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General Information

• Evidence
• Gene
• mRNA
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Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
22996610	2012	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	-	Up-regulation	-	This study provides evidence for cytokeratin 18 (CK18) as a prognostic and PD biomarker in patients with CRC and supports continued deployment of circulating CK18 in biomarker-enhanced trials.

Gene Details

Chromosome: 12; NC_000012.11 (53342655..53346685)
View Larger Image   

Gene Type	protein coding
Gene Family	Intermediate filaments type I, keratins (acidic)
Description	KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	12
Location	12q13
Start	52948871
End	52952901
Strand	+
Gene Sequence	>gi|568815586:52948871-52952901 Homo sapiens chromosome 12, GRCh38.p2 Primary Assembly GCAGCCTCGAGGGCCAACAACACCTGCTGTCCGTGTCCATGCCCGGTTGGCCACCCCGTTTCTGGGGGGT GAGCGGGGCTTGGCAGGGCTGCGCGGAGGGCGCGGGGGTGGGGCCCGGGGCGGAGCGGCCCGGGGCGGAG GGCGCGGGCTCCGAGCCGTCCACCTGTGGCTCCGGCTTCCGAAGCGGCTCCGGGGCGGGGGCGGGGCCTC ACTCTGCGATATAACTCGGGTCGCGCGGCTCGCGCAGGCCGCCACCGTCGTCCGCAAAGCCTGAGTCCTG TCCTTTCTCTCTCCCCGGACAGCATGAGCTTCACCACTCGCTCCACCTTCTCCACCAACTACCGGTCCCT GGGCTCTGTCCAGGCGCCCAGCTACGGCGCCCGGCCGGTCAGCAGCGCGGCCAGCGTCTATGCAGGCGCT GGGGGCTCTGGTTCCCGGATCTCCGTGTCCCGCTCCACCAGCTTCAGGGGCGGCATGGGGTCCGGGGGCC TGGCCACCGGGATAGCCGGGGGTCTGGCAGGAATGGGAGGCATCCAGAACGAGAAGGAGACCATGCAAAG CCTGAACGACCGCCTGGCCTCTTACCTGGACAGAGTGAGGAGCCTGGAGACCGAGAACCGGAGGCTGGAG AGCAAAATCCGGGAGCACTTGGAGAAGAAGGGACCCCAGGTCAGAGACTGGAGCCATTACTTCAAGATCA TCGAGGACCTGAGGGCTCAGGTAAGGGGTAGGAGGGACCTCAACTCCCAGCCTTGTCTGACCCTCCAATT ATACACTCCTTTGCCTCTTTCCGTCATTCCATAACCACCCAACCCCTACTCCACCGGGAGGGGGTTGGGC ATACCTGGATTTCCATCCGCGCACCTAGCCACAGGGTCCCTAAGAGCAGCAGCTAGGCATGGGAGGGCTC TTTCCCAGGAGAGAGGGGGAAGGGGACAGGGTTGAGAGCTTTACAGAGGAAGTGGACAGCATGGAGGGAG GTAAGGAAAGGCCTGTAAAGAGGAGGAGACACTGGCTCTGGCGGAATGGGGACTATTGGAGGGTTAAGCG GATGTGGCTAAGGCTGAGTCATCTAGGAGTAAACAAGAGGCCTTCCTTTGGGAGGAGCCAATCCAGGGTG TAGGGGGCCCAGAGTGACCAGGTGCACTAGGGAAAAAATGCCAGGAGAGGGCCAGGAAGAGGACTTGTTA GTAGCGACTCACTTCTGGGCAGGCAGGCCAGCCAGCTAGCCAGCCTGCTGAGGCTTCCCAAGAGGGGCAG AGTGCTGGGATCTGGGAATCCAGGAAAGGAGGGAATGGGGTGGGGCTAGATGAAAAGGGATAGGTGTCCA GGGAGAGCCTCTGGCTATTCCTGGGACCAGGAAGTTTTCACTAGGATACATAACACTTTTTACACACTCA CCCCACCCATCCCTGGCTTTCTATTCATGGAACAACCTCTCTCTACAATCCCTCCAGATCTTCGCAAATA CTGTGGACAATGCCCGCATCGTTCTGCAGATTGACAATGCCCGTCTTGCTGCTGATGACTTTAGAGTCAA GTAAGTTTGGGGGCTAGAGAGCTGGGGGTCCAGGGGTGGAGCTAAGAAGGATCTGCTCCCCAGGCTGGGT CAGTTAGGGGCTCACAGTGGGATCCTGTTAGGTGTGGGTGGATGAGAGTCAGGGTCCATCAGTGTATTCA TTTAACTGTTCATTTGTATAACCCCGTTTAAGAATACTGTCCTCCAAGTGCCAAGAATGGTGCTCAGGGG ATTACCACCTAATTGCTGACTCAAGTTGCTGGTTTGCAATGGGCACAGAACTTCTCTTAGTAGGTGGCAT GAGTTGAGAAGGTTCTGGATCAGAGATAGGGGCCCCTCTGATCACCTCCACTCCTATAGGTATGAGACAG AGCTGGCCATGCGCCAGTCTGTGGAGAACGACATCCATGGGCTCCGCAAGGTCATTGATGACACCAATAT CACACGACTGCAGCTGGAGACAGAGATCGAGGCTCTCAAGGAGGAGCTGCTCTTCATGAAGAAGAACCAC GAAGAGGCAAGCAGGGGCCACTGGCCAGGCCAGGGATTGAGGGGCCAAGAGAAGTCTGGGTCGGAGAATA GACAAGACAAACCAACTGCAAGTAGCCTTGCTAAGACGTTTAGAAATAGCAGCCTGGGCTCTTCTTAAAT AAGACCGTTCTGATGAAGAGCATTCTCAGGGGGTCGAGTACACCCTGGCTCACCTGAATTACAGGTCAAA ATGATATGGGTTAGAAAATGAGATGAGAACAGAAGTAGAAGCAGCTAACACTAGGAGCTGGGGGTGATAA AGGAATGACAGCAGATGGAGTTGGCAGCGCTTCCTAAAAGATGGTAGAAGGAGCAGGTTTGTGAAGGGGA GGGTGGATAAAGGAACAGGGTGAAGTTACAGAGAAACCATCAGTGAGTGGGTGGCATTTCTACCCACTGG AGTAGAAAGGCCAGAACTGGCATTGCCCTGAGTGCAAGCCAAGGGGTTCCTCCTGTCTCTTCTCCAACTG TAGGCCTCCTAGAAGAGGCAATCACAGAAGAAAGGCCTTGTTGGAGCTCTGACCCTGAACCCTCCTCACT TTTGCCCCTGTCACCTTTAGGAAGTAAAAGGCCTACAAGCCCAGATTGCCAGCTCTGGGTTGACCGTGGA GGTAGATGCCCCCAAATCTCAGGACCTCGCCAAGATCATGGCAGACATCCGGGCCCAATATGACGAGCTG GCTCGGAAGAACCGAGAGGAGCTAGACAAGTACTGGTCTCAGCAGGTGCGTGAGGGGAGGGGATGGCTGC CAAGGTGTGGGAGGGAGGCAGACGGAATGAGGGGCCTGATGGACTGTCCCCATCCTGCAGATTGAGGAGA GCACCACAGTGGTCACCACACAGTCTGCTGAGGTTGGAGCTGCTGAGACGACGCTCACAGAGCTGAGACG TACAGTCCAGTCCTTGGAGATCGACCTGGACTCCATGAGAAATCTGGTGAGTGCCTTCACATCACCTGCC CAGCTCCTCCTTCACTTGGCCTCAGACCCAACCCTGTCTCAACCCAAATCCTATCCCTCATATCATGAGT TCCTTTAGCTCAGAAAGAGTCAGTTTCCTCTTTGCATTTCCCTCCACTCCTATCCCTTATCCCAGTACTT GGCACATAGCAGGTGCCCAAAAAAGTTTCCAAAAGTGAAGGGATGAGCAGTCCTGGGACTCTGGGCTCAC CCTGCCCCTCCTCTCTGTGCCCCTGCAGAAGGCCAGCTTGGAGAACAGCCTGAGGGAGGTGGAGGCCCGC TACGCCCTACAGATGGAGCAGCTCAACGGGATCCTGCTGCACCTTGAGTCAGAGCTGGCACAGACCCGGG CAGAGGGACAGCGCCAGGCCCAGGAGTATGAGGCCCTGCTGAACATCAAGGTCAAGCTGGAGGCTGAGAT CGCCACCTACCGCCGCCTGCTGGAAGATGGCGAGGACTTTAAGTGAGTGGGGCTCTCCTACCCACACGTG CTGGGATCAGGAGATCACTTCTCCCCAAAGTCTGAGCTTTTGGAAGCACCCCATGTGTCTGTTCACTGGT ATCCACTGAGCACTGGGCCGTTGCTCCGTGGGTGCTCCTGTGTCTTCAAGGGAGTAACAGTTACAGAGGT CTCCCCCTTGAAGAAAGCAAACTAAGTATTGTCCCTAGCTGTACTTAGTATGCAAATGAAGTTTGGCCTT GAGTTTCCCTTTTCTGGAGGAAGAGGCTGAGGGTGATTTGGAGATAAAGGTAGAGGTCAGGAGGCTTTTT CCCTCTACCTTTCTTGTCTCCCTTCTACTCCACGGGGCTGTTTATAACTTGGGCTTGGTCTTCTGTTACA GTCTTGGTGATGCCTTGGACAGCAGCAACTCCATGCAAACCATCCAAAAGACCACCACCCGCCGGATAGT GGATGGCAAAGTGGTGTCTGAGACCAATGACACCAAAGTTCTGAGGCATTAAGCCAGCAGAAGCAGGGTA CCCTTTGGGGAGCAGGAGGCCAATAAAAAGTTCAGAGTTCA    Download   Select all
Length	4031
OMIM ID	148070
HGNC ID	HGNC:6430
Unigene ID	Hs.406013
Ensembl ID	ENSG00000111057
PharmGKB ID	-

mRNA Information

mRNA ID	NM_001256293.1
Exon	complement(845..996)
mRNA Sequence	>3875 GCAGCCTCGAGGGCCAACAACACCTGCTGTCCGTGTCCATGCCCGGTTGGCCACCCCGTTTCTG GGGGCATGAGCTTCACCACTCGCTCCACCTTCTCCACCAACTACCGGTCCCTGGGCTCTGTCCA GGCGCCCAGCTACGGCGCCCGGCCGGTCAGCAGCGCGGCCAGCGTCTATGCAGGCGCTGGGGGC TCTGGTTCCCGGATCTCCGTGTCCCGCTCCACCAGCTTCAGGGGCGGCATGGGGTCCGGGGGCC TGGCCACCGGGATAGCCGGGGGTCTGGCAGGAATGGGAGGCATCCAGAACGAGAAGGAGACCAT GCAAAGCCTGAACGACCGCCTGGCCTCTTACCTGGACAGAGTGAGGAGCCTGGAGACCGAGAAC CGGAGGCTGGAGAGCAAAATCCGGGAGCACTTGGAGAAGAAGGGACCCCAGGTCAGAGACTGGA GCCATTACTTCAAGATCATCGAGGACCTGAGGGCTCAGATCTTCGCAAATACTGTGGACAATGC CCGCATCGTTCTGCAGATTGACAATGCCCGTCTTGCTGCTGATGACTTTAGAGTCAAGTATGAG ACAGAGCTGGCCATGCGCCAGTCTGTGGAGAACGACATCCATGGGCTCCGCAAGGTCATTGATG ACACCAATATCACACGACTGCAGCTGGAGACAGAGATCGAGGCTCTCAAGGAGGAGCTGCTCTT CATGAAGAAGAACCACGAAGAGGAAGTAAAAGGCCTACAAGCCCAGATTGCCAGCTCTGGGTTG ACCGTGGAGGTAGATGCCCCCAAATCTCAGGACCTCGCCAAGATCATGGCAGACATCCGGGCCC AATATGACGAGCTGGCTCGGAAGAACCGAGAGGAGCTAGACAAGTACTGGTCTCAGCAGATTGA GGAGAGCACCACAGTGGTCACCACACAGTCTGCTGAGGTTGGAGCTGCTGAGACGACGCTCACA GAGCTGAGACGTACAGTCCAGTCCTTGGAGATCGACCTGGACTCCATGAGAAATCTGAAGGCCA GCTTGGAGAACAGCCTGAGGGAGGTGGAGGCCCGCTACGCCCTACAGATGGAGCAGCTCAACGG GATCCTGCTGCACCTTGAGTCAGAGCTGGCACAGACCCGGGCAGAGGGACAGCGCCAGGCCCAG GAGTATGAGGCCCTGCTGAACATCAAGGTCAAGCTGGAGGCTGAGATCGCCACCTACCGCCGCC TGCTGGAAGATGGCGAGGACTTTAATCTTGGTGATGCCTTGGACAGCAGCAACTCCATGCAAAC CATCCAAAAGACCACCACCCGCCGGATAGTGGATGGCAAAGTGGTGTCTGAGACCAATGACACC AAAGTTCTGAGGCATTAAGCCAGCAGAAGCAGGGTACCCTTTGGGGAGCAGGAGGCCAATAAAA AGTTCAGAGTTCAAAAAAAAAAAAAAAAAAA    Download   Select all
Length	1439

CDS Information

   

Location	join(304..720,1458..1540,1880..2036,2611..2775,2861..2986, 3249..3472,3852..3972)
CDS Sequence	>gi|40354194:70-1362 Homo sapiens keratin 18 (KRT18), transcript variant 2, mRNA ATGAGCTTCACCACTCGCTCCACCTTCTCCACCAACTACCGGTCCCTGGGCTCTGTCCAGGCGCCCAGCT ACGGCGCCCGGCCGGTCAGCAGCGCGGCCAGCGTCTATGCAGGCGCTGGGGGCTCTGGTTCCCGGATCTC CGTGTCCCGCTCCACCAGCTTCAGGGGCGGCATGGGGTCCGGGGGCCTGGCCACCGGGATAGCCGGGGGT CTGGCAGGAATGGGAGGCATCCAGAACGAGAAGGAGACCATGCAAAGCCTGAACGACCGCCTGGCCTCTT ACCTGGACAGAGTGAGGAGCCTGGAGACCGAGAACCGGAGGCTGGAGAGCAAAATCCGGGAGCACTTGGA GAAGAAGGGACCCCAGGTCAGAGACTGGAGCCATTACTTCAAGATCATCGAGGACCTGAGGGCTCAGATC TTCGCAAATACTGTGGACAATGCCCGCATCGTTCTGCAGATTGACAATGCCCGTCTTGCTGCTGATGACT TTAGAGTCAAGTATGAGACAGAGCTGGCCATGCGCCAGTCTGTGGAGAACGACATCCATGGGCTCCGCAA GGTCATTGATGACACCAATATCACACGACTGCAGCTGGAGACAGAGATCGAGGCTCTCAAGGAGGAGCTG CTCTTCATGAAGAAGAACCACGAAGAGGAAGTAAAAGGCCTACAAGCCCAGATTGCCAGCTCTGGGTTGA CCGTGGAGGTAGATGCCCCCAAATCTCAGGACCTCGCCAAGATCATGGCAGACATCCGGGCCCAATATGA CGAGCTGGCTCGGAAGAACCGAGAGGAGCTAGACAAGTACTGGTCTCAGCAGATTGAGGAGAGCACCACA GTGGTCACCACACAGTCTGCTGAGGTTGGAGCTGCTGAGACGACGCTCACAGAGCTGAGACGTACAGTCC AGTCCTTGGAGATCGACCTGGACTCCATGAGAAATCTGAAGGCCAGCTTGGAGAACAGCCTGAGGGAGGT GGAGGCCCGCTACGCCCTACAGATGGAGCAGCTCAACGGGATCCTGCTGCACCTTGAGTCAGAGCTGGCA CAGACCCGGGCAGAGGGACAGCGCCAGGCCCAGGAGTATGAGGCCCTGCTGAACATCAAGGTCAAGCTGG AGGCTGAGATCGCCACCTACCGCCGCCTGCTGGAAGATGGCGAGGACTTTAATCTTGGTGATGCCTTGGA CAGCAGCAACTCCATGCAAACCATCCAAAAGACCACCACCCGCCGGATAGTGGATGGCAAAGTGGTGTCT GAGACCAATGACACCAAAGTTCTGAGGCATTAA    Download   Select all
CCDS ID	CCDS31809.1

Protein Information

      

Protein ID	NP_000215.1
Protein Name	Keratin 18
Molecular Wt. (Da)	47927
Protein Sequence	>3875 MSFTTRSTFSTNYRSLGSVQAPSYGARPVSSAASVYAGAGGSGSRISVSRSTSFRGGMGSGGLA TGIAGGLAGMGGIQNEKETMQSLNDRLASYLDRVRSLETENRRLESKIREHLEKKGPQVRDWSH YFKIIEDLRAQIFANTVDNARIVLQIDNARLAADDFRVKYETELAMRQSVENDIHGLRKVIDDT NITRLQLETEIEALKEELLFMKKNHEEEVKGLQAQIASSGLTVEVDAPKSQDLAKIMADIRAQY DELARKNREELDKYWSQQIEESTTVVTTQSAEVGAAETTLTELRRTVQSLEIDLDSMRNLKASL ENSLREVEARYALQMEQLNGILLHLESELAQTRAEGQRQAQEYEALLNIKVKLEAEIATYRRLL EDGEDFNLGDALDSSNSMQTIQKTTTRRIVDGKVVSETNDTKVLRH    Download   Select all
Length	430
Uniprot ID	Q08722
Ensembl Protein ID	ENSP00000347512

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Glycosylation	30
S	Glycosylation	31
S	Glycosylation	49
S	Glycosylation	30
S	Glycosylation	31
S	Glycosylation	49
S	Phosphorylation	53
S	Phosphorylation	53
S	Phosphorylation	53
S	Phosphorylation	53
D	Proteolytic Cleavage	238
D	Proteolytic Cleavage	238
S	Phosphorylation	34
S	Phosphorylation	53
D	Proteolytic Cleavage	238
S	Phosphorylation	34
S	Phosphorylation	53
S	Phosphorylation	53
S	Phosphorylation	53
D	Proteolytic Cleavage	238
D	Proteolytic Cleavage	238
D	Proteolytic Cleavage	397
D	Proteolytic Cleavage	397
D	Proteolytic Cleavage	238
Y	Phosphorylation	13;-
Y	Phosphorylation	13;-
S	Phosphorylation	399;-
S	Phosphorylation	399;-
T	Phosphorylation	65;-
T	Phosphorylation	65;-
S	Phosphorylation	7
S	Phosphorylation	7
T	Phosphorylation	8
T	Phosphorylation	8
S	Phosphorylation	10
S	Phosphorylation	10
S	Phosphorylation	15
S	Phosphorylation	15
S	Phosphorylation	18
S	Phosphorylation	18
S	Phosphorylation	23
S	Phosphorylation	23
Y	Phosphorylation	24
Y	Phosphorylation	24
S	Phosphorylation	31
S	Phosphorylation	31
Y	Phosphorylation	36
Y	Phosphorylation	36
S	Phosphorylation	42
S	Phosphorylation	42
S	Phosphorylation	51
S	Phosphorylation	51
T	Phosphorylation	52
T	Phosphorylation	52
S	Phosphorylation	60
S	Phosphorylation	60
S	Phosphorylation	398
S	Phosphorylation	398
S	Phosphorylation	401
S	Phosphorylation	401
S	Phosphorylation	47
S	Phosphorylation	47
T	Phosphorylation	404
T	Phosphorylation	404
S	Phosphorylation	44
S	Phosphorylation	44
S	Phosphorylation	420
S	Phosphorylation	420
S	Phosphorylation	100
S	Phosphorylation	100
K	Acetylation	426
K	Acetylation	426
K	Acetylation	131
K	Acetylation	131
K	Acetylation	167
K	Acetylation	167
K	Acetylation	111
K	Acetylation	111
K	Acetylation	214
K	Acetylation	214
S	Phosphorylation	305
S	Phosphorylation	305
T	Phosphorylation	425
T	Phosphorylation	425
T	Phosphorylation	11
T	Phosphorylation	11
T	Phosphorylation	302
T	Phosphorylation	302
S	Phosphorylation	49
S	Phosphorylation	49
S	Phosphorylation	127
S	Phosphorylation	127
S	Phosphorylation	177
S	Phosphorylation	177
S	Phosphorylation	319
S	Phosphorylation	319
S	Phosphorylation	30
S	Phosphorylation	30

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                             

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
836	CASP3	2799	NP_004337.2	in vitro	11   356   849   929   899   200   000   000
839	CASP6	3321	NP_001217.2	in vitro	9298992
840	CASP7	3457	NP_203124.1	in vitro	9298992
841	CASP8	3459	NP_001073594.1	in vitro	10891503
1308	COL17A1	223	NP_000485.3	in vitro;yeast 2-hybrid	10022517
1956	EGFR	579	NP_005219.2	in vitro;in vivo	12577067
3303	HSPA1A	774	NP_005336.3	in vitro	7529764
3309	HSPA5	682	NP_005338.1	in vivo	9409741
3852	KRT5	1010	NP_000415.2	in vivo	9786957
3856	KRT8	1015	NP_002264.1	in vivo	9630597
5894	RAF1	1265	NP_002871.1	in vivo	15314064
7283	TUBG1	1853	NP_001061.2	in vivo	10444072
7533	YWHAH	215	NP_003396.1	in vivo	9524113
9146	HGS	5085	NP_004703.1	yeast 2-hybrid	16189514
11007	CCDC85B	16101	NP_006839.2	yeast 2-hybrid	16189514
23641	LDOC1	2322	NP_036449.1	yeast 2-hybrid	16189514
27229	TUBGCP4	10616	NP_055259.2	yeast 2-hybrid	16189514
29922	NME7	11394	NP_037462.1	yeast 2-hybrid	16189514
149371	EXOC8	9943	NP_787072.2	yeast 2-hybrid	16189514

Pathway Information

      

Pathway Name	Pathway ID
Pathogenic Escherichia coli infection	hsa05130

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
TIGR00219	148-290	mreC
cl19252	148-290	MreC superfamily
pfam00038	79-389	Filament
TIGR02168	179-386	SMC_prok_B
COG1196	67-376	Smc
COG1196	77-389	Smc
TIGR02168	59-377	SMC_prok_B
TIGR02168	133-389	SMC_prok_B
TIGR02169	61-393	SMC_prok_A
TIGR02169	167-376	SMC_prok_A
COG1196	175-386	Smc
TIGR02168	190-390	SMC_prok_B
TIGR02168	185-414	SMC_prok_B
COG1196	77-338	Smc
PRK02224	81-330	PRK02224
pfam05622	81-361	HOOK
PRK03918	74-391	PRK03918
smart00787	196-385	Spc7
TIGR02169	162-386	SMC_prok_A
pfam05483	77-329	SCP-1
TIGR04523	77-379	Mplasa_alph_rch
pfam01576	77-397	Myosin_tail_1
COG1196	264-386	Smc
PRK10361	268-368	PRK10361
pfam13514	81-385	AAA_27
COG1579	273-385	COG1579
PTZ00491	280-381	PTZ00491
TIGR02169	76-362	SMC_prok_A
COG0419	77-390	SbcC
COG4942	175-367	EnvC

Ontology Information

   

HPRD ID	825
Molecular Class	Cytoskeletal protein
Molecular Function	MHC class I receptor activity (GO:0030106); MHC class II receptor activity (GO:0045012)
Biological Process	Immune response (GO:0006955)

SNP Information

View SNP Geneview Report   

Drug Information

No matching records could be found.

External Links

                                 

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO