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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| KLK6 | 5653 | kallikrein-related peptidase 6 | 19 | Bssp, Klk7, neurosin |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24430362 | 2014 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 110 primary colorectal adenocarcinomas and 39 paired noncancerous colorectal Stage : - | - | Up-regulation | - | KLK6 mRNA expression could be considered as an independent, unfavorable molecular prognostic biomarker in colorectal adenocarcinoma, with additional prognostic value in patients without regional or distant metastases. A dramatic upregulation of KLK6 mRNA expression was observed in colorectal tumors. |
| 22699826 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 166 patients and 108 controls Stage : TNM Stage I-IV | Microarray and real timeRT- PCR | Up-regulation | - | KLK6 mRNA as a most promising progression biomarker for CRC. Kallikrein-related peptidase 6 mRNA was expressed in all analysed primary tumours, but was not expressed in normal colon. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Kallikreins, "Serine peptidases / Serine peptidases" |
| Description | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene. | Chromosome | 19 |
| Location | 19q13.3 |
| Start | 50958631 |
| End | 50969673 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 11043 |
| OMIM ID | 602652 |
| HGNC ID | HGNC:6367 |
| Unigene ID | Hs.79361 |
| Ensembl ID | ENSG00000167755 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_002774.3 |
|---|---|
| Exon | join(1..184,1083..1133,1562..1609,2349..2505,6125..6372, 7794..7930,10358..11043) | mRNA Sequence | Download Select all |
| Length | 1527 |
CDS Information
| Location | join(1570..1609,2349..2505,6125..6372,7794..7930, 10358..10510) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS12811.1 |
Protein Information
| Protein ID | NP_001012982.1 |
|---|---|
| Protein Name | kallikrein-related peptidase 6 |
| Molecular Wt. (Da) | 25129 |
| Protein Sequence | Download Select all |
| Length | 244 |
| Uniprot ID | P15428 |
| Ensembl Protein ID | ENSP00000296521 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| C | Disulfide Bridge | 131;231 |
| N | Glycosylation | 134 |
| C | Disulfide Bridge | 138;203 |
| C | Disulfide Bridge | 168;182 |
| C | Disulfide Bridge | 193;218 |
| C | Disulfide Bridge | 28;157 |
| C | Disulfide Bridge | 47;63 |
| C | Disulfide Bridge | 131;231 |
| N | Glycosylation | 134 |
| C | Disulfide Bridge | 138;203 |
| C | Disulfide Bridge | 168;182 |
| C | Disulfide Bridge | 193;218 |
| C | Disulfide Bridge | 28;157 |
| C | Disulfide Bridge | 47;63 |
| N | Glycosylation | 27 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 462 | SERPINC1 | 122 | NP_000479.1 | in vitro | 12878203 |
| 5345 | SERPINF2 | 2029 | NP_000925.2 | in vitro | 12878203 |
| 6622 | SNCA | 1227 | NP_000336.1 | in vitro | 12928483 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00190 | 23-240 | Tryp_SPc |
| cl21584 | 23-240 | Tryp_SPc superfamily |
| smart00020 | 23-237 | Tryp_SPc |
| pfam00089 | 25-237 | Trypsin |
| COG5640 | 1-239 | COG5640 |
| pfam09342 | 34-124 | DUF1986 |
Ontology Information
| HPRD ID | 185 |
|---|---|
| Molecular Class | Serine protease |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.