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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
KEAP1 9817 kelch-like ECH-associated protein 1  19KIAA0132, MGC10630, MGC1114, MGC20887, MGC4407, MGC9454, INrf2, KLHL19 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22325485   2012Cell line : HT29 , WiDr, LoVo, DLD-1, SW837, Colo320DM , HCT15, SW480

Source : ATCC, Human Science Research Resources Bank (Osaka, Japan),Cell Resource Center for Biomedical Research Institute of Development, Aging, and Cancer, Tohoku University.

Sample Type : -

No. of Sample : -

Stage : -

DNA sequencing,Methylation-specific PCR and bisulfite sequencing PCR,real time RT-PCR,Western blottingHypermethylation-Hypermethylation of the KEAP1 promoter region suppressed its mRNA expression and increased nuclear Nrf2 and downstream ARE gene expression in CRC cells and tissues.


Gene Details



NC_000019.9 (10596796..10614054, complement)

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Gene Type protein coding
Gene Family Kelch-like, "BTB/POZ domain containing"
Description This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]  
Chromosome 19
Location 19p13.2
Start 10596796  
End 10614054  
Strand -  
Gene Sequence

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Length 17259  
OMIM ID 606016   
HGNC ID HGNC:23177   
Unigene ID Hs.465870   
Ensembl ID -   
PharmGKB ID PA134887774   

mRNA Information


mRNA ID ?NM_012289.3
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS12239.1



Protein Information


      
Protein IDNP_036421.2
Protein Namekelch-like ECH-associated protein 1
Molecular Wt. (Da)0
Protein Sequence

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Length 624  
Uniprot IDQ9UM07
Ensembl Protein ID ENSP00000364597  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation293
SPhosphorylation295
SPhosphorylation293
SPhosphorylation295

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
4647MYO7A2043NP_000251.3in vivo;yeast 2-hybrid11921171   
4780NFE2L22732NP_006155.2in vitro;in vivo11   439   354   988   710   100   000   000   


Pathway Information


      
Pathway Name Pathway ID
Ubiquitin mediated proteolysis hsa04120


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd14735179-237  BACK_Kelch
cl06652179-237  BACK_like superfamily
pfam07707184-286  BACK
smart00875184-282  BACK
pfam0065167-179  BTB
cl0251867-179  BTB superfamily
smart0022578-179  BTB
smart00612471-517  Kelch
cl02701471-517  Kelch_1 superfamily
smart00612565-611  Kelch
cl02701565-611  Kelch_1 superfamily
smart00612518-564  Kelch
cl02701518-564  Kelch_1 superfamily
smart00612424-469  Kelch
cl02701424-469  Kelch_1 superfamily
pfam01344507-551  Kelch_1
pfam01344553-598  Kelch_1
smart00612373-423  Kelch
cl02701373-423  Kelch_1 superfamily
pfam01344459-504  Kelch_1
pfam01344412-456  Kelch_1
pfam01344361-410  Kelch_1
smart00612327-372  Kelch
cl02701327-372  Kelch_1 superfamily
pfam13964554-601  Kelch_6
pfam13964506-554  Kelch_6
pfam13415564-608  Kelch_3
pfam13964361-413  Kelch_6
pfam13964412-460  Kelch_6
pfam07646553-597  Kelch_2
cd14733179-236  BACK_like
pfam07646361-410  Kelch_2
pfam13964460-507  Kelch_6
pfam13418559-599  Kelch_4
pfam07646507-551  Kelch_2
pfam13964324-362  Kelch_6
pfam13415325-370  Kelch_3
pfam13418507-550  Kelch_4
pfam01344324-359  Kelch_1
pfam13415517-562  Kelch_3
PHA0309895-596  PHA03098
PHA0279087-544  PHA02790
PLN02193461-594  PLN02193
PHA02713396-569  PHA02713
PHA0271376-599  PHA02713
PHA02713514-608  PHA02713
PLN02193370-571  PLN02193
PLN02153412-594  PLN02153
TIGR03547507-577  muta_rot_YjhT
TIGR03547323-431  muta_rot_YjhT
PRK14131507-611  PRK14131
PRK14131323-431  PRK14131
PLN02153342-404  PLN02153


Ontology Information


   
HPRD ID9905
Molecular ClassRegulatory/other subunit
Molecular FunctionProtein serine/threonine kinase activity (GO:0004674)
Biological ProcessApoptosis (GO:0006915)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q14145DB08908Dimethyl fumarateSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO