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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19367279 | 2009 | Cell line : - Source : Oncologic Hospital of Athens Saint Savvas Sample Type : Population based case control study No. of Sample : 122 Stage : - | Immunofluorometric ELISA | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Kallikreins, "Serine peptidases / Serine peptidases" |
| Description | This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011] | Chromosome | 19 |
| Location | 19q13.33 |
| Start | 51479735 |
| End | 51487320 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 7586 |
| OMIM ID | 604438 |
| HGNC ID | HGNC:6368 |
| Unigene ID | Hs.151254 |
| Ensembl ID | - |
| PharmGKB ID | PA30157 |
mRNA Information
| mRNA ID | ?NM_001207053.1 |
|---|---|
| Exon | join(1..214,2151..2298,3578..3825,4141..4277,6374..7586) | mRNA Sequence | Download Select all |
| Length | 1973 |
Protein Information
| Protein ID | NP_001193982.1 |
|---|---|
| Protein Name | kallikrein-related peptidase 7 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 253 |
| Uniprot ID | Q92569 |
| Ensembl Protein ID | ENSP00000262741 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 196 |
| S | Phosphorylation | 196 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00190 | 30-248 | Tryp_SPc |
| cl21584 | 30-248 | Tryp_SPc superfamily |
| COG3591 | 49-120 | eMpr |
| smart00020 | 29-245 | Tryp_SPc |
| pfam00089 | 30-245 | Trypsin |
| COG5640 | 28-250 | COG5640 |
Ontology Information
| HPRD ID | 5122 |
|---|---|
| Molecular Class | Serine protease |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.