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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
KRT8 3856 keratin 8  12CARD2, K8, CK8, CYK8, K2C8, KO 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
19115206   2009Cell line : SW480

Source : -

Sample Type : -

No. of Sample : -

Stage : -

-Down-regulation-PRL-3 may play an important role for the promotion of CRC cell migration and metastatic potential through direct KRT8 dephosphorylation.


Gene Details



NC_000012.11 (53290971..53343650, complement)

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Gene Type protein coding
Gene Family -, "Intermediate filaments type II, keratins (basic)"
Description This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]  
Chromosome 12
Location 12q13.13
Start 53290971  
End 53343650  
Strand -  
Gene Sequence

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Length 52680  
OMIM ID 148060   
HGNC ID HGNC:6446   
Unigene ID Hs.533782   
Ensembl ID ENSG00000170421   
PharmGKB ID PA30234   

mRNA Information


mRNA ID NM_001256293.1
Exon join(1..152,44840..45209,47795..48003,48648..48708, 49184..49279,49802..50092,50968..51188,51348..51406, 52249..52680)  
mRNA Sequence

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Length 1901  



CDS Information


   
Location 199..1650
CDS Sequence

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CCDS ID CCDS58234.1



Protein Information


      
Protein IDNP_001243222.1
Protein Namekeratin 8
Molecular Wt. (Da)47975
Protein Sequence

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Length 483  
Uniprot IDQ15831
Ensembl Protein ID ENSP00000324856  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation22
SPhosphorylation24
SPhosphorylation74
SPhosphorylation74
SPhosphorylation74
SPhosphorylation432
SPhosphorylation74
SPhosphorylation37
SPhosphorylation21
SPhosphorylation43
SPhosphorylation451
SPhosphorylation37;-
YPhosphorylation204;-
YPhosphorylation267;-
SPhosphorylation330;-
SPhosphorylation34;-
SPhosphorylation475;-
SPhosphorylation478;-
YPhosphorylation25;-
SPhosphorylation27;-
SPhosphorylation35
SPhosphorylation36
SPhosphorylation39
SPhosphorylation240
SPhosphorylation243
SPhosphorylation251
SPhosphorylation253
SPhosphorylation258
SPhosphorylation274
SPhosphorylation400
SPhosphorylation424
YPhosphorylation427
TPhosphorylation431
SPhosphorylation441
SPhosphorylation436
YPhosphorylation437
SPhosphorylation438
SPhosphorylation442
SPhosphorylation445
SPhosphorylation477
TPhosphorylation26
SPhosphorylation410
SPhosphorylation456
SPhosphorylation13
TPhosphorylation14
KAcetylation393
KAcetylation117
KAcetylation347
KAcetylation207
KAcetylation325
KAcetylation295
SPhosphorylation104
SPhosphorylation44
SPhosphorylation9
SGlycosylation13
SGlycosylation15
SGlycosylation475
SPhosphorylation315
YPhosphorylation228

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                            
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1956EGFR579NP_005219.2in vitro;in vivo12577067   
3309HSPA5682NP_005338.1in vivo9409741   
5894RAF11265NP_002871.1in vivo15314064   
9191DEDD6022NP_127491.1in vivo12235123   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam15003279-376  HAUS2
cl20881279-376  HAUS2 superfamily
pfam0003890-401  Filament
COG1196144-404  Smc
TIGR0216885-403  SMC_prok_B
TIGR0216979-377  SMC_prok_A
COG1196141-409  Smc
TIGR02168156-404  SMC_prok_B
PRK09039229-373  PRK09039
TIGR0216993-357  SMC_prok_A
TIGR0216888-383  SMC_prok_B
COG119683-314  Smc
PRK0391892-396  PRK03918
TIGR0216991-396  SMC_prok_A
pfam01576124-376  Myosin_tail_1
TIGR0452392-377  Mplasa_alph_rch
pfam13166169-353  AAA_13
COG119684-365  Smc
TIGR02169158-409  SMC_prok_A
TIGR0216885-376  SMC_prok_B
TIGR0100076-370  bacteriocin_acc
pfam06637113-389  PV-1
COG1579282-408  COG1579
COG1196209-403  Smc
TIGR02168230-412  SMC_prok_B
TIGR02168251-404  SMC_prok_B
pfam01576109-374  Myosin_tail_1
TIGR0216892-331  SMC_prok_B
TIGR0216890-354  SMC_prok_B
PHA02562107-373  46
COG4477135-380  EzrA
COG3883152-363  CwlO1
COG1196206-410  Smc
TIGR0452389-381  Mplasa_alph_rch
COG119690-334  Smc
PRK09039285-401  PRK09039
COG4372144-375  COG4372
COG494271-368  EnvC
pfam13514230-392  AAA_27
TIGR02168209-403  SMC_prok_B
TIGR0161285-314  235kDa-fam
PRK0391892-377  PRK03918
TIGR02169141-342  SMC_prok_A
COG041978-387  SbcC
pfam12128138-373  DUF3584
COG1579185-381  COG1579
PHA02562232-410  46
COG5283229-410  COG5283
COG041979-389  SbcC
COG0419147-403  SbcC
pfam01576126-357  Myosin_tail_1
COG1196228-414  Smc
pfam10186275-376  Atg14
pfam05557119-415  MAD
TIGR01843194-370  type_I_hlyD


Ontology Information


   
HPRD ID2514
Molecular ClassStructural protein
Molecular FunctionProtein-tyrosine kinase activity (GO:0004713)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P05787DB00031TenecteplaseBiotechDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
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