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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
KMT2C 58508 lysine (K)-specific methyltransferase 2C  7KIAA1506, HALR 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23259788   2013Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 32 gastric cancers (GC) with high MSI (MSI-H), 59 GC with low MSI (MSI-L)/stable MSI (MSS), 40 CRC with MSI-H and 59 CRC with MSI-L/MSS

Stage : -

Single-strand conformation polymorphism and DNA sequencing,immunohistochemistry.Frameshift Mutation-Frameshift mutations of MLL genes and loss of expression of MLL3 protein are common in GC and CRC with MSI-H.


Gene Details



NC_000007.13 (151832010..152133090, complement)

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Gene Type protein coding
Gene Family Chromatin-modifying enzymes / K-methyltransferases, "Zinc fingers, PHD-type"
Description This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. [provided by RefSeq, Jul 2008]  
Chromosome 7
Location 7q36
Start 151832010  
End 152133090  
Strand -  
Gene Sequence

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Length 301081  
OMIM ID 606833   
HGNC ID HGNC:13726   
Unigene ID Hs.647120   
Ensembl ID ENSG00000055609   
PharmGKB ID PA30847   

mRNA Information


mRNA ID ?NM_170606.2
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS5931.1



Protein Information


      
Protein IDNP_733751.2
Protein Namelysine (K)-specific methyltransferase 2C
Molecular Wt. (Da)0
Protein Sequence

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Length 4911  
Uniprot IDQ8WWW0
Ensembl Protein ID ENSP00000462576  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation4018;-
SPhosphorylation4022;-
YPhosphorylation3136;-
SPhosphorylation3140;-
SPhosphorylation2930
TPhosphorylation2942
SPhosphorylation1991
TPhosphorylation2003
SPhosphorylation2935
SPhosphorylation2946
SPhosphorylation1996
SPhosphorylation2007
SPhosphorylation2937
SPhosphorylation1998
SPhosphorylation2952
SPhosphorylation2013
SPhosphorylation625
SPhosphorylation631
KAcetylation2809
KAcetylation1870
KAcetylation2009
KAcetylation1070
KAcetylation1508
KAcetylation569
KAcetylation2832
KAcetylation1893
KAcetylation1772
KAcetylation833
KAcetylation3714
KAcetylation2775
KAcetylation3945
KAcetylation3063
KAcetylation827
KAcetylation2802
KAcetylation1863
KAcetylation758
KAcetylation2814
KAcetylation1875
SPhosphorylation4034
SPhosphorylation3152
SPhosphorylation4006
SPhosphorylation3124
SPhosphorylation1493
SPhosphorylation554
SPhosphorylation111
SPhosphorylation113
SPhosphorylation46
TPhosphorylation1219
TPhosphorylation280
TPhosphorylation2824
SPhosphorylation2831
TPhosphorylation1885
SPhosphorylation1892
SPhosphorylation4267
SPhosphorylation3385
SPhosphorylation4300
SPhosphorylation4304
SPhosphorylation3418
SPhosphorylation3422
TPhosphorylation4388
TPhosphorylation3506
SPhosphorylation4227
SPhosphorylation3345

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


      
Pathway Name Pathway ID
Lysine degradation hsa00310


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd156974402-4506  ePHD2_KMT2C
cl228514402-4506  PHD_SF superfamily
cd15696247-330  ePHD1_KMT2C
cl22851247-330  PHD_SF superfamily
cd15596952-1008  PHD4_KMT2C
cl22851952-1008  PHD_SF superfamily
cd156001086-1136  PHD6_KMT2C
cl228511086-1136  PHD_SF superfamily
cd155131009-1055  PHD5_KMT2C_like
cl228511009-1055  PHD_SF superfamily
cd15594390-435  PHD2_KMT2C
cl22851390-435  PHD_SF superfamily
cd15511466-517  PHD3_KMT2C
cl22851466-517  PHD_SF superfamily
cd15509343-388  PHD1_KMT2C_like
cl22851343-388  PHD_SF superfamily
cd013901655-1703  HMGB-UBF_HMG-box
cl000821655-1703  HMG-box superfamily
cd156664402-4506  ePHD2_KMT2C_like
cd156984402-4507  ePHD2_KMT2D
cd15665247-330  ePHD1_KMT2C_like
cd156644402-4506  ePHD_KMT2A_like
smart003174772-4893  SET
cl025664772-4893  SET superfamily
cd156934400-4507  ePHD_KMT2A
pfam008564782-4886  SET
cd15512959-1007  PHD4_KMT2C_like
cd15695247-330  ePHD1_KMT2D
cd155714402-4506  ePHD
cd156944402-4506  ePHD_KMT2B
cd15597958-1007  PHD3_KMT2D
pfam137714429-4507  zf-HC5HC2H
cd155141086-1136  PHD6_KMT2C_like
cd15510390-435  PHD2_KMT2C_like
pfam059654606-4691  FYRC
cl026514606-4691  FYRC superfamily
smart005424610-4697  FYRC
cd15595390-435  PHD2_KMT2D
cd156011086-1136  PHD5_KMT2D
pfam059644550-4604  FYRN
cl026504550-4604  FYRN superfamily
cd156684402-4506  ePHD_RAI1_like
pfam13771252-330  zf-HC5HC2H
cd15571241-330  ePHD
cd156654402-4506  ePHD1_KMT2C_like
smart005414561-4604  FYRN
cd15664249-330  ePHD_KMT2A_like
cd155191009-1054  PHD1_Lid2p_like
cd156031009-1054  PHD1_KDM5B
cd156994402-4506  ePHD_TCF20
cd15627391-435  PHD_BAZ1A
cd15666250-330  ePHD2_KMT2C_like
cd155151009-1054  PHD1_KDM5A_like
cd155431010-1054  PHD_RSF1
cd155941009-1054  PHD2_KMT2C
cd15697250-330  ePHD2_KMT2C
cd156051009-1054  PHD1_Lid_like
cd157004402-4506  ePHD_RAI1
cd156271010-1054  PHD_BAZ1A
cd155101009-1054  PHD2_KMT2C_like
cd156964425-4506  ePHD1_KMT2C
cd156021009-1055  PHD1_KDM5A
cd15545391-435  PHD_BAZ2A_like
cd156734402-4506  ePHD_PHF6_like
cd155441010-1054  PHD_BAZ1A_like
cd156954425-4506  ePHD1_KMT2D
cd15668250-330  ePHD_RAI1_like
cd15513390-435  PHD5_KMT2C_like
pfam138324400-4495  zf-HC5HC2H_2
cd156041009-1054  PHD1_KDM5C_5D
cd15529390-435  PHD2_PHF10
cd15693250-311  ePHD_KMT2A
pfam006281009-1055  PHD
cd15544391-435  PHD_BAZ1A_like
cd15694250-330  ePHD_KMT2B
cd15543391-435  PHD_RSF1
cd156694402-4506  ePHD_PHF7_G2E3_like
cd155361010-1054  PHD_PHRF1
cd155251010-1054  PHD_UHRF1_2
cd156161010-1054  PHD_UHRF1
cd15700250-330  ePHD_RAI1
smart002491009-1054  PHD
cd155951009-1054  PHD2_KMT2D
pfam00628390-438  PHD
cd155271007-1054  PHD2_KAT6A_6B
cd155301010-1054  PHD2_d4
cd155451010-1054  PHD_BAZ2A_like
cd15669251-330  ePHD_PHF7_G2E3_like
cd15515390-435  PHD1_KDM5A_like
cd15698250-330  ePHD2_KMT2D
cd15604390-435  PHD1_KDM5C_5D
cd156171010-1054  PHD_UHRF2
cd15628391-435  PHD_BAZ1B
pfam00628960-1010  PHD
cd15629391-435  PHD_BAZ2A
smart00249390-435  PHD
cd15532390-435  PHD2_CHD_II
cd15605390-435  PHD1_Lid_like
smart00249959-1007  PHD
cd15527388-435  PHD2_KAT6A_6B
cd155321009-1054  PHD2_CHD_II
cd155291009-1054  PHD2_PHF10
cd156281010-1054  PHD_BAZ1B
cd157124425-4506  ePHD_PHF11
cd155391006-1054  PHD1_AIRE
cd155231009-1054  PHD_PHF21A
cd15602390-435  PHD1_KDM5A
cd15536391-435  PHD_PHRF1
cd155621009-1054  PHD2_PHF14
pfam00628344-391  PHD
cd15603390-435  PHD1_KDM5B
cd15673249-330  ePHD_PHF6_like
cd154891009-1054  PHD_SF
cd15519390-435  PHD1_Lid2p_like
cd15699250-330  ePHD_TCF20
cd15530391-435  PHD2_d4
cd156291010-1055  PHD_BAZ2A
pfam13832250-330  zf-HC5HC2H_2
cd15489388-435  PHD_SF
cd15525388-435  PHD_UHRF1_2
cd155331009-1054  PHD1_PHF12
cd15489959-1007  PHD_SF
cd15489467-517  PHD_SF
pfam00628467-518  PHD
cd15592466-517  PHD3_KMT2A
cd155631006-1054  PHD3_PHF14
cd15531391-435  PHD1_CHD_II
cd154891086-1136  PHD_SF
cd155081086-1136  PHD3_KMT2A_like
cd156301010-1055  PHD_BAZ2B
cd15523390-435  PHD_PHF21A
cd155311010-1054  PHD1_CHD_II
cd155411006-1054  PHD_TIF1_like
cd15630391-435  PHD_BAZ2B
smart00249467-517  PHD
cd15563390-435  PHD3_PHF14
smart00249344-388  PHD
cd15489344-388  PHD_SF
cd15562390-435  PHD2_PHF14
cd154991009-1060  PHD1_MTF2_PHF19_like
cd155351010-1054  PHD1_Rco1
cd15615466-517  PHD_ARID4_like
cd157104429-4492  ePHD1_PHF6
cd15539391-435  PHD1_AIRE
cd15508466-517  PHD3_KMT2A_like
cd15509960-1007  PHD1_KMT2C_like
cd155591010-1054  PHD1_BPTF
cd157114402-4498  ePHD2_PHF6
cd155341009-1051  PHD2_PHF12_Rco1
cd15616391-435  PHD_UHRF1
cd155091010-1054  PHD1_KMT2C_like
pfam005051654-1708  HMG_box
pfam006281087-1138  PHD
smart003981652-1705  HMG
cd15712251-330  ePHD_PHF11
cd156754402-4495  ePHD_JMJD2
cd155241010-1054  PHD_PHF21B
cd155041009-1054  PHD_PRHA_like
cd15526973-1007  PHD1_MOZ_d4
cd154971010-1054  PHD1_Snt2p_like
cd157144402-4491  ePHD_JMJD2B
cd15534390-434  PHD2_PHF12_Rco1
cd15671246-315  ePHD_JADE
cd155021007-1054  PHD_Phf1p_Phf2p_like
cd157134402-4498  ePHD_JMJD2A
cd15541387-435  PHD_TIF1_like
cd155921087-1136  PHD3_KMT2A
cd15499388-435  PHD1_MTF2_PHF19_like
cd155071007-1054  PHD2_KMT2A_like
cd15502388-435  PHD_Phf1p_Phf2p_like
pfam019203178-3270  Prefoldin_2
cl091113178-3270  Prefoldin superfamily
cd15562344-388  PHD2_PHF14
cd156714427-4490  ePHD_JADE
cd15593467-517  PHD3_KMT2B
cd15563343-388  PHD3_PHF14
cd155931087-1120  PHD3_KMT2B
cd15514467-517  PHD6_KMT2C_like
cd156231010-1054  PHD_TIF1beta
cd15506390-435  PHD1_KMT2A_like
cd15662241-319  ePHD_ATX1_2_like
cd15710240-311  ePHD1_PHF6
cd15497391-435  PHD1_Snt2p_like
cd15559391-435  PHD1_BPTF
cd000841654-1703  HMG-box
cd15504388-435  PHD_PRHA_like
cd157154402-4488  ePHD_JMJD2C
cd15538971-1007  PHD_PRKCBP1
cd15711251-311  ePHD2_PHF6
cd15617391-435  PHD_UHRF2
cd15596344-388  PHD4_KMT2C
cd15501960-1007  PHD_Int12
cd15675284-330  ePHD_JMJD2
cd156704427-4491  ePHD_BRPF
cd15523344-388  PHD_PHF21A
smart005084895-4911  PostSET
cl026364895-4911  PostSET superfamily
cd15512388-435  PHD4_KMT2C_like
cd156611010-1053  PHD5_NSD3
cd15506959-1007  PHD1_KMT2A_like
cd15527344-388  PHD2_KAT6A_6B
cd15528959-1007  PHD1_PHF10
cd154921007-1054  PHD_BRPF_JADE_like
cd15707246-311  ePHD_RNO
cd15596388-435  PHD4_KMT2C
smart002491087-1136  PHD
cd15591960-1007  PHD2_KMT2B
cd15623388-435  PHD_TIF1beta
cd15510960-1007  PHD2_KMT2C_like
cd15539344-388  PHD1_AIRE
cd156601013-1053  PHD5_NSD2
cd15565959-1004  PHD2_NSD
cd157034427-4491  ePHD_BRPF3
smart002494462-4506  PHD
cd15507388-435  PHD2_KMT2A_like
cd15706246-311  ePHD_JADE3
cd15578388-435  PHD1_MTF2
cd157014427-4508  ePHD_BRPF1
cd155671010-1054  PHD4_NSD
cd15625391-436  PHD_TIF1delta
cd15539959-1007  PHD1_AIRE
cd15692969-1007  PHD1_DPF3
cd154894462-4506  PHD_SF
cd076533176-3265  F-BAR_CIP4-like
cl120133176-3265  BAR superfamily
cd15705246-311  ePHD_JADE2
cd15624388-436  PHD_TIF1gamma
cd15517390-435  PHD_TCF19_like
cd15541344-388  PHD_TIF1_like
cd15545960-1007  PHD_BAZ2A_like
cd15632473-518  PHD_PHF13
cd15597344-388  PHD3_KMT2D
cd15531344-388  PHD1_CHD_II
cd155781007-1055  PHD1_MTF2
cd157024402-4491  ePHD_BRPF2
cd155831089-1140  PHD_ash2p_like
cd15524391-435  PHD_PHF21B
COG29404725-4911  SET
PHA032471876-2353  PHA03247
PHA032471861-2298  PHA03247
PHA032471890-2459  PHA03247
PHA032472012-2596  PHA03247
PHA033072107-2519  PHA03307
PHA033071871-2282  PHA03307
PHA033071877-2265  PHA03307
PHA033071951-2358  PHA03307
PRK140862028-2223  dnaA
pfam097703117-3434  PAT1
PHA033782031-2430  PHA03378
PHA033791871-2332  PHA03379
pfam072232089-2315  DUF1421
pfam031541862-2276  Atrophin-1
PHA033781869-2377  PHA03378
PHA033772045-2549  PHA03377
PRK077641871-2227  PRK07764
PRK102631954-2469  PRK10263
pfam031541863-2198  Atrophin-1
PRK070032010-2314  PRK07003
PTZ004491972-2318  PTZ00449
PRK102631882-2242  PRK10263
PRK077642051-2479  PRK07764
pfam138683176-3270  Trichoplein
PHA032471856-2150  PHA03247
PTZ003952038-2188  PTZ00395
PRK070031885-2135  PRK07003
pfam051091979-2362  Herpes_BLLF1
PTZ003952089-2325  PTZ00395
PRK077642097-2308  PRK07764
pfam060701954-2324  Herpes_UL32
PLN032092028-2227  PLN03209
PHA033782220-2620  PHA03378
pfam051091920-2270  Herpes_BLLF1
PHA033771859-2333  PHA03377
pfam033262045-2314  Herpes_TAF50
PRK077642112-2342  PRK07764
COG51414396-4510  COG5141
pfam072231986-2227  DUF1421
PRK140862170-2360  dnaA
PRK123232048-2298  PRK12323
pfam097702039-2268  PAT1
PHA032692093-2212  PHA03269
pfam046522073-2212  DUF605
PHA033792123-2652  PHA03379
PRK077642049-2297  PRK07764
COG51411004-1140  COG5141
pfam127371875-2185  Mating_C
pfam046522089-2228  DUF605
PRK048633178-3271  mukB
pfam007693172-3287  ERM
pfam097702417-2642  PAT1
pfam059562093-2341  APC_basic
PLN032091891-2187  PLN03209
PRK123232008-2210  PRK12323
PHA032472093-2328  PHA03247
pfam072713239-3381  Cytadhesin_P30
PRK004093175-3272  PRK00409
TIGR028133151-3376  omega_3_PfaA
pfam153012047-2242  SLAIN
pfam031542408-2668  Atrophin-1
PLN032091873-2106  PLN03209
pfam072232109-2356  DUF1421
pfam138633174-3267  DUF4200
TIGR021683177-3264  SMC_prok_B
PHA033072098-2284  PHA03307
pfam153512033-2391  JCAD
pfam139043177-3292  DUF4207
PRK070032093-2295  PRK07003
pfam152793268-3383  SOBP
PRK089443142-3270  motB
pfam122872248-2486  Caprin-1_C


Ontology Information


   
HPRD ID16543
Molecular ClassNot Available
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessApoptosis (GO:0006915)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO