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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
LAMA2 3908 laminin, alpha 2  6- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22038115   2012Cell line : -

Source : -

Sample Type : CRC tumor and adjecent normal tissue

No. of Sample : 134

Stage : -

PyrosequencingMethylation-GABRA1 and LAMA2, may have roles in colorectal tumorigenesis and could be potential biomarkers for the screening and the detection of colorectal cancer in clinical practice.


Gene Details



NC_000006.11 (129204286..129837711)

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Gene Type protein coding
Gene Family Laminins
Description Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008]  
Chromosome 6
Location 6q22-q23
Start 129204286  
End 129837711  
Strand +  
Gene Sequence

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Length 633426  
OMIM ID 156225   
HGNC ID HGNC:6482   
Unigene ID Hs.200841   
Ensembl ID ENSG00000196569   
PharmGKB ID PA30271   

mRNA Information


mRNA ID XM_005266981.2
Exon join(1..217,166778..166948,176644..176756,215033..215275, 260761..260940,263819..263908,265839..265956, 271365..271543,282436..282535,294566..294726, 307065..307205,309540..309713,366972..367073, 368944..369155,377571..377682,383966..384079, 387484..387611,396921..397007,404707..404918, 408474..408580,409663..409926,414545..414725, 417596..417732,429721..429957,431515..431658, 432336..432515,432622..432810,432898..433031, 437398..437515,445138..445272,459203..459327, 466158..466244,470024..470217,483079..483221, 486752..486850,499982..500093,508351..508513, 509905..510115,518084..518200,519184..519347, 520681..520819,544612..544714,555506..555622, 557676..557858,559923..559928,562527..562681,  
mRNA Sequence

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Length 9960  



CDS Information


   
Location106..9738
CDS Sequence

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CCDS ID CCDS5138.1



Protein Information


      
Protein IDXP_005267038.1
Protein Namelaminin, alpha 2
Molecular Wt. (Da)363035
Protein Sequence

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Length 3210  
Uniprot IDP43405
Ensembl Protein ID ENSP00000364898  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation1249
KAcetylation1756
KAcetylation1756
SPhosphorylation1358
TPhosphorylation1369
SPhosphorylation1358
TPhosphorylation1369

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1605DAG1546NP_004384.3in vitro;in vivo792   594   116   709   410   
3921RPSA1038NP_002286.2in vitro11054877   


Pathway Information


                                                                  
Pathway Name Pathway ID
Amoebiasis hsa05146
Arrhythmogenic right ventricular cardiomyopathy (ARVC) hsa05412
Dilated cardiomyopathy hsa05414
ECM-receptor interaction hsa04512
Focal adhesion hsa04510
Hypertrophic cardiomyopathy (HCM) hsa05410
Pathways in cancer hsa05200
PI3K-Akt signaling pathway hsa04151
Small cell lung cancer hsa05222
Toxoplasmosis hsa05145
Viral myocarditis hsa05416


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd001102766-2915  LamG
cl228612766-2915  LamG superfamily
cd001102941-3093  LamG
cl228612941-3093  LamG superfamily
cd001102340-2501  LamG
cl228612340-2501  LamG superfamily
cd001102528-2690  LamG
cl228612528-2690  LamG superfamily
cd001102150-2309  LamG
cl228612150-2309  LamG superfamily
cd00055917-965  EGF_Lam
cl22875917-965  EGF_Lam superfamily
cd00055966-1012  EGF_Lam
cl22875966-1012  EGF_Lam superfamily
cd00055864-916  EGF_Lam
cl22875864-916  EGF_Lam superfamily
cd00055756-805  EGF_Lam
cl22875756-805  EGF_Lam superfamily
cd000551527-1574  EGF_Lam
cl228751527-1574  EGF_Lam superfamily
cd000551419-1467  EGF_Lam
cl228751419-1467  EGF_Lam superfamily
cd000551059-1101  EGF_Lam
cl228751059-1101  EGF_Lam superfamily
cd000551106-1163  EGF_Lam
cl228751106-1163  EGF_Lam superfamily
cd000551013-1058  EGF_Lam
cl228751013-1058  EGF_Lam superfamily
cd00055413-465  EGF_Lam
cl22875413-465  EGF_Lam superfamily
cd00055287-334  EGF_Lam
cl22875287-334  EGF_Lam superfamily
cd00055806-863  EGF_Lam
cl22875806-863  EGF_Lam superfamily
cd00055468-515  EGF_Lam
cl22875468-515  EGF_Lam superfamily
cd000551469-1525  EGF_Lam
cl228751469-1525  EGF_Lam superfamily
pfam0005539-285  Laminin_N
cl0280639-285  Laminin_N superfamily
smart0013637-285  LamNT
pfam060092037-2173  Laminin_II
cl055152037-2173  Laminin_II superfamily
smart002811229-1364  LamB
cl025481229-1364  Laminin_B superfamily
pfam000542793-2921  Laminin_G_1
smart00281578-710  LamB
cl02548578-710  Laminin_B superfamily
pfam000542368-2507  Laminin_G_1
pfam000542174-2314  Laminin_G_1
smart002822788-2915  LamG
pfam000542554-2695  Laminin_G_1
pfam000521234-1378  Laminin_B
smart002822964-3093  LamG
smart002822363-2503  LamG
pfam022102793-2915  Laminin_G_2
smart002822169-2311  LamG
smart002822549-2692  LamG
pfam022102368-2501  Laminin_G_2
pfam022102968-3093  Laminin_G_2
pfam000542968-3102  Laminin_G_1
pfam00052583-722  Laminin_B
pfam022102554-2692  Laminin_G_2
pfam022102174-2311  Laminin_G_2
smart00180967-1011  EGF_Lam
smart00180918-964  EGF_Lam
pfam00053918-964  Laminin_EGF
pfam00053967-1014  Laminin_EGF
pfam000531420-1466  Laminin_EGF
pfam000531060-1108  Laminin_EGF
smart001801527-1570  EGF_Lam
pfam000531106-1163  Laminin_EGF
smart001801106-1163  EGF_Lam
smart001801014-1057  EGF_Lam
smart00180865-908  EGF_Lam
pfam000531527-1562  Laminin_EGF
pfam000531014-1057  Laminin_EGF
smart001801060-1101  EGF_Lam
pfam00053469-515  Laminin_EGF
pfam00053757-797  Laminin_EGF
pfam00053414-471  Laminin_EGF
pfam00053865-918  Laminin_EGF
cd001761684-1885  SPEC
cl024881684-1885  SPEC superfamily
smart00180757-799  EGF_Lam
smart00180414-466  EGF_Lam
smart001801420-1466  EGF_Lam
pfam00053807-862  Laminin_EGF
pfam127181640-1780  Tropomyosin_1
cl228571640-1780  Tropomyosin_1 superfamily
smart00180469-515  EGF_Lam
pfam000531469-1524  Laminin_EGF
pfam127181731-1885  Tropomyosin_1
smart00180807-855  EGF_Lam
cd089151971-2133  V_Alix_like
cl146541971-2133  V_Alix_like superfamily
COG37931654-1777  TerB
cl119651654-1777  terB_like superfamily
pfam074641673-1800  ApoLp-III
cl215091673-1800  ApoLp-III_like superfamily
COG47681808-1908  COG4768
cl019721808-1908  DUF948 superfamily
COG13821814-1909  GimC
cl091111814-1909  Prefoldin superfamily
pfam128892029-2171  DUF3829
cl204752029-2171  DUF3829 superfamily
pfam101531682-1780  DUF2361
cl108501682-1780  DUF2361 superfamily
smart001801469-1520  EGF_Lam
cd13416785-919  TNFRSF16
cl22855785-919  TNFRSF superfamily
smart00180306-330  EGF_Lam
pfam103681790-1946  YkyA
PHA025571691-1901  22
cl201731691-1901  22 superfamily
pfam019201807-1900  Prefoldin_2
pfam047401867-2095  LXG
cl199571867-2095  LXG superfamily
cd006321814-1901  Prefoldin_beta
pfam103681667-1845  YkyA
pfam123251712-1799  TMF_TATA_bd
cl224381712-1799  TMF_TATA_bd superfamily
pfam133852994-3093  Laminin_G_3
cd13406886-973  TNFRSF4
cl22855886-973  TNFRSF superfamily
pfam127181775-1946  Tropomyosin_1
cd134371826-1900  SPFH_alloslipin
cl191071826-1900  SPFH_like superfamily
pfam127291667-1783  4HB_MCP_1
cl001441667-1783  Tar_Tsr_LBD superfamily
cd075961926-2141  BAR_SNX
cl120131926-2141  BAR superfamily
cd10583823-929  TNFRSF21
pfam060081588-1853  Laminin_I
pfam139491790-2085  ALIX_LYPXL_bnd
COG04191577-2178  SbcC
TIGR045231675-2164  Mplasa_alph_rch
TIGR045231669-2164  Mplasa_alph_rch
PRK039181636-2145  PRK03918
COG11961662-2164  Smc
COG04191653-2145  SbcC
TIGR045231668-2145  Mplasa_alph_rch
COG11961612-2145  Smc
COG11961746-2141  Smc
TIGR021681630-2150  SMC_prok_B
pfam015761630-2124  Myosin_tail_1
PRK022241650-2141  PRK02224
COG11961612-2145  Smc
pfam015761646-2121  Myosin_tail_1
TIGR045231612-2137  Mplasa_alph_rch
PRK011561670-2228  PRK01156
TIGR021691640-2167  SMC_prok_A
TIGR021691717-2207  SMC_prok_A
pfam024631630-2165  SMC_N
PTZ004401656-2184  PTZ00440
COG13401740-2005  COG1340
PRK022241635-2133  PRK02224
COG11961612-1980  Smc
TIGR021681733-2140  SMC_prok_B
TIGR021681718-2077  SMC_prok_B
COG11961810-2150  Smc
COG15111746-2146  YhgE
TIGR021681617-1946  SMC_prok_B
PRK022241640-2133  PRK02224
pfam061601740-2112  EzrA
pfam054831613-2179  SCP-1
TIGR021681706-2207  SMC_prok_B
pfam024631680-2164  SMC_N
TIGR021691813-2148  SMC_prok_A
TIGR021691618-2164  SMC_prok_A
PTZ004401639-2143  PTZ00440
TIGR021691612-1964  SMC_prok_A
PTZ004401630-2181  PTZ00440
TIGR016121713-2168  235kDa-fam
TIGR016121669-2145  235kDa-fam
pfam055571710-2149  MAD
PTZ001211684-2140  PTZ00121
pfam101741607-2114  Cast
PRK011561682-2149  PRK01156
PRK039181782-2145  PRK03918
pfam055571649-2159  MAD
PRK047781740-2112  PRK04778
COG11961612-1912  Smc
pfam101741644-2140  Cast
PTZ004401680-2176  PTZ00440
TIGR021691680-2064  SMC_prok_A
TIGR016121637-2170  235kDa-fam
pfam061601717-2145  EzrA
TIGR006061612-2140  rad50
pfam056671647-1917  DUF812
TIGR045231609-1883  Mplasa_alph_rch
pfam007691766-1992  ERM
PTZ004401647-2153  PTZ00440
PRK039181612-1888  PRK03918
pfam154501720-2144  DUF4631
pfam121281641-2141  DUF3584
COG13401676-1975  COG1340
TIGR021691712-2080  SMC_prok_A
PTZ001211648-2148  PTZ00121
pfam131661731-2182  AAA_13
COG08401630-1886  Tar
pfam057011682-2060  WEMBL
pfam135141683-2141  AAA_27
PTZ001211684-2052  PTZ00121
pfam015761822-2143  Myosin_tail_1
pfam131661711-2036  AAA_13
COG13401630-1835  COG1340
TIGR006061610-2141  rad50
TIGR016121676-2162  235kDa-fam
pfam056221630-2123  HOOK
PTZ004401645-2175  PTZ00440
TIGR016121612-2148  235kDa-fam
PRK047781717-2145  PRK04778
COG52831780-2132  COG5283
pfam002611682-1897  Tropomyosin
pfam101741714-2164  Cast
pfam135141630-2118  AAA_27
PTZ004401700-2185  PTZ00440
COG38831815-2054  CwlO1
pfam054831612-2145  SCP-1
TIGR006061717-2183  rad50
COG52831633-2144  COG5283
PRK047781607-1843  PRK04778
TIGR006061613-1849  rad50
COG44771588-1947  EzrA
COG13401623-1776  COG1340
PTZ001211649-1948  PTZ00121
pfam054831577-1906  SCP-1
pfam097551624-1915  DUF2046
COG08401887-2142  Tar
TIGR045231976-2164  Mplasa_alph_rch
pfam057011641-1954  WEMBL
pfam061601639-1849  EzrA
pfam139491714-2000  ALIX_LYPXL_bnd
smart002831826-2078  MA
TIGR016121680-2148  235kDa-fam
PRK022241630-1823  PRK02224
COG50221666-2134  COG5022
COG44771717-2145  EzrA
COG51851612-1879  HEC1
pfam039991600-1895  MAP65_ASE1
pfam015401818-2119  Lipoprotein_7
pfam138681646-1902  Trichoplein
COG08401763-2148  Tar
pfam015401713-1929  Lipoprotein_7
COG08401630-1990  Tar
PRK011561631-1938  PRK01156
TIGR006061646-2148  rad50
TIGR021681612-1806  SMC_prok_B
COG08401852-2153  Tar
PHA025621795-1999  46
pfam156191682-1834  Lebercilin
COG18421605-1799  PspA
smart002831639-1892  MA
COG15791713-1894  COG1579
COG38831737-1956  CwlO1
pfam014421680-1888  Apolipoprotein
COG15111628-2068  YhgE
COG06101681-1804  COG0610
COG43721613-1749  COG4372
COG51851612-1948  HEC1
TIGR045231979-2136  Mplasa_alph_rch
pfam057011808-2150  WEMBL
TIGR031851627-1899  DNA_S_dndD
PRK011561672-1889  PRK01156
pfam097281684-1849  Taxilin
TIGR006181570-1897  sbcc
pfam121281670-1879  DUF3584
smart007871727-1883  Spc7
pfam007691662-1892  ERM
COG14632006-2164  MlaD
pfam083171711-1862  Spc7
PRK127041728-1953  PRK12704
COG15791630-1799  COG1579
pfam048491682-1915  HAP1_N
pfam079261766-1878  TPR_MLP1_2
pfam083172033-2163  Spc7
pfam070831713-1918  DUF1351
COG06101670-1993  COG0610
pfam015761615-1851  Myosin_tail_1
PRK056581646-1899  PRK05658
pfam041111714-1852  APG6
PRK004091720-1890  PRK00409
pfam138511717-1916  GAS
PRK048631691-2134  mukB
pfam079261636-1785  TPR_MLP1_2
pfam131661672-2052  AAA_13
PRK047781719-1892  PRK04778
COG47171608-1944  YhaN
COG13401979-2145  COG1340
COG04971763-1956  RecN
COG13901718-1857  NtpE
pfam046151683-1992  Utp14
COG18421717-1822  PspA
pfam097311641-1899  Mitofilin
pfam079262032-2144  TPR_MLP1_2
COG07111790-1941  AtpF
COG07111676-1797  AtpF
COG28111811-1897  NtpH
COG07111651-1760  AtpF
COG44871633-1829  COG4487
pfam138681662-1870  Trichoplein
COG13901682-1840  NtpE
pfam138631760-1894  DUF4200
PHA025621825-2073  46
pfam041111680-1816  APG6
COG12931666-1819  YloA
pfam083171789-1955  Spc7
pfam054781859-2104  Prominin
pfam06873876-1128  SerH
PRK002901797-1912  dnaK
pfam120721674-1757  DUF3552
pfam041561711-1828  IncA
COG15611712-1900  YicC
pfam142651718-1825  DUF4355
TIGR045271825-1940  mycoplas_twoTM
PTZ00214766-1134  PTZ00214


Ontology Information


   
HPRD ID1207
Molecular ClassExtracellular matrix protein
Molecular FunctionG-protein coupled receptor activity (GO:0004930)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO