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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21531817 | 2011 | Cell line : HCT116, SW480 Source : Tissue Bank at Shanghai Jiaotong University Affiliated First Peoples Hospital (Shanghai, PR China), ATCC. Sample Type : CRC tumor and normal tissue No. of Sample : 203 CRC patients Stage : - | Tissue microarray, Immunohistochemistry, RT-PCR, Western blotting, Cell proliferation assay | Down-regulation | - | IFITM3 is a direct transcriptional target of KLF4 and that dysregulated KLF4 expression leads to aberrant IFITM3 expression, thus contributing to colon cancer progression and metastasis. |
| 21814594 | 2011 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 109 colorectal specimens (40 normal appearing mucosa, 7 adenomas, and 62 carcinomas) Stage : - | Immunohistochemistry, Tissue microarray, Western blotting and RT-PCR | Down-regulation | - | KLF4 protein expression significantly correlates with the degree of differentiation in colorectal cancers. Downregulation of KLF4 expression may lead to more poorly differentiated tumors. KLF4 expression in 109 colorectal specimens (40 normal appearing mucosa, 7 adenomas, and 62 carcinomas) were detected. |
| 22170051 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Western Blotting and Histone Extraction, real time RT-PCR, Interference RNA, Chromatin immunoprecepetation,Luciferase assay | Down-regulation | - | Demonstrated that KLF4 directly inhibits the expression of Bmi1 in colon cancer cells and KLF4 cross-talks with Wnt/beta-catenin in regulating intestinal homeostasis. KLF4 is down-regulated in most tumors but is also unregulated in a number of tumors, suggesting that the expression and function of KLF4 is dependent on the context of different tumors. |
| 22205615 | 2012 | Cell line : SW620, SW480, HT29 Source : ATCC Sample Type : - No. of Sample : - Stage : - | RT-PCR, Cell proliferation assay, Plate colony formation assay and Statistical analysis | Down-regulation | - | - |
| 22284679 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Immunohistochemistry | Down-regulation | - | pVHL, via the degradation of KLF4, is a facilitating factor in colorectal tumorigenesis. Elevated pVHL and reduced KLF4 levels in colon cancer tissues observed. |
| 23024650 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Down-regulation | - | Over-expression of KLF4 in colon cancer cells caused inhibition of DNA synthesis and cell growth. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Kruppel-like transcription factors, Zinc fingers, C2H2-type |
| Description | - | Chromosome | 9 |
| Location | 9q31 |
| Start | 107484852 |
| End | 107489766 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 4915 |
| OMIM ID | 602253 |
| HGNC ID | HGNC:6348 |
| Unigene ID | Hs.376206 |
| Ensembl ID | ENSG00000136826 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_004235.4 |
|---|---|
| Exon | join(1..599,717..837,1500..2472,2575..2739,3841..4915) | mRNA Sequence | Download Select all |
| Length | 2949 |
CDS Information
| Location | join(595..599,717..837,1500..2472,2575..2739,3841..4016) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS6770.2 |
Protein Information
| Protein ID | NP_004226.3 |
|---|---|
| Protein Name | Kruppel-like factor 4 (gut) |
| Molecular Wt. (Da) | 50945 |
| Protein Sequence | Download Select all |
| Length | 479 |
| Uniprot ID | P54849 |
| Ensembl Protein ID | ENSP00000256951 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 245 |
| S | Phosphorylation | 254 |
| T | Phosphorylation | 307 |
| T | Phosphorylation | 316 |
| S | Phosphorylation | 227 |
| S | Phosphorylation | 235 |
| S | Phosphorylation | 236 |
| S | Phosphorylation | 244 |
Enzyme Information
No matching records could be found.
PPi Information
No STRING Network could be found.
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1316 | KLF6 | 3632 | NP_001291.3 | in vivo | 10802067 |
| 1387 | CREBBP | 2534 | NP_004371.2 | in vitro;in vivo | 10666450 |
| 2002 | ELK1 | 2407 | NP_005220.2 | in vivo | 18768922 |
| 6667 | SP1 | 1796 | NP_612482.2 | in vitro | 120 348 139 651 398 |
| 7157 | TP53 | 1859 | NP_000537.3 | in vivo | 10749849 |
| 10014 | HDAC5 | 9246 | NP_001015053.1 | in vivo | 18768922 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
Structure Information
| PDB ID | 1AUI |
|---|---|
| Resolution | 2.1 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | SERINE/THREONINE PHOSPHATASE 2B |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam13465 | 476-501 | zf-H2C2_2 |
| cl22375 | 476-501 | zf-H2C2_2 superfamily |
| pfam00096 | 490-512 | zf-C2H2 |
| cl23491 | 490-512 | zf-C2H2 superfamily |
| pfam13465 | 446-463 | zf-H2C2_2 |
| cl22375 | 446-463 | zf-H2C2_2 superfamily |
| smart00355 | 490-512 | ZnF_C2H2 |
| cl18194 | 490-512 | ZnF_C2H2 superfamily |
| COG5048 | 425-508 | COG5048 |
| COG5048 | 437-492 | COG5048 |
| COG5048 | 437-495 | COG5048 |
Ontology Information
| HPRD ID | 1400 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.