Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| KRT20 | 54474 | Keratin 20 | 17 | K20; CD20; CK20; CK-20; KRT21 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20812987 | 2010 | Cell line : - Source : Nanfang Hospital tumour tissue bank. Sample Type : CRC tumor and normal tissue No. of Sample : 150 Stage : - | 2-D Gel electrophoresis, and mass spectrometry,Western blotting , Immunohistochemistry | Down-regulation | - | This gene differentially expressed in between normal colorectal tissue and colorectal cancer tissue experiment done by 2-D Gel eclectrophotesis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Intermediate filaments type I, keratins (acidic) |
| Description | The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008] | Chromosome | 17 |
| Location | 17q21.2 |
| Start | 40875889 |
| End | 40885243 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 9355 |
| OMIM ID | 608218 |
| HGNC ID | HGNC:20412 |
| Unigene ID | Hs.84905 |
| Ensembl ID | ENSG00000171431 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_019010.2 |
|---|---|
| Exon | join(1..448,2590..2672,4474..4630,4983..5144,5306..5431, 6879..7099,7827..7864,8786..9355) | mRNA Sequence | Download Select all |
| Length | 1805 |
CDS Information
| Location | join(59..448,2590..2672,4474..4630,4983..5144,5306..5431, 6879..7099,7827..7864,8786..8883) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS11379.1 |
Protein Information
| Protein ID | NP_061883.1 |
|---|---|
| Protein Name | Keratin 20 |
| Molecular Wt. (Da) | 48356 |
| Protein Sequence | Download Select all |
| Length | 424 |
| Uniprot ID | P12034 |
| Ensembl Protein ID | ENSP00000311697 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 34 |
| T | Phosphorylation | 168 |
| S | Phosphorylation | 94 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 9055 | PRC1 | 17899 | NP_003972.1 | yeast 2-hybrid | 16189514 |
| 11007 | CCDC85B | 16101 | NP_006839.2 | yeast 2-hybrid | 16189514 |
| 51421 | AMOTL2 | 16485 | NP_057285.3 | yeast 2-hybrid | 16189514 |
| 79095 | C9orf16 | 12946 | NP_077017.1 | yeast 2-hybrid | 16189514 |
| 79696 | FAM164C | 16607 | NP_078919.2 | yeast 2-hybrid | 16189514 |
| 79882 | ZC3H14 | 13348 | NP_079100.2 | yeast 2-hybrid | 16189514 |
| 80347 | COASY | 13080 | NP_001035997.2 | yeast 2-hybrid | 16189514 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00038 | 69-380 | Filament |
| COG1196 | 122-396 | Smc |
| COG1196 | 122-409 | Smc |
| TIGR02168 | 48-377 | SMC_prok_B |
| TIGR02169 | 122-344 | SMC_prok_A |
| TIGR02168 | 113-366 | SMC_prok_B |
| TIGR02169 | 170-409 | SMC_prok_A |
| TIGR02168 | 124-407 | SMC_prok_B |
| TIGR02169 | 109-424 | SMC_prok_A |
| COG1196 | 252-409 | Smc |
| PRK11281 | 250-352 | PRK11281 |
| TIGR02169 | 241-419 | SMC_prok_A |
| TIGR04211 | 244-349 | SH3_and_anchor |
| COG0419 | 71-383 | SbcC |
| TIGR03319 | 238-377 | RNase_Y |
| PRK03918 | 252-422 | PRK03918 |
| TIGR01843 | 250-417 | type_I_hlyD |
Ontology Information
| HPRD ID | 3303 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Growth factor activity (GO:0008083) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.