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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
KDM5B 10765 lysine (K)-specific demethylase 5B  1RBBP2H1A, PLU-1, CT31, PPP1R98 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23354547   2013Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

-Up-regulation-JARID1B�plays a role in CRC maintenance.�JARID1B�may be a novel molecular target for therapy?resistant�cancer�cells by the induction of cellular senescence.


Gene Details



NC_000001.10 (202696532..202777549, complement)

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Gene Type protein coding
Gene Family Chromatin-modifying enzymes / K-demethylases, "Zinc fingers, PHD-type"
Description This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing resultsi n multiple transcript variants. [provided by RefSeq, Sep 2015]  
Chromosome 1
Location 1q32.1
Start 202696532  
End 202777549  
Strand -  
Gene Sequence

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Length 81018  
OMIM ID 605393   
HGNC ID HGNC:18039   
Unigene ID Hs.18891   
Ensembl ID ENSG00000117139   
PharmGKB ID PA164721626   

mRNA Information


mRNA ID ?NM_001314042.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS30974.1



Protein Information


      
Protein IDNP_001300971.1
Protein Namelysine (K)-specific demethylase 5B
Molecular Wt. (Da)0
Protein Sequence

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Length 1544  
Uniprot IDQ9UKV8
Ensembl Protein ID ENSP00000220592  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation1384;-
SPhosphorylation1383;-
SPhosphorylation1405
SPhosphorylation986

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2290FOXG11283NP_005240.3in vivo;yeast 2-hybrid12657635   
5925RB11574NP_000312.2in vivo15803180   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd156871486-1535  PHD3_KDM5B
cl228511486-1535  PHD_SF superfamily
cd15603311-356  PHD1_KDM5B
cl22851311-356  PHD_SF superfamily
cd156071178-1221  PHD2_KDM5B
cl228511178-1221  PHD_SF superfamily
pfam02373486-602  JmjC
cl22893486-602  JmjC superfamily
pfam0138894-183  ARID
cl0263394-183  ARID superfamily
smart0050198-188  BRIGHT
cd15515311-356  PHD1_KDM5A_like
smart0101498-182  ARID
cd15602311-359  PHD1_KDM5A
cd15605311-356  PHD1_Lid_like
pfam02928692-745  zf-C5HC2
cl03786692-745  zf-C5HC2 superfamily
cd156101486-1535  PHD3_KDM5A_like
cd15604311-356  PHD1_KDM5C_5D
cd156861485-1536  PHD3_KDM5A
cd155161178-1221  PHD2_KDM5A_like
smart0054531-72  JmjN
cl1584031-72  JmjN superfamily
cd15545312-356  PHD_BAZ2A_like
cd15543312-356  PHD_RSF1
cd15513311-356  PHD5_KMT2C_like
cd15627312-356  PHD_BAZ1A
cd15519311-356  PHD1_Lid2p_like
cd15536312-356  PHD_PHRF1
pfam0237533-66  JmjN
smart00558459-516  JmjC
pfam00628311-356  PHD
cd15525312-356  PHD_UHRF1_2
cd15629312-357  PHD_BAZ2A
cd15544312-356  PHD_BAZ1A_like
smart00249311-356  PHD
cd15532311-356  PHD2_CHD_II
cd15628312-356  PHD_BAZ1B
cd15616312-356  PHD_UHRF1
cd15630312-358  PHD_BAZ2B
cd15594311-356  PHD2_KMT2C
cd15527312-356  PHD2_KAT6A_6B
cd15539312-356  PHD1_AIRE
cd15529311-356  PHD2_PHF10
cd15530312-356  PHD2_d4
cd156061179-1221  PHD2_KDM5A
cd155171485-1535  PHD_TCF19_like
cd15510311-356  PHD2_KMT2C_like
cd15595311-356  PHD2_KMT2D
cd15617312-356  PHD_UHRF2
cd156091487-1530  PHD_TCF19
cd15504311-356  PHD_PRHA_like
cd155601492-1535  PHD2_3_BPTF
cd15489311-356  PHD_SF
cd15523311-356  PHD_PHF21A
cd155221486-1535  PHD_TAF3
pfam006281492-1538  PHD
cd156081178-1229  PHD2_KDM5C_5D
cd15541311-356  PHD_TIF1_like
cd15562311-356  PHD2_PHF14
cd15531312-356  PHD1_CHD_II
smart002491492-1535  PHD
cd15506311-356  PHD1_KMT2A_like
cd155521492-1535  PHD_PHF3_like
cd15502311-356  PHD_Phf1p_Phf2p_like
cd15533311-356  PHD1_PHF12
cd154891490-1535  PHD_SF
cd15499311-357  PHD1_MTF2_PHF19_like
cd15492311-356  PHD_BRPF_JADE_like
pfam006281179-1224  PHD
cd15524312-356  PHD_PHF21B
cd15535315-356  PHD1_Rco1
cd15534311-354  PHD2_PHF12_Rco1
smart002491179-1221  PHD
cd15509312-356  PHD1_KMT2C_like
cd15559324-356  PHD1_BPTF
cd154891179-1221  PHD_SF
cd04718334-366  BAH_plant_2
cl02608334-366  BAH superfamily
cd156141496-1535  PHD_HAC_like
cd15623324-356  PHD_TIF1beta
cd15563311-356  PHD3_PHF14
cd155221188-1221  PHD_TAF3
cd15568311-354  PHD5_NSD
cd155181179-1221  PHD_Ecm5p_Lid2p_like
cd156351488-1521  PHD_PYGO1
cd156151485-1535  PHD_ARID4_like
cd15522311-356  PHD_TAF3
cd156401179-1221  PHD_KDM7
cd15567312-356  PHD4_NSD
cd15517311-356  PHD_TCF19_like
cd155541179-1221  PHD_PHF2_like
cd15578311-357  PHD1_MTF2
cd155601179-1221  PHD2_3_BPTF
cd156771178-1224  PHD_BRPF2
cd155521179-1221  PHD_PHF3_like
cd156381490-1535  PHD_PHF3
cd15512311-356  PHD4_KMT2C_like
cd155511492-1522  PHD_PYGO
cd156361488-1521  PHD_PYGO2
cd15624312-356  PHD_TIF1gamma
cd15596311-356  PHD4_KMT2C
cd155501503-1535  PHD_MLL5
cd15622312-356  PHD_TIF1alpha
cd15507312-356  PHD2_KMT2A_like
pfam08429756-1088  PLU-1
COG5141311-357  COG5141


Ontology Information


   
HPRD ID10549
Molecular ClassTranscription regulatory protein
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessApoptosis (GO:0006915)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO