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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21388066 | 2010 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 33 CRC samples with MSI-H, 15 CRC samples with MSI-L, and 45 CRC samples that were MSS Stage : - | SSCP and DNA sequencing | Frameshift Mutation | - | Found somatic frameshit mutations of the KNTC1 (6.7% GC, 12.1% CRC), ZC3H13 (3.3% GC, 15.2% CRC), CENPH (6.7% GC), TOPBP1 (3.0% CRC), NDCO80 (3.0% CRC), RIF1 (6.7% GC), and NBS1 (3.3% GC, 3.0% CRC) genes in the cancers with MSI-H. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. Experimental evidence indicated that the encoded protein functioned in a similar manner to that of the Drosophila rough deal protein. [provided by RefSeq, Jul 2008] | Chromosome | 12 |
| Location | 12q24.31 |
| Start | 123011796 |
| End | 123110947 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 99152 |
| OMIM ID | 607363 |
| HGNC ID | HGNC:17255 |
| Unigene ID | Hs.300559 |
| Ensembl ID | ENSG00000184445 |
| PharmGKB ID | PA30184 |
Protein Information
| Protein ID | NP_055523.1 |
|---|---|
| Protein Name | kinetochore associated 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 2209 |
| Uniprot ID | Q92623 |
| Ensembl Protein ID | ENSP00000256367 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 2098 |
| K | Acetylation | 1316 |
| S | Phosphorylation | 535 |
| Y | Phosphorylation | 1994 |
| S | Phosphorylation | 1034 |
| T | Phosphorylation | 1545 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam10493 | 1579-2130 | Rod_C |
| cl20400 | 1579-2130 | Rod_C superfamily |
Ontology Information
| HPRD ID | 11433 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Kinase binding (GO:0019900); Protein binding (GO:0005515) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.