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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
KDM4B 23030 lysine (K)-specific demethylase 4B  19KIAA0876, TDRD14B 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24957706   2014Cell line : HCT116, LoVo

Source : -

Sample Type : -

No. of Sample : -

Stage : -

JC-1 fluorescence probe,Flow cytometry and fluorescence microscopy, Immunofluorescence, Western blottingUp-regulation-JMJD2B silencing induced CRC cell apoptosis via both mitochondria-related and death receptor-related pathways.


Gene Details



NC_000019.9 (4969123..5153609)

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Gene Type protein coding
Gene Family Chromatin-modifying enzymes / K-demethylases, "Tudor domain containing"
Description -  
Chromosome 19
Location 19p13.3
Start 4969123  
End 5153609  
Strand +  
Gene Sequence

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Length 184487  
OMIM ID 609765   
HGNC ID HGNC:29136   
Unigene ID Hs.654816   
Ensembl ID -   
PharmGKB ID PA164721452   

mRNA Information


mRNA ID ?NM_015015.2
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS12138.1



Protein Information


      
Protein IDNP_055830.1
Protein Namelysine (K)-specific demethylase 4B
Molecular Wt. (Da)0
Protein Sequence

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Length 1096  
Uniprot IDQ9UHQ7
Ensembl Protein ID ENSP00000361740  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation566
KAcetylation602

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
84246MED1014680NP_115662.2yeast 2-hybrid16169070   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd15714797-906  ePHD_JMJD2B
cl22851797-906  PHD_SF superfamily
cd15576683-788  PHD_JMJD2B
cl22851683-788  PHD_SF superfamily
cd15675797-906  ePHD_JMJD2
cd15715797-906  ePHD_JMJD2C
pfam13832795-906  zf-HC5HC2H_2
cd15713797-906  ePHD_JMJD2A
pfam02373176-292  JmjC
cl22893176-292  JmjC superfamily
cd15571797-906  ePHD
cd15670797-891  ePHD_BRPF
cd15577683-788  PHD_JMJD2C
cd15575683-788  PHD_JMJD2A
cd15701797-891  ePHD_BRPF1
cd15671797-906  ePHD_JADE
cd15703797-893  ePHD_BRPF3
cd15662797-891  ePHD_ATX1_2_like
cd15702797-891  ePHD_BRPF2
pfam13771817-907  zf-HC5HC2H
cd15672797-891  ePHD_AF10_like
cd15707797-891  ePHD_RNO
cd15708797-891  ePHD_AF10
cd15705797-890  ePHD_JADE2
cd15706797-906  ePHD_JADE3
cd15674797-894  ePHD_PHF14
cd15663797-891  ePHD_ATX3_4_5_like
cd15709797-893  ePHD_AF17
cd15704796-891  ePHD_JADE1
smart0054515-56  JmjN
cl1584015-56  JmjN superfamily
pfam0237516-50  JmjN
smart00558149-206  JmjC
pfam13831755-788  PHD_2
cd15493756-788  PHD_JMJD2
smart00333921-973  TUDOR
cl02573921-973  TUDOR superfamily
smart00333975-1030  TUDOR
cl02573975-1030  TUDOR superfamily
cd15667797-883  ePHD_Snt2p_like
cd15495751-788  PHD_ATX3_4_5_like
cd15665797-887  ePHD1_KMT2C_like
cd15664797-906  ePHD_KMT2A_like
smart00249750-788  PHD
cd15669837-883  ePHD_PHF7_G2E3_like
cd15492756-788  PHD_BRPF_JADE_like
pfam09465980-1023  LBR_tudor
cd15666797-883  ePHD2_KMT2C_like
smart00249852-894  PHD
cd15673849-906  ePHD_PHF6_like
cd15489750-788  PHD_SF
cd15498749-788  PHD2_Snt2p_like
cd15712849-906  ePHD_PHF11
cd15668849-906  ePHD_RAI1_like
pfam00628757-788  PHD
cd15694797-906  ePHD_KMT2B
cd15700850-906  ePHD_RAI1
cd15697797-886  ePHD2_KMT2C
COG5141752-907  COG5141
PLN03209474-744  PLN03209
PHA03379480-646  PHA03379
PHA03378443-682  PHA03378


Ontology Information


   
HPRD ID7087
Molecular ClassUnclassified
Molecular FunctionGuanyl-nucleotide exchange factor activity (GO:0005085)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO