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General Information
- Evidence
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26010933 | 2015 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 111 Stage : TNM stage III, IV | Immunohistochemistry and image analysis | Up-regulation | - | larger and advanced colorectal cancers express more KISS1, without reaching the former normal Levels, and increased KISS1 levels are associated with worse prognosis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class A : RF amide peptide receptors |
| Description | The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that this gene appears to play a role in the onset of puberty. Mutations in this gene have been associated with hypogonadotropic hypogonadism and central precocious puberty. [provided by RefSeq, Jul 2008] | Chromosome | 19 |
| Location | 19p13.3 |
| Start | 917342 |
| End | 921015 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 3674 |
| OMIM ID | 604161 |
| HGNC ID | HGNC:4510 |
| Unigene ID | Hs.208229 |
| Ensembl ID | ENSG00000116014 |
| PharmGKB ID | PA28899 |
Protein Information
| Protein ID | NP_115940.2 |
|---|---|
| Protein Name | KISS1 receptor |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 398 |
| Uniprot ID | Q8IVF2 |
| Ensembl Protein ID | ENSP00000353114 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3814 | KISS1 | 4475 | NP_002247.3 | in vitro;in vivo | 11457843 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Neuroactive ligand-receptor interaction | hsa04080 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam10320 | 53-157 | 7TM_GPCR_Srsx |
| cl21561 | 53-157 | 7tm_4 superfamily |
| pfam10328 | 52-168 | 7TM_GPCR_Srx |
| pfam00001 | 65-323 | 7tm_1 |
| PHA03087 | 52-336 | PHA03087 |
| PHA02638 | 45-176 | PHA02638 |
| PHA02834 | 43-337 | PHA02834 |
Ontology Information
| HPRD ID | 19097 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.