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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23499583 | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : 190 colorectal samples Stage : - | real timeRT- PCR | Up-regulation | - | KLK10 may serve as a new marker of unfavourable prognosis of colorectal cancer. KLK10 expression was significantly higher in cancer tissues. |
| 21487810 | 2011 | Cell line : - Source : Saint Savvas Oncologic Hospital of Athens Sample Type : - No. of Sample : 119 CRC patients Stage : - | real time RT-PCR | Up-regulation | - | KLK10 may represent not only a novel biomarker, but also a promising future therapeutic target for the disease. KLK10 expression is statistically significantly associated with TNM stage (p?=?0.028; Table 3), meaning that high KLK10 expression is significantly more often found in advanced and less differentiated CRCs. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Kallikreins |
| Description | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. | Chromosome | 19 |
| Location | 19q13 |
| Start | 51012744 |
| End | 51020175 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 7432 |
| OMIM ID | 602673 |
| HGNC ID | HGNC:6358 |
| Unigene ID | Hs.275464 |
| Ensembl ID | ENSG00000129451 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001077500.1 |
|---|---|
| Exon | join(1..108,1034..1133,2886..3066,4020..4294,4626..4759, 5224..7432) | mRNA Sequence | Download Select all |
| Length | 3024 |
CDS Information
| Location | join(1046..1133,2886..3066,4020..4294,4626..4759, 5224..5376) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS12817.1 |
Protein Information
| Protein ID | NP_001070968.1 |
|---|---|
| Protein Name | kallikrein-related peptidase 10 |
| Molecular Wt. (Da) | 26708 |
| Protein Sequence | Download Select all |
| Length | 276 |
| Uniprot ID | P01112 |
| Ensembl Protein ID | ENSP00000309845 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 55791 | C1orf103 | 17975 | NP_060842.3 | yeast 2-hybrid | 16169070 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00190 | 49-272 | Tryp_SPc |
| cl21584 | 49-272 | Tryp_SPc superfamily |
| smart00020 | 49-269 | Tryp_SPc |
| pfam00089 | 49-269 | Trypsin |
| COG5640 | 24-275 | COG5640 |
Ontology Information
| HPRD ID | 774 |
|---|---|
| Molecular Class | Serine protease |
| Molecular Function | Chaperone activity (GO:0003754) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.