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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
KDM4C 23081 lysine (K)-specific demethylase 4C  9GASC1, KIAA0780, TDRD14C 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23698634   2013Cell line : WiDr, NCI-H630, DLD1 and HCT116, Panc1

Source : ATCC

Sample Type : -

No. of Sample : -

Stage : -

 Transfection,real time RT-PCR,Immunoblotting,Chromatin immunoprecipitation,Sphere formation?assayUp-regulation-KDM4C maintains the sphere-forming capacity in CRCs by mediating the ?-catenin-dependent transcription of JAG1 in a feed-forward manner.The expression of KDM4C gene was increased in spheres from colorectal cancer (CRC) cells .


Gene Details



NC_000009.11 (6720863..7175648)

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Gene Type protein coding
Gene Family Chromatin-modifying enzymes / K-demethylases, "Tudor domain containing"
Description This gene is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and converts specific trimethylated histone residues to the dimethylated form. This enzymatic action regulates gene expression and chromosome segregation. Chromosomal aberrations and changes in expression of this gene may be found in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]  
Chromosome 9
Location 9p24-p23
Start 6720863  
End 7175648  
Strand +  
Gene Sequence

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Length 454786  
OMIM ID 605469   
HGNC ID HGNC:17071   
Unigene ID Hs.709425   
Ensembl ID ENSG00000107077   
PharmGKB ID PA164721503   

mRNA Information


mRNA ID ?NM_001146695.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS55285.1



Protein Information


      
Protein IDNP_001140167.1
Protein Namelysine (K)-specific demethylase 4C
Molecular Wt. (Da)0
Protein Sequence

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Length 1056  
Uniprot IDQ9NPC2
Ensembl Protein ID ENSP00000302166  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd15715755-864  ePHD_JMJD2C
cl22851755-864  PHD_SF superfamily
cd15577644-746  PHD_JMJD2C
cl22851644-746  PHD_SF superfamily
cd15675755-864  ePHD_JMJD2
cd15714755-864  ePHD_JMJD2B
cd15713755-864  ePHD_JMJD2A
pfam13832753-864  zf-HC5HC2H_2
pfam02373177-293  JmjC
cl22893177-293  JmjC superfamily
cd15571755-864  ePHD
cd15575644-746  PHD_JMJD2A
cd15576644-746  PHD_JMJD2B
cd15670755-849  ePHD_BRPF
cd15701755-849  ePHD_BRPF1
cd15671755-848  ePHD_JADE
cd15672755-849  ePHD_AF10_like
cd15702755-849  ePHD_BRPF2
cd15703755-851  ePHD_BRPF3
pfam13771775-852  zf-HC5HC2H
cd15662755-849  ePHD_ATX1_2_like
cd15707755-849  ePHD_RNO
cd15708755-849  ePHD_AF10
cd15674755-852  ePHD_PHF14
cd15706755-849  ePHD_JADE3
cd15705755-848  ePHD_JADE2
cd15709755-851  ePHD_AF17
cd15663755-849  ePHD_ATX3_4_5_like
cd15704754-849  ePHD_JADE1
smart00558148-207  JmjC
pfam13831713-746  PHD_2
pfam0237517-51  JmjN
cl1584017-51  JmjN superfamily
smart0054516-57  JmjN
cd15493715-746  PHD_JMJD2
smart00333879-933  TUDOR
cl02573879-933  TUDOR superfamily
cd15665755-845  ePHD1_KMT2C_like
cd15667755-841  ePHD_Snt2p_like
cd15664755-851  ePHD_KMT2A_like
smart00333935-990  TUDOR
cl02573935-990  TUDOR superfamily
cd15666755-841  ePHD2_KMT2C_like
smart00249708-746  PHD
cd15697755-844  ePHD2_KMT2C
cd15698755-866  ePHD2_KMT2D
cd15495708-746  PHD_ATX3_4_5_like
cd15693754-865  ePHD_KMT2A
cd15492715-746  PHD_BRPF_JADE_like
cd15550709-746  PHD_MLL5
pfam00628708-747  PHD
cd15669755-841  ePHD_PHF7_G2E3_like
cd15489710-746  PHD_SF
smart00249810-864  PHD
pfam09465938-983  LBR_tudor
cd15696773-845  ePHD1_KMT2C
cd15695755-845  ePHD1_KMT2D
cd15694755-851  ePHD_KMT2B
cd15673807-841  ePHD_PHF6_like
COG5141708-848  COG5141
pfam09528352-574  Ehrlichia_rpt


Ontology Information


   
HPRD ID6335
Molecular ClassTranscription regulatory protein
Molecular FunctionCytokine activity (GO:0005125)
Biological ProcessBiological_process unknown (GO:0000004)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO