivo;yeast 2-hybrid | 12433946 |
| 7529 | YWHAB | 3184 | NP_003395.1 | in vivo;yeast 2-hybrid | 12433946 |
| 7531 | YWHAE | 5457 | NP_006752.1 | in vivo;yeast 2-hybrid | 12433946 |
| 7532 | YWHAG | 5639 | NP_036611.2 | in vivo;yeast 2-hybrid | 12433946 |
| 7533 | YWHAH | 215 | NP_003396.1 | in vivo;yeast 2-hybrid | 12433946 |
| 7534 | YWHAZ | 3183 | NP_003397.1 | in vivo;yeast 2-hybrid | 12433946 |
| 10971 | YWHAQ | 886 | NP_006817.1 | in vivo;yeast 2-hybrid | 12433946 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Aldosterone synthesis and secretion | hsa04925 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam07885 | 77-129 | Ion_trans_2 |
| cl21560 | 77-129 | Ion_trans_2 superfamily |
| pfam07885 | 182-243 | Ion_trans_2 |
| cl21560 | 182-243 | Ion_trans_2 superfamily |
| PLN03192 | 173-280 | PLN03192 |
| pfam00520 | 74-243 | Ion_trans |
Ontology Information
| HPRD ID | 5662 |
|---|---|
| Molecular Class | Ion channel |
| Molecular Function | Metallopeptidase activity (GO:0008237) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q9NPC2 | DB00561 | Doxapram | SmallMoleculeDrug |
| Q9NPC2 | DB01159 | Halothane | SmallMoleculeDrug |