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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
LAMA4 3910 laminin, alpha 4  6LAMA3 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25257191   2015Cell line : -

Source : Korean

Sample Type : CRC Tumor

No. of Sample : 139

Stage : TNM stage I-IV

SSCP, DNA sequencing,ImmunohistochemistryMutation--


Gene Details



NC_000006.11 (112429134..112575924, complement)

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Gene Type protein coding
Gene Family Laminins
Description Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost. Laminin, alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and gamma chains. The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific utilization of alternative polyA-signal has been described in literature. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]  
Chromosome 6
Location 6q21
Start 112429134  
End 112575924  
Strand -  
Gene Sequence

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Length 146791  
OMIM ID 600133   
HGNC ID HGNC:6484   
Unigene ID Hs.654572   
Ensembl ID ENSG00000112769   
PharmGKB ID PA30273   

mRNA Information


mRNA ID NM_002290.4
Exon join(8..264,432..767,38254..38355,47578..47702, 53035..53115,62873..63087,65518..65592,67122..67273, 69376..69486,76491..76602,79243..79410,81919..82112, 89447..89563,95843..95991,99017..99158,99776..99872, 104096..104212,106387..106566,109790..109929, 112431..112604,113220..113365,113801..113963, 114838..114971,115432..115603,118469..118600, 120114..120256,121236..121374,121833..121970, 123622..123755,124683..124847,125648..125801, 132522..132709,134251..134440,135412..135567, 136825..136984,138730..138860,139967..140060, 140528..140647,145141..146792)  
mRNA Sequence

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Length 7355  



CDS Information


   
Location 399..5849
CDS Sequence

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CCDS ID CCDS34514.1



Protein Information


      
Protein IDNP_002281.3
Protein Namelaminin, alpha 4
Molecular Wt. (Da)0
Protein Sequence

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Length 1816  
Uniprot IDP21452
Ensembl Protein ID ENSP00000362403  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation1586

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                        
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
9094UNC1194927NP_005139.1yeast 2-hybrid16169070   
10980COPS616735NP_006824.2yeast 2-hybrid16169070   
11244ZHX110379NP_009153.3yeast 2-hybrid16169070   
29117BRD712531AAF19526.1yeast 2-hybrid16169070   
51003MED3114382NP_057144.1yeast 2-hybrid16169070   
55729ATF7IP9811NP_060649.3yeast 2-hybrid15231748   
55791C1orf10317975NP_060842.3yeast 2-hybrid16169070   
197131UBR19342NP_777576.1yeast 2-hybrid16169070   


Pathway Information


                                                
Pathway Name Pathway ID
African trypanosomiasis hsa05143
Amoebiasis hsa05146
ECM-receptor interaction hsa04512
Focal adhesion hsa04510
Pathways in cancer hsa05200
PI3K-Akt signaling pathway hsa04151
Small cell lung cancer hsa05222
Toxoplasmosis hsa05145


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd001101492-1624  LamG
cl228611492-1624  LamG superfamily
cd001101648-1799  LamG
cl228611648-1799  LamG superfamily
cd001101049-1207  LamG
cl228611049-1207  LamG superfamily
cd001101237-1376  LamG
cl228611237-1376  LamG superfamily
cd00110835-1012  LamG
cl22861835-1012  LamG superfamily
cd00055187-238  EGF_Lam
cl22875187-238  EGF_Lam superfamily
cd00055131-185  EGF_Lam
cl22875131-185  EGF_Lam superfamily
cd0005581-130  EGF_Lam
cl2287581-130  EGF_Lam superfamily
pfam06009734-861  Laminin_II
cl05515734-861  Laminin_II superfamily
smart002821494-1625  LamG
pfam022101499-1625  Laminin_G_2
smart002821671-1801  LamG
pfam022101676-1801  Laminin_G_2
pfam000541500-1628  Laminin_G_1
smart002821074-1210  LamG
pfam022101079-1207  Laminin_G_2
smart00282860-1013  LamG
pfam000541676-1803  Laminin_G_1
pfam022101263-1376  Laminin_G_2
smart002821261-1379  LamG
pfam00053187-233  Laminin_EGF
pfam02210875-1013  Laminin_G_2
smart00180187-231  EGF_Lam
pfam000541079-1203  Laminin_G_1
pfam00053132-184  Laminin_EGF
smart00180132-177  EGF_Lam
cd1341665-257  TNFRSF16
cl2285565-257  TNFRSF superfamily
pfam0005382-129  Laminin_EGF
smart0018082-121  EGF_Lam
cd00176339-531  SPEC
cl02488339-531  SPEC superfamily
cd13769710-836  ApoLp-III_like
cl21509710-836  ApoLp-III_like superfamily
pfam000541263-1376  Laminin_G_1
pfam00054882-1013  Laminin_G_1
pfam133851650-1798  Laminin_G_3
PRK03947510-609  PRK03947
cl09111510-609  Prefoldin superfamily
cd10579112-252  TNFRSF6
cd13423157-249  TNFRSF6_teleost
cl22855157-249  TNFRSF superfamily
smart002101670-1798  TSPN
pfam06008296-555  Laminin_I
pfam06008526-751  Laminin_I
TIGR02168276-672  SMC_prok_B
COG1196321-656  Smc
pfam05483322-723  SCP-1
COG1196318-621  Smc
TIGR02168279-866  SMC_prok_B
PRK02224347-821  PRK02224
TIGR02168321-647  SMC_prok_B
COG1196407-752  Smc
COG4477338-677  EzrA
PRK02224305-669  PRK02224
COG1196311-833  Smc
COG0419321-733  SbcC
COG1196280-608  Smc
COG1196305-583  Smc
pfam10174306-806  Cast
COG0419321-670  SbcC
COG1196296-609  Smc
PRK04778321-677  PRK04778
TIGR04523313-674  Mplasa_alph_rch
pfam12128312-832  DUF3584
TIGR02169309-573  SMC_prok_A
TIGR00606314-574  rad50
TIGR00618313-718  sbcc
PRK04863440-821  mukB
pfam12128407-833  DUF3584
TIGR02169309-579  SMC_prok_A
pfam0330265-265  VSP
PTZ00121320-608  PTZ00121
pfam06160338-677  EzrA
TIGR02169477-806  SMC_prok_A
COG1196311-751  Smc
pfam00529675-857  HlyD
TIGR01612321-678  235kDa-fam
TIGR01612521-764  235kDa-fam
COG4372545-844  COG4372
TIGR02169321-611  SMC_prok_A
pfam03207480-693  OspD
pfam01576325-724  Myosin_tail_1
PRK03918313-579  PRK03918
COG1340426-724  COG1340
pfam01576309-757  Myosin_tail_1
pfam01576500-801  Myosin_tail_1
pfam10174408-833  Cast
COG1340324-608  COG1340
pfam01576486-819  Myosin_tail_1
PRK01156311-725  PRK01156
TIGR02169313-575  SMC_prok_A
PHA02562476-679  46
TIGR02169322-511  SMC_prok_A
pfam07888371-689  CALCOCO1
pfam14662448-605  CCDC155
pfam05622358-612  HOOK
pfam13868311-527  Trichoplein
TIGR02169312-507  SMC_prok_A
TIGR02956474-804  TMAO_torS
COG0419414-836  SbcC
COG0497315-609  RecN
TIGR01843314-495  type_I_hlyD
PRK01156312-678  PRK01156


Ontology Information


   
HPRD ID2891
Molecular ClassAdhesion molecule
Molecular FunctionCytoskeletal protein binding (GO:0008092)
Biological ProcessMuscle development (GO:0007517)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO