Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
LAMC3 10319 laminin, gamma 3  9DKFZp434E202 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23585368   2013Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 50

Stage : -

Whole exome analysis, Mutation-Somatic mutations in the corresponding genes in the CRCs of the patients harboring the germline lesions and found biallelic inactivation of FANCM, LAMB4, PTCHD3, LAMC3, and TREX2, potentially implicating these genes as tumor suppressors.


Gene Details



NC_000009.11 (133884504..133968446)

View Larger Image
   
Gene Type protein coding
Gene Family Laminins
Description Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 3. The gamma 3 chain is most similar to the gamma 1 chain, and contains all the 6 domains expected of the gamma chain. It is a component of laminin 12. The gamma 3 chain is broadly expressed in skin, heart, lung, and the reproductive tracts. In skin, it is seen within the basement membrane of the dermal-epidermal junction at points of nerve penetration. Gamma 3 is also a prominent element of the apical surface of ciliated epithelial cells of lung, oviduct, epididymis, ductus deferens, and seminiferous tubules. The distribution of gamma 3-containing laminins along ciliated epithelial surfaces suggests that the apical laminins are important in the morphogenesis and structural stability of the ciliated processes of these cells. [provided by RefSeq, Aug 2011]  
Chromosome 9
Location 9q31-q34
Start 133884504  
End 133968446  
Strand +  
Gene Sequence

   Download   Select all

Length 83943  
OMIM ID 604349   
HGNC ID HGNC:6494   
Unigene ID Hs.201805   
Ensembl ID ENSG00000050555   
PharmGKB ID PA30282   

mRNA Information


mRNA ID ?NM_006059.3
Exon  
mRNA Sequence

   Download   Select all

Length  



CDS Information


   
Location
CDS Sequence

   Download   Select all

CCDS ID CCDS6938.1



Protein Information


      
Protein IDNP_006050.3
Protein Namelaminin, gamma 3
Molecular Wt. (Da)0
Protein Sequence

   Download   Select all

Length 1575  
Uniprot IDQ9C075
Ensembl Protein ID ENSP00000209718  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


                                          
Pathway Name Pathway ID
Amoebiasis hsa05146
ECM-receptor interaction hsa04512
Focal adhesion hsa04510
Pathways in cancer hsa05200
PI3K-Akt signaling pathway hsa04151
Small cell lung cancer hsa05222
Toxoplasmosis hsa05145


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00055916-961  EGF_Lam
cl22875916-961  EGF_Lam superfamily
cd00055706-753  EGF_Lam
cl22875706-753  EGF_Lam superfamily
cd00055865-915  EGF_Lam
cl22875865-915  EGF_Lam superfamily
cd00055429-477  EGF_Lam
cl22875429-477  EGF_Lam superfamily
cd00055382-428  EGF_Lam
cl22875382-428  EGF_Lam superfamily
cd00055810-857  EGF_Lam
cl22875810-857  EGF_Lam superfamily
cd00055964-1011  EGF_Lam
cl22875964-1011  EGF_Lam superfamily
cd00055270-317  EGF_Lam
cl22875270-317  EGF_Lam superfamily
cd00055754-802  EGF_Lam
cl22875754-802  EGF_Lam superfamily
cd00055326-377  EGF_Lam
cl22875326-377  EGF_Lam superfamily
smart0013629-269  LamNT
cl0280629-269  Laminin_N superfamily
pfam0005535-269  Laminin_N
pfam00052542-671  Laminin_B
cl02548542-671  Laminin_B superfamily
smart00180917-962  EGF_Lam
pfam00053917-965  Laminin_EGF
smart00281542-661  LamB
pfam00053430-477  Laminin_EGF
pfam00053866-914  Laminin_EGF
pfam00053707-744  Laminin_EGF
smart00180866-914  EGF_Lam
smart00180707-747  EGF_Lam
smart00180430-472  EGF_Lam
pfam00053810-857  Laminin_EGF
pfam00053383-430  Laminin_EGF
smart00180383-427  EGF_Lam
pfam00053965-1002  Laminin_EGF
smart00180810-853  EGF_Lam
smart00180965-1002  EGF_Lam
pfam00053271-313  Laminin_EGF
PRK073531392-1492  PRK07353
cl214781392-1492  Mt_ATP-synt_B superfamily
pfam00053327-383  Laminin_EGF
cd10575684-777  TNFRSF6B
cl22855684-777  TNFRSF superfamily
PRK144751354-1447  PRK14475
TIGR024731415-1492  flagell_FliJ
cl214771415-1492  FliJ superfamily
cd13407681-756  TNFRSF5
pfam00053755-799  Laminin_EGF
COG28821415-1492  FliJ
cd13406824-915  TNFRSF4
cl22855824-915  TNFRSF superfamily
smart00180271-308  EGF_Lam
smart00180348-376  EGF_Lam
pfam040121191-1420  PspA_IM30
pfam146621338-1518  CCDC155
pfam135141022-1516  AAA_27
pfam135141083-1504  AAA_27
PRK048631200-1520  mukB
TIGR006181151-1562  sbcc
COG52811172-1518  COG5281
pfam121281050-1491  DUF3584
TIGR021681264-1564  SMC_prok_B
TIGR021681078-1503  SMC_prok_B
COG30961200-1520  MukB
pfam071111073-1520  HCR
TIGR021681074-1364  SMC_prok_B
COG11961302-1571  Smc
PRK022241193-1569  PRK02224
PRK022241086-1516  PRK02224
TIGR026801056-1516  TIGR02680
TIGR006181072-1516  sbcc
TIGR021681199-1485  SMC_prok_B
COG49421349-1573  EnvC
PRK022241070-1570  PRK02224
COG49421072-1331  EnvC
COG49131272-1501  COG4913
TIGR021681083-1489  SMC_prok_B
COG11961074-1570  Smc
COG04191074-1562  SbcC
TIGR021681074-1567  SMC_prok_B
COG43721230-1470  COG4372
TIGR021691083-1502  SMC_prok_A
COG18421401-1504  PspA
COG11961082-1492  Smc
COG43721097-1451  COG4372
TIGR021681257-1519  SMC_prok_B
pfam057011284-1509  WEMBL
PTZ001211261-1459  PTZ00121
pfam015761198-1516  Myosin_tail_1
TIGR021681395-1570  SMC_prok_B
TIGR027941225-1476  tolA_full
COG11961195-1491  Smc
COG11961257-1519  Smc
pfam101741074-1516  Cast
COG04191072-1498  SbcC
PRK048631194-1486  mukB
COG22681353-1519  YqiK
COG32061293-1516  GumC
COG07111400-1491  AtpF
COG11961261-1564  Smc
TIGR006181089-1493  sbcc
pfam121281278-1526  DUF3584
COG04191077-1495  SbcC
COG15381156-1520  TolC
TIGR021691355-1562  SMC_prok_A
COG07111348-1495  AtpF
pfam053001348-1480  DUF737
pfam007691359-1490  ERM
pfam101741064-1575  Cast
pfam101741139-1565  Cast
pfam120721360-1514  DUF3552
pfam015761271-1520  Myosin_tail_1
pfam004301399-1490  ATP-synt_B
pfam005291350-1520  HlyD
TIGR026801205-1514  TIGR02680
COG30641259-1462  TolA
COG24251409-1491  ViaA
PRK109291212-1509  PRK10929
TIGR026801168-1565  TIGR02680
pfam060081358-1528  Laminin_I
COG11961106-1497  Smc
TIGR033191378-1509  RNase_Y
pfam004301372-1447  ATP-synt_B
COG08451172-1388  AcrA
COG43721331-1519  COG4372
TIGR026801216-1516  TIGR02680
PRK102461202-1522  PRK10246
PRK050351208-1412  PRK05035
COG08451371-1519  AcrA
TIGR021691399-1567  SMC_prok_A
COG32641371-1518  MscK


Ontology Information


   
HPRD ID10828
Molecular ClassStructural protein
Molecular FunctionDNA binding (GO:0003677)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO